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[192513_at] tyrosine-protein kinase

Description K07F5.4 /REP_DB=WormBase Gene ID /WP=CE06119 /GEN=kin-24 /TR=Q21292 /GB=CAA94277.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=tyrosine-protein kinase
Cluster 6grp_total > 88      4grp_total > 0      6grp_cgc > 59      6grp_cgc_sub > Da      6grp_total_sub > Increase      6grp_rule_based > S6      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 10
1 2 3 4 range
A 1.7
(-3)
A 		3.4
(-1.9)
A 		11.2
(3)
A 		6.7
(0.2)
A 		10
B 5.9
(-2.4)
A 		5.5
(-3)
A 		6.3
(-1.7)
A 		9.3
(3)
A 		4
C 9.4
(3)
A 		4.5
(-2.7)
A 		4.2
(-3)
A 		7.2
(0.5)
A 		5
avr 5.7
(-0.8) 		4.5
(-3) 		7.2
(2.1) 		7.7
(3) 		3

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 65
1 2 3 4 5 6 range
A 10.5
(-2.3)
A 		6.7
(-2.7)
A 		3.6
(-3)
A 		5.4
(-2.8)
A 		37.6
(0.2)
A 		66.9
(3)
A 		63
B 2.9
(-2.8)
A 		1.6
(-3)
A 		5.9
(-2.3)
A 		4.5
(-2.6)
A 		18.8
(-0.4)
A 		41.2
(3)
A 		40
C 2
(-3)
A 		9.2
(-1.6)
A 		4.4
(-2.5)
A 		3
(-2.8)
A 		32.1
(2.9)
A 		32.8
(3)
P 		31
avr 5.1
(-2.9) 		5.8
(-2.8) 		4.6
(-3) 		4.3
(-3) 		29.5
(0.5) 		47
(3) 		43
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 3
1 2 3 4 range
A 0.6
(-3)
A 		0.7
(-2.7)
A 		2.9
(3)
A 		1
(-2)
A 		2
B 1.9
(2)
A 		1.4
(-3)
A 		1.5
(-2)
A 		2
(3)
A 		1
C 3.1
(3)
A 		1.3
(-2.7)
A 		1.5
(-2.1)
A 		1.2
(-3)
A 		2
avr 1.9
(2.3) 		1.1
(-3) 		2
(3) 		1.4
(-1) 		1

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 16
1 2 3 4 5 6 range
A 1.9
(-2.6)
A 		2.4
(-2.4)
A 		0.8
(-3)
A 		1.4
(-2.8)
A 		11.4
(1.1)
A 		16.3
(3)
A 		16
B 1
(-2.8)
A 		0.5
(-3)
A 		1.4
(-2.6)
A 		1.2
(-2.7)
A 		7.7
(-0.1)
A 		15.4
(3)
A 		15
C 0.7
(-2.9)
A 		2.8
(-1.7)
A 		1.1
(-2.7)
A 		0.6
(-3)
A 		10.4
(2.7)
A 		11
(3)
P 		10
avr 1.2
(-3) 		1.9
(-2.6) 		1.1
(-3) 		1.1
(-3) 		9.8
(1) 		14.2
(3) 		13
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192513_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.10342
Sequence Type Exemplar sequence
Representative Public ID K07F5.4 NCBI
Target Description K07F5.4 /REP_DB=WormBase Gene ID /WP=CE06119 /GEN=kin-24 /TR=Q21292 /GB=CAA94277.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=tyrosine-protein kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_069360(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_069360 NCBI Caenorhabditis elegans protein KINase family member (kin-24) (kin-24) mRNA, complete cds. 11/11 None
SNAP00000004245 ENSEMBL cdna:SNAP chromosome:CEL140:IV:9839083:9840949:-1 11/11 None
GENEFINDER00000004267 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:9839083:9840949:-1 11/11 None
K07F5.4 ENSEMBL cdna:known chromosome:CEL140:IV:9839083:9840949:-1 gene:K07F5.4 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:9839088-9840955(-) 100.0 100.0
Public Domain and Genome References
Gene Title tyrosine-protein kinase
Gene Symbol kin-24
Ensembl K07F5.4
Entrez Gene 177829 Entrez gene
WormBase CE06119 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA94277 Hypothetical protein K07F5.4 [Caenorhabditis elegans] ref|NP_501761.1| protein KINase family member (kin-24) [Caenorhabditis elegans] 0.0
blast CAE67214 Hypothetical protein CBG12650 [Caenorhabditis briggsae] 0.0
blast CAE60278 Hypothetical protein CBG03859 [Caenorhabditis briggsae] 6.0E-44
blast CAE60278 Hypothetical protein CBG03859 [Caenorhabditis briggsae] 7.0E-44
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 4.0E-15
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 8.0E-63
Pfam IPR000719 EMBL-EBI Protein kinase 8.0E-63
Sequence
Target Sequence 
>C. ELEGANS:192513_AT
agaagcgccacttgcatggcttgctccggaatgcattcagcgtgagtctgaattctcaac
taaaactgacgtttgggcgtttggagttgtcattttcgaggtctacaacaacgcggaaaa
actgtttgccggagaggaagacatagcgattcttcggaagatcaagaaagccaacatgcc
aactatcgagaatcggacaaaggttccagcaatgcaggctgttctcagttcaatttggac
taggaagccggacgatcgaccagaaatgcagaaagttcttgaaaaactcgtggcagcttt
ggtgccgattcaaccagatgatctgaaacggctccaaatcaacagcctcaaaggtgtcag
cagaactcagatgccaaacacagacctggagatggatgtgtcggtggtgaacgaagaggt
agatcaggatggatcggagaaaaaccgcaaggtgaagggaggatccaaaaagaaaaccgg
aaatcgccataaccgaagtggcaagagaactccaaaacaagaagaatccccaaaaagcaa
aaagccagttccactacgcaat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AGAAGCGCCACTTGCATGGCTTGCT 111 75 969 Antisense
TGGCTTGCTCCGGAATGCATTCAGC 701 545 985 Antisense
GGGCGTTTGGAGTTGTCATTTTCGA 702 489 1043 Antisense
TTTTCGAGGTCTACAACAACGCGGA 229 675 1061 Antisense
GAAAGCCAACATGCCAACTATCGAG 428 359 1134 Antisense
GCAATGCAGGCTGTTCTCAGTTCAA 56 323 1177 Antisense
CTAGGAAGCCGGACGATCGACCAGA 235 213 1208 Antisense
AACTCGTGGCAGCTTTGGTGCCGAT 535 141 1253 Antisense
GGTGCCGATTCAACCAGATGATCTG 701 501 1269 Antisense
GAACTCAGATGCCAAACACAGACCT 337 349 1331 Antisense
CAAAAAGCCAGTTCCACTACGCAAT 474 189 1506 Antisense
Sequence Source Affymetrix Proprietary Database