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[192590_at] ring canal protein like

Description C47D12.7 /REP_DB=WormBase Gene ID /WP=CE20569 /GEN=kel-1 /TR=Q18670 /GB=CAA93769.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=ring canal protein like
Cluster 6grp_total > 28      4grp_total > 03      6grp_cgc > 07      6grp_total_sub > Cup      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 645
1 2 3 4 range
A 167.6
(-2)
P 		128
(-2.5)
A 		80.5
(-3)
A 		616.2
(3)
P 		536
B 173.4
(-1.3)
P 		131
(-1.9)
A 		46.7
(-3)
A 		494.9
(3)
P 		448
C 110.5
(-2.8)
A 		100.4
(-2.9)
A 		93.5
(-3)
M 		691.2
(3)
P 		598
avr 150.5
(-2.1) 		119.8
(-2.5) 		73.6
(-3) 		600.8
(3) 		527

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 106
1 2 3 4 5 6 range
A 151.5
(2.5)
A 		71.1
(-3)
A 		114.6
(-0)
A 		158.7
(3)
P 		103.9
(-0.8)
P 		156.8
(2.9)
A 		88
B 168.1
(2.2)
P 		146.8
(0.4)
P 		177.4
(3)
M 		106.5
(-3)
A 		133.9
(-0.7)
P 		116.7
(-2.1)
P 		71
C 150.2
(1.9)
P 		166.7
(3)
A 		133.2
(0.8)
A 		75.5
(-3)
A 		166.7
(3)
P 		131
(0.7)
P 		91
avr 156.6
(3) 		128.2
(-1) 		141.7
(0.9) 		113.6
(-3) 		134.8
(-0) 		134.8
(-0) 		43
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 106
1 2 3 4 range
A 61
(0.5)
P 		27.8
(-2.4)
A 		21
(-3)
A 		90.2
(3)
P 		69
B 55.3
(-0.2)
P 		32.4
(-1.6)
A 		10.8
(-3)
A 		105.5
(3)
P 		95
C 36.6
(-2.5)
A 		28.9
(-3)
A 		32.6
(-2.7)
M 		116.5
(3)
P 		88
avr 51
(-0.9) 		29.7
(-2.4) 		21.5
(-3) 		104.1
(3) 		83

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 43
1 2 3 4 5 6 range
A 27.9
(-1.9)
A 		25.3
(-2.9)
A 		25
(-3)
A 		40.2
(3)
P 		31.3
(-0.5)
P 		38.2
(2.2)
A 		15
B 58.5
(3)
P 		48.9
(1.1)
P 		43.1
(-0)
M 		28.2
(-3)
A 		54.4
(2.2)
P 		43.5
(0)
P 		30
C 55.7
(3)
P 		50.9
(2.3)
A 		33.9
(-0.2)
A 		15.2
(-3)
A 		53.9
(2.7)
P 		43.9
(1.3)
P 		41
avr 47.4
(3) 		41.7
(1.2) 		34
(-1.1) 		27.9
(-3) 		46.5
(2.7) 		41.9
(1.3) 		20
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192590_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.2946
Sequence Type Exemplar sequence
Representative Public ID C47D12.7 NCBI
Target Description C47D12.7 /REP_DB=WormBase Gene ID /WP=CE20569 /GEN=kel-1 /TR=Q18670 /GB=CAA93769.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=ring canal protein like
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_064095(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_064095 NCBI Caenorhabditis elegans KELch-repeat containing protein family member (kel-1) (kel-1) mRNA, complete cds. 11/11 A 
SNAP00000023907 ENSEMBL cdna:SNAP chromosome:CEL140:II:11688875:11695908:1 11/11 None
GENEFINDER00000023918 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:11688875:11691233:1 9/11 None
C47D12.7 ENSEMBL cdna:known chromosome:CEL140:II:11688856:11695965:1 gene:C47D12.7 11/11 A 
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
GENEFINDER00000023913 2/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:11688871-11695905(+) 100.0 100.0
Public Domain and Genome References
Gene Title ring canal protein like
Gene Symbol kel-1
Ensembl C47D12.7
Entrez Gene 174791 Entrez gene
SwissProt Q18670 EMBL-EBI
WormBase CE20569 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.2565.1.S1_AT similar to Kelch-like protein 3 cfa
CANINE_2:CFAAFFX.2567.1.S1_AT similar to Kelch-like protein 3 cfa
CANINE_2:CFAAFFX.2567.1.S1_S_AT similar to Kelch-like protein 3 cfa
HG-U133_PLUS_2:221221_S_AT kelch-like 3 (Drosophila) hs
HG-U133A:221221_S_AT kelch-like 3 (Drosophila) hs
HG-FOCUS:221221_S_AT kelch-like 3 (Drosophila) hs
HG-U133A_2:221221_S_AT kelch-like 3 (Drosophila) hs
HU35KSUBA:RC_AA460949_AT kelch-like 3 (Drosophila) hs
HU35KSUBD:RC_R51524_AT kelch-like 3 (Drosophila) hs
U133_X3P:G8393671_3P_A_AT kelch-like 3 (Drosophila) hs
U133_X3P:HS2.7388.3.S1_3P_X_AT kelch-like 3 (Drosophila) hs
U133_X3P:HS2.7388.3.S1_3P_AT kelch-like 3 (Drosophila) hs
U133_X3P:1555110_3P_A_AT kelch-like 3 (Drosophila) hs
HG-U133_PLUS_2:1555110_A_AT kelch-like 3 (Drosophila) hs
HG-U95B:46757_AT kelch-like 3 (Drosophila) hs
HG-U95B:51950_AT kelch-like 3 (Drosophila) hs
HG-U95E:85255_AT kelch-like 3 (Drosophila) hs
MU11KSUBA:AA273932_S_AT heterogeneous nuclear ribonucleoprotein A0 mm
MU11KSUBB:MSA.18074.0_F_AT heterogeneous nuclear ribonucleoprotein A0 mm
MG-U74BV2:116354_R_AT PREDICTED: Mus musculus similar to heterogeneous nuclear ribonucleoprotein A0 (LOC544935), mRNA mm
MG-U74CV2:133858_AT PREDICTED: heterogeneous nuclear ribonucleoprotein A0 [Mus musculus], mRNA sequence mm
MU19KSUBA:TC14773_AT PREDICTED: Mus musculus similar to heterogeneous nuclear ribonucleoprotein A0 (LOC544935), mRNA mm
MU19KSUBC:TC39150_AT PREDICTED: Mus musculus similar to heterogeneous nuclear ribonucleoprotein A0 (LOC544935), mRNA mm
MU19KSUBC:TC39151_AT PREDICTED: Mus musculus similar to heterogeneous nuclear ribonucleoprotein A0 (LOC544935), mRNA mm
RAE230B:1392340_AT similar to Kelch-like protein 3 rn
RAT230_2:1392340_AT similar to Kelch-like protein 3 rn
RAE230A:1384301_AT Similar to Kelch-like protein 3 rn
RAT230_2:1384301_AT Similar to Kelch-like protein 3 rn
RAE230B:1392081_AT Similar to Kelch-like protein 3 rn
RAT230_2:1392081_AT Similar to Kelch-like protein 3 rn
RAE230B:1398570_AT Similar to Kelch-like protein 3 rn
RAT230_2:1398570_AT Similar to Kelch-like protein 3 rn
RG-U34A:RC_AA893206_AT Similar to Kelch-like protein 3 rn
Gene Ontology
GO Molecular Function (view graph)
ID Description Evidence Links
5515 protein binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA93769 Hypothetical protein C47D12.7 [Caenorhabditis elegans] ref|NP_496496.1| KELch-repeat containing protein family member (kel-1) [Caenorhabditis elegans] dbj|BAA82800.1| kel-1: a novel Kelch-related gene in C.elegans [Caenorhabditis elegans] 0.0
blast CAE59711 Hypothetical protein CBG03143 [Caenorhabditis briggsae] 0.0
blast Q9UH77 Kelch-like protein 1.0E-124
Protein Domains
Database ID Description E-Value
Pfam IPR006652 EMBL-EBI Kelch repeat 2.1E-4
Pfam IPR006652 EMBL-EBI Kelch repeat 6.3E-15
Pfam IPR006652 EMBL-EBI Kelch repeat 3.8E-14
Pfam IPR006652 EMBL-EBI Kelch repeat 5.6E-16
Pfam IPR006652 EMBL-EBI Kelch repeat 2.3E-7
Pfam IPR006652 EMBL-EBI Kelch repeat 5.6E-9
Pfam IPR000210 EMBL-EBI BTB/POZ domain 1.9E-43
Pfam IPR006652 EMBL-EBI Kelch repeat 2.1E-4
Pfam IPR006652 EMBL-EBI Kelch repeat 6.3E-15
Pfam IPR006652 EMBL-EBI Kelch repeat 3.8E-14
Pfam IPR006652 EMBL-EBI Kelch repeat 1.7E-6
Pfam IPR000210 EMBL-EBI BTB/POZ domain 4.1E-14
Pfam IPR000210 EMBL-EBI BTB/POZ domain 3.0E-21
Sequence
Target Sequence 
>C. ELEGANS:192590_AT
ccgatccactcacgggataaccacgtgtcaacaggtgttgtatgcagttgggggattcga
tggaactaccgggcttgcgagtgcagaatatttcgatccacacacaggaaattggtttcc
acttccatcaatgagcacgagaagatcaagtgttggagtggcagcgttcgaagaggatat
ctatgcgattgggggattcgatggtgtctcaaagcaatgcctgaatacggtagaaatttt
cgatcgaagagctcacaaatggcgtccagggcctgcaatgctgaatgt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CCGATCCACTCACGGGATAACCACG 3 265 1251 Antisense
GATAACCACGTGTCAACAGGTGTTG 216 423 1266 Antisense
GGTGTTGTATGCAGTTGGGGGATTC 627 499 1284 Antisense
TGGGGGATTCGATGGAACTACCGGG 390 497 1299 Antisense
AACTACCGGGCTTGCGAGTGCAGAA 466 139 1314 Antisense
GAATATTTCGATCCACACACAGGAA 681 325 1336 Antisense
AGGAAATTGGTTTCCACTTCCATCA 47 55 1356 Antisense
CAAGTGTTGGAGTGGCAGCGTTCGA 299 183 1397 Antisense
GGGGGATTCGATGGTGTCTCAAAGC 494 497 1441 Antisense
GAGCTCACAAATGGCGTCCAGGGCC 626 383 1499 Antisense
GTCCAGGGCCTGCAATGCTGAATGT 689 475 1514 Antisense
Sequence Source Affymetrix Proprietary Database