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[192474_s_at] D-3-Phosphoglycerate dehydrogenase

Description C31C9.2 /REP_DB=WormBase Gene ID /WP=CE08497 /TR=O17626 /GB=CAB05694.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=D-3-Phosphoglycerate dehydrogenase
Cluster 6grp_highest_10_10 > 49      6grp_high1_10_10 > 94      4grp_highest_8_8 > 13      4grp_high_8_8 > 30      6grp_highest_nonorm > 55      6grp_total > 84      4grp_total > 24      6grp_highest_sub > 04_05_06      6grp_high1_sub > In      6grp_total_sub > Hat      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 3646
1 2 3 4 range
A 671.9
(-3)
P 		2512.3
(0.2)
P 		2891.9
(0.9)
P 		4076.3
(3)
P 		3404
B 687.4
(-3)
P 		2634.1
(0.2)
P 		3032
(0.9)
P 		4317.9
(3)
P 		3631
C 704
(-3)
P 		2717.8
(0.5)
P 		2922.9
(0.8)
P 		4191.1
(3)
P 		3487
avr 687.8
(-3) 		2621.4
(0.3) 		2948.9
(0.9) 		4195.1
(3) 		3507

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1113
1 2 3 4 5 6 range
A 907.8
(-3)
P 		1569.4
(0.6)
P 		1328.4
(-0.7)
P 		1965.1
(2.7)
P 		1433.8
(-0.2)
P 		2021
(3)
P 		1113
B 988.4
(-3)
P 		1532
(1)
P 		1307.3
(-0.7)
P 		1808.3
(3)
P 		1630.3
(1.7)
P 		1595.3
(1.4)
P 		820
C 1319.2
(-3)
P 		1383.2
(-2.3)
P 		1530.7
(-0.8)
P 		1720
(1.2)
P 		1885.4
(3)
P 		1586
(-0.2)
P 		566
avr 1071.8
(-3) 		1494.9
(0.3) 		1388.8
(-0.5) 		1831.1
(3) 		1649.8
(1.6) 		1734.1
(2.2) 		759
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 800
1 2 3 4 range
A 244.6
(-3)
P 		545.4
(0.5)
P 		756
(3)
P 		596.7
(1.1)
P 		511
B 219.2
(-3)
P 		650.5
(0.7)
P 		702.6
(1.1)
P 		920.1
(3)
P 		701
C 233.1
(-3)
P 		781.4
(1.2)
P 		1018.7
(3)
P 		706.7
(0.6)
P 		786
avr 232.3
(-3) 		659.1
(1.3) 		825.8
(3) 		741.2
(2.1) 		594

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 495
1 2 3 4 5 6 range
A 167.3
(-3)
P 		558.2
(3)
P 		289.3
(-1.1)
P 		498.4
(2.1)
P 		432.7
(1.1)
P 		492
(2)
P 		391
B 343.9
(-2.5)
P 		509.9
(0.3)
P 		317.5
(-3)
P 		479
(-0.2)
P 		662.4
(3)
P 		594.9
(1.8)
P 		345
C 489
(0.2)
P 		422.1
(-1.3)
P 		389.6
(-2)
P 		345.9
(-3)
P 		610.1
(3)
P 		530.9
(1.2)
P 		264
avr 333.4
(-3) 		496.7
(1.2) 		332.1
(-3) 		441.1
(-0.2) 		568.4
(3) 		539.3
(2.3) 		236
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 192474_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.3266
Sequence Type Exemplar sequence
Representative Public ID C31C9.2 NCBI
Target Description C31C9.2 /REP_DB=WormBase Gene ID /WP=CE08497 /TR=O17626 /GB=CAB05694.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=D-3-Phosphoglycerate dehydrogenase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_064467(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_064467 NCBI Caenorhabditis elegans C31C9.2 (C31C9.2) mRNA, complete cds. 11/11 None
SNAP00000002043 ENSEMBL cdna:SNAP chromosome:CEL140:II:13636990:13638375:-1 11/11 None
GENEFINDER00000002052 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:13636990:13638375:-1 11/11 None
C31C9.2.3 ENSEMBL cdna:known chromosome:CEL140:II:13636486:13638378:-1 gene:C31C9.2 11/11 None
C31C9.2.1 ENSEMBL cdna:known chromosome:CEL140:II:13636879:13638381:-1 gene:C31C9.2 11/11 None
C31C9.2.2 ENSEMBL cdna:known chromosome:CEL140:II:13636901:13638376:-1 gene:C31C9.2 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:13636986-13638372(-) 100.0 100.0
Public Domain and Genome References
Gene Title D-3-Phosphoglycerate dehydrogenase
Ensembl C31C9.2
Entrez Gene 175012 Entrez gene
SwissProt O17626 EMBL-EBI
WormBase CE08497 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1583212_AT similar to D-3-phosphoglycerate dehydrogenase (3-PGDH) cfa
CANINE:1583213_S_AT similar to D-3-phosphoglycerate dehydrogenase (3-PGDH) cfa
CANINE_2:CFA.1293.1.A1_AT similar to D-3-phosphoglycerate dehydrogenase (3-PGDH) cfa
CANINE_2:CFA.20876.1.S1_S_AT similar to D-3-phosphoglycerate dehydrogenase (3-PGDH) cfa
CANINE_2:CFAAFFX.15790.1.S1_AT similar to D-3-phosphoglycerate dehydrogenase (3-PGDH) cfa
CANINE_2:CFAAFFX.15790.1.S1_S_AT similar to D-3-phosphoglycerate dehydrogenase (3-PGDH) cfa
CANINE_2:CFAAFFX.16936.1.S1_S_AT similar to D-3-phosphoglycerate dehydrogenase (3-PGDH) cfa
DROSOPHILA_2:1629207_AT dm
DROSGENOME1:151909_AT dm
HG-U133A_2:201397_AT phosphoglycerate dehydrogenase hs
HG-U133A:201397_AT phosphoglycerate dehydrogenase hs
HG-U133_PLUS_2:201397_AT phosphoglycerate dehydrogenase hs
HG-FOCUS:201397_AT phosphoglycerate dehydrogenase hs
HU35KSUBA:AA093396_AT phosphoglycerate dehydrogenase hs
HU35KSUBA:RC_AA236365_S_AT phosphoglycerate dehydrogenase hs
U133_X3P:G5729973_3P_AT phosphoglycerate dehydrogenase hs
HG-U95AV2:34367_AT phosphoglycerate dehydrogenase hs
HG-U95C:63911_AT phosphoglycerate dehydrogenase hs
HG-U95D:73599_AT phosphoglycerate dehydrogenase hs
HG-U95C:62861_AT Phosphoglycerate dehydrogenase hs
MOUSE430_2:1426657_S_AT 3-phosphoglycerate dehydrogenase mm
MOUSE430A_2:1426657_S_AT 3-phosphoglycerate dehydrogenase mm
MOE430A:1426657_S_AT 3-phosphoglycerate dehydrogenase mm
MOE430B:1432707_AT 3-phosphoglycerate dehydrogenase mm
MOUSE430_2:1432707_AT 3-phosphoglycerate dehydrogenase mm
MOUSE430_2:1437621_X_AT 3-phosphoglycerate dehydrogenase mm
MOUSE430A_2:1437621_X_AT 3-phosphoglycerate dehydrogenase mm
MOE430A:1437621_X_AT 3-phosphoglycerate dehydrogenase mm
MOUSE430_2:1456471_X_AT 3-phosphoglycerate dehydrogenase mm
MOUSE430A_2:1456471_X_AT 3-phosphoglycerate dehydrogenase mm
MOE430A:1456471_X_AT 3-phosphoglycerate dehydrogenase mm
MOUSE430_2:1426658_X_AT 3-phosphoglycerate dehydrogenase mm
MOE430A:1426658_X_AT 3-phosphoglycerate dehydrogenase mm
MOUSE430A_2:1426658_X_AT 3-phosphoglycerate dehydrogenase mm
MOUSE430A_2:1456584_X_AT 3-phosphoglycerate dehydrogenase mm
MOE430A:1456584_X_AT 3-phosphoglycerate dehydrogenase mm
MOUSE430_2:1456584_X_AT 3-phosphoglycerate dehydrogenase mm
MU11KSUBA:L21027_S_AT 3-phosphoglycerate dehydrogenase mm
MG-U74AV2:93127_AT 3-phosphoglycerate dehydrogenase mm
MG-U74AV2:162168_R_AT 3-phosphoglycerate dehydrogenase mm
MOE430A:1454714_X_AT 3-phosphoglycerate dehydrogenase mm
MOUSE430A_2:1454714_X_AT 3-phosphoglycerate dehydrogenase mm
MOUSE430_2:1454714_X_AT 3-phosphoglycerate dehydrogenase mm
MOE430B:1459081_AT A10 mm
MOUSE430_2:1459081_AT A10 mm
MU19KSUBA:TC22957_S_AT A10 mm
RG-U34A:X97772_AT 3-phosphoglycerate dehydrogenase rn
RG-U34A:X97772_G_AT 3-phosphoglycerate dehydrogenase rn
RG-U34A:RC_AI008677_S_AT 3-phosphoglycerate dehydrogenase rn
RG-U34B:RC_AA899141_S_AT 3-phosphoglycerate dehydrogenase rn
RAE230A:1367811_AT 3-phosphoglycerate dehydrogenase rn
RAT230_2:1367811_AT 3-phosphoglycerate dehydrogenase rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6564 L-serine biosynthesis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
16616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB05694 Hypothetical protein C31C9.2 [Caenorhabditis elegans] ref|NP_496868.1| C31C9.2 [Caenorhabditis elegans] 1.0E-176
blast CAB05694 Hypothetical protein C31C9.2 [Caenorhabditis elegans] ref|NP_496868.1| C31C9.2 [Caenorhabditis elegans] 1.0E-174
blast CAB05694 Hypothetical protein C31C9.2 [Caenorhabditis elegans] ref|NP_496868.1| C31C9.2 [Caenorhabditis elegans] 1.0E-173
blast CAE73309 Hypothetical protein CBG20736 [Caenorhabditis briggsae] 1.0E-166
Protein Domains
Database ID Description E-Value
Pfam IPR006140 EMBL-EBI D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 5.3E-85
Pfam IPR006139 EMBL-EBI D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 3.5E-22
Pfam IPR006140 EMBL-EBI D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 4.0E-78
Pfam IPR006139 EMBL-EBI D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 5.1E-23
Pfam IPR006140 EMBL-EBI D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 5.3E-85
Sequence
Target Sequence 
>C. ELEGANS:192474_S_AT
gccgccgcatcgatgaaggccggcaaatgggcccgcaaggatttcatgggagaggaggtc
tacggacgcaccctagccgttctcggcctcggacgaattggatctgaggtggccgtcagg
cttcaggcctttggaatgaaggttattggatttgatccaatggtcacgaaggagcaggct
gaggcgaagaacattgagctgctctcgttggagcagatttggccacaggccgattatatt
acggtccacgtaccgctgatcaagcagactgagaatttgatcaataaagagaccctcgcg
aaatgcaaaaaaggagtccgtatcatcaacgtggcgcgtggaggaattgtgaacgaggtc
gacctggtggaatccctgaacgctggacacgccaagggagcagcattcgacgtgtttgag
caagaaccaccaacgttcagagagctcatcgatcatccactcgtcattgcgacaccacat
ctcggagcatcaacgattgacgcgcagctccgtgtcgcatcggaaatcgcc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GCCGCCGCATCGATGAAGGCCGGCA 454 281 382 Antisense
GCAAATGGGCCCGCAAGGATTTCAT 78 319 404 Antisense
TTCTCGGCCTCGGACGAATTGGATC 200 685 461 Antisense
GGCGAAGAACATTGAGCTGCTCTCG 210 543 564 Antisense
GTTGGAGCAGATTTGGCCACAGGCC 654 435 588 Antisense
TATTACGGTCCACGTACCGCTGATC 247 661 618 Antisense
GGAGTCCGTATCATCAACGTGGCGC 321 517 694 Antisense
ACGAGGTCGACCTGGTGGAATCCCT 326 91 734 Antisense
AAGGGAGCAGCATTCGACGTGTTTG 489 159 775 Antisense
ACACCACATCTCGGAGCATCAACGA 667 109 853 Antisense
GCTCCGTGTCGCATCGGAAATCGCC 36 299 888 Antisense
Sequence Source Affymetrix Proprietary Database