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[192445_at] Eukaryotic protein kinase domain

Description Y38F1A.10 /REP_DB=WormBase Gene ID /WP=CE21615 /TR=Q9XWL8 /GB=CAA21637.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=Eukaryotic protein kinase domain
Cluster 6grp_total > 56      4grp_total > 14      6grp_cgc > 37      6grp_cgc_sub > Cu      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 79
1 2 3 4 range
A 50.1
(0.8)
A 		4.2
(-3)
A 		20.9
(-1.6)
A 		77.1
(3)
A 		73
B 52.9
(-0.7)
A 		83.6
(3)
A 		33.2
(-3)
A 		72.2
(1.6)
A 		50
C 48.6
(1.5)
A 		20.4
(-3)
A 		58.4
(3)
A 		34.1
(-0.8)
A 		38
avr 50.5
(0.5) 		36.1
(-3) 		37.5
(-2.7) 		61.1
(3) 		25

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 53
1 2 3 4 5 6 range
A 41.4
(-1)
A 		67.7
(2.6)
A 		47.4
(-0.2)
A 		65.2
(2.3)
A 		27.1
(-3)
A 		70.6
(3)
A 		44
B 30.6
(-1.4)
A 		27.1
(-2)
A 		36.5
(-0.4)
A 		21.1
(-3)
A 		23.2
(-2.6)
A 		56
(3)
A 		35
C 40.1
(-0.1)
A 		57.8
(2.2)
A 		35.9
(-0.7)
A 		18
(-3)
A 		41.9
(0.1)
A 		63.9
(3)
A 		46
avr 37.4
(-1.8) 		50.9
(0.7) 		39.9
(-1.3) 		34.8
(-2.3) 		30.7
(-3) 		63.5
(3) 		33
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 20
1 2 3 4 range
A 18.2
(3)
A 		0.9
(-3)
A 		5.5
(-1.4)
A 		11.3
(0.6)
A 		17
B 16.9
(1.3)
A 		20.6
(3)
A 		7.7
(-3)
A 		15.4
(0.6)
A 		13
C 16.1
(1.2)
A 		5.9
(-3)
A 		20.4
(3)
A 		5.8
(-3)
A 		15
avr 17.1
(3) 		9.1
(-3) 		11.2
(-1.4) 		10.8
(-1.7) 		8

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 21
1 2 3 4 5 6 range
A 7.6
(-3)
A 		24.1
(3)
A 		10.3
(-2)
A 		16.5
(0.2)
A 		8.2
(-2.8)
A 		17.2
(0.5)
A 		17
B 10.7
(-1)
A 		9
(-1.7)
A 		8.9
(-1.7)
A 		5.6
(-3)
A 		9.4
(-1.5)
A 		20.9
(3)
A 		15
C 14.9
(0.8)
A 		17.7
(1.8)
A 		9.1
(-1.1)
A 		3.6
(-3)
A 		13.6
(0.4)
A 		21.4
(3)
A 		18
avr 11.1
(-1.7) 		16.9
(1.4) 		9.4
(-2.6) 		8.6
(-3) 		10.4
(-2) 		19.8
(3) 		11
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192445_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.2948
Sequence Type Exemplar sequence
Representative Public ID Y38F1A.10 NCBI
Target Description Y38F1A.10 /REP_DB=WormBase Gene ID /WP=CE21615 /TR=Q9XWL8 /GB=CAA21637.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=Eukaryotic protein kinase domain
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_064368(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_064368 NCBI Caenorhabditis elegans Y38F1A.10 (Y38F1A.10) mRNA, complete cds. 11/11 None
SNAP00000020288 ENSEMBL cdna:SNAP chromosome:CEL140:II:13015264:13020407:-1 11/11 None
GENEFINDER00000020292 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:13015264:13020428:-1 11/11 None
Y38F1A.10 ENSEMBL cdna:known chromosome:CEL140:II:13014295:13020428:-1 gene:Y38F1A.10 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:13015260-13020425(-) 100.0 100.0
Public Domain and Genome References
Gene Title Eukaryotic protein kinase domain
Gene Symbol pak-8
Ensembl Y38F1A.10
Entrez Gene 3565400 Entrez gene
SwissProt Q9XWL8 EMBL-EBI
WormBase CE35656 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA21637 Hypothetical protein Y38F1A.10 [Caenorhabditis elegans] ref|NP_496769.2| Y38F1A.10 [Caenorhabditis elegans] 0.0
blast CAE59430 Hypothetical protein CBG02802 [Caenorhabditis briggsae] 0.0
blast AAN13373 CG10295-PC, isoform C [Drosophila melanogaster] gb|AAF54132.1| CG10295-PB, isoform B [Drosophila melanogaster] gb|AAF54131.1| CG10295-PA, isoform A [Drosophila melanogaster] gb|AAQ23609.1| LD20767p [Drosophila melanogaster] ref|NP_731074.1| CG10295-PC, isoform C [Drosophila melanogaster] ref|NP_731073.1| CG10295-PA, isoform A [Drosophila melanogaster] ref|NP_524681.1| CG10295-PB, isoform B [Drosophila melanogaster] 1.0E-101
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 9.0E-61
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 6.0E-61
hanks 2.1.17 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; TWITCH 2.0E-70
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 9.7E-78
Pfam IPR000719 EMBL-EBI Protein kinase 9.7E-78
Sequence
Target Sequence 
>C. ELEGANS:192445_AT
gaatgtcttaaagcgcttcacttccttcatagacactccatagtgcaccgagatatcaag
agtgacaacgtgctgctcggcatgaacggagaggttaagctcaccgatatgggattctgt
gctcagattcagccgggatcgaaaagagatactgtcgtcggaactccatattggatgtcg
ccggagatattgaacaagaagcagtacaactataaggttgacatttggtcgctgggaatt
atggctctagagatgattgatggagagccaccatatttgagagaaacacctttgaaggct
atctacttgattgctcaaaacgggaagccagagatcaagcaacgcgacagactgtcttca
gagttcaacaatttccttgacaagtgtcttgttgttgatccggatcagagagccgataca
acggagctcttggcacatccattcctgaaaaaggcgaagccactctcaagcct

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAATGTCTTAAAGCGCTTCACTTCC 3 331 643 Antisense
CTTCCTTCATAGACACTCCATAGTG 33 213 663 Antisense
CAAGAGTGACAACGTGCTGCTCGGC 508 183 699 Antisense
ACCGATATGGGATTCTGTGCTCAGA 409 89 745 Antisense
TGTGCTCAGATTCAGCCGGGATCGA 592 555 760 Antisense
GATACTGTCGTCGGAACTCCATATT 489 423 790 Antisense
GGTCGCTGGGAATTATGGCTCTAGA 645 501 869 Antisense
GATCAAGCAACGCGACAGACTGTCT 216 421 975 Antisense
AAGTGTCTTGTTGTTGATCCGGATC 687 157 1024 Antisense
GATACAACGGAGCTCTTGGCACATC 332 423 1057 Antisense
AAAAGGCGAAGCCACTCTCAAGCCT 328 133 1091 Antisense
Sequence Source Affymetrix Proprietary Database