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[192436_s_at] PH (pleckstrin homology) domain

Description Y49E10.19 /REP_DB=WormBase Gene ID /WP=CE22234 /TR=Q9XTT4 /GB=CAB11565.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=PH (pleckstrin homology) domain
Cluster 6grp_highest_10_10 > 97      6grp_high1_10_10 > 79      4grp_highest_8_8 > 32      4grp_high_8_8 > 43      6grp_highest_nonorm > 93      6grp_total > 69      4grp_total > 61      6grp_highest_sub > Cu      6grp_cgc > 39      6grp_high1_sub > Cu      6grp_cgc_sub > Cu      6grp_total_sub > Cup      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 220
1 2 3 4 range
A 449
(3)
P 		387.2
(1.3)
P 		342.5
(0.1)
P 		229.3
(-3)
P 		220
B 420.9
(2.7)
P 		429.4
(3)
P 		364.4
(0.8)
P 		254.3
(-3)
P 		175
C 440.6
(3)
P 		412.6
(2.2)
P 		417
(2.3)
P 		234.2
(-3)
P 		206
avr 436.8
(3) 		409.7
(2.2) 		374.6
(1.1) 		239.3
(-3) 		198

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 566
1 2 3 4 5 6 range
A 274.7
(-1.7)
P 		334.7
(-1)
P 		148.3
(-3)
P 		211.5
(-2.3)
P 		395.1
(-0.4)
P 		714.7
(3)
P 		566
B 359.4
(-0.2)
P 		229.2
(-2.4)
P 		192
(-3)
P 		288.1
(-1.4)
P 		360.9
(-0.2)
P 		554.1
(3)
P 		362
C 455
(0.8)
P 		185.2
(-3)
P 		199.9
(-2.8)
P 		183.9
(-3)
P 		507
(1.5)
P 		612.2
(3)
P 		428
avr 363
(-0.5) 		249.7
(-2.1) 		180.1
(-3) 		227.8
(-2.4) 		421
(0.2) 		627
(3) 		447
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 130
1 2 3 4 range
A 163.5
(3)
P 		84
(-0.7)
P 		89.5
(-0.4)
P 		33.6
(-3)
P 		130
B 134.2
(3)
P 		106
(0.9)
P 		84.4
(-0.7)
P 		54.2
(-3)
P 		80
C 145.9
(3)
P 		118.6
(1.5)
P 		145.3
(3)
P 		39.5
(-3)
P 		106
avr 147.9
(3) 		102.9
(0.4) 		106.4
(0.6) 		42.4
(-3) 		106

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 174
1 2 3 4 5 6 range
A 50.6
(-2.2)
P 		119
(0.7)
P 		32.3
(-3)
P 		53.6
(-2.1)
P 		119.2
(0.7)
P 		174
(3)
P 		142
B 125
(-0.1)
P 		76.3
(-1.9)
P 		46.6
(-3)
P 		76.3
(-1.9)
P 		146.6
(0.8)
P 		206.6
(3)
P 		160
C 168.7
(1.7)
P 		56.5
(-2.3)
P 		50.9
(-2.5)
P 		37
(-3)
P 		164.1
(1.5)
P 		204.9
(3)
P 		168
avr 114.8
(-0.2) 		83.9
(-1.4) 		43.3
(-3) 		55.6
(-2.5) 		143.3
(0.9) 		195.2
(3) 		152
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 192436_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.8031
Sequence Type Exemplar sequence
Representative Public ID Y49E10.19 NCBI
Target Description Y49E10.19 /REP_DB=WormBase Gene ID /WP=CE22234 /TR=Q9XTT4 /GB=CAB11565.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=PH (pleckstrin homology) domain
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_067223(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_067223 NCBI Caenorhabditis elegans ANIllin (actin binding protein) family member (ani-1) (ani-1) mRNA, complete cds. 11/11 None
SNAP00000016087 ENSEMBL cdna:SNAP chromosome:CEL140:III:12446550:12453059:-1 11/11 None
GENEFINDER00000016121 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:12446550:12456721:-1 11/11 None
Y49E10.19 ENSEMBL cdna:known chromosome:CEL140:III:12446241:12453077:-1 gene:Y49E10.19 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:12446545-12453055(-) 99.97 100.0
Public Domain and Genome References
Gene Title PH (pleckstrin homology) domain
Gene Symbol ani-1
Ensembl Y49E10.19
Entrez Gene 176672 Entrez gene
SwissProt Q9XTT4 EMBL-EBI
WormBase CE33878 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1606077_AT similar to anillin, actin binding protein (scraps homolog, Drosophila) cfa
CANINE_2:CFA.20116.1.S1_S_AT similar to anillin, actin binding protein (scraps homolog, Drosophila) cfa
CANINE_2:CFA.3333.1.A1_AT similar to anillin, actin binding protein (scraps homolog, Drosophila) cfa
CANINE_2:CFAAFFX.5799.1.S1_S_AT similar to anillin, actin binding protein (scraps homolog, Drosophila) cfa
DROSOPHILA_2:1637214_A_AT scraps dm
DROSGENOME1:154201_AT scraps dm
CHICKEN:GGA.3212.2.S1_S_AT similar to anillin, actin binding protein (scraps homolog, Drosophila); anillin (Drosophila Scraps homolog), actin binding protein gga
CHICKEN:GGAAFFX.23783.1.S1_AT similar to anillin, actin binding protein (scraps homolog, Drosophila); anillin (Drosophila Scraps homolog), actin binding protein gga
HU35KSUBB:RC_AA133250_AT anillin, actin binding protein (scraps homolog, Drosophila) hs
HU35KSUBC:RC_AA347193_AT anillin, actin binding protein (scraps homolog, Drosophila) hs
U133_X3P:HS2.62180.1.S1_3P_S_AT anillin, actin binding protein (scraps homolog, Drosophila) hs
U133_X3P:HS.62180.0.S2_3P_A_AT anillin, actin binding protein (scraps homolog, Drosophila) hs
HG-U133_PLUS_2:1552619_A_AT anillin, actin binding protein (scraps homolog, Drosophila) hs
HG-U133_PLUS_2:222608_S_AT anillin, actin binding protein (scraps homolog, Drosophila) hs
HG-U133B:222608_S_AT anillin, actin binding protein (scraps homolog, Drosophila) hs
HG-U95B:46194_AT anillin, actin binding protein (scraps homolog, Drosophila) hs
HG-U95E:77096_AT anillin, actin binding protein (scraps homolog, Drosophila) hs
MU11KSUBA:C78101_RC_AT anillin, actin binding protein (scraps homolog, Drosophila) mm
MU11KSUBA:AA673431_RC_F_AT anillin, actin binding protein (scraps homolog, Drosophila) mm
MG-U74AV2:96784_AT anillin, actin binding protein (scraps homolog, Drosophila) mm
MG-U74CV2:134014_AT anillin, actin binding protein (scraps homolog, Drosophila) mm
MOE430A:1433543_AT anillin, actin binding protein (scraps homolog, Drosophila) mm
MOUSE430A_2:1433543_AT anillin, actin binding protein (scraps homolog, Drosophila) mm
MOUSE430_2:1433543_AT anillin, actin binding protein (scraps homolog, Drosophila) mm
MOE430B:1439648_AT anillin, actin binding protein (scraps homolog, Drosophila) mm
MOUSE430_2:1439648_AT anillin, actin binding protein (scraps homolog, Drosophila) mm
MU19KSUBA:TC24486_AT Anillin, actin binding protein (scraps homolog, Drosophila) (Anln), mRNA mm
MU19KSUBB:TC27078_AT Anillin, actin binding protein (scraps homolog, Drosophila) (Anln), mRNA mm
Protein Similarities
Method ID Description E-Value
blast CAB11565 Hypothetical protein Y49E10.19 [Caenorhabditis elegans] ref|NP_499624.2| ANIllin (actin binding protein) family member (ani-1) [Caenorhabditis elegans] 0.0
blast CAE66422 Hypothetical protein CBG11691 [Caenorhabditis briggsae] 0.0
blast CAB11566 Hypothetical protein Y49E10.20 [Caenorhabditis elegans] ref|NP_499625.2| Y49E10.20 [Caenorhabditis elegans] 0.0
blast CAA61954 actin binding protein [Drosophila melanogaster] 1.0E-32
Protein Domains
Database ID Description E-Value
Pfam IPR001849 EMBL-EBI Pleckstrin-like 1.8E-9
Pfam IPR002159 EMBL-EBI CD36 antigen 4.2E-93
Pfam IPR001849 EMBL-EBI Pleckstrin-like 1.8E-9
Pfam IPR001849 EMBL-EBI Pleckstrin-like 1.8E-9
Trans Membrane
ID Number Of Domains Domain Boundaries
GENEFINDER00000016121 2 10-32,488-510
Sequence
Target Sequence 
>C. ELEGANS:192436_S_AT
ggcggatcaacttcatcagcaaaccagagcctattcgtcgatccagcagcatcgtcatca
tcaacttcgtcgaccacatccaacttcaatttgctcggaacattctcgttcgacatcaat
tgccctggaaaacatttgtacaacatgtcacatactgtatatccgctcgaaggtattaca
cagatgaaagtacgcaaacaggcgatcgatggagctgatatcacttatcacggattcttg
tcaatgtatcagagaactggcgaggggctcggatcgtggacgagatactggtgtgctctt
gagaatggagagatgaagttttggaagcagccagaagatgagggaactaagggttacact
gcactaatggatctttcaacgtgttgccgttccgaaggtgcatcggtagttgaagacatt
tgcccattcccgaatagcttccacattgatgtttgggctccaaaaatggatacatcggat
ccacgtggcattgagcgtcttcgagttatgctggcggccgatacagctcaagatcttcaa
acatggctgtcactgatcaattctacgtcga

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GGCGGATCAACTTCATCAGCAAACC 304 541 3019 Antisense
CAGCAAACCAGAGCCTATTCGTCGA 70 203 3035 Antisense
GCATCGTCATCATCAACTTCGTCGA 1 311 3067 Antisense
GACCACATCCAACTTCAATTTGCTC 669 383 3090 Antisense
GCTCGGAACATTCTCGTTCGACATC 619 297 3111 Antisense
TCACATACTGTATATCCGCTCGAAG 26 627 3166 Antisense
GGATCTTTCAACGTGTTGCCGTTCC 149 511 3387 Antisense
CATTCCCGAATAGCTTCCACATTGA 331 217 3443 Antisense
GATCCACGTGGCATTGAGCGTCTTC 583 415 3496 Antisense
AGCGTCTTCGAGTTATGCTGGCGGC 650 81 3512 Antisense
CTGTCACTGATCAATTCTACGTCGA 568 239 3565 Antisense
Sequence Source Affymetrix Proprietary Database