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[192394_s_at] ser/thr protein kinase

Description K07A9.2 /REP_DB=WormBase Gene ID /WP=CE25046 /GEN=cmk-1 /TR=Q9TXJ0 /GB=AAF23187.1 /SUBMIT=ST.LOUIS /CHR=4 /FEA=Sanger Annotation /DEF=ser-thr protein kinase
Cluster 6grp_total > 17      4grp_total > 47      6grp_cgc > 12      6grp_cgc_sub > De      6grp_total_sub > Decrease      6grp_rule_based > S1      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 191
1 2 3 4 range
A 242.9
(3)
P 		88.9
(-2.5)
A 		91
(-2.4)
A 		73.9
(-3)
A 		169
B 196.2
(3)
P 		54.5
(-3)
A 		74.3
(-2.2)
A 		133.3
(0.3)
A 		142
C 245.7
(3)
P 		117.6
(-1.7)
A 		80.8
(-3)
A 		111.4
(-1.9)
A 		165
avr 228.3
(3) 		87
(-2.8) 		82
(-3) 		106.2
(-2) 		146

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 242
1 2 3 4 5 6 range
A 206.9
(3)
A 		104.6
(-0.1)
A 		52.7
(-1.7)
A 		11.8
(-3)
A 		12.4
(-3)
A 		74.8
(-1.1)
A 		195
B 103.2
(3)
A 		89.2
(1.8)
A 		55.7
(-1.1)
A 		59.6
(-0.8)
A 		62.9
(-0.5)
A 		33.8
(-3)
A 		69
C 253.7
(3)
P 		88.6
(-1.2)
A 		80
(-1.5)
A 		19.6
(-3)
A 		87.8
(-1.3)
A 		48.5
(-2.3)
A 		234
avr 187.9
(3) 		94.1
(-0.6) 		62.8
(-1.8) 		30.3
(-3) 		54.4
(-2.1) 		52.4
(-2.2) 		158
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 78
1 2 3 4 range
A 88.4
(3)
P 		19.3
(-2.3)
A 		23.8
(-2)
A 		10.8
(-3)
A 		78
B 62.6
(3)
P 		13.5
(-3)
A 		17.2
(-2.5)
A 		28.4
(-1.2)
A 		49
C 81.3
(3)
P 		33.8
(-1.6)
A 		28.2
(-2.1)
A 		18.8
(-3)
A 		63
avr 77.4
(3) 		22.2
(-2.7) 		23.1
(-2.6) 		19.3
(-3) 		58

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 91
1 2 3 4 5 6 range
A 38.1
(3)
A 		37.2
(2.8)
A 		11.5
(-1.5)
A 		3
(-3)
A 		3.7
(-2.9)
A 		18.2
(-0.4)
A 		35
B 35.9
(3)
A 		29.7
(1.4)
A 		13.5
(-2.8)
A 		15.8
(-2.2)
A 		25.6
(0.3)
A 		12.6
(-3)
A 		23
C 94
(3)
P 		27
(-1.5)
A 		20.4
(-1.9)
A 		3.9
(-3)
A 		28.4
(-1.4)
A 		16.3
(-2.2)
A 		90
avr 56
(3) 		31.3
(-0.1) 		15.1
(-2.1) 		7.6
(-3) 		19.2
(-1.6) 		15.7
(-2) 		48
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 192394_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.10510
Sequence Type Exemplar sequence
Representative Public ID K07A9.2 NCBI
Target Description K07A9.2 /REP_DB=WormBase Gene ID /WP=CE25046 /GEN=cmk-1 /TR=Q9TXJ0 /GB=AAF23187.1 /SUBMIT=ST.LOUIS /CHR=4 /FEA=Sanger Annotation /DEF=ser-thr protein kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_067738(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_067738 NCBI Caenorhabditis elegans CaM Kinase family member (cmk-1) (cmk-1) mRNA, complete cds. 11/11 A 
SNAP00000040812 ENSEMBL cdna:SNAP chromosome:CEL140:IV:1832264:1833597:1 10/11 None
GENEFINDER00000040816 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:1824548:1833597:1 11/11 None
K07A9.2 ENSEMBL cdna:known chromosome:CEL140:IV:1824485:1834049:1 gene:K07A9.2 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:1824531-1833603(+) 100.0 100.0
Public Domain and Genome References
Gene Title ser/thr protein kinase
Gene Symbol cmk-1
Ensembl K07A9.2
Entrez Gene 176989 Entrez gene
SwissProt Q9TXJ0 EMBL-EBI
WormBase CE25046 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:20242_AT calcium-dependent protein kinase, putative / CDPK, putative at
ATH1-121501:255039_AT calcium-dependent protein kinase, putative / CDPK, putative at
CANINE_2:CFA.4396.1.A1_AT similar to calcium/calmodulin-dependent protein kinase ID isoform 2 cfa
CANINE_2:CFAAFFX.8113.1.S1_AT similar to calcium/calmodulin-dependent protein kinase ID isoform 2 cfa
DROSOPHILA_2:1637380_S_AT Calcium/calmodulin-dependent protein kinase I dm
DROSGENOME1:151997_AT Calcium/calmodulin-dependent protein kinase I dm
CHICKEN:GGAAFFX.6185.1.S1_AT similar to calcium/calmodulin-dependent protein kinase 1D gga
HG-U133_PLUS_2:220246_AT calcium/calmodulin-dependent protein kinase ID hs
HG-U133A:220246_AT calcium/calmodulin-dependent protein kinase ID hs
HG-FOCUS:220246_AT calcium/calmodulin-dependent protein kinase ID hs
HG-U133A_2:220246_AT calcium/calmodulin-dependent protein kinase ID hs
HU35KSUBC:RC_N54908_AT calcium/calmodulin-dependent protein kinase ID hs
U133_X3P:G9966874_3P_X_AT calcium/calmodulin-dependent protein kinase ID hs
U133_X3P:G9966874_3P_AT calcium/calmodulin-dependent protein kinase ID hs
U133_X3P:HS.47883.0.A1_3P_AT calcium/calmodulin-dependent protein kinase ID hs
U133_X3P:220246_3P_AT calcium/calmodulin-dependent protein kinase ID hs
HG-U133_PLUS_2:235626_AT calcium/calmodulin-dependent protein kinase ID hs
HG-U133B:235626_AT calcium/calmodulin-dependent protein kinase ID hs
HG-U95B:51085_AT calcium/calmodulin-dependent protein kinase ID hs
HG-U133_PLUS_2:233738_AT Calcium/calmodulin-dependent protein kinase ID hs
HG-U133B:233738_AT Calcium/calmodulin-dependent protein kinase ID hs
HG-U95D:71706_AT Calcium/calmodulin-dependent protein kinase ID hs
MU11KSUBB:MSA.25621.0_S_AT calcium/calmodulin-dependent protein kinase ID mm
MG-U74BV2:107465_AT calcium/calmodulin-dependent protein kinase ID mm
MG-U74CV2:139187_AT calcium/calmodulin-dependent protein kinase ID mm
MG-U74BV2:163290_AT calcium/calmodulin-dependent protein kinase ID mm
MOE430A:1452050_AT calcium/calmodulin-dependent protein kinase ID mm
MOUSE430A_2:1452050_AT calcium/calmodulin-dependent protein kinase ID mm
MOUSE430_2:1452050_AT calcium/calmodulin-dependent protein kinase ID mm
MOE430A:1426389_AT calcium/calmodulin-dependent protein kinase ID mm
MOUSE430A_2:1426389_AT calcium/calmodulin-dependent protein kinase ID mm
MOUSE430_2:1426389_AT calcium/calmodulin-dependent protein kinase ID mm
MG-U74CV2:133311_AT Calcium/calmodulin-dependent protein kinase ID, mRNA (cDNA clone IMAGE:5052777) mm
MOE430B:1438643_AT Calcium/calmodulin-dependent protein kinase ID, mRNA (cDNA clone IMAGE:5052777) mm
MOUSE430_2:1438643_AT Calcium/calmodulin-dependent protein kinase ID, mRNA (cDNA clone IMAGE:5052777) mm
MU19KSUBB:TC28890_AT Calcium/calmodulin-dependent protein kinase ID, mRNA (cDNA clone IMAGE:5052777) mm
MU19KSUBC:TC42086_AT Calcium/calmodulin-dependent protein kinase ID, mRNA (cDNA clone IMAGE:5052777) mm
YEAST_2:1776672_AT Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk1p and mammalian Cam Kinase II Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAF23187 Cam kinase protein 1 [Caenorhabditis elegans] ref|NP_500139.1| CaM Kinase family member (cmk-1) [Caenorhabditis elegans] 0.0
blast BAA82674.1 Ca2+/calmodulin-dependent protein kinase I [Caenorhabditis elegans] 0.0
blast AAQ54691 calcium/calmodulin-dependent protein kinase 1 [Caenorhabditis elegans] 0.0
blast AAQ54691 calcium/calmodulin-dependent protein kinase 1 [Caenorhabditis elegans] 1.0E-108
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 2.0E-61
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 1.0E-67
hanks 2.1.6 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; CamKI 1.0E-102
hanks 2.1.6 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; CamKI 1.0E-109
hanks 1.1.1 AGC group; AGC I Cyclic nucleotide regulated protein kinase (PKA & PKG); cAPKa 6.0E-30
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 1.6E-97
Pfam IPR000719 EMBL-EBI Protein kinase 3.4E-45
Pfam IPR000719 EMBL-EBI Protein kinase 3.6E-90
Sequence
Target Sequence 
>C. ELEGANS:192394_S_AT
gtccatcgtgacctgaaacctgaaaaccttttatattacaaccaagacgaggactccaaa
ataatgatctcagattttggactttcaaaaaccgaagattcaggagtaatggctacagcg
tgtggaacaccgggatacgtggcaccagaggtcctacagcagaaaccgtatggaaaagca
gtcgatgtttggtcgattggagttatagcgtatattttgctttgcggatatccaccattc
tacgacgagagcgatgcaaacctattcgcacagatcatcaaaggagaatacgagttcgac
gcgccctactgggatcagatttccgattcggctaaagattttatcacacacttaatgtgt
tgtgacccagaagcccgattcacgtgtcaggatgctctgtcacatccgtggatcagtgga
aatacggcgtacacacacgatattcacggaactgtcgccgtacatcttaagaagagtttg
gcaaaacggaactggaaaaaggcttacaacgcagccgcagcaatccgccagcttcaaatg
ctccgtctctcctcaaatagcaatcgccta

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTCCATCGTGACCTGAAACCTGAAA 67 475 433 Antisense
ATACGTGGCACCAGAGGTCCTACAG 279 23 567 Antisense
TATTTTGCTTTGCGGATATCCACCA 337 663 645 Antisense
ATATCCACCATTCTACGACGAGAGC 480 19 660 Antisense
GCAAACCTATTCGCACAGATCATCA 119 317 688 Antisense
ACGCGCCCTACTGGGATCAGATTTC 633 91 731 Antisense
TAATGTGTTGTGACCCAGAAGCCCG 362 637 785 Antisense
TGCTCTGTCACATCCGTGGATCAGT 17 581 825 Antisense
AATACGGCGTACACACACGATATTC 172 171 853 Antisense
GAACTGTCGCCGTACATCTTAAGAA 284 349 881 Antisense
TCTCTCCTCAAATAGCAATCGCCTA 590 611 978 Antisense
Sequence Source Affymetrix Proprietary Database