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[192710_s_at] Zinc-binding metalloprotease domain

Description Y42A5A.1 /REP_DB=WormBase Gene ID /WP=CE20255 /TR=Q9U2H2 /GB=CAB63366.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=Zinc-binding metalloprotease domain
Cluster 6grp_high1_10_10 > 12      4grp_highest_8_8 > 46      4grp_high_8_8 > 02      6grp_total > 24      4grp_total > 14      6grp_high1_sub > De      6grp_total_sub > Decrease      6grp_rule_based > S2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 350
1 2 3 4 range
A 363.4
(1.5)
P 		100.8
(-3)
P 		136.6
(-2.4)
P 		450.4
(3)
P 		350
B 298.9
(1.6)
P 		154.8
(-2)
P 		115.4
(-3)
P 		353.1
(3)
P 		238
C 339.5
(2.5)
P 		143.5
(-2.9)
P 		141
(-3)
P 		355.6
(3)
P 		215
avr 333.9
(1.8) 		133
(-3) 		131
(-3) 		386.4
(3) 		255

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 182
1 2 3 4 5 6 range
A 177.7
(-0.9)
P 		221.7
(2.2)
P 		233.6
(3)
P 		158
(-2.2)
P 		147.1
(-3)
P 		155.2
(-2.4)
P 		87
B 271
(3)
P 		238.9
(1.5)
P 		238.9
(1.5)
P 		232.8
(1.2)
P 		165
(-2.1)
P 		145.6
(-3)
P 		125
C 252.9
(2.8)
P 		257.2
(3)
P 		210
(1.3)
P 		124.1
(-1.8)
A 		89.4
(-3)
P 		138.6
(-1.2)
P 		168
avr 233.9
(2.7) 		239.3
(3) 		227.5
(2.3) 		171.6
(-0.9) 		133.8
(-3) 		146.5
(-2.3) 		106
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 110
1 2 3 4 range
A 132.3
(3)
P 		21.9
(-3)
P 		35.7
(-2.3)
P 		65.9
(-0.6)
P 		110
B 95.3
(3)
P 		38.2
(-2)
P 		26.7
(-3)
P 		75.2
(1.2)
P 		69
C 112.4
(3)
P 		41.3
(-3)
P 		49.1
(-2.3)
P 		60
(-1.4)
P 		71
avr 113.3
(3) 		33.8
(-3) 		37.2
(-2.7) 		67
(-0.5) 		80

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 69
1 2 3 4 5 6 range
A 32.8
(-3)
P 		78.8
(3)
P 		50.9
(-0.6)
P 		40.1
(-2)
P 		44.4
(-1.5)
P 		37.8
(-2.3)
P 		46
B 94.3
(3)
P 		79.5
(0.8)
P 		58
(-2.4)
P 		61.7
(-1.9)
P 		67
(-1.1)
P 		54.3
(-3)
P 		40
C 93.7
(3)
P 		78.5
(1.7)
P 		53.4
(-0.5)
P 		25
(-3)
A 		28.9
(-2.7)
P 		46.4
(-1.1)
P 		69
avr 73.6
(2.1) 		78.9
(3) 		54.1
(-1.1) 		42.3
(-3) 		46.8
(-2.3) 		46.2
(-2.4) 		37
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 192710_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.13837
Sequence Type Exemplar sequence
Representative Public ID Y42A5A.1 NCBI
Target Description Y42A5A.1 /REP_DB=WormBase Gene ID /WP=CE20255 /TR=Q9U2H2 /GB=CAB63366.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=Zinc-binding metalloprotease domain
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_073419(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_073419 NCBI Caenorhabditis elegans Y42A5A.1 (Y42A5A.1) mRNA, complete cds. 11/11 None
SNAP00000034855 ENSEMBL cdna:SNAP chromosome:CEL140:V:11098887:11100209:1 11/11 None
GENEFINDER00000034860 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:11096527:11100209:1 11/11 None
Y42A5A.1 ENSEMBL cdna:known chromosome:CEL140:V:11090742:11100568:1 gene:Y42A5A.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:11090741-11100209(+) 100.0 100.0
Public Domain and Genome References
Gene Title Zinc-binding metalloprotease domain
Ensembl Y42A5A.1
Entrez Gene 179536 Entrez gene
SwissProt Q9U2H2 EMBL-EBI
WormBase CE20255 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4179 membrane alanyl aminopeptidase activity inferred from electronic annotation QuickGO AmiGO
8237 metallopeptidase activity inferred from electronic annotation QuickGO AmiGO
8270 zinc ion binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB63366 Hypothetical protein Y42A5A.1 [Caenorhabditis elegans] ref|NP_505820.1| Y42A5A.1 [Caenorhabditis elegans] 0.0
blast CAB63366 Hypothetical protein Y42A5A.1 [Caenorhabditis elegans] ref|NP_505820.1| Y42A5A.1 [Caenorhabditis elegans] 1.0E-157
blast CAE75152 Hypothetical protein CBG23086 [Caenorhabditis briggsae] 4.0E-88
blast NP_112274 kidney aminopeptidase M [Rattus norvegicus] sp|P15684|AMPN_RAT Aminopeptidase N (rAPN) (Alanyl aminopeptidase) (Microsomal aminopeptidase) (CD13) (Aminopeptidase M) (APM) (Kidney Zn peptidase) (KZP) gb|AAA41502.1| kidney Zn-peptidase precursor 6.0E-87
blast CAE75149 Hypothetical protein CBG23083 [Caenorhabditis briggsae] 1.0E-85
blast CAE75149 Hypothetical protein CBG23083 [Caenorhabditis briggsae] 9.0E-78
Protein Domains
Database ID Description E-Value
Pfam IPR001930 EMBL-EBI Peptidase M1, membrane alanine aminopeptidase 3.7E-124
Pfam IPR001930 EMBL-EBI Peptidase M1, membrane alanine aminopeptidase 2.0E-50
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_505820.1 1 73-95
Y42A5A.1 1 73-95
Sequence
Target Sequence 
>C. ELEGANS:192710_S_AT
gaacttcgtgtaaactgctcgggagaaaatcaattgctgagtggaatggaatgcaataaa
atcccatattacctccggccacatgtatattctgctgcgataaacgatggaacacaagaa
gattttgactttttatacaaaaaatggatgattgagcactatatgatggaacatgataac
attttcacaggattatgtacaacaaatatacgagaaaatagtgatagagcatggagacaa
gtaattaagaacggagcacgagaaaacgtcatggttcgtgctcagttatgctctaaaaag
ttgtcgaaaaataatttcatattagatttattatacgaagataaagtttatttgaaagaa
tttgttgacaaagaccgcaaatcattatttgcgcttcaacaattgttgtatcgaaaaata
aattacgaagaggaagttttgaaagccgatgaagtttttaaaccatatccacagcttagg
tggattccgaagcttcgtgcaatagcgtctgatcgacttgattggcgaaaaactgttgcc
gctcagtttacaggaaatg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAACTTCGTGTAAACTGCTCGGGAG 451 349 2545 Antisense
TATTACCTCCGGCCACATGTATATT 391 661 2611 Antisense
GAAAACGTCATGGTTCGTGCTCAGT 630 353 2806 Antisense
GGTTCGTGCTCAGTTATGCTCTAAA 79 507 2817 Antisense
AAATCATTATTTGCGCTTCAACAAT 315 117 2923 Antisense
AGTTTTTAAACCATATCCACAGCTT 497 63 2997 Antisense
TTAGGTGGATTCCGAAGCTTCGTGC 238 669 3020 Antisense
AGCTTCGTGCAATAGCGTCTGATCG 93 77 3035 Antisense
GCGTCTGATCGACTTGATTGGCGAA 626 291 3049 Antisense
GATTGGCGAAAAACTGTTGCCGCTC 105 435 3064 Antisense
GTTGCCGCTCAGTTTACAGGAAATG 551 439 3079 Antisense
Sequence Source Affymetrix Proprietary Database