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[192463_s_at] Yeast regulatory protein SIR2 like

Description R11A8.4 /REP_DB=WormBase Gene ID /WP=CE06302 /TR=Q21921 /GB=CAA94364.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Yeast regulatory protein SIR2 like
Cluster 6grp_highest_10_10 > 55      6grp_high1_10_10 > 44      4grp_highest_8_8 > 61      4grp_high_8_8 > 17      6grp_highest_nonorm > 86      6grp_total > 55      4grp_total > 30      6grp_cgc > 55      6grp_high1_sub > 02      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 724
1 2 3 4 range
A 1366.8
(3)
P 		1033.6
(-0)
P 		701.6
(-3)
P 		1291.5
(2.3)
P 		665
B 1354.8
(3)
P 		803.5
(-1.7)
P 		658.1
(-3)
P 		1057
(0.4)
P 		697
C 1381.9
(3)
P 		826.5
(-3)
P 		850.3
(-2.7)
P 		1031.6
(-0.8)
P 		555
avr 1367.8
(3) 		887.9
(-1.6) 		736.7
(-3) 		1126.7
(0.7) 		631

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 425
1 2 3 4 5 6 range
A 969.1
(-1.5)
P 		1022.5
(0)
P 		1126.8
(3)
P 		1071.4
(1.4)
P 		917.6
(-3)
P 		943.3
(-2.3)
P 		209
B 931.3
(-3)
P 		1066.8
(1.3)
P 		1118.4
(3)
P 		948.6
(-2.4)
P 		961.5
(-2)
P 		1102.4
(2.5)
P 		187
C 859
(-1.3)
P 		1133.4
(2.6)
P 		937
(-0.2)
P 		1146.8
(2.8)
P 		737.4
(-3)
P 		1162
(3)
P 		425
avr 919.8
(-1.6) 		1074.2
(3) 		1060.7
(2.6) 		1055.6
(2.4) 		872.2
(-3) 		1069.2
(2.9) 		202
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 345
1 2 3 4 range
A 497.7
(3)
P 		224.4
(-2.2)
P 		183.4
(-3)
P 		189.1
(-2.9)
P 		314
B 432
(3)
P 		198.4
(-2)
P 		152.5
(-3)
P 		225.2
(-1.4)
P 		280
C 457.4
(3)
P 		237.6
(-1.7)
P 		296.4
(-0.4)
P 		173.9
(-3)
P 		284
avr 462.4
(3) 		220.1
(-2.5) 		210.8
(-2.7) 		196.1
(-3) 		266

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 232
1 2 3 4 5 6 range
A 178.7
(-3)
P 		363.6
(3)
P 		245.4
(-0.8)
P 		271.7
(0)
P 		276.9
(0.2)
P 		229.7
(-1.3)
P 		185
B 324.1
(-0.3)
P 		355.1
(0.9)
P 		271.6
(-2.2)
P 		251.3
(-3)
P 		390.7
(2.2)
P 		411.1
(3)
P 		160
C 318.4
(0.3)
P 		345.8
(1.4)
P 		238.5
(-2.7)
P 		230.6
(-3)
P 		238.6
(-2.7)
P 		389
(3)
P 		158
avr 273.7
(-1.7) 		354.8
(3) 		251.8
(-3) 		251.2
(-3) 		302.1
(-0.1) 		343.3
(2.3) 		104
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 192463_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.8527
Sequence Type Exemplar sequence
Representative Public ID R11A8.4 NCBI
Target Description R11A8.4 /REP_DB=WormBase Gene ID /WP=CE06302 /TR=Q21921 /GB=CAA94364.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Yeast regulatory protein SIR2 like
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_069511(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_069511 NCBI Caenorhabditis elegans yeast SIR related family member (sir-2.1) (sir-2.1) mRNA, complete cds. 11/11 None
SNAP00000003244 ENSEMBL cdna:SNAP chromosome:CEL140:IV:10363458:10366160:-1 11/11 None
GENEFINDER00000003253 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:10363458:10366160:-1 11/11 None
R11A8.4.1 ENSEMBL cdna:known chromosome:CEL140:IV:10363297:10366201:-1 gene:R11A8.4 11/11 None
R11A8.4.2 ENSEMBL cdna:known chromosome:CEL140:IV:10363298:10366209:-1 gene:R11A8.4 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000026517 1/11 Cross Hyb Matching Probes None
GENEFINDER00000026528 3/11 Cross Hyb Matching Probes None
F53B2.7 1/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:10363463-10366166(-) 100.0 100.0
Public Domain and Genome References
Gene Title Yeast regulatory protein SIR2 like
Gene Symbol sir-2.1
Ensembl R11A8.4
Entrez Gene 177924 Entrez gene
SwissProt Q21921 EMBL-EBI
WormBase CE06302 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1605859_AT similar to NAD-dependent deacetylase sirtuin-1 (hSIRT1) (hSIR2) (SIR2-like protein 1) cfa
CANINE:1605424_AT similar to NAD-dependent deacetylase sirtuin-1 (hSIRT1) (hSIR2) (SIR2-like protein 1) cfa
CANINE_2:CFAAFFX.20596.1.S1_AT similar to NAD-dependent deacetylase sirtuin-1 (hSIRT1) (hSIR2) (SIR2-like protein 1) cfa
DROSOPHILA_2:1628368_AT dm
DROSGENOME1:153597_AT dm
HU35KSUBB:RC_N68314_AT sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) hs
HU35KSUBC:RC_H98832_AT sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) hs
HG-U133A:218878_S_AT sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) hs
HG-U133_PLUS_2:218878_S_AT sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) hs
HG-FOCUS:218878_S_AT sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) hs
HG-U133A_2:218878_S_AT sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) hs
U133_X3P:G13775598_3P_A_AT sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) hs
HG-U95B:46399_AT sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) hs
HG-U95C:61678_AT sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) hs
HG-U95C:64265_S_AT sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) hs
HG-U95D:70093_AT Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) hs
MG-U74BV2:111531_AT sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae) mm
MG-U74BV2:115059_AT sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae) mm
MOE430A:1418640_AT sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae) mm
MOUSE430A_2:1418640_AT sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae) mm
MOUSE430_2:1418640_AT sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae) mm
MOUSE430_2:1441508_AT Sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae), mRNA (cDNA clone IMAGE:3587177) mm
MOE430B:1441508_AT Sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae), mRNA (cDNA clone IMAGE:3587177) mm
MOE430B:1458538_AT Sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae), mRNA (cDNA clone IMAGE:3587177) mm
MOUSE430_2:1458538_AT Sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae), mRNA (cDNA clone IMAGE:3587177) mm
MG-U74AV2:92333_AT Sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae), mRNA (cDNA clone IMAGE:3587177) mm
MU11KSUBB:MSA.14387.0_S_AT Sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae), mRNA (cDNA clone IMAGE:3587177) mm
MU19KSUBA:TC19291_AT Sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae), mRNA (cDNA clone IMAGE:3587177) mm
MU19KSUBC:TC35310_AT Sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae), mRNA (cDNA clone IMAGE:3587177) mm
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6342 chromatin silencing inferred from electronic annotation QuickGO AmiGO
6355 regulation of transcription, DNA-dependent inferred from electronic annotation QuickGO AmiGO
6476 protein amino acid deacetylation inferred from direct assay QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5677 chromatin silencing complex inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3677 DNA binding inferred from electronic annotation QuickGO AmiGO
19213 deacetylase activity inferred from direct assay QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA94364 Hypothetical protein R11A8.4 [Caenorhabditis elegans] ref|NP_501912.1| yeast SIR related family member (sir-2.1) [Caenorhabditis elegans] 0.0
blast CAE56143 Hypothetical protein CBG23756 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR003000 EMBL-EBI Silent information regulator protein Sir2 6.0E-110
Sequence
Target Sequence 
>C. ELEGANS:192463_S_AT
gaatgtcggtggctgacgattcgatggattccgagaagaataatttccaagaaatacaaa
aacataagtcagaagatgacgatgatacacggaattcggacgatattctcaagaaaataa
agcatccaaggctgctgagcattactgagatgctccatgacaataagtgtgtcgcgattt
ctgctcatcaaaccgtctttcctggagccgaatgctcatttgatctagaaacattgaaac
tggttcgtgatgttcatcacgagacacattgcgaaagttcgtgtggttcgtcttgctcat
caaatgccgattcagaagcaaatcaattatctagagcacaatcgctagatgactttgtac
tatctgacgaggatcgaaaaaacacgatacatctggacttgcaacgagccgattcatgtg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAATGTCGGTGGCTGACGATTCGAT 37 333 1337 Antisense
AAAGCATCCAAGGCTGCTGAGCATT 549 123 1455 Antisense
TAAGTGTGTCGCGATTTCTGCTCAT 525 637 1500 Antisense
CTCATCAAACCGTCTTTCCTGGAGC 444 227 1520 Antisense
GAGCCGAATGCTCATTTGATCTAGA 68 387 1541 Antisense
TGTTCATCACGAGACACATTGCGAA 63 563 1587 Antisense
TGGTTCGTCTTGCTCATCAAATGCC 525 549 1620 Antisense
AGAGCACAATCGCTAGATGACTTTG 374 69 1669 Antisense
ATGACTTTGTACTATCTGACGAGGA 494 45 1685 Antisense
ACACGATACATCTGGACTTGCAACG 248 109 1718 Antisense
GACTTGCAACGAGCCGATTCATGTG 347 371 1732 Antisense
Sequence Source Affymetrix Proprietary Database