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[192747_at] beta-hexosaminidase beta subunit

Description T14F9.3 /REP_DB=WormBase Gene ID /WP=CE07499 /TR=SW:Q22492 /GB=AAA91263.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=beta-hexosaminidase beta subunit
Cluster 6grp_highest_10_10 > 18      6grp_high1_10_10 > 71      4grp_highest_8_8 > 02      4grp_high_8_8 > 45      6grp_highest_nonorm > 63      6grp_total > 72      4grp_total > 50      6grp_highest_sub > 04_05      6grp_high1_sub > 04      6grp_total_sub > Hat      6grp_rule_based > S4      4grp_rule_based > L2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 223
1 2 3 4 range
A 433.8
(-3)
P 		657.2
(3)
P 		577.3
(0.9)
P 		466.3
(-2.1)
P 		223
B 469.8
(-2.4)
P 		646.4
(3)
P 		592.6
(1.4)
P 		450
(-3)
P 		196
C 444.8
(-2.9)
P 		613.6
(3)
P 		599.5
(2.5)
P 		441.5
(-3)
P 		172
avr 449.5
(-3) 		639.1
(3) 		589.8
(1.4) 		452.6
(-2.9) 		190

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 507
1 2 3 4 5 6 range
A 468
(-1.5)
P 		640.6
(0.6)
P 		612.9
(0.2)
P 		846.8
(3)
P 		664.7
(0.8)
P 		340.1
(-3)
P 		507
B 522
(-1.5)
P 		695.5
(1.1)
P 		817.4
(3)
P 		619.9
(-0)
P 		703.4
(1.2)
P 		426.6
(-3)
P 		391
C 406.3
(-3)
P 		545.3
(-0.7)
P 		628.9
(0.6)
P 		774.6
(3)
P 		714.8
(2)
P 		458.4
(-2.2)
P 		368
avr 465.4
(-2) 		627.1
(0.9) 		686.4
(1.9) 		747.1
(3) 		694.3
(2.1) 		408.4
(-3) 		339
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 141
1 2 3 4 range
A 158
(3)
P 		142.7
(2)
P 		150.9
(2.5)
P 		68.3
(-3)
P 		90
B 149.8
(2.1)
P 		159.7
(3)
P 		137.3
(0.9)
P 		95.9
(-3)
P 		64
C 147.2
(0.2)
P 		176.4
(1.6)
P 		208.9
(3)
P 		74.4
(-3)
P 		135
avr 151.7
(2) 		159.6
(2.6) 		165.7
(3) 		79.5
(-3) 		86

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 203
1 2 3 4 5 6 range
A 86.3
(-2.9)
P 		227.8
(3)
P 		133.5
(-0.9)
P 		214.8
(2.5)
P 		200.6
(1.9)
P 		82.8
(-3)
P 		145
B 181.6
(-1.9)
P 		231.5
(0.4)
P 		198.5
(-1.1)
P 		164.2
(-2.8)
P 		285.8
(3)
P 		159.1
(-3)
P 		127
C 150.6
(-3)
P 		166.4
(-1.8)
P 		160.1
(-2.3)
P 		155.8
(-2.6)
P 		231.3
(3)
P 		153.4
(-2.8)
P 		81
avr 139.5
(-2.6) 		208.6
(1.3) 		164
(-1.2) 		178.3
(-0.4) 		239.2
(3) 		131.8
(-3) 		107
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192747_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.18353
Sequence Type Exemplar sequence
Representative Public ID T14F9.3 NCBI
Target Description T14F9.3 /REP_DB=WormBase Gene ID /WP=CE07499 /TR=SW:Q22492 /GB=AAA91263.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=beta-hexosaminidase beta subunit
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_076008(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_076008 NCBI Caenorhabditis elegans T14F9.3 (T14F9.3) mRNA, complete cds. 11/11 A 
SNAP00000024568 ENSEMBL cdna:SNAP chromosome:CEL140:X:2223479:2226504:1 11/11 None
GENEFINDER00000024575 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:2223479:2226504:1 11/11 None
T14F9.3 ENSEMBL cdna:known chromosome:CEL140:X:2223476:2226593:1 gene:T14F9.3 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:2223478-2226504(+) 100.0 100.0
Public Domain and Genome References
Gene Title beta-hexosaminidase beta subunit
Ensembl T14F9.3
Entrez Gene 180533 Entrez gene
SwissProt Q22492 EMBL-EBI
WormBase CE07499 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:264684_AT glycosyl hydrolase family 20 protein at
ATGENOME1:15375_AT glycosyl hydrolase family 20 protein at
ATGENOME1:13561_AT glycosyl hydrolase family 20 protein at
CANINE:1587489_AT similar to Beta-hexosaminidase beta chain precursor (N-acetyl-beta-glucosaminidase) (Beta-N-acetylhexosaminidase) (Hexosaminidase B) (Cervical cancer proto-oncogene 7) (HCC-7) cfa
CANINE_2:CFA.10953.1.S1_S_AT similar to Beta-hexosaminidase beta chain precursor (N-acetyl-beta-glucosaminidase) (Beta-N-acetylhexosaminidase) (Hexosaminidase B) (Cervical cancer proto-oncogene 7) (HCC-7) cfa
CHICKEN:GGA.9970.1.S1_AT similar to Beta-hexosaminidase beta chain precursor (N-acetyl-beta-glucosaminidase) (Beta-N-acetylhexosaminidase) (Hexosaminidase B) (Cervical cancer proto-oncogene 7) (HCC-7) gga
HG-U133A:201944_AT hexosaminidase B (beta polypeptide) hs
HG-U133_PLUS_2:201944_AT hexosaminidase B (beta polypeptide) hs
HG-FOCUS:201944_AT hexosaminidase B (beta polypeptide) hs
HG-U133A_2:201944_AT hexosaminidase B (beta polypeptide) hs
HU35KSUBB:RC_N23214_AT hexosaminidase B (beta polypeptide) hs
HUGENEFL:M23294_AT hexosaminidase B (beta polypeptide) hs
U133_X3P:G13128866_3P_S_AT hexosaminidase B (beta polypeptide) hs
HG-U95AV2:34888_AT hexosaminidase B (beta polypeptide) hs
HG-U95C:64507_AT hexosaminidase B (beta polypeptide) hs
HU35KSUBB:RC_AA101833_AT Hexosaminidase B (beta polypeptide) hs
HG-U95C:57929_AT Hexosaminidase B (beta polypeptide) hs
MOUSE430_2:1437874_S_AT hexosaminidase B mm
MOE430A:1437874_S_AT hexosaminidase B mm
MOUSE430A_2:1437874_S_AT hexosaminidase B mm
MU11KSUBB:Y00964_S_AT hexosaminidase B mm
MG-U74AV2:97232_AT hexosaminidase B mm
MOE430A:1460180_AT hexosaminidase B mm
MOUSE430A_2:1460180_AT hexosaminidase B mm
MOUSE430_2:1460180_AT hexosaminidase B mm
MG-U74CV2:133421_AT Hexosaminidase B (Hexb), mRNA mm
MU19KSUBA:TC14889_AT Hexosaminidase B (Hexb), mRNA mm
RG-U34C:RC_AI235455_AT hexosaminidase B (predicted) rn
RAE230A:1372706_AT hexosaminidase B (predicted) rn
RAT230_2:1372706_AT hexosaminidase B (predicted) rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
5975 carbohydrate metabolism inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4563 beta-N-acetylhexosaminidase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAA91263 Hypothetical protein T14F9.3 [Caenorhabditis elegans] ref|NP_508409.1| T14F9.3 [Caenorhabditis elegans] sp|Q22492|HEXA_CAEEL Probable beta-hexosaminidase A precursor (N-acetyl-beta-glucosaminidase) (Beta-N-acetylhexosaminidase) 0.0
blast CAE68337 Hypothetical protein CBG14058 [Caenorhabditis briggsae] 0.0
blast NP_034552 hexosaminidase B [Mus musculus] emb|CAA68781.1| beta-hexosaminidase [Mus musculus] dbj|BAE34877.1| unnamed protein product [Mus musculus] dbj|BAE34846.1| unnamed protein product [Mus musculus] dbj|BAE30155.1| unnamed protein product [Mus musculus] dbj|BAE40652.1| unnamed protein product [Mus musculus] dbj|BAE35874.1| unnamed protein product [Mus musculus] gb|AAB60667.1| beta-hexosaminidase beta-subunit [Mus musculus] pir||B54745 beta-N-acetylhexosaminidase (EC 3.2.1.52) beta chain - mouse sp|P20060|HEXB_MOUSE Beta-hexosaminidase beta chain precursor (N-acetyl-beta-glucosaminidase) (Beta-N-acetylhexosaminidase) (Hexosaminidase B) gb|AAA74738.1| beta-N-acetylhexosaminidase gb|AAA18776.1| beta-hexosaminidase 1.0E-109
Protein Domains
Database ID Description E-Value
Pfam IPR001540 EMBL-EBI Glycoside hydrolase, family 20 2.4E-125
Pfam IPR001540 EMBL-EBI Glycoside hydrolase, family 20 4.4E-13
Pfam IPR001540 EMBL-EBI Glycoside hydrolase, family 20 5.8E-58
Pfam IPR001540 EMBL-EBI Glycoside hydrolase, family 20 4.1E-52
Pfam IPR001540 EMBL-EBI Glycoside hydrolase, family 20 4.4E-13
Sequence
Target Sequence 
>C. ELEGANS:192747_AT
aatgacactgtgcttctggaaaactatttcttcgaaaagttgtacaaaattgtagaaaat
ttgaagttaaagcgtaagccaatattttggcaagaagtctttgataacaacattcctgat
ccaaacgcggtgatccatatttggaaaggaaacactcacgaggagatttacgagcaagtg
aagaacatcacatctcaaaacttcccagtgattgtgtccgcgtgctggtacttgaactat
atcaaatatggcgctgactggagggatgagattcgcggaactgcaccatcaaactcaaga
tactactattgtgatccaacaaacttcaatggaacggtggcgcagaaggaattggtttgg
ggtggtattgctgca

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AATGACACTGTGCTTCTGGAAAACT 160 165 1063 Antisense
ACAACATTCCTGATCCAAACGCGGT 333 111 1169 Antisense
CAAACGCGGTGATCCATATTTGGAA 500 191 1184 Antisense
ACATCACATCTCAAAACTTCCCAGT 670 105 1247 Antisense
AAAACTTCCCAGTGATTGTGTCCGC 96 131 1259 Antisense
TCCGCGTGCTGGTACTTGAACTATA 513 595 1279 Antisense
ATATGGCGCTGACTGGAGGGATGAG 306 21 1308 Antisense
GGATGAGATTCGCGGAACTGCACCA 478 513 1326 Antisense
CGGAACTGCACCATCAAACTCAAGA 343 241 1338 Antisense
AACTTCAATGGAACGGTGGCGCAGA 194 139 1384 Antisense
ATTGGTTTGGGGTGGTATTGCTGCA 555 1 1413 Antisense
Sequence Source Affymetrix Proprietary Database