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[192753_at] serine/threonine kinase (2 domains)

Description H01G02.2 /REP_DB=WormBase Gene ID /WP=CE11556 /TR=O17903 /GB=CAB07422.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=serine-threonine kinase (2 domains)
Cluster 6grp_high1_10_10 > 27      4grp_high_8_8 > 24      6grp_total > 17      4grp_total > 39      6grp_high1_sub > Cu      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 126
1 2 3 4 range
A 167.4
(3)
P 		108.9
(-1.9)
A 		96.3
(-3)
P 		105.7
(-2.2)
P 		71
B 148.7
(3)
P 		71.8
(-1.3)
P 		41.7
(-3)
A 		97.6
(0.1)
P 		107
C 150.1
(3)
P 		74
(-3)
P 		79.9
(-2.5)
P 		106.6
(-0.4)
P 		76
avr 155.4
(3) 		84.9
(-2.1) 		72.6
(-3) 		103.3
(-0.8) 		83

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 104
1 2 3 4 5 6 range
A 94.2
(3)
P 		89.6
(2.4)
P 		78.9
(0.9)
P 		51
(-3)
P 		65
(-1.1)
P 		90.1
(2.4)
P 		43
B 152.9
(3)
P 		69.9
(-1.8)
P 		80.3
(-1.2)
P 		48.5
(-3)
A 		80.8
(-1.1)
P 		83.8
(-1)
P 		104
C 144.3
(3)
P 		108.5
(0.7)
P 		75.9
(-1.5)
P 		87.5
(-0.7)
P 		52.4
(-3)
P 		58.5
(-2.6)
P 		92
avr 130.5
(3) 		89.3
(-0.6) 		78.4
(-1.6) 		62.3
(-3) 		66.1
(-2.7) 		77.5
(-1.7) 		68
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 51
1 2 3 4 range
A 61
(3)
P 		23.6
(-1.9)
A 		25.2
(-1.7)
P 		15.5
(-3)
P 		46
B 47.4
(3)
P 		17.7
(-1.7)
P 		9.7
(-3)
A 		20.8
(-1.2)
P 		38
C 49.7
(3)
P 		21.3
(-2.4)
P 		27.9
(-1.1)
P 		18
(-3)
P 		32
avr 52.7
(3) 		20.9
(-2.5) 		20.9
(-2.5) 		18.1
(-3) 		35

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 41
1 2 3 4 5 6 range
A 17.4
(-1.6)
P 		31.9
(3)
P 		17.2
(-1.6)
P 		12.9
(-3)
P 		19.6
(-0.9)
P 		21.9
(-0.2)
P 		19
B 53.2
(3)
P 		23.3
(-1.4)
P 		19.5
(-2)
P 		12.8
(-3)
A 		32.8
(-0)
P 		31.3
(-0.3)
P 		40
C 53.5
(3)
P 		33.1
(-0.4)
P 		19.3
(-2.6)
P 		17.6
(-2.9)
P 		17
(-3)
P 		19.6
(-2.6)
P 		37
avr 41.4
(3) 		29.4
(0.3) 		18.7
(-2) 		14.4
(-3) 		23.1
(-1.1) 		24.3
(-0.8) 		27
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192753_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.9696
Sequence Type Exemplar sequence
Representative Public ID H01G02.2 NCBI
Target Description H01G02.2 /REP_DB=WormBase Gene ID /WP=CE11556 /TR=O17903 /GB=CAB07422.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=serine-threonine kinase (2 domains)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_069831(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_069831 NCBI Caenorhabditis elegans H01G02.2 (H01G02.2) mRNA, complete cds. 11/11 None
SNAP00000027242 ENSEMBL cdna:SNAP chromosome:CEL140:IV:11798670:11801058:-1 10/11 None
GENEFINDER00000027248 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:11787132:11801058:-1 11/11 None
H01G02.2 ENSEMBL cdna:known chromosome:CEL140:IV:11798670:11801058:-1 gene:H01G02.2 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:11798675-11801064(-) 100.0 100.0
Public Domain and Genome References
Gene Title serine/threonine kinase (2 domains)
Ensembl H01G02.2
Entrez Gene 186662 Entrez gene
SwissProt O17903 EMBL-EBI
WormBase CE35567 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB07422 Hypothetical protein H01G02.2 [Caenorhabditis elegans] ref|NP_502232.2| H01G02.2 [Caenorhabditis elegans] 0.0
blast CAE62127 Hypothetical protein CBG06171 [Caenorhabditis briggsae] 1.0E-139
blast CAE62127 Hypothetical protein CBG06171 [Caenorhabditis briggsae] 1.0E-138
blast CAB07422 Hypothetical protein H01G02.2 [Caenorhabditis elegans] ref|NP_502232.2| H01G02.2 [Caenorhabditis elegans] 1.0E-129
blast CAE62127 Hypothetical protein CBG06171 [Caenorhabditis briggsae] 6.0E-86
blast CAE46676 Hypothetical protein H01G02.3a [Caenorhabditis elegans] ref|NP_001023250.1| H01G02.3a [Caenorhabditis elegans] 4.0E-62
blast XP_624845 PREDICTED: similar to CDK-related protein kinase PNQLARE [Apis mellifera] 7.0E-52
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 2.0E-70
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 3.0E-71
hanks 3.1.7 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; PCTAIRE1 2.0E-67
hanks 3.1.1 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; CDC2Hs 1.0E-68
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 1.8E-71
Pfam IPR000719 EMBL-EBI Protein kinase 0.3
Pfam IPR000719 EMBL-EBI Protein kinase 1.3E-20
Pfam IPR000719 EMBL-EBI Protein kinase 0.0065
Pfam IPR000719 EMBL-EBI Protein kinase 3.5E-71
Trans Membrane
ID Number Of Domains Domain Boundaries
GENEFINDER00000027248 1 516-538
Sequence
Target Sequence 
>C. ELEGANS:192753_AT
gaatattctagtcacatctcgcaatgtggtgaaaattgcagattttgggcaagcatgctt
ctacatgccaaaagatccaaatcaagaatatgatgtgaatgttgcgactcgatggtatcg
tgctccagaattactttttggatcgaaaaagtacaaaccggatgtagatatttgggcaat
agggtgtattttggcagagttggtgcgaggaaaacctatttttcccggaagaagtgagtt
ggagcagatttccataattttcggagttctcggaactccaaacgaagacaactggccaaa
ctggagaacaatgcctgatgcaaataaattgctatttgagccgaaagagccgaggaataa
ttggacggaaattctactgtgcaaagaaatatccaacaatttcaccgagtttttgggctc
acatcttcaatttttcaaacgattaaaagccagtgaactgttgaaagagccatggatcaa
gcaaggattgcccctcgttgagccaaattat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAATATTCTAGTCACATCTCGCAAT 680 325 351 Antisense
GGGCAAGCATGCTTCTACATGCCAA 199 493 397 Antisense
TGATGTGAATGTTGCGACTCGATGG 334 567 441 Antisense
GACTCGATGGTATCGTGCTCCAGAA 49 375 456 Antisense
GTTCTCGGAACTCCAAACGAAGACA 96 441 616 Antisense
AACGAAGACAACTGGCCAAACTGGA 171 143 631 Antisense
AACTGGAGAACAATGCCTGATGCAA 275 143 649 Antisense
ATTTCACCGAGTTTTTGGGCTCACA 74 17 749 Antisense
TTGGGCTCACATCTTCAATTTTTCA 691 707 763 Antisense
GGATCAAGCAAGGATTGCCCCTCGT 392 511 824 Antisense
ATTGCCCCTCGTTGAGCCAAATTAT 646 5 837 Antisense
Sequence Source Affymetrix Proprietary Database