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[192778_at] proteasome component C3

Description D1054.2 /REP_DB=WormBase Gene ID /WP=CE05521 /GEN=pas-2 /TR=SW:Q27488 /GB=CAA98441.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=proteasome component C3
Cluster 6grp_highest_10_10 > 17      6grp_high1_10_10 > 71      4grp_highest_8_8 > 10      4grp_high_8_8 > 54      6grp_highest_nonorm > 46      6grp_total > 70      4grp_total > 57      6grp_highest_sub > 04      6grp_cgc > 85      6grp_high1_sub > 04      6grp_cgc_sub > 04      6grp_total_sub > Hat      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 2596
1 2 3 4 range
A 2348.2
(-2.2)
P 		3642
(1.1)
P 		4358
(3)
P 		2044.5
(-3)
P 		2314
B 2697
(-1.8)
P 		3765.4
(1)
P 		4532.5
(3)
P 		2214.2
(-3)
P 		2318
C 2338.1
(-1.9)
P 		3884
(2.4)
P 		4113.1
(3)
P 		1936.9
(-3)
P 		2176
avr 2461.1
(-2) 		3763.8
(1.5) 		4334.5
(3) 		2065.2
(-3) 		2269

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 2021
1 2 3 4 5 6 range
A 3094.7
(0.4)
P 		2605.5
(-1.9)
P 		3671.4
(3)
P 		3430.3
(1.9)
P 		2768.3
(-1.1)
P 		2361.4
(-3)
P 		1310
B 2807.5
(-2.6)
P 		2955.8
(-1.6)
P 		2755.9
(-3)
P 		3619
(3)
P 		3371.1
(1.3)
P 		2770.9
(-2.9)
P 		863
C 2803.8
(-2.8)
P 		2950.2
(-2.3)
P 		3528.3
(-0.2)
P 		4382.1
(3)
P 		2779.1
(-2.9)
P 		2759.5
(-3)
P 		1623
avr 2902
(-1.6) 		2837.2
(-1.9) 		3318.5
(0.5) 		3810.5
(3) 		2972.8
(-1.3) 		2630.6
(-3) 		1180
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1134
1 2 3 4 range
A 855
(1)
P 		790.6
(0.5)
P 		1139.3
(3)
P 		299.3
(-3)
P 		840
B 860
(1)
P 		930
(1.8)
P 		1050.3
(3)
P 		471.8
(-3)
P 		579
C 774
(-0.6)
P 		1116.7
(1.3)
P 		1433.5
(3)
P 		326.6
(-3)
P 		1107
avr 829.7
(0.3) 		945.8
(1.1) 		1207.7
(3) 		365.9
(-3) 		842

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 799
1 2 3 4 5 6 range
A 570.5
(-3)
P 		926.6
(3)
P 		799.5
(0.9)
P 		870
(2)
P 		835.3
(1.5)
P 		574.9
(-2.9)
P 		356
B 976.9
(-0.4)
P 		983.9
(-0.3)
P 		669.2
(-3)
P 		958.6
(-0.5)
P 		1369.6
(3)
P 		1033.3
(0.1)
P 		700
C 1039.2
(3)
P 		900.2
(-2.3)
P 		898
(-2.4)
P 		881.2
(-3)
P 		899.3
(-2.3)
P 		923.8
(-1.4)
P 		158
avr 862.2
(-1.2) 		936.9
(0.6) 		788.9
(-3) 		903.3
(-0.2) 		1034.7
(3) 		844
(-1.7) 		246
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192778_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.13958
Sequence Type Exemplar sequence
Representative Public ID D1054.2 NCBI
Target Description D1054.2 /REP_DB=WormBase Gene ID /WP=CE05521 /GEN=pas-2 /TR=SW:Q27488 /GB=CAA98441.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=proteasome component C3
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_073349(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_073349 NCBI Caenorhabditis elegans Proteasome Alpha Subunit family member (pas-2) (pas-2) mRNA, complete cds. 11/11 None
SNAP00000017213 ENSEMBL cdna:SNAP chromosome:CEL140:V:10772967:10773804:1 11/11 None
GENEFINDER00000017242 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:10772967:10773804:1 11/11 None
D1054.2 ENSEMBL cdna:known chromosome:CEL140:V:10772954:10773918:1 gene:D1054.2 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:10772966-10773804(+) 100.0 100.0
Public Domain and Genome References
Gene Title proteasome component C3
Gene Symbol pas-2
Ensembl D1054.2
Entrez Gene 179493 Entrez gene
SwissProt Q27488 EMBL-EBI
WormBase CE05521 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:262716_AT 20S proteasome alpha subunit B (PAB1) (PRC3) at
ATGENOME1:19651_S_AT 20S proteasome alpha subunit B (PAB1) (PRC3) at
CANINE:1588337_AT similar to Proteasome subunit alpha type 2 (Proteasome component C3) (Macropain subunit C3) (Multicatalytic endopeptidase complex subunit C3) cfa
CANINE_2:CFAAFFX.29177.1.S1_S_AT similar to Proteasome subunit alpha type 2 (Proteasome component C3) (Macropain subunit C3) (Multicatalytic endopeptidase complex subunit C3) cfa
CANINE_2:CFAAFFX.6214.1.S1_AT similar to Proteasome subunit alpha type 2 (Proteasome component C3) (Macropain subunit C3) (Multicatalytic endopeptidase complex subunit C3) cfa
DROSOPHILA_2:1635872_AT Proteasome 25kD subunit dm
DROSGENOME1:153303_AT Proteasome 25kD subunit dm
CHICKEN:GGAAFFX.13122.1.S1_AT proteasome (prosome, macropain) subunit, alpha type, 2 gga
CHICKEN:GGAAFFX.13122.1.S1_S_AT proteasome (prosome, macropain) subunit, alpha type, 2 gga
HG-U133_PLUS_2:201317_S_AT proteasome (prosome, macropain) subunit, alpha type, 2 hs
HG-U133A:201317_S_AT proteasome (prosome, macropain) subunit, alpha type, 2 hs
HG-U133A_2:201317_S_AT proteasome (prosome, macropain) subunit, alpha type, 2 hs
HG-FOCUS:201317_S_AT proteasome (prosome, macropain) subunit, alpha type, 2 hs
HG-U95AV2:1446_AT proteasome (prosome, macropain) subunit, alpha type, 2 hs
HC-G110:1446_AT proteasome (prosome, macropain) subunit, alpha type, 2 hs
HUGENEFL:D00760_AT proteasome (prosome, macropain) subunit, alpha type, 2 hs
HG-U133A_2:201316_AT proteasome (prosome, macropain) subunit, alpha type, 2 hs
HG-U133_PLUS_2:201316_AT proteasome (prosome, macropain) subunit, alpha type, 2 hs
HG-U133A:201316_AT proteasome (prosome, macropain) subunit, alpha type, 2 hs
HU35KSUBA:HUM_ALU_AT proteasome (prosome, macropain) subunit, alpha type, 2 hs
HU35KSUBB:HUM_ALU_AT proteasome (prosome, macropain) subunit, alpha type, 2 hs
HU35KSUBC:HUM_ALU_AT proteasome (prosome, macropain) subunit, alpha type, 2 hs
HU35KSUBD:HUM_ALU_AT proteasome (prosome, macropain) subunit, alpha type, 2 hs
HUGENEFL:HUM_ALU_AT proteasome (prosome, macropain) subunit, alpha type, 2 hs
HC-G110:HUM_ALU_AT proteasome (prosome, macropain) subunit, alpha type, 2 hs
HU35KSUBB:RC_AA083382_AT proteasome (prosome, macropain) subunit, alpha type, 2 hs
U133_X3P:G4506180_3P_A_AT proteasome (prosome, macropain) subunit, alpha type, 2 hs
U133_X3P:HS.181309.0.S2_3P_AT proteasome (prosome, macropain) subunit, alpha type, 2 hs
HG-U95AV2:41240_AT proteasome (prosome, macropain) subunit, alpha type, 2 hs
MOE430A:1448206_AT proteasome (prosome, macropain) subunit, alpha type 2 mm
MOUSE430A_2:1448206_AT proteasome (prosome, macropain) subunit, alpha type 2 mm
MOUSE430_2:1448206_AT proteasome (prosome, macropain) subunit, alpha type 2 mm
MU11KSUBB:X70303_F_AT proteasome (prosome, macropain) subunit, alpha type 2 mm
MU11KSUBB:MSA.2441.0_F_AT proteasome (prosome, macropain) subunit, alpha type 2 mm
MG-U74AV2:100733_AT proteasome (prosome, macropain) subunit, alpha type 2 mm
MU19KSUBA:TC18483_F_AT Proteasome (prosome, macropain) subunit, alpha type 2, mRNA (cDNA clone MGC:25330 IMAGE:3156907) mm
MU19KSUBA:TC18484_F_AT Proteasome (prosome, macropain) subunit, alpha type 2, mRNA (cDNA clone MGC:25330 IMAGE:3156907) mm
RG-U34A:E03358CDS_AT proteasome (prosome, macropain) subunit, alpha type 2 rn
RG-U34A:E03358CDS_G_AT proteasome (prosome, macropain) subunit, alpha type 2 rn
RG-U34A:RC_AI170403_AT proteasome (prosome, macropain) subunit, alpha type 2 rn
RAE230A:1398856_AT proteasome (prosome, macropain) subunit, alpha type 2 rn
RAT230_2:1398856_AT proteasome (prosome, macropain) subunit, alpha type 2 rn
YEAST_2:1775131_AT 20S proteasome beta-type subunit Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6511 ubiquitin-dependent protein catabolism inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5839 proteasome core complex (sensu Eukaryota) inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4175 endopeptidase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA98441 Hypothetical protein D1054.2 [Caenorhabditis elegans] ref|NP_505750.1| Proteasome Alpha Subunit family member (pas-2) [Caenorhabditis elegans] sp|Q27488|PSA2_CAEEL Proteasome subunit alpha type 2 (Proteasome subunit alpha 2) 1.0E-122
blast CAE64887 Hypothetical protein CBG09700 [Caenorhabditis briggsae] 1.0E-119
blast NP_001016382 hypothetical protein LOC549136 [Xenopus tropicalis] gb|AAH72254.1| Psma2 protein [Xenopus laevis] gb|AAB19485.1| proteasome subunit XC3 [Xenopus laevis] sp|P24495|PSA2_XENLA Proteasome subunit alpha type 2 (Proteasome component C3) (Macropain subunit C3) (Multicatalytic endopeptidase complex subunit C3) (xC3) 9.0E-78
Protein Domains
Database ID Description E-Value
Pfam IPR001353 EMBL-EBI Peptidase T1, 20S proteasome 6.4E-69
Sequence
Target Sequence 
>C. ELEGANS:192778_AT
aagacggagtcgttcttgcgaccgagaatgtcggatctgttctcaccgatgaccagccaa
aggtagaacaaatcagcaagcatattggatgcgtctacagtggaatgggaccagacttcc
gtattttggtgaagaaagctcgcaagattgctatggaatacgaaatgatgtacggcgagg
aaatgccaaccattcaacttgtcactgacatcgcggccgtaatgcaggaatatactcaat
ctggtggtgttcgtccgtttggagcatcgcttcttatcgcaggttgggacaaaaatccag
gacggccattgctcttccaatgtgatccatctggagcttacttcgcatggaaagcaacag
cactcgggaaaaacgacgtcaatgcgaaaacattcctcgagaagcgcttcagcgaggccc
tcgagctcgatgatggaattcacactgctcttctgacactgagagaatcgttcgatgttg
gcatgaacgagaacaacgttgaggtggctgtttgtaactcgaccggattccatc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AAGACGGAGTCGTTCTTGCGACCGA 328 143 131 Antisense
GAATGTCGGATCTGTTCTCACCGAT 138 333 156 Antisense
TTCTCACCGATGACCAGCCAAAGGT 415 691 170 Antisense
AATGCCAACCATTCAACTTGTCACT 63 167 312 Antisense
TGACATCGCGGCCGTAATGCAGGAA 670 571 336 Antisense
TCAATCTGGTGGTGTTCGTCCGTTT 237 633 366 Antisense
TCGCTTCTTATCGCAGGTTGGGACA 692 599 397 Antisense
TGCTCTTCCAATGTGATCCATCTGG 409 581 440 Antisense
CATCTGGAGCTTACTTCGCATGGAA 87 213 458 Antisense
CATTCCTCGAGAAGCGCTTCAGCGA 198 217 521 Antisense
GTTTGTAACTCGACCGGATTCCATC 478 451 640 Antisense
Sequence Source Affymetrix Proprietary Database