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[192561_at] Metallo-beta-lactamase superfamily

Description Y17G7B.3 /REP_DB=WormBase Gene ID /WP=CE19036 /TR=Q9XXJ1 /GB=CAA19450.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=Metallo-beta-lactamase superfamily
Cluster 6grp_highest_10_10 > 98      6grp_high1_10_10 > 89      4grp_highest_8_8 > 36      4grp_high_8_8 > 0      6grp_highest_nonorm > 74      6grp_total > 95      4grp_total > 55      6grp_highest_sub > Cu      6grp_high1_sub > Cu      6grp_total_sub > Increase      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 492
1 2 3 4 range
A 695.5
(3)
P 		452.6
(-3)
P 		696
(3)
P 		598.7
(0.6)
P 		243
B 856
(3)
P 		505
(-3)
P 		539.7
(-2.4)
P 		579.1
(-1.7)
P 		351
C 667.7
(3)
P 		363.8
(-3)
P 		651.6
(2.7)
P 		594.3
(1.6)
P 		304
avr 739.7
(3) 		440.5
(-3) 		629.1
(0.8) 		590.7
(0) 		299

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 237
1 2 3 4 5 6 range
A 526.7
(-2.4)
P 		645.7
(0.8)
P 		504.1
(-3)
P 		729.3
(3)
P 		567.6
(-1.3)
P 		654.8
(1)
P 		225
B 668
(1)
P 		629.3
(-0.1)
P 		521.3
(-3)
P 		602.8
(-0.8)
P 		741.5
(3)
P 		672.8
(1.1)
P 		220
C 726.3
(2.6)
P 		563.2
(-3)
P 		659.6
(0.3)
P 		609.1
(-1.4)
P 		708.9
(2)
P 		739.5
(3)
P 		176
avr 640.3
(0.7) 		612.7
(-0.6) 		561.7
(-3) 		647.1
(1) 		672.7
(2.2) 		689
(3) 		127
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 185
1 2 3 4 range
A 253.2
(3)
P 		98.3
(-2.6)
P 		181.9
(0.4)
P 		87.6
(-3)
P 		166
B 273
(3)
P 		124.7
(-2.9)
P 		125.1
(-2.9)
P 		123.4
(-3)
P 		150
C 221
(2.7)
P 		104.6
(-2.8)
P 		227.1
(3)
P 		100.2
(-3)
P 		127
avr 249.1
(3) 		109.2
(-2.8) 		178
(0.1) 		103.7
(-3) 		145

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 204
1 2 3 4 5 6 range
A 97.1
(-3)
P 		229.6
(3)
P 		109.8
(-2.4)
P 		185
(1)
P 		171.3
(0.4)
P 		159.4
(-0.2)
P 		133
B 232.4
(0.6)
P 		209.5
(-0.2)
P 		126.6
(-3)
P 		159.7
(-1.9)
P 		301.3
(3)
P 		250.9
(1.3)
P 		175
C 269.2
(3)
P 		171.9
(-1)
P 		167.9
(-1.1)
P 		122.5
(-3)
P 		229.4
(1.4)
P 		247.6
(2.1)
P 		147
avr 199.6
(0.9) 		203.7
(1.2) 		134.8
(-3) 		155.7
(-1.7) 		234
(3) 		219.3
(2.1) 		99
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192561_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.3479
Sequence Type Exemplar sequence
Representative Public ID Y17G7B.3 NCBI
Target Description Y17G7B.3 /REP_DB=WormBase Gene ID /WP=CE19036 /TR=Q9XXJ1 /GB=CAA19450.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=Metallo-beta-lactamase superfamily
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_064155(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_064155 NCBI Caenorhabditis elegans Y17G7B.3 (Y17G7B.3) mRNA, complete cds. 11/11 None
SNAP00000030317 ENSEMBL cdna:SNAP chromosome:CEL140:II:11980378:12001314:1 9/11 None
GENEFINDER00000030407 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:11988939:11991892:1 11/11 None
Y17G7B.3 ENSEMBL cdna:known chromosome:CEL140:II:11988927:11992726:1 gene:Y17G7B.3 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:11988935-11991736(+) 98.47 100.0
Public Domain and Genome References
Gene Title Metallo-beta-lactamase superfamily
Ensembl Y17G7B.3
Entrez Gene 174839 Entrez gene
SwissProt Q9XXJ1 EMBL-EBI
WormBase CE19036 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:15595_S_AT hydroxyacylglutathione hydrolase, cytoplasmic / glyoxalase II (GLX2-2) at
ATH1-121501:258775_AT hydroxyacylglutathione hydrolase, cytoplasmic / glyoxalase II (GLX2-2) at
CANINE_2:CFAAFFX.29801.1.S1_AT similar to hydroxyacyl glutathione hydrolase cfa
DROSOPHILA_2:1624638_A_AT dm
DROSGENOME1:154364_AT dm
CHICKEN:GGA.8337.1.S1_AT hydroxyacylglutathione hydrolase gga
CHICKEN:GGAAFFX.13064.1.S1_S_AT hydroxyacylglutathione hydrolase gga
HG-U133_PLUS_2:205012_S_AT hydroxyacylglutathione hydrolase hs
HG-U133A:205012_S_AT hydroxyacylglutathione hydrolase hs
HG-FOCUS:205012_S_AT hydroxyacylglutathione hydrolase hs
HG-U133A_2:205012_S_AT hydroxyacylglutathione hydrolase hs
HU35KSUBC:RC_T23986_S_AT hydroxyacylglutathione hydrolase hs
HUGENEFL:X90999_AT hydroxyacylglutathione hydrolase hs
U133_X3P:G4885388_3P_A_AT hydroxyacylglutathione hydrolase hs
HG-U95AV2:40120_AT hydroxyacylglutathione hydrolase hs
MU11KSUBB:MSA.3647.0_F_AT hydroxyacyl glutathione hydrolase mm
MG-U74AV2:100042_AT hydroxyacyl glutathione hydrolase mm
MOE430A:1437519_X_AT hydroxyacyl glutathione hydrolase mm
MOUSE430A_2:1437519_X_AT hydroxyacyl glutathione hydrolase mm
MOUSE430_2:1437519_X_AT hydroxyacyl glutathione hydrolase mm
MOE430A:1424172_AT hydroxyacyl glutathione hydrolase mm
MOUSE430A_2:1424172_AT hydroxyacyl glutathione hydrolase mm
MOUSE430_2:1424172_AT hydroxyacyl glutathione hydrolase mm
MOE430A:1424171_A_AT hydroxyacyl glutathione hydrolase mm
MOUSE430A_2:1424171_A_AT hydroxyacyl glutathione hydrolase mm
MOUSE430_2:1424171_A_AT hydroxyacyl glutathione hydrolase mm
MU19KSUBA:TC15552_AT Hydroxyacyl glutathione hydrolase (Hagh), mRNA mm
MU19KSUBA:TC15553_AT Hydroxyacyl glutathione hydrolase (Hagh), mRNA mm
RG-U34A:RC_AI012802_AT hydroxyacyl glutathione hydrolase rn
RAE230A:1369986_AT hydroxyacyl glutathione hydrolase rn
RAT230_2:1369986_AT hydroxyacyl glutathione hydrolase rn
Protein Similarities
Method ID Description E-Value
blast CAA19449 Hypothetical protein Y17G7B.2a [Caenorhabditis elegans] ref|NP_496555.1| Y17G7B.2a [Caenorhabditis elegans] 0.0
blast CAA19468 Hypothetical protein Y17G7B.2b [Caenorhabditis elegans] ref|NP_496553.1| Y17G7B.2b [Caenorhabditis elegans] 0.0
blast CAE73557 Hypothetical protein CBG21026 [Caenorhabditis briggsae] 0.0
blast CAA19450 Hypothetical protein Y17G7B.3 [Caenorhabditis elegans] ref|NP_496556.1| Y17G7B.3 [Caenorhabditis elegans] 1.0E-150
blast CAA19450 Hypothetical protein Y17G7B.3 [Caenorhabditis elegans] ref|NP_496556.1| Y17G7B.3 [Caenorhabditis elegans] 1.0E-139
blast CAE73556 Hypothetical protein CBG21025 [Caenorhabditis briggsae] 1.0E-105
blast CAE73556 Hypothetical protein CBG21025 [Caenorhabditis briggsae] 1.0E-96
blast NP_077246 hydroxyacyl glutathione hydrolase [Mus musculus] gb|AAH19817.1| Hydroxyacyl glutathione hydrolase [Mus musculus] gb|AAH04749.1| Hydroxyacyl glutathione hydrolase [Mus musculus] sp|Q99KB8|GLO2_MOUSE Hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 4.0E-64
Protein Domains
Database ID Description E-Value
Pfam IPR001279 EMBL-EBI Beta-lactamase-like 4.6E-28
Pfam IPR003877 EMBL-EBI SPla/RYanodine receptor SPRY 2.8E-15
Pfam IPR003877 EMBL-EBI SPla/RYanodine receptor SPRY 7.6E-11
Pfam IPR001279 EMBL-EBI Beta-lactamase-like 4.6E-28
Pfam IPR002773 EMBL-EBI Deoxyhypusine synthase 1.0E-126
Pfam IPR001279 EMBL-EBI Beta-lactamase-like 1.5E-27
Trans Membrane
ID Number Of Domains Domain Boundaries
GENEFINDER00000030407 1 308-326
Sequence
Target Sequence 
>C. ELEGANS:192561_AT
ccacccatcaccactatgatcattgtggtggaaatgaaggatttcgtcgtcaattcccga
atgtcatgattctcggtggagattcaaggattccggcaatggatcggcacgtgaagcatg
gtgatatggcagagttcgctgggcttcagataaaatgtctatccactccatgtcacacat
ccggtcacatctgctaccacatcacaaatcctgccgcagattccacttcccctggagtcg
ttttcaccggtgacaccctattcatcgccggttgtgggcggttcttcgagggcacggcac
cacaaatggacgtggcactcaacgaaattctcaaaaatcttccagtcgagacccaaatat
ttccgggacacgagtacactgtcgccaacctgaaattcgcgtgccacgtggaacctggca
acgagaaagctgctcagaagctcgagtgggctcaacgacaaattgagcagggtggattta
cggttccgagtactgtagctgaggaaaaagcaacgaatccatttatgagggtacgggaat
ctgaggaaattcaaaaatcgattgggacatgcgatgcggtcgtgggaat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CCACCCATCACCACTATGATCATTG 149 275 173 Antisense
GAAGGATTTCGTCGTCAATTCCCGA 9 335 208 Antisense
GGATTCCGGCAATGGATCGGCACGT 64 507 260 Antisense
GATATGGCAGAGTTCGCTGGGCTTC 414 425 295 Antisense
TAAAATGTCTATCCACTCCATGTCA 110 641 323 Antisense
TTTTCACCGGTGACACCCTATTCAT 555 675 413 Antisense
ACCCTATTCATCGCCGGTTGTGGGC 603 61 427 Antisense
TCCGGGACACGAGTACACTGTCGCC 285 595 534 Antisense
GTCGCCAACCTGAAATTCGCGTGCC 653 475 553 Antisense
TACGGTTCCGAGTACTGTAGCTGAG 592 645 651 Antisense
GGACATGCGATGCGGTCGTGGGAAT 323 525 737 Antisense
Sequence Source Affymetrix Proprietary Database