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[192600_s_at] serine/threonine kinase (2 domains)

Description F52B5.2 /REP_DB=WormBase Gene ID /WP=CE24993 /TR=Q20643 /GB=CAA99854.2 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=serine-threonine kinase (2 domains)
Cluster 6grp_highest_10_10 > 79      6grp_high1_10_10 > 96      4grp_highest_8_8 > 11      4grp_high_8_8 > 47      6grp_highest_nonorm > 93      6grp_total > 97      4grp_total > 40      6grp_highest_sub > In      6grp_high1_sub > In      6grp_total_sub > Increase      6grp_rule_based > S6      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 114
1 2 3 4 range
A 159.5
(-3)
P 		263.6
(2.5)
P 		273.6
(3)
P 		215
(-0.1)
P 		114
B 173.2
(-3)
P 		207
(-0.9)
P 		272.1
(3)
P 		189.3
(-2)
P 		99
C 181.9
(-3)
P 		224.4
(0.9)
P 		247.2
(3)
P 		240.3
(2.4)
P 		65
avr 171.5
(-3) 		231.7
(0.9) 		264.3
(3) 		214.9
(-0.2) 		93

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 769
1 2 3 4 5 6 range
A 163.6
(-3)
P 		191.9
(-2.8)
P 		239.1
(-2.4)
P 		392.4
(-1.2)
P 		565.7
(0.2)
P 		915.6
(3)
P 		752
B 168.4
(-3)
P 		195.1
(-2.7)
P 		271.1
(-1.9)
P 		312.6
(-1.4)
P 		601.5
(1.8)
P 		706.8
(3)
P 		538
C 185.7
(-2.7)
P 		147
(-3)
P 		284.3
(-1.9)
P 		398.3
(-1)
P 		509
(-0.1)
P 		907
(3)
P 		760
avr 172.6
(-3) 		178
(-3) 		264.8
(-2.2) 		367.8
(-1.3) 		558.7
(0.5) 		843.1
(3) 		671
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 55
1 2 3 4 range
A 58.1
(1)
P 		57.2
(0.9)
P 		71.5
(3)
P 		31.5
(-3)
P 		40
B 55.2
(0.9)
P 		51.1
(-0.2)
P 		63.1
(3)
P 		40.3
(-3)
P 		23
C 60.2
(-0.4)
P 		64.5
(0.2)
P 		86.1
(3)
P 		40.5
(-3)
P 		46
avr 57.8
(0.4) 		57.6
(0.3) 		73.6
(3) 		37.4
(-3) 		36

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 273
1 2 3 4 5 6 range
A 30.2
(-3)
P 		68.3
(-1.8)
P 		52.1
(-2.3)
P 		99.5
(-0.8)
P 		170.7
(1.4)
P 		222.9
(3)
P 		193
B 58.6
(-3)
P 		64.9
(-2.8)
P 		65.8
(-2.8)
P 		82.8
(-2.3)
P 		244.4
(2.4)
P 		263.6
(3)
P 		205
C 68.8
(-2.4)
P 		44.9
(-3)
P 		72.3
(-2.4)
P 		80.1
(-2.2)
P 		164.7
(-0.2)
P 		303.6
(3)
P 		259
avr 52.5
(-3) 		59.4
(-2.8) 		63.4
(-2.7) 		87.5
(-2) 		193.3
(1) 		263.4
(3) 		211
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 192600_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.2102
Sequence Type Exemplar sequence
Representative Public ID F52B5.2 NCBI
Target Description F52B5.2 /REP_DB=WormBase Gene ID /WP=CE24993 /TR=Q20643 /GB=CAA99854.2 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=serine-threonine kinase (2 domains)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_059858(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_059858 NCBI Caenorhabditis elegans F52B5.2 (F52B5.2) mRNA, complete cds. 11/11 None
SNAP00000039361 ENSEMBL cdna:SNAP chromosome:CEL140:I:8324374:8332107:-1 11/11 None
GENEFINDER00000039366 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:8324374:8332107:-1 11/11 None
F52B5.2 ENSEMBL cdna:known chromosome:CEL140:I:8324077:8326374:-1 gene:F52B5.2 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:8324304-8326305(-) 100.0 100.0
Public Domain and Genome References
Gene Title serine/threonine kinase (2 domains)
Ensembl F52B5.2
Entrez Gene 172614 Entrez gene
SwissProt Q20643 EMBL-EBI
WormBase CE24993 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA99855 Hypothetical protein F52B5.3 [Caenorhabditis elegans] ref|NP_492260.1| F52B5.3 [Caenorhabditis elegans] 0.0
blast CAE60471 Hypothetical protein CBG04082 [Caenorhabditis briggsae] 0.0
blast CAA99854 Hypothetical protein F52B5.2 [Caenorhabditis elegans] ref|NP_492259.1| F52B5.2 [Caenorhabditis elegans] 1.0E-164
blast CAA99854 Hypothetical protein F52B5.2 [Caenorhabditis elegans] ref|NP_492259.1| F52B5.2 [Caenorhabditis elegans] 1.0E-163
blast CAA99854 Hypothetical protein F52B5.2 [Caenorhabditis elegans] ref|NP_492259.1| F52B5.2 [Caenorhabditis elegans] 1.0E-159
blast XP_624845 PREDICTED: similar to CDK-related protein kinase PNQLARE [Apis mellifera] 4.0E-27
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 9.0E-20
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 1.0E-23
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 7.0E-24
hanks 3.1.3 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; Cdk3 8.0E-19
hanks 3.1.3 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; Cdk3 2.0E-22
hanks 3.1.3 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; Cdk3 1.0E-22
Protein Domains
Database ID Description E-Value
Pfam IPR007502 EMBL-EBI Helicase-associated region 6.1E-21
Pfam IPR001374 EMBL-EBI Single-stranded nucleic acid binding R3H 1.1E-16
Pfam IPR000719 EMBL-EBI Protein kinase 3.5E-39
Pfam IPR001650 EMBL-EBI Helicase, C-terminal 8.3E-15
Pfam IPR000719 EMBL-EBI Protein kinase 3.3E-9
Pfam IPR000719 EMBL-EBI Protein kinase 1.1E-21
Pfam IPR000719 EMBL-EBI Protein kinase 3.5E-39
Sequence
Target Sequence 
>C. ELEGANS:192600_S_AT
ttgttcggaatactcggcgaccgccaacgacttcaaccatctactattcaaaagtatatg
aaaggattgatggaaggacttcaatttattcatcggatggattacattcacagagatatt
aagccggaaaatttgctgatcgacggtgaaaccatctgcattgctgatttcggggagaca
gttctcagcacctcagacaaagttgttaaacctggcaccctaccgtatctcacaatcgaa
catatattggggtataaggagaacactaaatctatggatatttgggctgctgcttgcgtc
ttgggtgcaatgtttcaaggaagtcatcttttctctcagaattccaatttgcaaacaatc
catgcaattcgtcttcttcttggaaatcatacgaaggagacgtggccggaaatggacaaa
cttcccttaatgcaatccatcgagctgccacccgttggtgagaaaacattttcgaaaatc
gagaatattacaaaagaagcagctgatttgatggaacaaatgatgaagtatgatccgacg
aagcgattgatggcatcacaagttctcaatcat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TTGTTCGGAATACTCGGCGACCGCC 268 677 307 Antisense
CAACGACTTCAACCATCTACTATTC 315 187 331 Antisense
GCTGATCGACGGTGAAACCATCTGC 572 293 441 Antisense
AACCATCTGCATTGCTGATTTCGGG 369 147 456 Antisense
AGTTCTCAGCACCTCAGACAAAGTT 110 65 486 Antisense
CCTACCGTATCTCACAATCGAACAT 149 269 525 Antisense
ATGGATATTTGGGCTGCTGCTTGCG 690 51 580 Antisense
GGAAGTCATCTTTTCTCTCAGAATT 614 531 625 Antisense
ACAAACTTCCCTTAATGCAATCCAT 135 111 722 Antisense
GAGCTGCCACCCGTTGGTGAGAAAA 457 379 748 Antisense
GATGGCATCACAAGTTCTCAATCAT 294 407 855 Antisense
Sequence Source Affymetrix Proprietary Database