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[192405_s_at] phosphatidylinositol 3-kinase like

Description F39B1.1 /REP_DB=WormBase Gene ID /WP=CE05832 /TR=Q20187 /GB=CAA93776.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=phosphatidylinositol 3-kinase like
Cluster 6grp_highest_10_10 > 42      6grp_high1_10_10 > 24      4grp_highest_8_8 > 60      4grp_high_8_8 > 25      6grp_highest_nonorm > 61      6grp_total > 02      4grp_total > 38      6grp_highest_sub > 02      6grp_high1_sub > 02      6grp_rule_based > S2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 194
1 2 3 4 range
A 483.6
(3)
P 		399.9
(0.1)
P 		313.1
(-3)
P 		391.6
(-0.2)
P 		171
B 491.7
(3)
P 		316.4
(-3)
P 		387.4
(-0.6)
P 		418.6
(0.5)
P 		175
C 492.5
(3)
P 		377.9
(-0.5)
P 		298.7
(-3)
P 		379.6
(-0.5)
P 		194
avr 489.3
(3) 		364.7
(-1.8) 		333.1
(-3) 		396.6
(-0.6) 		156

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 239
1 2 3 4 5 6 range
A 502.3
(3)
P 		492.2
(2.6)
P 		340.6
(-3)
P 		395.1
(-1)
P 		394.7
(-1)
P 		383.4
(-1.4)
P 		162
B 422.3
(0.3)
P 		528
(3)
P 		356.5
(-1.4)
P 		386.2
(-0.7)
P 		295.2
(-3)
P 		334.3
(-2)
P 		233
C 359.7
(-1.2)
P 		525.6
(3)
P 		409.8
(0.1)
P 		306.1
(-2.6)
P 		380.8
(-0.7)
P 		289.2
(-3)
P 		236
avr 428.1
(0.1) 		515.3
(3) 		369
(-1.9) 		362.5
(-2.1) 		356.9
(-2.3) 		335.6
(-3) 		180
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 119
1 2 3 4 range
A 176.1
(3)
P 		86.8
(-1.5)
P 		81.8
(-1.8)
P 		57.3
(-3)
P 		119
B 156.8
(3)
P 		78.1
(-3)
P 		89.8
(-2.1)
P 		89.2
(-2.2)
P 		79
C 163
(3)
P 		108.6
(-0.3)
P 		104.1
(-0.6)
P 		64
(-3)
P 		99
avr 165.3
(3) 		91.2
(-1.7) 		91.9
(-1.6) 		70.2
(-3) 		95

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 114
1 2 3 4 5 6 range
A 92.6
(-1.9)
P 		175.1
(3)
P 		74.2
(-3)
P 		100.2
(-1.5)
P 		119.1
(-0.3)
P 		93.3
(-1.9)
P 		101
B 146.9
(1.1)
P 		175.7
(3)
P 		86.6
(-3)
P 		102.3
(-1.9)
P 		120
(-0.8)
P 		124.7
(-0.4)
P 		89
C 133.3
(1.4)
P 		160.4
(3)
P 		104.3
(-0.4)
P 		61.6
(-3)
P 		123.2
(0.7)
P 		96.8
(-0.9)
P 		99
avr 124.3
(-0.4) 		170.4
(3) 		88.4
(-3) 		88
(-3) 		120.8
(-0.6) 		104.9
(-1.8) 		82
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 192405_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.17921
Sequence Type Exemplar sequence
Representative Public ID F39B1.1 NCBI
Target Description F39B1.1 /REP_DB=WormBase Gene ID /WP=CE05832 /TR=Q20187 /GB=CAA93776.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=phosphatidylinositol 3-kinase like
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_078128(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_078128 NCBI Caenorhabditis elegans F39B1.1 (F39B1.1) mRNA, complete cds. 11/11 None
SNAP00000003514 ENSEMBL cdna:SNAP chromosome:CEL140:X:15235039:15235864:-1 9/11 None
F39B1.1 ENSEMBL cdna:known chromosome:CEL140:X:15234764:15246282:-1 gene:F39B1.1 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:15235038-15246282(-) 100.0 100.0
Public Domain and Genome References
Gene Title phosphatidylinositol 3-kinase like
Ensembl F39B1.1
Entrez Gene 181618 Entrez gene
SwissProt Q20187 EMBL-EBI
WormBase CE05832 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.13770.1.S1_S_AT similar to phosphoinositide-3-kinase, class 2, alpha polypeptide cfa
DROSOPHILA_2:1625233_AT Phosphotidylinositol 3 kinase 68D dm
DROSOPHILA_2:1641006_S_AT Phosphotidylinositol 3 kinase 68D dm
DROSGENOME1:151675_S_AT Phosphotidylinositol 3 kinase 68D dm
DROSGENOME1:142750_AT Phosphotidylinositol 3 kinase 68D dm
CHICKEN:GGA.12762.1.S1_AT similar to phosphoinositide-3-kinase, class 2, alpha polypeptide; C2-containing phosphatidylinositol kinase; PI3K-C2alpha gga
CHICKEN:GGAAFFX.26752.1.S1_S_AT similar to phosphoinositide-3-kinase, class 2, alpha polypeptide; C2-containing phosphatidylinositol kinase; PI3K-C2alpha gga
HG-U133_PLUS_2:1553694_A_AT phosphoinositide-3-kinase, class 2, alpha polypeptide hs
HG-U133_PLUS_2:1569022_A_AT phosphoinositide-3-kinase, class 2, alpha polypeptide hs
HG-U133A:213070_AT Phosphoinositide-3-kinase, class 2, alpha polypeptide hs
HG-U133A_2:213070_AT Phosphoinositide-3-kinase, class 2, alpha polypeptide hs
HG-U133_PLUS_2:213070_AT Phosphoinositide-3-kinase, class 2, alpha polypeptide hs
HU35KSUBB:RC_H13179_S_AT Phosphoinositide-3-kinase, class 2, alpha polypeptide hs
U133_X3P:HS2.249235.2.S1_3P_X_AT Phosphoinositide-3-kinase, class 2, alpha polypeptide hs
U133_X3P:HS2.249235.2.S1_3P_AT Phosphoinositide-3-kinase, class 2, alpha polypeptide hs
U133_X3P:HS2.249235.1.S1_3P_S_AT Phosphoinositide-3-kinase, class 2, alpha polypeptide hs
U133_X3P:HS.5848.0.S1_3P_AT Phosphoinositide-3-kinase, class 2, alpha polypeptide hs
U133_X3P:HS.259718.0.S1_3P_AT Phosphoinositide-3-kinase, class 2, alpha polypeptide hs
U133_X3P:HS.249235.0.S2_3P_AT Phosphoinositide-3-kinase, class 2, alpha polypeptide hs
U133_X3P:HS.207212.0.A1_3P_S_AT Phosphoinositide-3-kinase, class 2, alpha polypeptide hs
U133_X3P:HS.207212.0.A1_3P_AT Phosphoinositide-3-kinase, class 2, alpha polypeptide hs
U133_X3P:235792_3P_X_AT Phosphoinositide-3-kinase, class 2, alpha polypeptide hs
HG-U133_PLUS_2:1569021_AT Phosphoinositide-3-kinase, class 2, alpha polypeptide hs
HG-U133_PLUS_2:226094_AT Phosphoinositide-3-kinase, class 2, alpha polypeptide hs
HG-U133B:226094_AT Phosphoinositide-3-kinase, class 2, alpha polypeptide hs
HG-U133_PLUS_2:235792_X_AT Phosphoinositide-3-kinase, class 2, alpha polypeptide hs
HG-U133B:235792_X_AT Phosphoinositide-3-kinase, class 2, alpha polypeptide hs
HG-U133_PLUS_2:241905_AT Phosphoinositide-3-kinase, class 2, alpha polypeptide hs
HG-U133B:241905_AT Phosphoinositide-3-kinase, class 2, alpha polypeptide hs
HG-U95AV2:36509_AT Phosphoinositide-3-kinase, class 2, alpha polypeptide hs
HG-U95E:76325_AT Phosphoinositide-3-kinase, class 2, alpha polypeptide hs
HG-U95E:77866_AT Phosphoinositide-3-kinase, class 2, alpha polypeptide hs
HG-U95E:86523_AT Phosphoinositide-3-kinase, class 2, alpha polypeptide hs
HG-U95E:68966_AT Phosphoinositide-3-kinase, class 2, alpha polypeptide hs
HG-U95E:77869_S_AT Phosphoinositide-3-kinase, class 2, alpha polypeptide hs
MG-U74AV2:92312_AT phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide mm
MOUSE430_2:1425862_A_AT phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide mm
MOE430A:1425862_A_AT phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide mm
MOUSE430A_2:1425862_A_AT phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide mm
MU11KSUBA:U52193_S_AT phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide mm
MG-U74AV2:92311_S_AT phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide mm
MOE430A:1421023_AT phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide mm
MOUSE430A_2:1421023_AT phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide mm
MOUSE430_2:1421023_AT phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide mm
MOE430B:1443655_S_AT phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide mm
MOUSE430_2:1443655_S_AT phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide mm
MG-U74BV2:111831_AT Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Pik3c2a), mRNA mm
MG-U74CV2:140944_AT Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Pik3c2a), mRNA mm
MU19KSUBC:TC35015_AT Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Pik3c2a), mRNA mm
MU19KSUBC:TC35421_AT Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Pik3c2a), mRNA mm
RAE230B:1379433_AT Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (predicted) rn
RAT230_2:1379433_AT Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (predicted) rn
RG-U34B:RC_AI013939_AT Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (predicted) rn
RG-U34B:RC_AI059449_AT Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (predicted) rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5942 phosphoinositide 3-kinase complex inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4428 inositol or phosphatidylinositol kinase activity inferred from electronic annotation QuickGO AmiGO
16303 phosphatidylinositol 3-kinase activity inferred from electronic annotation QuickGO AmiGO
16773 phosphotransferase activity, alcohol group as acceptor inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA93776 Hypothetical protein F39B1.1 [Caenorhabditis elegans] emb|CAA93489.1| Hypothetical protein F39B1.1 [Caenorhabditis elegans] ref|NP_510529.1| F39B1.1 [Caenorhabditis elegans] 0.0
blast CAE63290 Hypothetical protein CBG07670 [Caenorhabditis briggsae] 0.0
blast XP_396869 PREDICTED: similar to GA11104-PA [Apis mellifera] 1.0E-163
blast CAA93776 Hypothetical protein F39B1.1 [Caenorhabditis elegans] emb|CAA93489.1| Hypothetical protein F39B1.1 [Caenorhabditis elegans] ref|NP_510529.1| F39B1.1 [Caenorhabditis elegans] 2.0E-94
blast CAE63290 Hypothetical protein CBG07670 [Caenorhabditis briggsae] 3.0E-58
blast XP_421003 PREDICTED: similar to phosphoinositide-3-kinase, class 2, alpha polypeptide; C2-containing phosphatidylinositol kinase; PI3K-C2alpha [Gallus gallus] 5.0E-17
Protein Domains
Database ID Description E-Value
Pfam IPR000008 EMBL-EBI C2 domain 3.1E-17
Pfam IPR000403 EMBL-EBI Phosphatidylinositol 3- and 4-kinase 6.2E-86
Pfam IPR003903 EMBL-EBI Ubiquitin interacting motif 0.0014
Pfam IPR001683 EMBL-EBI Phox-like 3.1E-24
Pfam IPR002420 EMBL-EBI Phosphoinositide 3-kinase, C2 domain 1.0E-34
Pfam IPR001263 EMBL-EBI Phosphoinositide 3-kinase accessory domain PIK 2.5E-17
Pfam IPR000008 EMBL-EBI C2 domain 3.1E-17
Sequence
Target Sequence 
>C. ELEGANS:192405_S_AT
tttgcgttccaatgtcagagctgttgcccagaagcggattatccacgtgcagaagttttt
gatctacctgtttaatcaagtggatgagatttgccactgcgacctggtctacactttctt
ccattcgattcttcgcgacaataagtgcgatacctacattgacgagtcgctcgacatgcc
atctcaatgtcaaatctatttgaaaattgagtataatagtgtaaaagagacgttgagtgt
atttatagggcatgccaaatatttggctcttcttcaaaataaccagcaaccggatccata
tgtgaagacttatgtcagaccggatttgcgtaatcaatcgaaacaaaagactcaggtggt
ccgcggaactcgtcacccaacgtttaatcaagatctcaactacacggagttcccaatcga
aattctctcaactcgggttctcgaagtgagcatctggaacaatggtggatacctggtaaa
gcacaaaatgtacatgttatgcatcccattgctgaaagtcaaaaagcttgctgagagccg
caaaaattgtcgcactctc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TTTGCGTTCCAATGTCAGAGCTGTT 158 667 4245 Antisense
GTTGCCCAGAAGCGGATTATCCACG 531 439 4267 Antisense
TCTTCCATTCGATTCTTCGCGACAA 279 617 4361 Antisense
AGTGCGATACCTACATTGACGAGTC 288 61 4388 Antisense
ATTGACGAGTCGCTCGACATGCCAT 268 5 4402 Antisense
ATAACCAGCAACCGGATCCATATGT 628 23 4523 Antisense
GAACTCGTCACCCAACGTTTAATCA 39 347 4610 Antisense
GGAGTTCCCAATCGAAATTCTCTCA 5 519 4650 Antisense
ATTCTCTCAACTCGGGTTCTCGAAG 415 11 4666 Antisense
GTACATGTTATGCATCCCATTGCTG 77 461 4734 Antisense
GAGCCGCAAAAATTGTCGCACTCTC 9 387 4779 Antisense
Sequence Source Affymetrix Proprietary Database