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[192750_at] serine/threonine protein phosphatase

Description F38H4.9 /REP_DB=WormBase Gene ID /WP=CE10074 /TR=Q27498 /GB=CAB01174.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=serine-threonine protein phosphatase
Cluster 6grp_highest_10_10 > 72      6grp_high1_10_10 > 28      4grp_highest_8_8 > 32      4grp_high_8_8 > 51      6grp_highest_nonorm > 40      6grp_total > 27      4grp_total > 61      6grp_highest_sub > Cu      6grp_cgc > 06      6grp_high1_sub > De      6grp_cgc_sub > Cu      6grp_total_sub > Decrease      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 431
1 2 3 4 range
A 914.7
(3)
P
869.8
(2.2)
P
865.3
(2.1)
P
578.5
(-3)
P
336
B 813.5
(2.2)
P
753.5
(1.2)
P
858.1
(3)
P
505.6
(-3)
P
353
C 931
(3)
P
931
(3)
P
819.1
(1.4)
P
499.6
(-3)
P
431
avr 886.4
(3)
851.4
(2.4)
847.5
(2.3)
527.9
(-3)
359

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1099
1 2 3 4 5 6 range
A 578
(-1.2)
P
923.1
(2.4)
P
405.5
(-3)
P
622.6
(-0.7)
P
437.2
(-2.7)
P
977.4
(3)
P
572
B 524.2
(3)
P
499.5
(1.9)
P
518
(2.7)
P
394.4
(-3)
P
470.8
(0.5)
P
419.2
(-1.9)
P
130
C 1493.5
(3)
P
441.9
(-3)
P
717.6
(-1.4)
P
457.7
(-2.9)
P
708.6
(-1.5)
P
463.8
(-2.9)
P
1052
avr 865.2
(3)
621.5
(-0.9)
547
(-2.1)
491.6
(-3)
538.9
(-2.2)
620.1
(-0.9)
374
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 249
1 2 3 4 range
A 333
(3)
P
188.8
(-0.5)
P
226.2
(0.4)
P
84.7
(-3)
P
248
B 259.4
(3)
P
186.1
(0.1)
P
198.8
(0.6)
P
107.7
(-3)
P
152
C 308.2
(3)
P
267.7
(1.9)
P
285.5
(2.4)
P
84.2
(-3)
P
224
avr 300.2
(3)
214.2
(0.5)
236.8
(1.2)
92.2
(-3)
208

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 465
1 2 3 4 5 6 range
A 106.6
(-2.5)
P
328.3
(3)
P
88.3
(-3)
P
157.9
(-1.3)
P
131.9
(-1.9)
P
238
(0.7)
P
240
B 182.4
(2.4)
P
166.2
(1.3)
P
125.8
(-1.5)
P
104.5
(-3)
P
191.3
(3)
P
156.3
(0.6)
P
87
C 553.6
(3)
P
134.8
(-2.4)
P
182.7
(-1.8)
P
92
(-3)
P
229.3
(-1.2)
P
155.3
(-2.2)
P
462
avr 280.9
(3)
209.8
(0.4)
132.3
(-2.5)
118.1
(-3)
184.2
(-0.6)
183.2
(-0.6)
163
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192750_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.9191
Sequence Type Exemplar sequence
Representative Public ID F38H4.9 NCBI
Target Description F38H4.9 /REP_DB=WormBase Gene ID /WP=CE10074 /TR=Q27498 /GB=CAB01174.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=serine-threonine protein phosphatase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_069846(11)
Transcript Assignments
Representative
Transcript
Description Matching Probes Related Probesets by Grade
NM_069846 NCBI Caenorhabditis elegans LEThal family member (let-92) (let-92) mRNA, complete cds. 11/11 None
SNAP00000007683 ENSEMBL cdna:SNAP chromosome:CEL140:IV:11858416:11859674:1 11/11 None
GENEFINDER00000007685 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:11858416:11859674:1 11/11 None
F38H4.9.2 ENSEMBL cdna:known chromosome:CEL140:IV:11858402:11860430:1 gene:F38H4.9 11/11 None
F38H4.9.1 ENSEMBL cdna:known chromosome:CEL140:IV:11858410:11860430:1 gene:F38H4.9 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:11858421-11859680(+) 100.0 100.0
Public Domain and Genome References
Gene Title serine/threonine protein phosphatase
Gene Symbol let-92
Ensembl F38H4.9
Entrez Gene 178117 Entrez gene
SwissProt Q27498 EMBL-EBI
WormBase CE10074 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:262909_AT serine/threonine protein phosphatase PP2A-2 catalytic subunit (PP2A2) at
ATGENOME1:16576_F_AT serine/threonine protein phosphatase PP2A-2 catalytic subunit (PP2A2) at
CANINE:1604369_AT similar to Serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform (PP2A-beta) cfa
CANINE:1597003_AT similar to Serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform (PP2A-beta) cfa
CANINE:1586503_AT similar to Serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform (PP2A-beta) cfa
CANINE_2:CFA.8858.1.A1_S_AT similar to Serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform (PP2A-beta) cfa
CANINE_2:CFAAFFX.10646.1.S1_S_AT similar to Serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform (PP2A-beta) cfa
DROSOPHILA_2:1640841_AT microtubule star dm
DROSGENOME1:154353_AT microtubule star dm
CHICKEN:GGA.4287.1.S1_AT protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform gga
HG-U133A:201374_X_AT protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform hs
HG-U133A_2:201374_X_AT protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform hs
HG-U133_PLUS_2:201374_X_AT protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform hs
HG-U133A:201375_S_AT protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform hs
HG-U133_PLUS_2:201375_S_AT protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform hs
HG-FOCUS:201375_S_AT protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform hs
HG-U133A_2:201375_S_AT protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform hs
HG-U95AV2:924_S_AT protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform hs
HC-G110:924_S_AT protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform hs
U133_X3P:201374_3P_X_AT protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform hs
HUGENEFL:J03805_S_AT protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform hs
U133_X3P:G4758951_3P_A_AT protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform hs
U133_X3P:HS.80350.0.S1_3P_X_AT protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform hs
U133_X3P:HS.80350.0.S1_3P_AT protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform hs
HG-U95B:50550_AT Protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform hs
HU35KSUBD:RC_N68423_AT Protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform hs
MU11KSUBB:Z67746_S_AT protein phosphatase 2a, catalytic subunit, beta isoform mm
MU11KSUBB:MSA.26899.0_F_AT protein phosphatase 2a, catalytic subunit, beta isoform mm
MU11KSUBB:MSA.24725.0_S_AT protein phosphatase 2a, catalytic subunit, beta isoform mm
MG-U74AV2:101101_AT protein phosphatase 2a, catalytic subunit, beta isoform mm
MOE430A:1421823_A_AT protein phosphatase 2a, catalytic subunit, beta isoform mm
MOUSE430A_2:1421823_A_AT protein phosphatase 2a, catalytic subunit, beta isoform mm
MOUSE430_2:1421823_A_AT protein phosphatase 2a, catalytic subunit, beta isoform mm
MOE430A:1421822_AT protein phosphatase 2a, catalytic subunit, beta isoform mm
MOUSE430A_2:1421822_AT protein phosphatase 2a, catalytic subunit, beta isoform mm
MOUSE430_2:1421822_AT protein phosphatase 2a, catalytic subunit, beta isoform mm
MOUSE430_2:1431341_AT Protein phosphatase 2a, catalytic subunit, beta isoform, mRNA (cDNA clone MGC:29430 IMAGE:3674696) mm
MOE430B:1431341_AT Protein phosphatase 2a, catalytic subunit, beta isoform, mRNA (cDNA clone MGC:29430 IMAGE:3674696) mm
MG-U74CV2:135325_AT Protein phosphatase 2a, catalytic subunit, beta isoform, mRNA (cDNA clone MGC:29430 IMAGE:3674696) mm
MU11KSUBB:MSA.26899.0_I_AT Protein phosphatase 2a, catalytic subunit, beta isoform, mRNA (cDNA clone MGC:29430 IMAGE:3674696) mm
MU11KSUBB:MSA.26899.0_R_AT Protein phosphatase 2a, catalytic subunit, beta isoform, mRNA (cDNA clone MGC:29430 IMAGE:3674696) mm
MU19KSUBB:TC33144_AT Protein phosphatase 2a, catalytic subunit, beta isoform, mRNA (cDNA clone MGC:29430 IMAGE:3674696) mm
RG-U34A:M23591MRNA#2_AT protein phosphatase 2a, catalytic subunit, beta isoform rn
RG-U34A:X16044CDS_S_AT protein phosphatase 2a, catalytic subunit, beta isoform rn
RAE230A:1367827_AT protein phosphatase 2a, catalytic subunit, beta isoform rn
RAT230_2:1367827_AT protein phosphatase 2a, catalytic subunit, beta isoform rn
YEAST_2:1779633_AT Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis Sc
Gene Ontology
GO Molecular Function (view graph)
ID Description Evidence Links
16787 hydrolase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB01174 Hypothetical protein F38H4.9 [Caenorhabditis elegans] ref|NP_502247.1| LEThal family member (let-92) [Caenorhabditis elegans] emb|CAE62135.1| Hypothetical protein CBG06179 [Caenorhabditis briggsae] 0.0
blast AAH64168 Protein phosphatase 2A, catalytic subunit, beta isoform [Xenopus tropicalis] ref|NP_989274.1| protein phosphatase 2A, catalytic subunit, beta isoform [Xenopus tropicalis] 1.0E-171
blast NP_059070 protein phosphatase 2a, catalytic subunit, beta isoform [Mus musculus] ref|NP_001009552.1| protein phosphatase 2, catalytic subunit, beta isoform [Homo sapiens] ref|NP_004147.1| protein phosphatase 2, catalytic subunit, beta isoform [Homo sapiens] ref|NP_058736.1| protein phosphatase 2a, catalytic subunit, beta isoform [Rattus norvegicus] gb|AAH85926.1| Protein phosphatase 2a, catalytic subunit, beta isoform [Rattus norvegicus] gb|AAH58582.1| Protein phosphatase 2a, catalytic subunit, beta isoform [Mus musculus] ref|XP_539988.1| PREDICTED: similar to Serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform (PP2A-beta) isoform 1 [Canis familiaris] emb|CAA32249.1| unnamed protein product [Rattus norvegicus] emb|CAG46547.1| PPP2CB [Homo sapiens] emb|CAA34167.1| unnamed protein product [Rattus rattus] sp|P62716|P2AB_RAT Serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform (PP2A-beta) sp|P62715|P2AB_MOUSE Serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform (PP2A-beta) sp|P62714|P2AB_HUMAN Serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform (PP2A-beta) emb|CAA91559.1| phosphatase 2A catalytic subunit isotype beta [Mus musculus] emb|CAA31183.1| unnamed protein product [Homo sapiens] gb|AAA41912.1| protein phosphatase 2A-beta catalytic subunit gb|AAA36467.1| protein phosphatase-2A catalytic subunit-beta gb|AAH12022.1| Protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform [Homo sapiens] 1.0E-170
Protein Domains
Database ID Description E-Value
Pfam IPR004843 EMBL-EBI Metallo-phosphoesterase 1.2E-39
Pfam IPR004843 EMBL-EBI Metallo-phosphoesterase 3.7E-35
Sequence
Target Sequence
>C. ELEGANS:192750_AT
aaatcactcaggtctacgggttctatgacgagtgtttgaggaaatatggaaactcgaatg
tgtggaagtacttcactgatctcttcgactgtttcccacttaccgctcttgttgatggtc
aaatcttctgccttcacggaggtctttcaccgtctattgatactcttgatcacatcagag
ctcttgaccgcattcaagaggttccacacgaaggaccaatgtgcgatcttctctggtctg
atccagatgacagaggtggctggggaatctctccacgtggagcaggatacacattcggtc
aggatatctcggagacgttcaaccattccaatggacttactctaatttctcgggcccatc
aacttgtcatggagggatacaactggagtcacgatcgtaacgtggtaacagtgttctcag
caccaaactactgctatcgttgtggaaatcaggcagcgatggtggagctggacgacgatc
tcaaatattcgttcttgcaattcgaccctg


BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position
Strandedness
AAATCACTCAGGTCTACGGGTTCTA 11 115 404 Antisense
GAAGTACTTCACTGATCTCTTCGAC 315 337 468 Antisense
CCACTTACCGCTCTTGTTGATGGTC 578 271 499 Antisense
TGATGGTCAAATCTTCTGCCTTCAC 252 567 516 Antisense
GGTCTTTCACCGTCTATTGATACTC 199 503 544 Antisense
AAGGACCAATGTGCGATCTTCTCTG 368 161 614 Antisense
GGAGCAGGATACACATTCGGTCAGG 209 521 682 Antisense
ATCTCGGAGACGTTCAACCATTCCA 595 31 709 Antisense
TCGGGCCCATCAACTTGTCATGGAG 453 605 753 Antisense
ACAGTGTTCTCAGCACCAAACTACT 551 107 811 Antisense
TATTCGTTCTTGCAATTCGACCCTG 237 663 889 Antisense
Sequence Source Affymetrix Proprietary Database