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[192588_s_at] DNA polymerase family B (3 domains)

Description F33H2.5 /REP_DB=WormBase Gene ID /WP=CE17767 /TR=O62218 /GB=CAB04263.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=DNA polymerase family B (3 domains)
Cluster 6grp_high1_10_10 > 57      6grp_total > 59      4grp_total > 60      6grp_high1_sub > Cu      6grp_total_sub > Cup      4grp_rule_based > L2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 443
1 2 3 4 range
A 343.4
(1.8)
P 		424.8
(3)
P 		380.4
(2.3)
P 		28.4
(-3)
A 		396
B 394
(2.2)
P 		446.9
(3)
P 		369.8
(1.9)
P 		25.6
(-3)
A 		421
C 330.9
(1.3)
P 		374.4
(1.9)
P 		456.7
(3)
P 		14
(-3)
A 		443
avr 356.1
(2.1) 		415.4
(3) 		402.3
(2.8) 		22.7
(-3) 		393

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 476
1 2 3 4 5 6 range
A 498.8
(0.8)
P 		337.9
(-1.2)
P 		198
(-3)
A 		353.3
(-1)
P 		451.8
(0.2)
P 		669.8
(3)
P 		472
B 404.8
(1.1)
P 		301.4
(-0.9)
P 		193.8
(-3)
P 		269.7
(-1.5)
P 		310.5
(-0.7)
P 		502.5
(3)
P 		309
C 403.4
(-0.2)
P 		266.6
(-3)
P 		323.8
(-1.8)
P 		343.5
(-1.4)
P 		303.1
(-2.2)
P 		558.2
(3)
P 		292
avr 435.7
(0.5) 		302
(-1.9) 		238.5
(-3) 		322.2
(-1.5) 		355.1
(-0.9) 		576.8
(3) 		338
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 157
1 2 3 4 range
A 125
(3)
P 		92.2
(1.4)
P 		99.5
(1.7)
P 		4.2
(-3)
A 		121
B 125.6
(3)
P 		110.4
(2.2)
P 		85.7
(1)
P 		5.5
(-3)
A 		120
C 109.5
(1.1)
P 		107.6
(1)
P 		159.2
(3)
P 		2.4
(-3)
A 		157
avr 120
(3) 		103.4
(2.1) 		114.8
(2.7) 		4
(-3) 		116

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 144
1 2 3 4 5 6 range
A 92
(-0.6)
P 		120.2
(0.9)
P 		43.1
(-3)
A 		89.6
(-0.7)
P 		136.3
(1.7)
P 		163.1
(3)
P 		120
B 140.8
(1)
P 		100.3
(-0.7)
P 		47.1
(-3)
P 		71.4
(-2)
P 		126.1
(0.4)
P 		187.4
(3)
P 		140
C 149.5
(1.1)
P 		81.4
(-2.4)
P 		82.4
(-2.3)
P 		69.1
(-3)
P 		98.1
(-1.5)
P 		186.8
(3)
P 		118
avr 127.4
(0.4) 		100.6
(-0.9) 		57.5
(-3) 		76.7
(-2.1) 		120.2
(0.1) 		179.1
(3) 		122
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 192588_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.1430
Sequence Type Exemplar sequence
Representative Public ID F33H2.5 NCBI
Target Description F33H2.5 /REP_DB=WormBase Gene ID /WP=CE17767 /TR=O62218 /GB=CAB04263.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=DNA polymerase family B (3 domains)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_061215(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_061215 NCBI Caenorhabditis elegans F33H2.5 (F33H2.5) mRNA, complete cds. 11/11 None
SNAP00000009477 ENSEMBL cdna:SNAP chromosome:CEL140:I:15013818:15021992:-1 11/11 None
GENEFINDER00000009489 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:15013818:15024697:-1 11/11 None
F33H2.5 ENSEMBL cdna:known chromosome:CEL140:I:15013737:15021992:-1 gene:F33H2.5 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:15013748-15021923(-) 100.0 100.0
Public Domain and Genome References
Gene Title DNA polymerase family B (3 domains)
Ensembl F33H2.5
Entrez Gene 173368 Entrez gene
SwissProt O62218 EMBL-EBI
WormBase CE17767 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:16825_AT DNA-directed DNA polymerase epsilon catalytic subunit, putative at
ATH1-121501:266305_AT DNA-directed DNA polymerase epsilon catalytic subunit, putative at
CANINE_2:CFAAFFX.10358.1.S1_AT similar to DNA polymerase epsilon catalytic subunit cfa
CANINE_2:CFAAFFX.10362.1.S1_S_AT similar to DNA polymerase epsilon catalytic subunit cfa
CANINE_2:CFAAFFX.10374.1.S1_AT similar to DNA polymerase epsilon catalytic subunit cfa
DROSOPHILA_2:1626355_AT DNA polymerase dm
DROSGENOME1:141750_AT DNA polymerase dm
CHICKEN:GGAAFFX.22320.1.S1_AT polymerase (DNA directed), epsilon gga
HG-U95AV2:40450_AT polymerase (DNA directed), epsilon hs
HU35KSUBA:RC_AA233317_AT polymerase (DNA directed), epsilon hs
HU35KSUBB:RC_R77631_AT polymerase (DNA directed), epsilon hs
U133_X3P:HS2.383930.1.S1_3P_AT polymerase (DNA directed), epsilon hs
U133_X3P:HS.166846.1.S1_3P_A_AT polymerase (DNA directed), epsilon hs
HG-U133_PLUS_2:1561940_AT polymerase (DNA directed), epsilon hs
HG-U133A_2:216026_S_AT polymerase (DNA directed), epsilon hs
HG-FOCUS:216026_S_AT polymerase (DNA directed), epsilon hs
HG-U133_PLUS_2:216026_S_AT polymerase (DNA directed), epsilon hs
HG-U133A:216026_S_AT polymerase (DNA directed), epsilon hs
HG-U95AV2:40451_AT polymerase (DNA directed), epsilon hs
HG-U95B:43905_I_AT polymerase (DNA directed), epsilon hs
HG-U95B:43906_R_AT polymerase (DNA directed), epsilon hs
HG-U133_PLUS_2:1560509_AT Polymerase (DNA directed), epsilon hs
MG-U74BV2:115837_AT polymerase (DNA directed), epsilon mm
MOE430A:1448650_A_AT polymerase (DNA directed), epsilon mm
MOUSE430A_2:1448650_A_AT polymerase (DNA directed), epsilon mm
MOUSE430_2:1448650_A_AT polymerase (DNA directed), epsilon mm
MOE430B:1441854_AT Polymerase (DNA directed), epsilon, mRNA (cDNA clone IMAGE:3496540) mm
MOUSE430_2:1441854_AT Polymerase (DNA directed), epsilon, mRNA (cDNA clone IMAGE:3496540) mm
RAE230A:1389421_AT polymerase (DNA directed), epsilon rn
RAT230_2:1389421_AT polymerase (DNA directed), epsilon rn
YEAST_2:1776235_AT Catalytic subunit of DNA polymerase epsilon, one of the major chromosomal DNA replication polymerases characterized by processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6260 DNA replication inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
166 nucleotide binding inferred from electronic annotation QuickGO AmiGO
3677 DNA binding inferred from electronic annotation QuickGO AmiGO
3887 DNA-directed DNA polymerase activity inferred from electronic annotation QuickGO AmiGO
8408 3'-5' exonuclease activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB04263 Hypothetical protein F33H2.5 [Caenorhabditis elegans] ref|NP_493616.1| F33H2.5 [Caenorhabditis elegans] 0.0
blast CAE72571 Hypothetical protein CBG19758 [Caenorhabditis briggsae] 0.0
blast NP_006222 DNA polymerase epsilon catalytic subunit [Homo sapiens] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR006133 EMBL-EBI DNA polymerase B, exonuclease domain 1.0E-126
Pfam IPR006133 EMBL-EBI DNA polymerase B, exonuclease domain 1.0E-126
Sequence
Target Sequence 
>C. ELEGANS:192588_S_AT
tttccggtcagactgcatctcacaaaagatctcacatcgtctctatcgaattgtgaacaa
gatggtgcataacaatgcggatattgcacattgttctgtgtatttggcgaatgcgctctg
tcgagctctatcctgtgatcagacctcccagttggcagtcgaaggaattcgggataatgc
gaagcgtcttctgcacaattctgttgtggaagccgacatgacaccactgcgttcaacgac
tctcttcgtctcaaatgtcttctgcaattcgtgttctcaggcctcgaacgtattcctttc
ctccactgatgagattctcacatgtgccacgtgtcagagtaagctcaactctgacgtcat
tgatatgatgatttgcgatcgattgaaccagctgctcactgcctaccagattcaggatca
tcagtgcacgaaatgcaaatcggttcgtcacgacacactatcaatgtactgcgaatgctg
ttcccagttcattccacaaatcacacctgcacagctgaagcacgaggcttccaccgtcga
gactgtctccatcgtccgcaatttcgcgttga

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TTTCCGGTCAGACTGCATCTCACAA 686 669 5838 Antisense
AAAAGATCTCACATCGTCTCTATCG 255 133 5861 Antisense
CGAATGCGCTCTGTCGAGCTCTATC 6 255 5945 Antisense
GAGCTCTATCCTGTGATCAGACCTC 497 387 5960 Antisense
GACTCTCTTCGTCTCAAATGTCTTC 548 373 6075 Antisense
AAATGTCTTCTGCAATTCGTGTTCT 242 121 6090 Antisense
TATTCCTTTCCTCCACTGATGAGAT 187 665 6128 Antisense
AGATTCTCACATGTGCCACGTGTCA 497 65 6149 Antisense
TTGCGATCGATTGAACCAGCTGCTC 703 701 6210 Antisense
GTACTGCGAATGCTGTTCCCAGTTC 56 457 6303 Antisense
TCCATCGTCCGCAATTTCGCGTTGA 576 589 6385 Antisense
Sequence Source Affymetrix Proprietary Database