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[192718_s_at] protein tyrosine kinase

Description C16B8.1 /REP_DB=WormBase Gene ID /WP=CE27692 /GEN=lin-18 /TR=Q18041 /GB=AAA82618.2 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=protein tyrosine kinase
Cluster 6grp_highest_10_10 > 11      6grp_high1_10_10 > 0      4grp_highest_8_8 > 49      4grp_high_8_8 > 41      6grp_highest_nonorm > 61      6grp_total > 13      4grp_total > 54      6grp_cgc > 40      6grp_total_sub > Decrease      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 468
1 2 3 4 range
A 720.9
(3)
P 		432.2
(-0.7)
P 		454.5
(-0.4)
P 		256.7
(-3)
P 		464
B 724.9
(3)
P 		488.7
(-0.5)
P 		394.2
(-2)
P 		325.1
(-3)
P 		400
C 687.7
(3)
P 		476
(-0.6)
P 		337.7
(-2.9)
P 		331.7
(-3)
P 		356
avr 711.2
(3) 		465.6
(-0.6) 		395.5
(-1.7) 		304.5
(-3) 		407

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 277
1 2 3 4 5 6 range
A 477
(2.9)
P 		478.5
(3)
P 		369
(-1.2)
P 		463.6
(2.4)
P 		336.2
(-2.4)
P 		320.3
(-3)
P 		158
B 485.7
(2.8)
P 		370.3
(-0.4)
P 		341.4
(-1.2)
P 		493.2
(3)
P 		283.1
(-2.8)
P 		276.3
(-3)
P 		217
C 543.7
(3)
P 		493.2
(1.9)
P 		461.5
(1.2)
P 		421.9
(0.4)
P 		323.1
(-1.8)
P 		266.5
(-3)
P 		277
avr 502.1
(3) 		447.3
(1.5) 		390.6
(-0.1) 		459.6
(1.8) 		314.1
(-2.3) 		287.7
(-3) 		214
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 225
1 2 3 4 range
A 262.5
(3)
P 		93.8
(-1.5)
P 		118.8
(-0.8)
P 		37.6
(-3)
P 		225
B 231.2
(3)
P 		120.7
(-1.1)
P 		91.3
(-2.2)
P 		69.3
(-3)
P 		162
C 227.7
(3)
P 		136.9
(-0.2)
P 		117.7
(-0.8)
P 		55.9
(-3)
P 		172
avr 240.5
(3) 		117.1
(-1) 		109.3
(-1.2) 		54.3
(-3) 		186

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 124
1 2 3 4 5 6 range
A 87.9
(-2.4)
P 		170.2
(3)
P 		80.4
(-2.8)
P 		117.6
(-0.4)
P 		101.5
(-1.5)
P 		78
(-3)
P 		92
B 169
(3)
P 		123.2
(-0.2)
P 		82.9
(-3)
P 		130.6
(0.3)
P 		115
(-0.8)
P 		103
(-1.6)
P 		86
C 201.5
(3)
P 		150.5
(0.4)
P 		117.5
(-1.3)
P 		84.8
(-3)
P 		104.5
(-2)
P 		89.2
(-2.8)
P 		117
avr 152.8
(3) 		148
(2.5) 		93.6
(-2.7) 		111
(-1) 		107
(-1.4) 		90.1
(-3) 		63
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 192718_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.18332
Sequence Type Exemplar sequence
Representative Public ID C16B8.1 NCBI
Target Description C16B8.1 /REP_DB=WormBase Gene ID /WP=CE27692 /GEN=lin-18 /TR=Q18041 /GB=AAA82618.2 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=protein tyrosine kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_076283(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_076283 NCBI Caenorhabditis elegans abnormal cell LINeage family member (lin-18) (lin-18) mRNA, complete cds. 11/11 None
SNAP00000002083 ENSEMBL cdna:SNAP chromosome:CEL140:X:3958538:3961762:1 11/11 None
GENEFINDER00000002089 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:3958538:3961762:1 11/11 None
C16B8.1 ENSEMBL cdna:known chromosome:CEL140:X:3958475:3961884:1 gene:C16B8.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:3958601-3961763(+) 100.0 100.0
Public Domain and Genome References
Gene Title protein tyrosine kinase
Gene Symbol lin-18
Ensembl C16B8.1
Entrez Gene 180679 Entrez gene
SwissProt Q18041 EMBL-EBI
WormBase CE27692 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1583857_AT similar to Tyrosine-protein kinase RYK precursor cfa
CANINE_2:CFA.11952.1.A1_AT similar to Tyrosine-protein kinase RYK precursor cfa
CANINE_2:CFA.11952.1.A1_S_AT similar to Tyrosine-protein kinase RYK precursor cfa
CANINE_2:CFAAFFX.10986.1.S1_AT similar to Tyrosine-protein kinase RYK precursor cfa
DROSGENOME1:142417_AT Derailed 2 dm
DROSOPHILA_2:1630095_A_AT Derailed 2 dm
DROSOPHILA_2:1625721_S_AT Derailed 2 dm
DROSGENOME1:151565_AT Derailed 2 dm
DROSGENOME1:147129_AT Derailed 2 dm
CHICKEN:GGA.3751.1.S1_AT RYK receptor-like tyrosine kinase gga
HG-U133_PLUS_2:216976_S_AT RYK receptor-like tyrosine kinase hs
HG-U133A_2:216976_S_AT RYK receptor-like tyrosine kinase hs
HG-U133A:216976_S_AT RYK receptor-like tyrosine kinase hs
HG-U95AV2:539_AT RYK receptor-like tyrosine kinase hs
HC-G110:539_AT RYK receptor-like tyrosine kinase hs
HG-U133_PLUS_2:202853_S_AT RYK receptor-like tyrosine kinase hs
HG-U133A:202853_S_AT RYK receptor-like tyrosine kinase hs
HG-FOCUS:202853_S_AT RYK receptor-like tyrosine kinase hs
HG-U133A_2:202853_S_AT RYK receptor-like tyrosine kinase hs
HUGENEFL:S59184_AT RYK receptor-like tyrosine kinase hs
HG-U133_PLUS_2:214172_X_AT RYK receptor-like tyrosine kinase hs
HG-U133A_2:214172_X_AT RYK receptor-like tyrosine kinase hs
HG-U133A:214172_X_AT RYK receptor-like tyrosine kinase hs
U133_X3P:G11863158_3P_X_AT RYK receptor-like tyrosine kinase hs
U133_X3P:G11863158_3P_A_AT RYK receptor-like tyrosine kinase hs
U133_X3P:HS.79350.2.S1_3P_A_AT RYK receptor-like tyrosine kinase hs
HG-U95AV2:37756_AT RYK receptor-like tyrosine kinase hs
HG-U133_PLUS_2:238210_AT RYK receptor-like tyrosine kinase hs
HG-U133B:238210_AT RYK receptor-like tyrosine kinase hs
HG-U95D:89629_AT RYK receptor-like tyrosine kinase hs
U133_X3P:HS.245869.0.A1_3P_AT RYK receptor-like tyrosine kinase hs
MOUSE430_2:1427166_A_AT receptor-like tyrosine kinase mm
MOE430A:1427166_A_AT receptor-like tyrosine kinase mm
MOUSE430A_2:1427166_A_AT receptor-like tyrosine kinase mm
MOUSE430_2:1451789_A_AT receptor-like tyrosine kinase mm
MOE430A:1451789_A_AT receptor-like tyrosine kinase mm
MOUSE430A_2:1451789_A_AT receptor-like tyrosine kinase mm
MU11KSUBA:L02210_S_AT receptor-like tyrosine kinase mm
MG-U74AV2:161548_R_AT receptor-like tyrosine kinase mm
MG-U74AV2:160453_AT receptor-like tyrosine kinase mm
MOE430A:1426388_S_AT receptor-like tyrosine kinase mm
MOUSE430A_2:1426388_S_AT receptor-like tyrosine kinase mm
MOUSE430_2:1426388_S_AT receptor-like tyrosine kinase mm
MOUSE430_2:1458960_AT Receptor-like tyrosine kinase, mRNA (cDNA clone MGC:40871 IMAGE:5370100) mm
MOE430B:1458960_AT Receptor-like tyrosine kinase, mRNA (cDNA clone MGC:40871 IMAGE:5370100) mm
MU19KSUBB:TC31490_S_AT Receptor-like tyrosine kinase, mRNA (cDNA clone MGC:40871 IMAGE:5370100) mm
MU19KSUBC:TC39598_AT Receptor-like tyrosine kinase, mRNA (cDNA clone MGC:40871 IMAGE:5370100) mm
RG-U34A:RC_AA892268_AT receptor-like tyrosine kinase rn
RG-U34C:RC_AI179559_AT receptor-like tyrosine kinase rn
RAE230A:1373028_AT receptor-like tyrosine kinase rn
RAT230_2:1373028_AT receptor-like tyrosine kinase rn
RAE230A:1371101_AT receptor-like tyrosine kinase rn
RAT230_2:1371101_AT receptor-like tyrosine kinase rn
RAE230B:1379973_AT Receptor-like tyrosine kinase rn
RAT230_2:1379973_AT Receptor-like tyrosine kinase rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAA82618 Abnormal cell lineage protein 18 [Caenorhabditis elegans] ref|NP_508684.3| abnormal cell LINeage family member (lin-18) [Caenorhabditis elegans] 0.0
blast AAD24877 tyrosine kinase receptor-related protein precursor RYK [Caenorhabditis elegans] 0.0
blast CAE68505 Hypothetical protein CBG14316 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 1.7E-40
Pfam IPR003306 EMBL-EBI WIF domain 4.2E-74
Pfam IPR000719 EMBL-EBI Protein kinase 1.7E-40
Pfam IPR003306 EMBL-EBI WIF domain 4.2E-74
Pfam IPR000719 EMBL-EBI Protein kinase 1.7E-40
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_508684.3 1 154-176
C16B8.1 1 154-176
SNAP00000002083 2 5-24,175-197
GENEFINDER00000002089 2 5-24,175-197
Sequence
Target Sequence 
>C. ELEGANS:192718_S_AT
aacctgaagaagttcctcaccatctgccgacatggtgataaaactaaaggagctcaaact
ctccgaactcatcaactcgtctctctggccacacaagtatcttctgcagtagctcatata
cacaaatatagaatagtgcataacgacattgccgctagaaactgcttgatcgcagaagtg
aatgggcgactccaagtgcaattatgcgactcggcgctgtcccgcgatctgttcccagct
gattatcactgcttgggtgacaatgagaacagaccattgaaatggatgtctccagaagct
attgcaaatgagctgtactcatcggccgctgatgtttggtcactgggagttctactgtgg
gagctcatgtcgctaggaggatctccacacgctgaaatagaccctgaggaagtgtacaca
atgattctcaaaggaaagcgtctgcaacagccgaacaattgtccggatcaattatacgaa
gtcatgctgtgctgttggagggtactcagcgaagatcgtcctagc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AACCTGAAGAAGTTCCTCACCATCT 135 147 1075 Antisense
CAAACTCTCCGAACTCATCAACTCG 471 191 1129 Antisense
TCTGGCCACACAAGTATCTTCTGCA 514 607 1158 Antisense
ACGACATTGCCGCTAGAAACTGCTT 662 91 1217 Antisense
TGCAATTATGCGACTCGGCGCTGTC 287 577 1271 Antisense
GATCTGTTCCCAGCTGATTATCACT 198 419 1300 Antisense
ACTCATCGGCCGCTGATGTTTGGTC 357 101 1391 Antisense
TACTGTGGGAGCTCATGTCGCTAGG 352 645 1427 Antisense
GTCGCTAGGAGGATCTCCACACGCT 546 473 1443 Antisense
GTCATGCTGTGCTGTTGGAGGGTAC 441 465 1555 Antisense
GGTACTCAGCGAAGATCGTCCTAGC 31 505 1575 Antisense
Sequence Source Affymetrix Proprietary Database