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[192703_s_at] serine/threonine kinase (2 domains)

Description T04C10.1 /REP_DB=WormBase Gene ID /WP=CE06352 /TR=Q22155 /GB=CAA93756.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=serine-threonine kinase (2 domains)
Cluster 6grp_highest_10_10 > 22      6grp_high1_10_10 > 02      4grp_highest_8_8 > 23      4grp_high_8_8 > 13      6grp_highest_nonorm > 51      6grp_total > 35      4grp_total > 03      6grp_highest_sub > De      6grp_cgc > 35      6grp_high1_sub > De      6grp_cgc_sub > Cu      6grp_total_sub > Cup      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 786
1 2 3 4 range
A 735
(-2.7)
P 		697.7
(-3)
P 		721.5
(-2.8)
P 		1422
(3)
P 		724
B 711
(-3)
P 		783.6
(-2.3)
P 		784.8
(-2.3)
P 		1369.6
(3)
P 		659
C 831.9
(-1.2)
P 		739.9
(-2)
P 		635.9
(-3)
P 		1278.8
(3)
P 		643
avr 759.3
(-2.6) 		740.4
(-2.8) 		714.1
(-3) 		1356.8
(3) 		643

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 345
1 2 3 4 5 6 range
A 775.2
(3)
P 		701.1
(1.4)
P 		534.2
(-2.1)
P 		588.1
(-0.9)
P 		490.4
(-3)
P 		555.3
(-1.6)
P 		285
B 799.1
(3)
P 		632.4
(0.1)
P 		746.2
(2.1)
P 		613.3
(-0.2)
P 		454.3
(-3)
P 		597.9
(-0.5)
P 		345
C 615.4
(1.2)
P 		680.6
(3)
P 		673.9
(2.8)
P 		581.1
(0.3)
P 		463.4
(-3)
P 		617.9
(1.3)
P 		217
avr 729.9
(3) 		671.4
(1.7) 		651.4
(1.2) 		594.2
(-0.1) 		469.4
(-3) 		590.4
(-0.2) 		261
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 141
1 2 3 4 range
A 267.6
(3)
P 		151.4
(-3)
P 		188.6
(-1.1)
P 		208.1
(-0.1)
P 		116
B 226.7
(-0.6)
P 		193.5
(-2.4)
P 		181.9
(-3)
P 		291.9
(3)
P 		110
C 275.4
(3)
P 		212.7
(-3)
P 		221.6
(-2.1)
P 		215.6
(-2.7)
P 		63
avr 256.6
(3) 		185.9
(-3) 		197.4
(-2) 		238.5
(1.5) 		71

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 162
1 2 3 4 5 6 range
A 142.9
(-1.8)
P 		249.3
(3)
P 		116.3
(-3)
P 		149.1
(-1.5)
P 		148
(-1.6)
P 		135.2
(-2.1)
P 		133
B 278.1
(3)
P 		210.5
(-0.5)
P 		181.2
(-2)
P 		162.4
(-3)
P 		184.6
(-1.8)
P 		223
(0.1)
P 		116
C 228.1
(3)
P 		207.7
(1.9)
P 		171.5
(-0.1)
P 		116.8
(-3)
P 		149.9
(-1.2)
P 		206.8
(1.9)
P 		111
avr 216.4
(2.5) 		222.5
(3) 		156.3
(-2) 		142.8
(-3) 		160.8
(-1.6) 		188.3
(0.4) 		80
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 192703_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.17878
Sequence Type Exemplar sequence
Representative Public ID T04C10.1 NCBI
Target Description T04C10.1 /REP_DB=WormBase Gene ID /WP=CE06352 /TR=Q22155 /GB=CAA93756.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=serine-threonine kinase (2 domains)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_078059(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_078059 NCBI Caenorhabditis elegans MiniBrain Kinase (Drosophila) homolog family member (mbk-1) (mbk-1) mRNA, complete cds. 11/11 None
SNAP00000038432 ENSEMBL cdna:SNAP chromosome:CEL140:X:14819943:14824452:-1 11/11 None
GENEFINDER00000038433 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:14819943:14824458:-1 10/11 None
T04C10.1.1 ENSEMBL cdna:known chromosome:CEL140:X:14819830:14824458:-1 gene:T04C10.1 11/11 None
T04C10.1.2 ENSEMBL cdna:known chromosome:CEL140:X:14819873:14824460:-1 gene:T04C10.1 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:14819942-14824842(-) 96.28 100.0
Public Domain and Genome References
Gene Title serine/threonine kinase (2 domains)
Gene Symbol mbk-1
Ensembl T04C10.1
Entrez Gene 181578 Entrez gene
SwissProt Q8WQL7 EMBL-EBI
WormBase CE33442 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1602699_AT similar to dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B isoform a cfa
CANINE:1584510_AT similar to dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B isoform a cfa
CANINE_2:CFA.11750.1.A1_S_AT similar to dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B isoform a cfa
CANINE_2:CFAAFFX.9078.1.S1_S_AT similar to dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B isoform a cfa
HG-U133_PLUS_2:217270_S_AT dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B hs
HG-U133A_2:217270_S_AT dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B hs
HG-U133A:217270_S_AT dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B hs
HG-U133_PLUS_2:204954_S_AT dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B hs
HG-U133A:204954_S_AT dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B hs
HG-FOCUS:204954_S_AT dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B hs
HG-U133A_2:204954_S_AT dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B hs
U133_X3P:G4758221_3P_A_AT dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B hs
U133_X3P:HS.249140.0.S1_3P_S_AT dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B hs
U133_X3P:204954_3P_S_AT dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B hs
HG-U95AV2:37834_AT dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B hs
MOUSE430_2:1422254_A_AT dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b mm
MOE430A:1422254_A_AT dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b mm
MOUSE430A_2:1422254_A_AT dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b mm
MG-U74AV2:102584_AT dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b mm
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA93756 Hypothetical protein T04C10.1 [Caenorhabditis elegans] ref|NP_510460.2| MiniBrain Kinase (Drosophila) homolog family member (mbk-1) [Caenorhabditis elegans] gb|AAL40874.1| minibrain kinase [Caenorhabditis elegans] 0.0
blast T24445 hypothetical protein T04C10.1 - Caenorhabditis elegans 0.0
blast CAE63235 Hypothetical protein CBG07597 [Caenorhabditis briggsae] 0.0
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 2.0E-53
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 6.0E-54
hanks 3.1.4 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; Cdk4 5.0E-57
hanks 3.1.4 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; Cdk4 2.0E-57
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 1.6E-64
Pfam IPR000719 EMBL-EBI Protein kinase 1.6E-64
Sequence
Target Sequence 
>C. ELEGANS:192703_S_AT
tacatacagcagccgtcaagccaaatgagtcaagtgatggaatctccgtcggttggatca
gtctatgtggaagataacgggatgtatcgccaggcgcctggatcttctgccaacccaatt
tccgtcacatcatcgtttgacgaaggagatgccatggaagttgatgctgggagaagacgc
ttctctgctcatcagcaaaattaccacaatccaaactatcagtactctcaaccacaacag
caacagcagcagcagtatcagcagacacagcgaacgcaactggagcagcagcagaaacag
gctcaactccaacagcagctccagcaacagcaaatgcagcaacagcagcaacagcaacaa
caacgccagcacatgccacaagcgcagagcagttcccaacagcacctccaatcacgggcg
cggccacgacaacaggatcagaacgagtggaggaatcagtttgagctggatgacacgttt
cagcagaagcagc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TACATACAGCAGCCGTCAAGCCAAA 279 641 2230 Antisense
GGAATCTCCGTCGGTTGGATCAGTC 343 533 2268 Antisense
GATGTATCGCCAGGCGCCTGGATCT 639 409 2310 Antisense
CAATTTCCGTCACATCATCGTTTGA 483 179 2345 Antisense
ACGCTTCTCTGCTCATCAGCAAAAT 608 91 2406 Antisense
CTATCAGTACTCTCAACCACAACAG 148 223 2445 Antisense
GTATCAGCAGACACAGCGAACGCAA 444 453 2484 Antisense
CAGAAACAGGCTCAACTCCAACAGC 680 203 2521 Antisense
CATGCCACAAGCGCAGAGCAGTTCC 67 211 2601 Antisense
GCGGCCACGACAACAGGATCAGAAC 584 293 2649 Antisense
GATGACACGTTTCAGCAGAAGCAGC 543 411 2698 Antisense
Sequence Source Affymetrix Proprietary Database