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[192727_at] G protein-coupled receptor kinase

Description F19C6.1 /REP_DB=WormBase Gene ID /WP=CE01554 /TR=SW:Q09537 /GB=CAA88047.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=G protein-coupled receptor kinase
Cluster 6grp_highest_10_10 > 60      6grp_high1_10_10 > 17      4grp_highest_8_8 > 60      4grp_high_8_8 > 17      6grp_highest_nonorm > 90      6grp_total > 07      4grp_total > 30      6grp_highest_sub > De      6grp_cgc > 12      6grp_high1_sub > De      6grp_cgc_sub > De      6grp_total_sub > Decrease      6grp_rule_based > S1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 190
1 2 3 4 range
A 281.8
(3)
P 		95.8
(-3)
P 		139.7
(-1.6)
P 		166.4
(-0.7)
P 		186
B 235.7
(3)
P 		132.8
(-2)
P 		111.9
(-3)
P 		153.6
(-1)
P 		124
C 202
(3)
P 		190.7
(2.4)
P 		92.1
(-3)
P 		196.9
(2.7)
P 		110
avr 239.8
(3) 		139.8
(-1.8) 		114.6
(-3) 		172.3
(-0.2) 		125

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 267
1 2 3 4 5 6 range
A 326.3
(3)
P 		204.8
(-0.3)
P 		125.6
(-2.4)
P 		133.4
(-2.2)
P 		104.4
(-3)
P 		149.2
(-1.8)
P 		222
B 257.1
(3)
P 		140.8
(-1.2)
P 		98.6
(-2.7)
P 		89.9
(-3)
P 		93
(-2.9)
P 		93.2
(-2.9)
P 		167
C 357.3
(3)
P 		195.9
(-0.7)
P 		116.9
(-2.6)
P 		125.2
(-2.4)
P 		103.6
(-2.9)
P 		98.3
(-3)
P 		259
avr 313.6
(3) 		180.5
(-0.7) 		113.7
(-2.6) 		116.2
(-2.6) 		100.3
(-3) 		113.6
(-2.6) 		213
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 82
1 2 3 4 range
A 102.6
(3)
P 		20.8
(-3)
P 		36.5
(-1.8)
P 		24.4
(-2.7)
P 		82
B 75.2
(3)
P 		32.8
(-2.2)
P 		25.9
(-3)
P 		32.7
(-2.2)
P 		49
C 66.9
(3)
P 		54.8
(0.9)
P 		32.1
(-3)
P 		33.2
(-2.8)
P 		35
avr 81.6
(3) 		36.1
(-2.3) 		31.5
(-2.8) 		30.1
(-3) 		52

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 109
1 2 3 4 5 6 range
A 60.2
(1.3)
P 		72.8
(3)
P 		27.4
(-3)
P 		33.8
(-2.2)
P 		31.5
(-2.5)
P 		36.3
(-1.8)
P 		45
B 89.5
(3)
P 		46.9
(-0.9)
P 		23.9
(-3)
P 		23.8
(-3)
P 		37.8
(-1.7)
P 		34.7
(-2)
P 		66
C 132.4
(3)
P 		59.8
(-1.1)
P 		29.7
(-2.7)
P 		25.2
(-3)
P 		33.5
(-2.5)
P 		32.9
(-2.6)
P 		107
avr 94
(3) 		59.8
(-0.1) 		27
(-3) 		27.6
(-2.9) 		34.3
(-2.3) 		34.6
(-2.3) 		67
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192727_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.16656
Sequence Type Exemplar sequence
Representative Public ID F19C6.1 NCBI
Target Description F19C6.1 /REP_DB=WormBase Gene ID /WP=CE01554 /TR=SW:Q09537 /GB=CAA88047.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=G protein-coupled receptor kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077275(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077275 NCBI Caenorhabditis elegans G-protein-coupled Receptor Kinase family member (grk-1) (grk-1) mRNA, complete cds. 11/11 None
GENEFINDER00000036259 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:9987492:9997118:-1 11/11 None
F19C6.1 ENSEMBL cdna:known chromosome:CEL140:X:9991212:9999108:-1 gene:F19C6.1 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000036248 3/11 Cross Hyb Matching Probes None
SNAP00000036249 6/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:9991943-9998981(-) 100.0 100.0
Public Domain and Genome References
Gene Title G protein-coupled receptor kinase
Gene Symbol grk-1
Ensembl F19C6.1
Entrez Gene 181212 Entrez gene
SwissProt Q09537 EMBL-EBI
WormBase CE01554 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.18891.1.S1_AT similar to G protein-coupled receptor kinase 5 (G protein-coupled receptor kinase GRK5) cfa
CANINE_2:CFAAFFX.18899.1.S1_S_AT similar to G protein-coupled receptor kinase 5 (G protein-coupled receptor kinase GRK5) cfa
DROSOPHILA_2:1624042_AT G protein-coupled receptor kinase 2 dm
DROSGENOME1:154978_AT G protein-coupled receptor kinase 2 dm
HG-U95AV2:1135_AT G protein-coupled receptor kinase 5 hs
HC-G110:1135_AT G protein-coupled receptor kinase 5 hs
HG-U133_PLUS_2:204396_S_AT G protein-coupled receptor kinase 5 hs
HG-U133A_2:204396_S_AT G protein-coupled receptor kinase 5 hs
HG-U133A:204396_S_AT G protein-coupled receptor kinase 5 hs
HG-FOCUS:204396_S_AT G protein-coupled receptor kinase 5 hs
HUGENEFL:L15388_AT G protein-coupled receptor kinase 5 hs
U133_X3P:G4885348_3P_A_AT G protein-coupled receptor kinase 5 hs
U133_X3P:HS2.304270.1.S1_3P_S_AT G protein-coupled receptor kinase 5 hs
U133_X3P:HS.211569.0.A1_3P_A_AT G protein-coupled receptor kinase 5 hs
U133_X3P:1569949_3P_AT G protein-coupled receptor kinase 5 hs
HG-U133_PLUS_2:1569949_AT G protein-coupled receptor kinase 5 hs
HG-U133A_2:204395_S_AT G protein-coupled receptor kinase 5 hs
HG-U133_PLUS_2:204395_S_AT G protein-coupled receptor kinase 5 hs
HG-U133A:204395_S_AT G protein-coupled receptor kinase 5 hs
HG-U95AV2:40994_AT G protein-coupled receptor kinase 5 hs
HG-U95B:41914_AT G protein-coupled receptor kinase 5 hs
HG-U95C:54185_AT G protein-coupled receptor kinase 5 hs
HG-U95D:67895_AT G protein-coupled receptor kinase 5 hs
HG-U95E:90819_AT G protein-coupled receptor kinase 5 hs
HU35KSUBB:RC_R43122_AT G protein-coupled receptor kinase 5 hs
HU35KSUBB:RC_AA011510_AT G protein-coupled receptor kinase 5 hs
HU35KSUBC:RC_N53370_AT G protein-coupled receptor kinase 5 hs
HU35KSUBD:RC_AA476915_AT G protein-coupled receptor kinase 5 hs
MOUSE430_2:1449514_AT G protein-coupled receptor kinase 5 mm
MOUSE430A_2:1449514_AT G protein-coupled receptor kinase 5 mm
MOE430A:1449514_AT G protein-coupled receptor kinase 5 mm
MU11KSUBB:MSA.9263.0_S_AT G protein-coupled receptor kinase 5 mm
MU11KSUBB:MSA.25108.0_S_AT G protein-coupled receptor kinase 5 mm
MG-U74AV2:102217_AT G protein-coupled receptor kinase 5 mm
MG-U74BV2:108320_AT G protein-coupled receptor kinase 5, mRNA (cDNA clone MGC:30358 IMAGE:5116510) mm
MOE430B:1446998_AT G protein-coupled receptor kinase 5 (GRK5) mm
MOUSE430_2:1446998_AT G protein-coupled receptor kinase 5 (GRK5) mm
MU19KSUBC:TC39716_AT G protein-coupled receptor kinase 5, mRNA (cDNA clone MGC:30358 IMAGE:5116510) mm
RG-U34A:RC_AA946251_AT G protein-coupled receptor kinase 5 rn
RG-U34B:RC_AA946204_G_AT G protein-coupled receptor kinase 5 rn
RAE230A:1368408_AT G protein-coupled receptor kinase 5 rn
RAT230_2:1368408_AT G protein-coupled receptor kinase 5 rn
RG-U34B:RC_AI044284_AT G protein-coupled receptor kinase 5 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7155 cell adhesion inferred from electronic annotation QuickGO AmiGO
7160 cell-matrix adhesion inferred from electronic annotation QuickGO AmiGO
7165 signal transduction inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
8305 integrin complex inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4703 G-protein coupled receptor kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
4871 signal transducer activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA88047 Hypothetical protein F19C6.1 [Caenorhabditis elegans] ref|NP_509676.1| G-protein-coupled Receptor Kinase family member (grk-1) [Caenorhabditis elegans] sp|Q09537|YQR1_CAEEL Probable G protein-coupled receptor kinase F19C6.1 0.0
blast CAE58755 Hypothetical protein CBG01947 [Caenorhabditis briggsae] 0.0
blast XP_689251 PREDICTED: similar to G protein-coupled receptor kinase 4 isoform alpha [Danio rerio] 1.0E-164
blast CAG03294 unnamed protein product [Tetraodon nigroviridis] 1.0E-144
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 3.0E-14
hanks 1.4.5 AGC group; AGC IV GPCR kinases; IT11 4.0E-94
hanks 1.4.5 AGC group; AGC IV GPCR kinases; IT11 8.0E-95
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 7.0E-78
Pfam IPR000342 EMBL-EBI Regulator of G protein 3.7E-51
Pfam IPR000719 EMBL-EBI Protein kinase 7.0E-78
Pfam IPR000342 EMBL-EBI Regulator of G protein 6.2E-8
Trans Membrane
ID Number Of Domains Domain Boundaries
GENEFINDER00000036259 1 533-555
Sequence
Target Sequence 
>C. ELEGANS:192727_AT
cgctgtgtcgagggttgcttcacaaagaaccggggttccgtcttggttgtcgacgagttg
gacgaccggaagacggtgctgaagagattcgagcacatccgtttttcaacacagcggata
cagttactggtcgagaaccagtgccatggaaaaagatggaagcggggaaggtaacacctc
cgttttgtcctgatccacgtgcagtttatgcaaaagacgtcttagacattgagcaattca
gcactgtaaaaggagtccgactcgatgcaaccgatactcaattttatgggaaattcaaca
ctggatgtgttagtattccctggcaaagcgagatgatcgaaacggaatgttttgcggagt
tgaacacgtttcacgatgaagatggaaatgttatgtggaatttgagacctgatggaataa
atatggatgaaaggaggaatgggaccagtaaacctggcttcttttcacgactttttcgca
agaagaatatcgaagtcaccaaatcccttcatgatctctcccatctcggtgtcgaacaac
aacaaccacccaaaacatcaactcaaactcctgctgttcgat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CGCTGTGTCGAGGGTTGCTTCACAA 658 253 1316 Antisense
GTTCCGTCTTGGTTGTCGACGAGTT 541 441 1350 Antisense
GCACATCCGTTTTTCAACACAGCGG 522 315 1408 Antisense
TTTGTCCTGATCCACGTGCAGTTTA 494 665 1499 Antisense
TCCGACTCGATGCAACCGATACTCA 562 591 1571 Antisense
GATGTGTTAGTATTCCCTGGCAAAG 215 409 1619 Antisense
GACCAGTAAACCTGGCTTCTTTTCA 533 377 1758 Antisense
CTTCTTTTCACGACTTTTTCGCAAG 534 221 1773 Antisense
GAAGTCACCAAATCCCTTCATGATC 86 337 1807 Antisense
CTCCCATCTCGGTGTCGAACAACAA 583 231 1833 Antisense
TCAACTCAAACTCCTGCTGTTCGAT 416 627 1873 Antisense
Sequence Source Affymetrix Proprietary Database