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[192577_at] zinc metallopeptidase (M12A family)

Description F45G2.1 /REP_DB=WormBase Gene ID /WP=CE16044 /TR=O62243 /GB=CAB07610.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=zinc metallopeptidase (M12A family)
Cluster 6grp_total > 89      4grp_total > 49      6grp_cgc > 65      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 167
1 2 3 4 range
A 2.4
(-3)
A 		139.7
(3)
P 		127.5
(2.5)
P 		67.4
(-0.2)
A 		137
B 2.4
(-3)
A 		114.5
(1)
P 		168.9
(3)
P 		29.8
(-2)
A 		167
C 17.2
(-3)
A 		162.1
(3)
P 		149.5
(2.5)
P 		43.8
(-1.9)
A 		145
avr 7.3
(-3) 		138.8
(2.6) 		148.6
(3) 		47
(-1.3) 		141

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 123
1 2 3 4 5 6 range
A 6.7
(-3)
A 		79.6
(0.6)
P 		62.7
(-0.2)
A 		76.4
(0.5)
P 		87.1
(1)
P 		126.7
(3)
P 		120
B 7
(-3)
A 		81.1
(1.1)
P 		40.2
(-1.2)
A 		9.4
(-2.9)
A 		116.1
(3)
P 		93
(1.7)
P 		109
C 3.5
(-3)
A 		105.7
(2.9)
P 		58.3
(0.1)
A 		53.6
(-0.1)
A 		83.4
(1.6)
P 		108
(3)
P 		105
avr 5.7
(-3) 		88.8
(1.8) 		53.7
(-0.2) 		46.5
(-0.6) 		95.5
(2.2) 		109.2
(3) 		104
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 51
1 2 3 4 range
A 0.9
(-3)
A 		30.3
(2.4)
P 		33.3
(3)
P 		9.9
(-1.3)
A 		32
B 0.8
(-3)
A 		28.3
(1.3)
P 		39.1
(3)
P 		6.4
(-2.1)
A 		38
C 5.7
(-3)
A 		46.6
(2.3)
P 		52.1
(3)
P 		7.4
(-2.8)
A 		46
avr 2.5
(-3) 		35.1
(2) 		41.5
(3) 		7.9
(-2.2) 		39

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 46
1 2 3 4 5 6 range
A 1.2
(-3)
A 		28.3
(2.5)
P 		13.7
(-0.5)
A 		19.4
(0.7)
P 		26.3
(2.1)
P 		30.9
(3)
P 		30
B 2.5
(-3)
A 		27
(0.3)
P 		9.8
(-2)
A 		2.5
(-3)
A 		47.2
(3)
P 		34.7
(1.3)
P 		45
C 1.3
(-3)
A 		32.3
(2.3)
P 		14.8
(-0.7)
A 		10.8
(-1.4)
A 		27
(1.4)
P 		36.2
(3)
P 		35
avr 1.7
(-3) 		29.2
(2.1) 		12.8
(-0.9) 		10.9
(-1.3) 		33.5
(2.9) 		33.9
(3) 		32
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192577_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.7031
Sequence Type Exemplar sequence
Representative Public ID F45G2.1 NCBI
Target Description F45G2.1 /REP_DB=WormBase Gene ID /WP=CE16044 /TR=O62243 /GB=CAB07610.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=zinc metallopeptidase (M12A family)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_067367(9)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_067367 NCBI Caenorhabditis elegans Nematode AStacin protease family member (nas-1) (nas-1) mRNA, complete cds. 9/11 None
SNAP00000011664 ENSEMBL cdna:SNAP chromosome:CEL140:III:13406132:13408691:1 9/11 None
GENEFINDER00000011684 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:13406141:13408691:1 10/11 None
F45G2.1 ENSEMBL cdna:known chromosome:CEL140:III:13406066:13408691:1 gene:F45G2.1 9/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:13406061-13408687(+) 100.0 100.0
Public Domain and Genome References
Gene Title zinc metallopeptidase (M12A family)
Gene Symbol nas-1
Ensembl F45G2.1
Entrez Gene 185811 Entrez gene
SwissProt O62243 EMBL-EBI
WormBase CE33784 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
8237 metallopeptidase activity inferred from electronic annotation QuickGO AmiGO
8270 zinc ion binding inferred from electronic annotation QuickGO AmiGO
8533 astacin activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB07610 Hypothetical protein F45G2.1 [Caenorhabditis elegans] ref|NP_499768.2| Nematode AStacin protease family member (nas-1) [Caenorhabditis elegans] sp|O62243|NAS1_CAEEL Zinc metalloproteinase nas-1 precursor (Nematode astacin 1) 1.0E-155
blast CAE73702 Hypothetical protein CBG21213 [Caenorhabditis briggsae] 1.0E-146
blast CAB07610 Hypothetical protein F45G2.1 [Caenorhabditis elegans] ref|NP_499768.2| Nematode AStacin protease family member (nas-1) [Caenorhabditis elegans] sp|O62243|NAS1_CAEEL Zinc metalloproteinase nas-1 precursor (Nematode astacin 1) 1.0E-142
blast CAE73702 Hypothetical protein CBG21213 [Caenorhabditis briggsae] 1.0E-136
blast CAB07610 Hypothetical protein F45G2.1 [Caenorhabditis elegans] ref|NP_499768.2| Nematode AStacin protease family member (nas-1) [Caenorhabditis elegans] sp|O62243|NAS1_CAEEL Zinc metalloproteinase nas-1 precursor (Nematode astacin 1) 1.0E-121
blast CAE73702 Hypothetical protein CBG21213 [Caenorhabditis briggsae] 1.0E-116
blast AAB00691 Nematode astacin protease protein 8 [Caenorhabditis elegans] ref|NP_501114.2| Nematode AStacin protease family member (nas-8) [Caenorhabditis elegans] sp|Q18439|NAS8_CAEEL Zinc metalloproteinase nas-8 precursor (Nematode astacin 8) 6.0E-55
Protein Domains
Database ID Description E-Value
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 2.2E-79
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 2.2E-79
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 3.7E-35
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 2.7E-23
Sequence
Target Sequence 
>C. ELEGANS:192577_AT
ggtggtgtcgcagtggctgctgaaaaggacaaatggccaaatggaagagttccctatatt
ctatctgcagcttacacaagtgcacaaagagccgtgctagcccgagcgtttgatacatac
gccaagagaacttgtattcgctttgttccaaagtcaccagctgataaggattatattgtc
attcagaagttggatggatgttacgcagacttctcacgtgttggaggccgtcaacaagtg
tctctggctgatgagtgtattgattacgcaactatcatccatgagttgatgcatgttatt
ggagctaacactgacttcgacaagctgtcaaacttgggactatcctattatggagaacat
tacgattatagttctatcatgcattacgaagcgaatgaaggatctcgaaatggaaagaac
acaattgaggcaaaggtgagatatttaattgtgcctgatttatgcctaataaactcccac
ttcacagcaataatgggaaaagccagcgacttctcgacttcagatcttcgac

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GGTGGTGTCGCAGTGGCTGCTGAAA 620 499 217 Antisense
AGAGTTCCCTATATTCTATCTGCAG 229 69 262 Antisense
GCTAGCCCGAGCGTTTGATACATAC 355 303 312 Antisense
GCTTTGTTCCAAAGTCACCAGCTGA 604 303 356 Antisense
GATGGATGTTACGCAGACTTCTCAC 369 407 409 Antisense
AGACTTCTCACGTGTTGGAGGCCGT 285 69 423 Antisense
TGGAGGCCGTCAACAAGTGTCTCTG 95 551 438 Antisense
TGGAGCTAACACTGACTTCGACAAG 323 549 516 Antisense
TAAACTCCCACTTCACAGCAATAAT 31 641 686 Antisense
ATGGGAAAAGCCAGCGACTTCTCGA 709 39 709 Antisense
GACTTCTCGACTTCAGATCTTCGAC 11 373 724 Antisense
Sequence Source Affymetrix Proprietary Database