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[192758_s_at] Zinc-binding metalloprotease domain

Description C04F12.10 /REP_DB=WormBase Gene ID /WP=CE19683 /TR=Q9XVE5 /GB=CAB03839.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=Zinc-binding metalloprotease domain
Cluster 6grp_highest_10_10 > 07      6grp_high1_10_10 > 70      4grp_highest_8_8 > 25      4grp_high_8_8 > 59      6grp_highest_nonorm > 55      6grp_total > 71      4grp_total > 60      6grp_highest_sub > 04      6grp_cgc > 84      6grp_high1_sub > 04      6grp_cgc_sub > 04      6grp_total_sub > Hat      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 973
1 2 3 4 range
A 1593.8
(2.7)
P 		1469
(1.7)
P 		1627.7
(3)
P 		874.4
(-3)
P 		753
B 1293
(-0.2)
P 		1628.1
(3)
P 		1434.7
(1.2)
P 		990.2
(-3)
P 		638
C 1429.5
(1.1)
P 		1201.6
(-0.3)
P 		1744.4
(3)
P 		771.9
(-3)
P 		973
avr 1438.8
(1.6) 		1432.9
(1.6) 		1602.3
(3) 		878.8
(-3) 		724

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 650
1 2 3 4 5 6 range
A 1380.2
(-3)
P 		1708.6
(1)
P 		1616.3
(-0.1)
P 		1869.4
(3)
P 		1702
(0.9)
P 		1482
(-1.8)
P 		489
B 1766.9
(2.6)
P 		1785.5
(3)
P 		1537.5
(-3)
P 		1634.9
(-0.6)
P 		1775.2
(2.8)
P 		1540.8
(-2.9)
P 		248
C 1575.3
(-1.7)
P 		1740
(-0)
P 		1789.3
(0.5)
P 		2030.6
(3)
P 		1454.3
(-3)
P 		1484.7
(-2.7)
P 		576
avr 1574.1
(-1.7) 		1744.7
(1.2) 		1647.7
(-0.5) 		1845
(3) 		1643.8
(-0.5) 		1502.5
(-3) 		343
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 480
1 2 3 4 range
A 580.3
(3)
P 		318.9
(-0.5)
P 		425.5
(0.9)
P 		128
(-3)
P 		452
B 412.3
(3)
P 		402.1
(2.7)
P 		332.5
(0.6)
P 		211
(-3)
P 		201
C 473.2
(1.3)
P 		345.5
(-0.3)
P 		608
(3)
P 		130.2
(-3)
P 		478
avr 488.6
(3) 		355.5
(0.6) 		455.3
(2.4) 		156.4
(-3) 		332

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 467
1 2 3 4 5 6 range
A 254.4
(-3)
P 		607.7
(3)
P 		352
(-1.3)
P 		474.1
(0.7)
P 		513.6
(1.4)
P 		360.8
(-1.2)
P 		353
B 614.8
(1.2)
P 		594.3
(0.8)
P 		373.3
(-3)
P 		433
(-2)
P 		721.2
(3)
P 		574.5
(0.5)
P 		348
C 583.9
(3)
P 		530.9
(1.2)
P 		455.4
(-1.4)
P 		408.4
(-3)
P 		470.6
(-0.9)
P 		497
(0)
P 		176
avr 484.4
(-0) 		577.6
(3) 		393.6
(-3) 		438.5
(-1.5) 		568.5
(2.7) 		477.4
(-0.3) 		184
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 192758_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.358
Sequence Type Exemplar sequence
Representative Public ID C04F12.10 NCBI
Target Description C04F12.10 /REP_DB=WormBase Gene ID /WP=CE19683 /TR=Q9XVE5 /GB=CAB03839.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=Zinc-binding metalloprotease domain
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_060181(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_060181 NCBI Caenorhabditis elegans Farnesylated-proteins Converting Enzyme (FACE) family member (fce-1) (fce-1) mRNA, complete cds. 11/11 A 
SNAP00000037409 ENSEMBL cdna:SNAP chromosome:CEL140:I:9719328:9720839:-1 11/11 None
GENEFINDER00000037412 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:9719328:9720839:-1 11/11 None
C04F12.10 ENSEMBL cdna:known chromosome:CEL140:I:9719185:9720840:-1 gene:C04F12.10 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:9719258-9720770(-) 100.0 100.0
Public Domain and Genome References
Gene Title Zinc-binding metalloprotease domain
Gene Symbol fce-1
Ensembl C04F12.10
Entrez Gene 172820 Entrez gene
SwissProt Q9XVE5 EMBL-EBI
WormBase CE19683 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:13962_AT CAAX protease, putative (STE24) at
ATH1-121501:255569_AT CAAX protease, putative (STE24) at
CANINE_2:CFAAFFX.5443.1.S1_AT similar to CAAX prenyl protease 1 homolog (Prenyl protein-specific endoprotease 1) (Farnesylated-proteins converting enzyme 1) (FACE-1) (Zinc metalloproteinase Ste24 homolog) cfa
DROSOPHILA_2:1624905_AT dm
DROSGENOME1:142548_AT dm
CHICKEN:GGAAFFX.561.1.S1_AT similar to CAAX prenyl protease 1 homolog (Prenyl protein-specific endoprotease 1) (Farnesylated-proteins converting enzyme 1) (FACE-1) (Zinc metalloproteinase Ste24 homolog) gga
HG-U133_PLUS_2:202939_AT zinc metallopeptidase (STE24 homolog, yeast) hs
HG-U133A:202939_AT zinc metallopeptidase (STE24 homolog, yeast) hs
HG-FOCUS:202939_AT zinc metallopeptidase (STE24 homolog, yeast) hs
HG-U133A_2:202939_AT zinc metallopeptidase (STE24 homolog, yeast) hs
HU35KSUBB:RC_W32176_S_AT zinc metallopeptidase (STE24 homolog, yeast) hs
HU35KSUBD:RC_D60639_AT zinc metallopeptidase (STE24 homolog, yeast) hs
U133_X3P:G5032128_3P_AT zinc metallopeptidase (STE24 homolog, yeast) hs
HG-U95AV2:33912_AT zinc metallopeptidase (STE24 homolog, yeast) hs
MG-U74BV2:111407_AT zinc metallopeptidase, STE24 homolog (S. cerevisiae) mm
MOE430A:1427923_AT zinc metallopeptidase, STE24 homolog (S. cerevisiae) mm
MOUSE430A_2:1427923_AT zinc metallopeptidase, STE24 homolog (S. cerevisiae) mm
MOUSE430_2:1427923_AT zinc metallopeptidase, STE24 homolog (S. cerevisiae) mm
MG-U74CV2:135209_AT Farnesylated-proteins converting enzyme-1 (Face-1 gene) mm
MU19KSUBB:TC31991_AT Farnesylated-proteins converting enzyme-1 (Face-1 gene) mm
RAE230A:1399085_AT Zinc metalloproteinase, STE24 homolog (S. cerevisiae) (predicted) rn
RAT230_2:1399085_AT Zinc metalloproteinase, STE24 homolog (S. cerevisiae) (predicted) rn
RG-U34C:RC_AI175477_AT Zinc metalloproteinase, STE24 homolog (S. cerevisiae) (predicted) rn
YEAST_2:1779388_AT Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4222 metalloendopeptidase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB03839 Hypothetical protein C04F12.10 [Caenorhabditis elegans] ref|NP_492582.1| Farnesylated-proteins Converting Enzyme (FACE) family member (fce-1) [Caenorhabditis elegans] 0.0
blast CAE60244 Hypothetical protein CBG03817 [Caenorhabditis briggsae] 0.0
blast XP_707999 PREDICTED: similar to Zinc metalloproteinase (STE24 homolog, yeast) isoform 2 [Danio rerio] 1.0E-105
Protein Domains
Database ID Description E-Value
Pfam IPR001915 EMBL-EBI Peptidase M48, Ste24p 1.2E-41
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_492582.1 5 63-85,147-166,173-195,307-329,342-364
C04F12.10 5 63-85,147-166,173-195,307-329,342-364
SNAP00000037409 5 63-85,147-166,173-195,307-329,342-364
GENEFINDER00000037412 5 63-85,147-166,173-195,307-329,342-364
Sequence
Target Sequence 
>C. ELEGANS:192758_S_AT
gctcactccaatgcttacatgtatggattctggaagaacaagcgcattgtgctctatgat
actttgctaagtggagctgaaaaggagaaagtacatgaattgtatgtggcagctggagag
aaaatcgaagaaactgaaaacgacaaaaagagaggaatgaacaacgatgaagttgtggcc
gttctgggccatgaattgggtcattgggctttatggcacactttgatcaatcttgtcatc
actgaagtcaacttgttcttctcttttgcagtttttggatacttttataaatgggaagcc
ctctatcaaggattcggctatcacgatactccaccagtcattggcatgatgctcatcttc
caatttgtcctcgctctctacaatcaactcgctagta

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GCTCACTCCAATGCTTACATGTATG 379 301 724 Antisense
GAAGAACAAGCGCATTGTGCTCTAT 142 341 756 Antisense
TGTGCTCTATGATACTTTGCTAAGT 263 557 771 Antisense
CGATGAAGTTGTGGCCGTTCTGGGC 433 249 888 Antisense
GCCGTTCTGGGCCATGAATTGGGTC 459 283 901 Antisense
GGGTCATTGGGCTTTATGGCACACT 526 495 921 Antisense
GGCACACTTTGATCAATCTTGTCAT 450 535 938 Antisense
CAACTTGTTCTTCTCTTTTGCAGTT 211 187 972 Antisense
GATACTCCACCAGTCATTGGCATGA 577 423 1048 Antisense
CATGATGCTCATCTTCCAATTTGTC 584 209 1068 Antisense
GCTCTCTACAATCAACTCGCTAGTA 634 299 1096 Antisense
Sequence Source Affymetrix Proprietary Database