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[192610_at] zinc metallopeptidase (M12A family)

Description C24F3.3 /REP_DB=WormBase Gene ID /WP=CE18520 /TR=Q9XTD6 /GB=CAB02899.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=zinc metallopeptidase (M12A family)
Cluster 6grp_total > 82      4grp_total > 49      6grp_cgc > 86      6grp_cgc_sub > 04      4grp_rule_based > L2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 254
1 2 3 4 range
A 35.9
(-3)
A 		262.2
(3)
P 		218.1
(1.8)
P 		111.2
(-1)
A 		226
B 23.8
(-3)
A 		224.1
(3)
P 		219.7
(2.9)
P 		61.8
(-1.9)
A 		200
C 8.1
(-3)
A 		191.4
(3)
P 		144
(1.4)
P 		9.9
(-2.9)
A 		183
avr 22.6
(-3) 		225.9
(3) 		193.9
(2.1) 		61
(-1.9) 		203

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 121
1 2 3 4 5 6 range
A 57.8
(-3)
A 		89.7
(-0.5)
P 		100.2
(0.3)
P 		135.3
(3)
P 		115.7
(1.5)
P 		97.2
(0.1)
P 		78
B 20
(-3)
A 		96.3
(0.8)
P 		72
(-0.4)
A 		140.9
(3)
P 		106.6
(1.3)
P 		69
(-0.6)
P 		121
C 30.9
(-3)
A 		100.1
(1.6)
P 		70
(-0.4)
P 		121.2
(3)
P 		113.5
(2.5)
P 		73.3
(-0.2)
P 		90
avr 36.2
(-3) 		95.4
(0.7) 		80.7
(-0.2) 		132.5
(3) 		111.9
(1.7) 		79.8
(-0.3) 		96
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 55
1 2 3 4 range
A 13.1
(-3)
A 		56.9
(3)
P 		57
(3)
P 		16.3
(-2.6)
A 		44
B 7.6
(-3)
A 		55.4
(3)
P 		50.9
(2.4)
P 		13.2
(-2.3)
A 		48
C 2.7
(-2.9)
A 		55
(3)
P 		50.2
(2.5)
P 		1.7
(-3)
A 		53
avr 7.8
(-3) 		55.8
(3) 		52.7
(2.6) 		10.4
(-2.7) 		48

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 36
1 2 3 4 5 6 range
A 10.7
(-3)
A 		31.9
(2.3)
P 		21.8
(-0.2)
P 		34.3
(2.9)
P 		34.9
(3)
P 		23.7
(0.2)
P 		24
B 7
(-3)
A 		32
(1.1)
P 		17.5
(-1.3)
A 		37.3
(2)
P 		43.3
(3)
P 		25.7
(0.1)
P 		36
C 11.5
(-3)
A 		30.6
(1.5)
P 		17.8
(-1.5)
P 		24.4
(0.1)
P 		36.7
(3)
P 		24.5
(0.1)
P 		25
avr 9.7
(-3) 		31.5
(1.6) 		19
(-1) 		32
(1.7) 		38.3
(3) 		24.6
(0.1) 		29
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192610_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.9196
Sequence Type Exemplar sequence
Representative Public ID C24F3.3 NCBI
Target Description C24F3.3 /REP_DB=WormBase Gene ID /WP=CE18520 /TR=Q9XTD6 /GB=CAB02899.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=zinc metallopeptidase (M12A family)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_069470(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_069470 NCBI Caenorhabditis elegans Nematode AStacin protease family member (nas-12) (nas-12) mRNA, complete cds. 11/11 None
C24F3.3 ENSEMBL cdna:known chromosome:CEL140:IV:10224025:10226286:1 gene:C24F3.3 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000043528 7/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:10224030-10226292(+) 100.0 100.0
Public Domain and Genome References
Gene Title zinc metallopeptidase (M12A family)
Gene Symbol nas-12
Ensembl C24F3.3
Entrez Gene 182848 Entrez gene
SwissProt Q9XTD6 EMBL-EBI
WormBase CE35408 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
8237 metallopeptidase activity inferred from electronic annotation QuickGO AmiGO
8270 zinc ion binding inferred from electronic annotation QuickGO AmiGO
8533 astacin activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB02899 Hypothetical protein C24F3.3 [Caenorhabditis elegans] emb|CAA18774.2| Hypothetical protein C24F3.3 [Caenorhabditis elegans] ref|NP_501871.2| Nematode AStacin protease family member (nas-12) [Caenorhabditis elegans] sp|Q9XTD6|NAS12_CAEEL Zinc metalloproteinase nas-12 precursor (Nematode astacin 12) 0.0
blast CAE59906 Hypothetical protein CBG03390 [Caenorhabditis briggsae] 0.0
blast CAE63308 Hypothetical protein CBG07697 [Caenorhabditis briggsae] 4.0E-39
Protein Domains
Database ID Description E-Value
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 1.3E-64
Pfam IPR003582 EMBL-EBI Metridin-like ShK toxin 1.1E-12
Pfam IPR003582 EMBL-EBI Metridin-like ShK toxin 5.6E-13
Sequence
Target Sequence 
>C. ELEGANS:192610_AT
gacccgatagagattcctttattcgagttgattatgcaaatgttattcctggacagatga
taaactttgataaactgaaaacttcccatgtcgagtaccctgacatttacgatttcaaat
caattatgcattatgatggttacgcatttggaagagttgacactgccagacgtgttagat
tagcaacaatgactccattaaaacccggtgtaactttggaagacaatatgaaattcactg
ctacagatattgaaaaactgaataggctcggtcaatgtggtgcccgtggcggacagtaca
gtaaccaaggagttgtcgcctcaacttgccaagatgttgcaaccgctgttagttgtgagg
gaaatagaaggcgtggaatgtgcaaaaatccgttctacaaacaaatgatgatcaagtctt
gccagaaaacatgcagactatgttcgtacacaaggatgattgatgaagatgacgatctaa
ctccaaatactacagtaaaatctgtaaagtgcgaggacaaacacccacgatgtgatattt
actcacacaatggtttctgcactcttccattttacgatga

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GACCCGATAGAGATTCCTTTATTCG 477 381 587 Antisense
TGAAAACTTCCCATGTCGAGTACCC 525 571 662 Antisense
GAGTACCCTGACATTTACGATTTCA 610 399 679 Antisense
TAGGCTCGGTCAATGTGGTGCCCGT 404 655 849 Antisense
GCCCGTGGCGGACAGTACAGTAACC 434 281 868 Antisense
CAAGGAGTTGTCGCCTCAACTTGCC 492 183 892 Antisense
GCCAAGATGTTGCAACCGCTGTTAG 567 277 914 Antisense
GATGACGATCTAACTCCAAATACTA 586 411 1054 Antisense
AGTGCGAGGACAAACACCCACGATG 648 59 1094 Antisense
ACTCACACAATGGTTTCTGCACTCT 160 101 1127 Antisense
TCTGCACTCTTCCATTTTACGATGA 52 609 1142 Antisense
Sequence Source Affymetrix Proprietary Database