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[192774_s_at] tRNA synthetases class I (E and Q)

Description Y41E3.4 /REP_DB=WormBase Gene ID /WP=CE18372 /TR=SW:O62431 /GB=CAB08998.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=tRNA synthetases class I (E and Q)
Cluster 6grp_highest_10_10 > 62      6grp_high1_10_10 > 29      4grp_highest_8_8 > 20      4grp_high_8_8 > 31      6grp_highest_nonorm > 66      6grp_total > 16      4grp_total > 32      6grp_highest_sub > Cu      6grp_cgc > 05      6grp_high1_sub > Cu      6grp_cgc_sub > Cu      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 432
1 2 3 4 range
A 2013.8
(-3)
P 		2129.7
(2.6)
P 		2137.9
(3)
P 		2067.6
(-0.4)
P 		124
B 1797.1
(-3)
P 		2118.1
(1.5)
P 		2108
(1.3)
P 		2227.9
(3)
P 		431
C 2013.6
(1)
P 		1796
(-3)
P 		2120.9
(3)
P 		2027.2
(1.3)
P 		325
avr 1941.5
(-3) 		2014.6
(-0.6) 		2122.3
(3) 		2107.6
(2.5) 		181

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 715
1 2 3 4 5 6 range
A 1626.9
(3)
P 		1455.3
(0.8)
P 		1556.3
(2.1)
P 		1164.6
(-3)
P 		1429.8
(0.4)
P 		1339.6
(-0.7)
P 		462
B 1748
(3)
P 		1569.4
(-0.9)
P 		1573.7
(-0.8)
P 		1486.1
(-2.7)
P 		1474.5
(-3)
P 		1522.5
(-1.9)
P 		274
C 1606.9
(3)
P 		1606.3
(3)
P 		1287.8
(-0.3)
P 		1032.9
(-3)
P 		1459.7
(1.5)
P 		1367.9
(0.5)
P 		574
avr 1660.6
(3) 		1543.7
(1.4) 		1472.6
(0.4) 		1227.9
(-3) 		1454.7
(0.1) 		1410
(-0.5) 		433
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 437
1 2 3 4 range
A 733.2
(3)
P 		462.3
(-0.8)
P 		558.9
(0.6)
P 		302.7
(-3)
P 		431
B 573.1
(3)
P 		523.1
(-0.1)
P 		488.5
(-2.2)
P 		474.8
(-3)
P 		98
C 666.6
(1.9)
P 		516.4
(-0.4)
P 		739.2
(3)
P 		341.8
(-3)
P 		397
avr 657.6
(3) 		500.6
(-0.3) 		595.5
(1.7) 		373.1
(-3) 		285

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 401
1 2 3 4 5 6 range
A 299.9
(-2.9)
P 		517.6
(3)
P 		338.9
(-1.8)
P 		295.4
(-3)
P 		431.5
(0.7)
P 		326.2
(-2.2)
P 		222
B 608.2
(3)
P 		522.4
(0.7)
P 		382.2
(-3)
P 		393.6
(-2.7)
P 		599.1
(2.8)
P 		567.7
(1.9)
P 		226
C 595.6
(3)
P 		490.1
(1.4)
P 		327.8
(-1.1)
P 		207.7
(-3)
P 		472.3
(1.1)
P 		457.9
(0.9)
P 		388
avr 501.2
(2.7) 		510
(3) 		349.6
(-1.6) 		298.9
(-3) 		501
(2.7) 		450.6
(1.3) 		211
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 192774_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.9627
Sequence Type Exemplar sequence
Representative Public ID Y41E3.4 NCBI
Target Description Y41E3.4 /REP_DB=WormBase Gene ID /WP=CE18372 /TR=SW:O62431 /GB=CAB08998.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=tRNA synthetases class I (E and Q)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_070411(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_070411 NCBI Caenorhabditis elegans glutamyl(E)/glutaminyl(Q) tRNA Synthetase family member (ers-1) (ers-1) mRNA, complete cds. 11/11 None
SNAP00000001440 ENSEMBL cdna:SNAP chromosome:CEL140:IV:15008592:15013138:-1 11/11 None
GENEFINDER00000001466 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:15008592:15013138:-1 11/11 None
Y41E3.4.2 ENSEMBL cdna:known chromosome:CEL140:IV:15008477:15013448:-1 gene:Y41E3.4 11/11 None
Y41E3.4.1 ENSEMBL cdna:known chromosome:CEL140:IV:15008477:15013145:-1 gene:Y41E3.4 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:15008597-15013144(-) 100.0 100.0
Public Domain and Genome References
Gene Title tRNA synthetases class I (E and Q)
Gene Symbol ers-1
Ensembl Y41E3.4
Entrez Gene 178415 Entrez gene
SwissProt O62431 EMBL-EBI
WormBase CE18372 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:245631_AT glutamine-tRNA ligase, putative / glutaminyl-tRNA synthetase, putative / GlnRS, putative at
CANINE:1606086_AT similar to glutaminyl-tRNA synthetase cfa
CANINE_2:CFA.1325.1.S1_AT similar to glutaminyl-tRNA synthetase cfa
CANINE_2:CFA.1325.1.S1_S_AT similar to glutaminyl-tRNA synthetase cfa
CANINE_2:CFA.18142.1.S1_S_AT similar to glutaminyl-tRNA synthetase cfa
CANINE_2:CFAAFFX.18464.1.S1_AT similar to glutaminyl-tRNA synthetase cfa
DROSOPHILA_2:1640088_AT Glutaminyl-tRNA synthetase dm
DROSGENOME1:152385_AT Glutaminyl-tRNA synthetase dm
HUGENEFL:X76013_AT glutaminyl-tRNA synthetase hs
HG-U133A:217846_AT glutaminyl-tRNA synthetase hs
HG-U133_PLUS_2:217846_AT glutaminyl-tRNA synthetase hs
HG-FOCUS:217846_AT glutaminyl-tRNA synthetase hs
HG-U133A_2:217846_AT glutaminyl-tRNA synthetase hs
U133_X3P:G4826959_3P_AT glutaminyl-tRNA synthetase hs
MU11KSUBA:AA645990_S_AT glutaminyl-tRNA synthetase mm
MU11KSUBB:MSA.42197.0_S_AT glutaminyl-tRNA synthetase mm
MG-U74AV2:94868_AT glutaminyl-tRNA synthetase mm
MOE430A:1423712_A_AT glutaminyl-tRNA synthetase mm
MOUSE430A_2:1423712_A_AT glutaminyl-tRNA synthetase mm
MOUSE430_2:1423712_A_AT glutaminyl-tRNA synthetase mm
MOE430A:1453237_AT glutaminyl-tRNA synthetase mm
MOUSE430A_2:1453237_AT glutaminyl-tRNA synthetase mm
MOUSE430_2:1453237_AT glutaminyl-tRNA synthetase mm
MOE430A:1456213_X_AT glutaminyl-tRNA synthetase mm
MOUSE430A_2:1456213_X_AT glutaminyl-tRNA synthetase mm
MOUSE430_2:1456213_X_AT glutaminyl-tRNA synthetase mm
MOE430A:1456726_X_AT glutaminyl-tRNA synthetase mm
MOUSE430A_2:1456726_X_AT glutaminyl-tRNA synthetase mm
MOUSE430_2:1456726_X_AT glutaminyl-tRNA synthetase mm
MU19KSUBA:TC23403_S_AT Glutaminyl-tRNA synthetase, mRNA (cDNA clone MGC:38911 IMAGE:5362353) mm
MU19KSUBB:TC31842_R_AT Glutaminyl-tRNA synthetase, mRNA (cDNA clone MGC:38911 IMAGE:5362353) mm
RAE230A:1371930_AT glutaminyl-tRNA synthetase rn
RAT230_2:1371930_AT glutaminyl-tRNA synthetase rn
RG-U34C:RC_AA818996_AT glutaminyl-tRNA synthetase rn
YEAST_2:1772939_AT Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6418 tRNA aminoacylation for protein translation inferred from electronic annotation QuickGO AmiGO
6424 glutamyl-tRNA aminoacylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4812 tRNA ligase activity inferred from electronic annotation QuickGO AmiGO
4818 glutamate-tRNA ligase activity inferred from electronic annotation QuickGO AmiGO
4819 glutamine-tRNA ligase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB08998 Hypothetical protein Y41E3.4 [Caenorhabditis elegans] ref|NP_502812.1| glutamyl(E)/glutaminyl(Q) tRNA Synthetase family member (ers-1) [Caenorhabditis elegans] sp|O62431|SYQ_CAEEL Probable glutaminyl-tRNA synthetase (Glutamine--tRNA ligase) (GlnRS) 0.0
blast CAE68128 Hypothetical protein CBG13773 [Caenorhabditis briggsae] 0.0
blast XP_623880 PREDICTED: similar to GA10360-PA [Apis mellifera] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000924 EMBL-EBI Glutamyl-tRNA synthetase, class Ic 1.0E-126
Pfam IPR007639 EMBL-EBI Glutaminyl-tRNA synthetase, non-specific RNA-binding region part 1 2.1E-92
Pfam IPR007638 EMBL-EBI Glutaminyl-tRNA synthetase, non-specific RNA-binding region part 2 5.9E-55
Pfam IPR000924 EMBL-EBI Glutamyl-tRNA synthetase, class Ic 9.3E-87
Pfam IPR000924 EMBL-EBI Glutamyl-tRNA synthetase, class Ic 1.0E-126
Pfam IPR007638 EMBL-EBI Glutaminyl-tRNA synthetase, non-specific RNA-binding region part 2 1.9E-14
Pfam IPR007638 EMBL-EBI Glutaminyl-tRNA synthetase, non-specific RNA-binding region part 2 1.8E-33
Pfam IPR000924 EMBL-EBI Glutamyl-tRNA synthetase, class Ic 9.3E-87
Sequence
Target Sequence 
>C. ELEGANS:192774_S_AT
ccatctgatccgactgatccacgaaagcactcggtatccgtcgatcgggagattttcatt
gaaaagtccgactataagccggatgattcggacaaatccttcagaaggctgacgccgaaa
caagccgtcggcctgaaacacattggattggtgctccgattcgtgaaagaagtcaaagat
gccgagggtcacgtcacagaagttgtggtgaaggctgagaagttgtcggagaaggataag
ccgaaagcatttattcattgggttgcaaagcctgtctcgtgtgaagttcggctctatgat
agactattcaagagtaagaatccagaggatgctcaactagttccaggtggattcctgtcg
gatatcaatccagattcattgacagttgtctacaatgctctaattgatcagtctattgca
aaatcaaaggtttatgatagattccaattcgaacgcatcggattcttctgtgtcgatcgt
gattcgacgtcttcaacgttggtcttcaaccgaactgtca

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CCATCTGATCCGACTGATCCACGAA 585 271 1819 Antisense
CACTCGGTATCCGTCGATCGGGAGA 400 195 1846 Antisense
ACAAGCCGTCGGCCTGAAACACATT 640 111 1938 Antisense
TTGGATTGGTGCTCCGATTCGTGAA 389 709 1961 Antisense
CAAAGATGCCGAGGGTCACGTCACA 64 193 1992 Antisense
GCAAAGCCTGTCTCGTGTGAAGTTC 138 319 2083 Antisense
GATGCTCAACTAGTTCCAGGTGGAT 7 415 2146 Antisense
AATTCGAACGCATCGGATTCTTCTG 669 177 2264 Antisense
GATTCTTCTGTGTCGATCGTGATTC 608 431 2279 Antisense
GATTCGACGTCTTCAACGTTGGTCT 211 433 2299 Antisense
ACGTTGGTCTTCAACCGAACTGTCA 518 89 2314 Antisense
Sequence Source Affymetrix Proprietary Database