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[192723_at] PH (pleckstrin homology) domain

Description ZK632.12 /REP_DB=WormBase Gene ID /WP=CE01110 /TR=SW:P34657 /GB=CAA80187.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=PH (pleckstrin homology) domain
Cluster 6grp_highest_10_10 > 38      6grp_high1_10_10 > 73      4grp_highest_8_8 > 38      4grp_high_8_8 > 03      6grp_highest_nonorm > 74      6grp_total > 74      4grp_total > 13      6grp_highest_sub > 04      6grp_high1_sub > 03_04      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 332
1 2 3 4 range
A 646.8
(3)
P 		436.7
(-2.1)
P 		400.3
(-3)
P 		611.1
(2.1)
P 		247
B 524.9
(-0.9)
P 		474
(-1.8)
P 		412.1
(-3)
P 		732.2
(3)
P 		320
C 469.8
(-1.7)
P 		400.4
(-3)
P 		441.4
(-2.3)
P 		729.2
(3)
P 		329
avr 547.2
(-0.2) 		437
(-2.6) 		417.9
(-3) 		690.8
(3) 		273

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 595
1 2 3 4 5 6 range
A 565.2
(-2.6)
P 		542.4
(-3)
P 		677.4
(-0.4)
P 		857.9
(3)
P 		791
(1.7)
P 		715.8
(0.3)
P 		316
B 586.8
(-2.6)
P 		560.9
(-3)
P 		988.9
(3)
P 		876.4
(1.4)
P 		698.7
(-1.1)
P 		765.7
(-0.1)
P 		428
C 405
(-3)
P 		732.2
(0.3)
P 		615.4
(-0.9)
P 		999.5
(3)
P 		456
(-2.5)
P 		712.8
(0.1)
P 		595
avr 519
(-3) 		611.8
(-1.6) 		760.6
(0.7) 		911.3
(3) 		648.6
(-1) 		731.4
(0.2) 		392
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 146
1 2 3 4 range
A 235.5
(3)
P 		94.8
(-2.8)
P 		104.6
(-2.4)
P 		89.5
(-3)
P 		146
B 167.4
(3)
P 		117.1
(-1.2)
P 		95.5
(-3)
P 		156
(2)
P 		72
C 155.5
(3)
P 		115.1
(-3)
P 		153.8
(2.7)
P 		122.9
(-1.8)
P 		40
avr 186.1
(3) 		109
(-3) 		118
(-2.3) 		122.8
(-1.9) 		77

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 181
1 2 3 4 5 6 range
A 104.2
(-3)
P 		192.9
(1)
P 		147.5
(-1.1)
P 		217.6
(2.1)
P 		238.7
(3)
P 		174.3
(0.1)
P 		135
B 204.2
(-1.9)
P 		186.7
(-3)
P 		240.1
(0.2)
P 		232.1
(-0.2)
P 		283.9
(2.9)
P 		285.5
(3)
P 		99
C 150.1
(-2.8)
P 		223.4
(2)
P 		156.6
(-2.4)
P 		201
(0.5)
P 		147.6
(-3)
P 		238.6
(3)
P 		91
avr 152.8
(-3) 		201
(0.6) 		181.4
(-0.9) 		216.9
(1.8) 		223.4
(2.3) 		232.8
(3) 		80
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192723_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.6822
Sequence Type Exemplar sequence
Representative Public ID ZK632.12 NCBI
Target Description ZK632.12 /REP_DB=WormBase Gene ID /WP=CE01110 /TR=SW:P34657 /GB=CAA80187.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=PH (pleckstrin homology) domain
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_066782(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_066782 NCBI Caenorhabditis elegans ZK632.12 (ZK632.12) mRNA, complete cds. 11/11 None
ZK632.12 ENSEMBL cdna:known chromosome:CEL140:III:9830696:9832315:1 gene:ZK632.12 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:9830727-9832148(+) 100.0 100.0
Public Domain and Genome References
Gene Title PH (pleckstrin homology) domain
Ensembl ZK632.12
Entrez Gene 176397 Entrez gene
SwissProt P34657 EMBL-EBI
WormBase CE01110 Wormbase
Functional Annotations
Ortholog
ID Title Organism
DROSOPHILA_2:1637328_AT dm
DROSGENOME1:153955_AT dm
CHICKEN:GGAAFFX.11702.1.S1_AT pleckstrin homology domain containing, family F (with FYVE domain) member 2 gga
CHICKEN:GGAAFFX.11702.1.S1_S_AT pleckstrin homology domain containing, family F (with FYVE domain) member 2 gga
HG-U133_PLUS_2:218640_S_AT pleckstrin homology domain containing, family F (with FYVE domain) member 2 hs
HG-U133A:218640_S_AT pleckstrin homology domain containing, family F (with FYVE domain) member 2 hs
HG-U133A_2:218640_S_AT pleckstrin homology domain containing, family F (with FYVE domain) member 2 hs
HU35KSUBB:RC_N46252_AT pleckstrin homology domain containing, family F (with FYVE domain) member 2 hs
U133_X3P:G13375826_3P_A_AT pleckstrin homology domain containing, family F (with FYVE domain) member 2 hs
U133_X3P:HS.29724.0.S1_3P_A_AT pleckstrin homology domain containing, family F (with FYVE domain) member 2 hs
HG-U133_PLUS_2:222699_S_AT pleckstrin homology domain containing, family F (with FYVE domain) member 2 hs
HG-U133B:222699_S_AT pleckstrin homology domain containing, family F (with FYVE domain) member 2 hs
HG-U95B:44531_AT pleckstrin homology domain containing, family F (with FYVE domain) member 2 hs
HG-U95E:88764_AT pleckstrin homology domain containing, family F (with FYVE domain) member 2 hs
MOE430A:1423861_AT pleckstrin homology domain containing, family F (with FYVE domain) member 2 mm
MOUSE430A_2:1423861_AT pleckstrin homology domain containing, family F (with FYVE domain) member 2 mm
MOUSE430_2:1423861_AT pleckstrin homology domain containing, family F (with FYVE domain) member 2 mm
MG-U74BV2:111394_AT pleckstrin homology domain containing, family F (with FYVE domain) member 2 mm
MG-U74CV2:166170_AT pleckstrin homology domain containing, family F (with FYVE domain) member 2 mm
MOE430A:1423862_AT pleckstrin homology domain containing, family F (with FYVE domain) member 2 mm
MOUSE430A_2:1423862_AT pleckstrin homology domain containing, family F (with FYVE domain) member 2 mm
MOUSE430_2:1423862_AT pleckstrin homology domain containing, family F (with FYVE domain) member 2 mm
MU19KSUBC:TC38926_AT Pleckstrin homology domain containing, family F (with FYVE domain) member 2, mRNA (cDNA clone MGC:36376 IMAGE:4987735) mm
RG-U34B:RC_AA965057_AT pleckstrin homology domain containing, family F (with FYVE domain) member 2 (predicted) rn
RG-U34C:RC_AI103367_S_AT pleckstrin homology domain containing, family F (with FYVE domain) member 2 (predicted) rn
RAE230A:1372824_AT pleckstrin homology domain containing, family F (with FYVE domain) member 2 (predicted) rn
RAT230_2:1372824_AT pleckstrin homology domain containing, family F (with FYVE domain) member 2 (predicted) rn
RAE230B:1379809_AT pleckstrin homology domain containing, family F (with FYVE domain) member 2 (predicted) rn
RAT230_2:1379809_AT pleckstrin homology domain containing, family F (with FYVE domain) member 2 (predicted) rn
Gene Ontology
GO Molecular Function (view graph)
ID Description Evidence Links
8270 zinc ion binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA80187 Hypothetical protein ZK632.12 [Caenorhabditis elegans] ref|NP_499183.1| ZK632.12 [Caenorhabditis elegans] sp|P34657|YOTB_CAEEL Hypothetical protein ZK632.12 in chromosome III 1.0E-149
blast S40944 hypothetical protein ZK632.12 - Caenorhabditis elegans 1.0E-141
blast CAE65106 Hypothetical protein CBG09969 [Caenorhabditis briggsae] 2.0E-87
Protein Domains
Database ID Description E-Value
Pfam IPR001849 EMBL-EBI Pleckstrin-like 2.5E-17
Pfam IPR000306 EMBL-EBI Zn-finger, FYVE type 1.4E-32
Sequence
Target Sequence 
>C. ELEGANS:192723_AT
gatgcgttacagatctccttgaaagaggaaataagcaagccgcgactgctcacgcagctg
tatgggttcccgatggtgaagcagtgaagtgtatggtctgcgggaaaactcaattcaatc
tggttcaaagaagacatcactgcagaaattgtggacgtgtcgtgtgtggcgcctgctcat
cgagaacattccgtattgacaatgtacataagaagcctgtccgagtttgtgatcattgct
ttgacagtctgagtagtgccacaccaggacaagaagaaagtgaaccaaaaacgggaaatc
gcttgcaccatgaggattcctcctcggatagtgaagacgaggtcaatggtagtggacgat
cgagtaatgagagccggccaac

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GATGCGTTACAGATCTCCTTGAAAG 659 409 395 Antisense
AAATAAGCAAGCCGCGACTGCTCAC 411 115 423 Antisense
ACTGCTCACGCAGCTGTATGGGTTC 630 97 439 Antisense
GTATGGGTTCCCGATGGTGAAGCAG 308 455 454 Antisense
ATTGTGGACGTGTCGTGTGTGGCGC 671 3 542 Antisense
CGCCTGCTCATCGAGAACATTCCGT 348 257 564 Antisense
GAAGCCTGTCCGAGTTTGTGATCAT 280 345 606 Antisense
TGACAGTCTGAGTAGTGCCACACCA 687 569 636 Antisense
AAACGGGAAATCGCTTGCACCATGA 446 127 683 Antisense
GCACCATGAGGATTCCTCCTCGGAT 242 313 699 Antisense
GATCGAGTAATGAGAGCCGGCCAAC 418 417 752 Antisense
Sequence Source Affymetrix Proprietary Database