[Home] | [Total List]

[192402_at] Eukaryotic protein kinase domain

Description Y18D10A.5 /REP_DB=WormBase Gene ID /WP=CE21401 /TR=Q9U2Q9 /GB=CAA22311.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=Eukaryotic protein kinase domain
Cluster 6grp_high1_10_10 > 16      6grp_total > 16      4grp_total > 05      6grp_cgc > 22      6grp_high1_sub > De      6grp_cgc_sub > De      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 140
1 2 3 4 range
A 54.2
(-3)
A 		92.8
(1.9)
A 		86.3
(1)
A 		101.8
(3)
A 		48
B 109.2
(0.5)
P 		52.2
(-2.8)
A 		48.4
(-3)
A 		152.1
(3)
A 		104
C 58.2
(0.1)
A 		12.1
(-3)
A 		51.2
(-0.4)
A 		101.8
(3)
A 		90
avr 73.9
(-1.1) 		52.4
(-3) 		62
(-2.1) 		118.6
(3) 		66

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 387
1 2 3 4 5 6 range
A 327.1
(3)
P 		6.6
(-3)
A 		196.7
(0.6)
P 		34.3
(-2.4)
A 		213.2
(0.9)
P 		4.1
(-3)
A 		323
B 391.5
(3)
P 		294.7
(0.7)
P 		208.7
(-1.4)
P 		142
(-3)
P 		144.3
(-2.9)
P 		156.6
(-2.6)
P 		250
C 6.2
(-3)
A 		285.8
(3)
P 		31.4
(-2.5)
A 		115.2
(-0.7)
A 		31.4
(-2.5)
A 		174.5
(0.6)
P 		280
avr 241.6
(3) 		195.7
(1.1) 		145.6
(-1) 		97.2
(-3) 		129.6
(-1.7) 		111.7
(-2.4) 		144
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 31
1 2 3 4 range
A 19.7
(0.7)
A 		20.1
(1.1)
A 		22.6
(3)
A 		14.9
(-3)
A 		8
B 34.8
(3)
P 		12.9
(-2.6)
A 		11.2
(-3)
A 		32.4
(2.4)
A 		24
C 19.3
(3)
A 		3.5
(-3)
A 		17.8
(2.4)
A 		17.2
(2.2)
A 		16
avr 24.6
(3) 		12.2
(-3) 		17.2
(-0.6) 		21.5
(1.5) 		12

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 135
1 2 3 4 5 6 range
A 60.3
(2.6)
P 		2.4
(-2.9)
A 		42.8
(1)
P 		8.7
(-2.3)
A 		64.3
(3)
P 		1
(-3)
A 		63
B 136.2
(3)
P 		98.1
(0.7)
P 		50.7
(-2.2)
P 		37.6
(-3)
P 		58.6
(-1.7)
P 		58.4
(-1.7)
P 		99
C 2.3
(-3)
A 		87.2
(3)
P 		8
(-2.6)
A 		23.2
(-1.5)
A 		10.2
(-2.4)
A 		58.4
(1)
P 		85
avr 66.3
(3) 		62.6
(2.5) 		33.8
(-1.5) 		23.2
(-3) 		44.4
(-0) 		39.3
(-0.8) 		43
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192402_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.2218
Sequence Type Exemplar sequence
Representative Public ID Y18D10A.5 NCBI
Target Description Y18D10A.5 /REP_DB=WormBase Gene ID /WP=CE21401 /TR=Q9U2Q9 /GB=CAA22311.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=Eukaryotic protein kinase domain
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_060842(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_060842 NCBI Caenorhabditis elegans Glycogen Synthase Kinase family member (gsk-3) (gsk-3) mRNA, complete cds. 11/11 None
SNAP00000000411 ENSEMBL cdna:SNAP chromosome:CEL140:I:12824025:12832786:1 11/11 None
GENEFINDER00000000442 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:12827483:12832786:1 11/11 None
Y18D10A.5 ENSEMBL cdna:known chromosome:CEL140:I:12827337:12832926:1 gene:Y18D10A.5 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:12827413-12832717(+) 100.0 100.0
Public Domain and Genome References
Gene Title Eukaryotic protein kinase domain
Gene Symbol gsk-3
Ensembl Y18D10A.5
Entrez Gene 173149 Entrez gene
SwissProt Q9U2Q9 EMBL-EBI
WormBase CE21401 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:250141_AT protein kinase family protein at
CANINE:1589473_S_AT similar to Glycogen synthase kinase-3 beta (GSK-3 beta) cfa
CANINE_2:CFA.913.1.A1_S_AT similar to Glycogen synthase kinase-3 beta (GSK-3 beta) cfa
CANINE_2:CFA.913.2.A1_AT similar to Glycogen synthase kinase-3 beta (GSK-3 beta) cfa
DROSOPHILA_2:1625322_AT shaggy dm
DROSOPHILA_2:1623084_AT shaggy dm
DROSOPHILA_2:1630774_S_AT shaggy dm
DROSGENOME1:143344_R_AT shaggy dm
DROSGENOME1:143343_I_AT shaggy dm
CHICKEN:GGA.7650.1.S1_AT similar to glycogen synthase kinase 3 beta gga
CHICKEN:GGAAFFX.24561.1.S1_AT similar to glycogen synthase kinase 3 beta gga
HG-U95AV2:1253_AT glycogen synthase kinase 3 beta hs
HC-G110:1253_AT glycogen synthase kinase 3 beta hs
HUGENEFL:L33801_AT glycogen synthase kinase 3 beta hs
HG-U133A:209945_S_AT glycogen synthase kinase 3 beta hs
HG-U133_PLUS_2:209945_S_AT glycogen synthase kinase 3 beta hs
HG-FOCUS:209945_S_AT glycogen synthase kinase 3 beta hs
HG-U133A_2:209945_S_AT glycogen synthase kinase 3 beta hs
U133_X3P:G12652980_3P_A_AT glycogen synthase kinase 3 beta hs
HG-U95AV2:40645_AT glycogen synthase kinase 3 beta hs
HU35KSUBA:Z43594_AT Glycogen synthase kinase 3 beta hs
HU35KSUBB:RC_R51305_AT Glycogen synthase kinase 3 beta hs
HU35KSUBB:RC_AA179320_AT Glycogen synthase kinase 3 beta hs
U133_X3P:HS.90063.1.A2_3P_AT Glycogen synthase kinase 3 beta hs
U133_X3P:HS.90063.1.A1_3P_AT Glycogen synthase kinase 3 beta hs
U133_X3P:HS.25777.0.A1_3P_AT Glycogen synthase kinase 3 beta hs
HG-U133_PLUS_2:226183_AT Glycogen synthase kinase 3 beta hs
HG-U133B:226183_AT Glycogen synthase kinase 3 beta hs
HG-U133_PLUS_2:226191_AT Glycogen synthase kinase 3 beta hs
HG-U133B:226191_AT Glycogen synthase kinase 3 beta hs
HG-U133_PLUS_2:242336_AT Glycogen synthase kinase 3 beta hs
HG-U133B:242336_AT Glycogen synthase kinase 3 beta hs
HG-U95B:49465_AT Glycogen synthase kinase 3 beta hs
HG-U95B:52456_AT Glycogen synthase kinase 3 beta hs
HG-U95B:42825_AT Glycogen synthase kinase 3 beta hs
HG-U95B:43373_S_AT Glycogen synthase kinase 3 beta hs
HG-U95D:80096_AT Glycogen synthase kinase 3 beta hs
HU35KSUBB:RC_N20039_AT Glycogen synthase kinase 3 beta hs
HU35KSUBD:RC_T71641_AT Glycogen synthase kinase 3 beta hs
HU35KSUBB:RC_T89350_S_AT Glycogen synthase kinase 3 beta hs
MU11KSUBB:MSA.26665.0_S_AT glycogen synthase kinase 3 beta mm
MG-U74BV2:111399_AT glycogen synthase kinase 3 beta mm
MG-U74BV2:111732_AT glycogen synthase kinase 3 beta mm
MG-U74CV2:140699_AT glycogen synthase kinase 3 beta mm
MG-U74BV2:162699_AT glycogen synthase kinase 3 beta mm
MOE430A:1451020_AT glycogen synthase kinase 3 beta mm
MOUSE430A_2:1451020_AT glycogen synthase kinase 3 beta mm
MOUSE430_2:1451020_AT glycogen synthase kinase 3 beta mm
MOE430B:1454958_AT glycogen synthase kinase 3 beta mm
MOUSE430_2:1454958_AT glycogen synthase kinase 3 beta mm
MOE430B:1434439_AT glycogen synthase kinase 3 beta mm
MOUSE430_2:1434439_AT glycogen synthase kinase 3 beta mm
MOE430B:1437001_AT glycogen synthase kinase 3 beta mm
MOUSE430_2:1437001_AT glycogen synthase kinase 3 beta mm
MOE430B:1439949_AT Glycogen synthase kinase 3 beta, mRNA (cDNA clone MGC:6814 IMAGE:2648507) mm
MOUSE430_2:1439949_AT Glycogen synthase kinase 3 beta, mRNA (cDNA clone MGC:6814 IMAGE:2648507) mm
MOE430B:1445653_AT Glycogen synthase kinase 3 beta, mRNA (cDNA clone MGC:6814 IMAGE:2648507) mm
MOUSE430_2:1445653_AT Glycogen synthase kinase 3 beta, mRNA (cDNA clone MGC:6814 IMAGE:2648507) mm
MG-U74CV2:171025_AT Glycogen synthase kinase 3 beta, mRNA (cDNA clone MGC:6814 IMAGE:2648507) mm
MU19KSUBA:TC16646_AT Glycogen synthase kinase 3 beta, mRNA (cDNA clone MGC:6814 IMAGE:2648507) mm
MU19KSUBA:TC20467_AT Glycogen synthase kinase 3 beta, mRNA (cDNA clone MGC:6814 IMAGE:2648507) mm
MU19KSUBB:TC28421_S_AT Glycogen synthase kinase 3 beta, mRNA (cDNA clone MGC:6814 IMAGE:2648507) mm
MU19KSUBC:TC40182_AT Glycogen synthase kinase 3 beta, mRNA (cDNA clone MGC:6814 IMAGE:2648507) mm
MU19KSUBC:TC40183_AT Glycogen synthase kinase 3 beta, mRNA (cDNA clone MGC:6814 IMAGE:2648507) mm
MU19KSUBC:TC40207_AT Glycogen synthase kinase 3 beta, mRNA (cDNA clone MGC:6814 IMAGE:2648507) mm
RN-U34:X73653_AT glycogen synthase kinase 3 beta rn
RG-U34A:X73653_AT glycogen synthase kinase 3 beta rn
RN-U34:X53428CDS_S_AT glycogen synthase kinase 3 beta rn
RT-U34:X53428CDS_S_AT glycogen synthase kinase 3 beta rn
RG-U34A:X53428CDS_S_AT glycogen synthase kinase 3 beta rn
RAE230A:1370267_AT glycogen synthase kinase 3 beta rn
RAT230_2:1370267_AT glycogen synthase kinase 3 beta rn
YEAST_2:1779962_AT Protein kinase required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA22311 Hypothetical protein Y18D10A.5 [Caenorhabditis elegans] ref|NP_493243.1| Glycogen Synthase Kinase family member (gsk-3) [Caenorhabditis elegans] 0.0
blast AAD45354 GSK-3 [Caenorhabditis elegans] 0.0
blast CAE63499 Hypothetical protein CBG07972 [Caenorhabditis briggsae] 0.0
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 7.0E-72
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 8.0E-73
hanks 3.1.7 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; PCTAIRE1 2.0E-69
hanks 3.1.6 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; Cdk5 3.0E-69
hanks 3.1.1 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; CDC2Hs 3.0E-69
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 2.3E-91
Pfam IPR000719 EMBL-EBI Protein kinase 2.3E-91
Trans Membrane
ID Number Of Domains Domain Boundaries
SNAP00000000411 3 54-76,86-108,129-151
Sequence
Target Sequence 
>C. ELEGANS:192402_AT
gtcaccgtgacattaagcctcagaatttgctcattgacccggaaagcggagtgcttaagc
tctgtgattttggatctgccaaatatttggttcgcaatgagccaaacgtctcgtacattt
gctcgcgatattatcgtgctccggagctcattttcggcgctacaaactacacgaactcga
ttgacgtttggtcggctggaactgtaatggcagagcttcttctcggccaaccaattttcc
ctggtgactctggagttgatcaactcgttgaaattattaaagttcttggaacaccgactc
gtgaacaaattcaaagtatgaatccgaactacaaggaattcaaatttccacagataaagg
cacatccatggaataaggtattccgtgtacacacgcctgctgaagcgattgatctcattt
cgaagattatcgagtatacgccgacgtctcggccaacacctcaagcggcctgccagcacg
cattctttgatgagctccgaaacccggatgcacgtcttccatctggtcgacctcttccaa
cacttgagatgg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTCACCGTGACATTAAGCCTCAGAA 660 465 485 Antisense
GCCTCAGAATTTGCTCATTGACCCG 268 279 501 Antisense
CCAAACGTCTCGTACATTTGCTCGC 391 275 586 Antisense
TTATCGTGCTCCGGAGCTCATTTTC 191 681 615 Antisense
GAGCTCATTTTCGGCGCTACAAACT 152 387 628 Antisense
TGACGTTTGGTCGGCTGGAACTGTA 687 565 666 Antisense
CCAATTTTCCCTGGTGACTCTGGAG 594 277 715 Antisense
GTGTACACACGCCTGCTGAAGCGAT 654 485 869 Antisense
ATCGAGTATACGCCGACGTCTCGGC 122 35 913 Antisense
GATGAGCTCCGAAACCCGGATGCAC 572 409 973 Antisense
CGACCTCTTCCAACACTTGAGATGG 280 251 1012 Antisense
Sequence Source Affymetrix Proprietary Database