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[192537_at]

Description K06C4.6 /REP_DB=WormBase Gene ID /WP=CE11812 /TR=Q9GYH1 /GB=AAF98227.1 /SUBMIT=ST.LOUIS /CHR=5 /FEA=Sanger Annotation /DEF=ligand-gated ionic channel protein
Cluster 4grp_high_8_8 > 16      6grp_total > 25      4grp_total > 31      6grp_cgc > 34      6grp_cgc_sub > Cu      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 360
1 2 3 4 range
A 390.4
(3)
P 		108.1
(-2.7)
A 		94.3
(-3)
A 		266.8
(0.5)
P 		296
B 399.4
(3)
P 		190.2
(-2)
P 		150
(-3)
P 		228.9
(-1.1)
P 		249
C 454
(3)
P 		172.9
(-3)
P 		171.9
(-3)
P 		277.4
(-0.8)
P 		282
avr 414.6
(3) 		157.1
(-2.6) 		138.7
(-3) 		257.7
(-0.4) 		276

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 212
1 2 3 4 5 6 range
A 245.2
(3)
P 		226
(2.3)
P 		224.9
(2.2)
P 		86.7
(-3)
A 		134.5
(-1.2)
A 		130.3
(-1.3)
P 		159
B 257.3
(2.2)
P 		283.8
(3)
P 		140.5
(-1.2)
P 		109.1
(-2.1)
M 		79.2
(-3)
M 		119.5
(-1.8)
A 		205
C 256.6
(3)
P 		254.6
(2.9)
P 		203.1
(1.3)
A 		158.9
(-0.2)
A 		71.8
(-3)
A 		146
(-0.6)
A 		185
avr 253
(2.9) 		254.8
(3) 		189.5
(0.5) 		118.2
(-2.1) 		95.2
(-3) 		131.9
(-1.6) 		160
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 127
1 2 3 4 range
A 142.1
(3)
P 		23.5
(-3)
A 		24.7
(-2.9)
A 		39.1
(-2.2)
P 		119
B 127.4
(3)
P 		47
(-2.2)
P 		34.7
(-3)
P 		48.8
(-2.1)
P 		93
C 150.3
(3)
P 		49.7
(-2.8)
P 		59.9
(-2.2)
P 		46.8
(-3)
P 		104
avr 139.9
(3) 		40.1
(-3) 		39.8
(-3) 		44.9
(-2.7) 		100

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 73
1 2 3 4 5 6 range
A 45.2
(-0.6)
P 		80.4
(3)
P 		49
(-0.2)
P 		22
(-3)
A 		40.6
(-1.1)
A 		31.7
(-2)
P 		58
B 89.5
(2.5)
P 		94.5
(3)
P 		34.1
(-2.5)
P 		28.9
(-3)
M 		32.2
(-2.7)
M 		44.6
(-1.6)
A 		66
C 95.1
(3)
P 		77.7
(1.5)
P 		51.7
(-0.6)
A 		32
(-2.3)
A 		23.2
(-3)
A 		48.9
(-0.9)
A 		72
avr 76.6
(2.2) 		84.2
(3) 		44.9
(-1.2) 		27.6
(-3) 		32
(-2.5) 		41.7
(-1.5) 		57
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192537_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.12339
Sequence Type Exemplar sequence
Representative Public ID K06C4.6 NCBI
Target Description K06C4.6 /REP_DB=WormBase Gene ID /WP=CE11812 /TR=Q9GYH1 /GB=AAF98227.1 /SUBMIT=ST.LOUIS /CHR=5 /FEA=Sanger Annotation /DEF=ligand-gated ionic channel protein
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_171495(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_171495 NCBI Caenorhabditis elegans Modulation Of locomotion Defective family member (mod-1) (mod-1) mRNA, complete cds. 11/11 None
K06C4.6a.1 ENSEMBL cdna:known chromosome:CEL140:V:8912312:8916620:-1 gene:K06C4.6 11/11 None
K06C4.6a.2 ENSEMBL cdna:known chromosome:CEL140:V:8912507:8916622:-1 gene:K06C4.6 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
NM_001028863 8/11 Cross Hyb Matching Probes None
NM_001028864 7/11 Cross Hyb Matching Probes None
SNAP00000018190 3/11 Cross Hyb Matching Probes None
SNAP00000018191 7/11 Cross Hyb Matching Probes None
GENEFINDER00000018205 7/11 Cross Hyb Matching Probes None
K06C4.6b 8/11 Cross Hyb Matching Probes None
Splice Variants
Entrez Total Refseq Isoforms Total Detected By This Probeset Refseq Probesets
179269 3 1 NM_171495 192537_at (11)
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:8912507-8916367(-) 100.0 100.0
Public Domain and Genome References
Ensembl K06C4.6
Functional Annotations
Protein Similarities
Method ID Description E-Value
blast AAF98227 Modulation of locomotion defective protein 1, isoform a [Caenorhabditis elegans] ref|NP_741580.1| Modulation Of locomotion Defective family member (mod-1) [Caenorhabditis elegans] gb|AAG36975.1| serotonin-gated chloride channel [Caenorhabditis elegans] 0.0
blast CAE72047 Hypothetical protein CBG19129 [Caenorhabditis briggsae] 0.0
blast AAM45353 Modulation of locomotion defective protein 1, isoform b [Caenorhabditis elegans] ref|NP_001024034.1| Modulation Of locomotion Defective family member (mod-1) [Caenorhabditis elegans] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR006029 EMBL-EBI Neurotransmitter-gated ion-channel transmembrane region 8.4E-19
Pfam IPR006029 EMBL-EBI Neurotransmitter-gated ion-channel transmembrane region 8.0E-5
Pfam IPR006202 EMBL-EBI Neurotransmitter-gated ion-channel ligand binding domain 3.2E-55
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_741580.1 4 240-262,267-289,304-326,459-481
K06C4.6a.1 4 240-262,267-289,304-326,459-481
K06C4.6a.2 4 240-262,267-289,304-326,459-481
Sequence
Target Sequence 
>C. ELEGANS:192537_AT
gtatcttgggtttcattctgcatggaaccaaaagctctgccggcaagaacaactgtcgga
atctcatctcttctagctcttactttccagtttggaaatattttgaaaaatcttccaagg
gtttcatatgtgaaagcaatggatgtgtggatgcttggatgcatatcatttgtcttcgga
accatggtagaattggcatttgtttgttacatttcccgttgtcagaacagcgtaagaaaa
ggatcacttcatcgaaacgggccaccatctccattaaaccttcaaatgactacatttgat
tcggagatccctctgacttttgatcagctgccagtttccatggaatccgatagacccctg
attgaagagatgcgatcaacatcaccacctccaccatctggatgtctggccagattccat
ccggaagcagtggacaaattctccattgtagcttttccattggcatttacaatgtttaat
cttgtctactggtggcactat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTATCTTGGGTTTCATTCTGCATGG 271 455 667 Antisense
AACAACTGTCGGAATCTCATCTCTT 332 135 714 Antisense
TCTAGCTCTTACTTTCCAGTTTGGA 42 613 738 Antisense
GCATATCATTTGTCTTCGGAACCAT 22 309 827 Antisense
GTTTGTTACATTTCCCGTTGTCAGA 473 449 868 Antisense
GAGATCCCTCTGACTTTTGATCAGC 327 397 970 Antisense
GATCAGCTGCCAGTTTCCATGGAAT 521 421 988 Antisense
GAGATGCGATCAACATCACCACCTC 308 395 1033 Antisense
GGATGTCTGGCCAGATTCCATCCGG 42 515 1066 Antisense
AATTCTCCATTGTAGCTTTTCCATT 124 177 1103 Antisense
TAATCTTGTCTACTGGTGGCACTAT 654 635 1143 Antisense
Sequence Source Affymetrix Proprietary Database