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[192677_at] Hydroxymethylglutaryl-coA reductase

Description F08F8.2 /REP_DB=WormBase Gene ID /WP=CE02598 /TR=Q19207 /GB=AAA68386.1 /SUBMIT=ST.LOUIS /CHR=3 /FEA=Sanger Annotation /DEF=Hydroxymethylglutaryl-coA reductase
Cluster 6grp_highest_10_10 > 48      6grp_high1_10_10 > 74      4grp_highest_8_8 > 33      4grp_high_8_8 > 58      6grp_highest_nonorm > 64      6grp_total > 74      4grp_total > 61      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 583
1 2 3 4 range
A 755.7
(3)
P 		636
(1.3)
P 		705.9
(2.3)
P 		326.4
(-3)
P 		429
B 711.9
(2.1)
P 		758.2
(3)
P 		572.6
(-0.4)
P 		431.7
(-3)
P 		327
C 880.8
(2.7)
P 		700.5
(0.5)
P 		909.8
(3)
P 		399.2
(-3)
P 		511
avr 782.8
(3) 		698.2
(1.7) 		729.4
(2.2) 		385.8
(-3) 		397

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 493
1 2 3 4 5 6 range
A 596.8
(-3)
P 		837.6
(0.9)
P 		901.5
(1.9)
P 		873.6
(1.5)
P 		666.9
(-1.9)
P 		969.2
(3)
P 		372
B 615.2
(-3)
P 		904.8
(1.2)
P 		843.6
(0.3)
P 		843.6
(0.3)
P 		1033.7
(3)
P 		885.6
(0.9)
P 		419
C 646.9
(-3)
P 		959.2
(1.2)
P 		1089.3
(3)
P 		1086.9
(3)
P 		927.5
(0.8)
P 		947.8
(1.1)
P 		442
avr 619.6
(-3) 		900.5
(2.2) 		944.8
(3) 		934.7
(2.8) 		876
(1.7) 		934.2
(2.8) 		325
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 269
1 2 3 4 range
A 275.1
(3)
P 		138.1
(-0.6)
P 		184.5
(0.6)
P 		47.8
(-3)
P 		227
B 227
(3)
P 		187.3
(1.2)
P 		132.7
(-1.2)
P 		92
(-3)
P 		135
C 291.6
(2.4)
P 		201.4
(0.2)
P 		317.1
(3)
P 		67.3
(-3)
P 		250
avr 264.6
(3) 		175.6
(0.3) 		211.4
(1.4) 		69
(-3) 		196

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 310
1 2 3 4 5 6 range
A 110
(-3)
P 		297.9
(3)
P 		196.3
(-0.2)
P 		221.6
(0.6)
P 		201.2
(-0.1)
P 		236
(1)
P 		188
B 214.1
(-2.7)
P 		301.2
(-0.3)
P 		204.8
(-3)
P 		223.4
(-2.5)
P 		420
(3)
P 		330.2
(0.5)
P 		215
C 239.8
(-1.7)
P 		292.7
(1.5)
P 		277.3
(0.6)
P 		218.6
(-3)
P 		300.1
(2)
P 		317.3
(3)
P 		99
avr 188
(-3) 		297.3
(2.5) 		226.1
(-1.1) 		221.2
(-1.3) 		307.1
(3) 		294.5
(2.4) 		119
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192677_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.6241
Sequence Type Exemplar sequence
Representative Public ID F08F8.2 NCBI
Target Description F08F8.2 /REP_DB=WormBase Gene ID /WP=CE02598 /TR=Q19207 /GB=AAA68386.1 /SUBMIT=ST.LOUIS /CHR=3 /FEA=Sanger Annotation /DEF=Hydroxymethylglutaryl-coA reductase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_066225(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_066225 NCBI Caenorhabditis elegans F08F8.2 (F08F8.2) mRNA, complete cds. 11/11 None
SNAP00000010815 ENSEMBL cdna:SNAP chromosome:CEL140:III:7359435:7361774:1 11/11 None
GENEFINDER00000010828 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:7359435:7361774:1 11/11 None
F08F8.2 ENSEMBL cdna:known chromosome:CEL140:III:7359418:7362021:1 gene:F08F8.2 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:7359086-7361772(+) 98.85 100.0
Public Domain and Genome References
Gene Title Hydroxymethylglutaryl-coA reductase
Ensembl F08F8.2
Entrez Gene 176047 Entrez gene
SwissProt Q19207 EMBL-EBI
WormBase CE30649 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:259983_AT 3-hydroxy-3-methylglutaryl-CoA reductase 1 / HMG-CoA reductase 1 (HMG1) at
ATGENOME1:12920_AT 3-hydroxy-3-methylglutaryl-CoA reductase 1 / HMG-CoA reductase 1 (HMG1) at
ATGENOME1:12921_S_AT 3-hydroxy-3-methylglutaryl-CoA reductase 1 / HMG-CoA reductase 1 (HMG1) at
CANINE:1599737_AT similar to 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) cfa
CANINE:1592029_AT similar to 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) cfa
CANINE:1584592_AT similar to 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) cfa
CANINE:1583263_AT similar to 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) cfa
CANINE_2:CFA.11625.1.A1_S_AT similar to 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) cfa
CANINE_2:CFA.11625.1.A2_AT similar to 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) cfa
CANINE_2:CFA.16390.1.S1_S_AT similar to 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) cfa
CANINE_2:CFA.16390.2.A1_AT similar to 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) cfa
CANINE_2:CFA.3293.1.A1_AT similar to 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) cfa
DROSOPHILA_2:1628990_AT HMG Coenzyme A reductase dm
DROSGENOME1:143190_AT HMG Coenzyme A reductase dm
CHICKEN:GGA.2785.1.S1_S_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase gga
CHICKEN:GGAAFFX.12414.1.S1_S_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase gga
CHICKEN:GGAAFFX.21726.1.S1_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase gga
HUGENEFL:M11058_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase hs
HG-U133A:202540_S_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase hs
HG-U133_PLUS_2:202540_S_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase hs
HG-U133A_2:202540_S_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase hs
U133_X3P:G4557642_3P_A_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase hs
U133_X3P:HS.11899.0.S2_3P_A_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase hs
HG-U133A_2:202539_S_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase hs
HG-FOCUS:202539_S_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase hs
HG-U133_PLUS_2:202539_S_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase hs
HG-U133A:202539_S_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase hs
HG-U95AV2:39328_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase hs
MOE430A:1451766_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase mm
MOUSE430_2:1451766_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase mm
MOUSE430A_2:1451766_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase mm
MU11KSUBB:MSA.756.0_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase mm
MU11KSUBB:MSA.2345.0_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase mm
MU11KSUBB:MSA.756.0_G_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase mm
MG-U74AV2:104285_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase mm
MG-U74AV2:99425_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase mm
MG-U74CV2:166342_R_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase mm
MOE430A:1427229_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase mm
MOUSE430A_2:1427229_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase mm
MOUSE430_2:1427229_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase mm
MU11KSUBA:M62766_RC_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase mm
MU19KSUBA:TC19900_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr), mRNA mm
RT-U34:X55286_G_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase rn
RG-U34A:X55286_G_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase rn
RT-U34:X55286_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase rn
RG-U34A:X55286_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase rn
RG-U34A:M29249CDS_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase rn
RG-U34A:S78687MRNA_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase rn
RG-U34B:RC_AA924210_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase rn
RAE230A:1375852_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase rn
RAT230_2:1375852_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase rn
RAE230A:1387848_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase rn
RAT230_2:1387848_AT 3-hydroxy-3-methylglutaryl-Coenzyme A reductase rn
YEAST_2:1771313_AT One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6629 lipid metabolism inferred from electronic annotation QuickGO AmiGO
9058 biosynthesis inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4420 hydroxymethylglutaryl-CoA reductase (NADPH) activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAA68386 Hypothetical protein F08F8.2 [Caenorhabditis elegans] ref|NP_498626.2| F08F8.2 [Caenorhabditis elegans] 0.0
blast CAE69249 Hypothetical protein CBG15296 [Caenorhabditis briggsae] 0.0
blast XP_605365 PREDICTED: similar to 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) [Bos taurus] 1.0E-114
Protein Domains
Database ID Description E-Value
Pfam IPR002202 EMBL-EBI Hydroxymethylglutaryl-coenzyme A reductase 1.0E-126
Sequence
Target Sequence 
>C. ELEGANS:192677_AT
acaactcccgaacaacttgcttatctgacaaccacgaaattacatataggatcttctcgt
gccggagcagtcggaggatcgaatgcacacgctgcaaatattgtcgcggctattttcatt
gcaacaggacaagatgctgctcaagtagtctcttcatccatgtgctcgacaagaatggaa
gttactgctgataagaatttgtatgtgtcatgtactttgccatgtgttgaagtaggaact
gtcggtggaggaactattcttgcaccacaaagagcatgccttgaaagtcttggatgtgct
gggccaaataaggagcaacctggacaaaatgcggaacgtcttgccgaagttattgcggcc
actgtgttagctggagaattatctttgatggcggctctgacaacgaatgagttggtgtca
agtcatatgaaactgaatagatcaaaacaacaattgtatgctgacgactctggaaaagca
actcattttgaaaaggaagttgaaaaagcgggcagccttctctcc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
ACAACTCCCGAACAACTTGCTTATC 366 111 1246 Antisense
TCTTCTCGTGCCGGAGCAGTCGGAG 474 617 1297 Antisense
CGGAGGATCGAATGCACACGCTGCA 658 243 1317 Antisense
ACGCTGCAAATATTGTCGCGGCTAT 277 91 1334 Antisense
TGCTGCTCAAGTAGTCTCTTCATCC 64 583 1380 Antisense
GGAGGAACTATTCTTGCACCACAAA 585 515 1492 Antisense
ATGCGGAACGTCTTGCCGAAGTTAT 620 1 1574 Antisense
TATTGCGGCCACTGTGTTAGCTGGA 528 663 1596 Antisense
TCTTTGATGGCGGCTCTGACAACGA 385 615 1627 Antisense
ACAATTGTATGCTGACGACTCTGGA 529 115 1695 Antisense
TGAAAAAGCGGGCAGCCTTCTCTCC 241 573 1746 Antisense
Sequence Source Affymetrix Proprietary Database