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[192392_at] SER/THR-protein kinase

Description R03G5.2 /REP_DB=WormBase Gene ID /WP=CE07399 /GEN=sek-1 /TR=Q21669 /GB=AAA96067.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=SER-THR-protein kinase
Cluster 6grp_highest_10_10 > 40      6grp_high1_10_10 > 05      4grp_highest_8_8 > 39      4grp_high_8_8 > 03      6grp_highest_nonorm > 51      6grp_total > 05      4grp_total > 13      6grp_highest_sub > De      6grp_cgc > 22      6grp_high1_sub > De      6grp_cgc_sub > De      6grp_rule_based > S1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 600
1 2 3 4 range
A 538.3
(-0.3)
P 		269.6
(-3)
P 		270.8
(-3)
P 		869.7
(3)
P 		600
B 487.8
(-0.9)
P 		306.8
(-2.7)
P 		279.8
(-3)
P 		869.7
(3)
P 		590
C 553.5
(0.4)
P 		427.9
(-1.9)
P 		364.8
(-3)
P 		695.4
(3)
P 		331
avr 526.5
(-0.4) 		334.8
(-2.6) 		305.1
(-3) 		811.6
(3) 		507

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 488
1 2 3 4 5 6 range
A 600.4
(3)
P 		587.8
(2.4)
P 		531.9
(-0)
P 		477.7
(-2.4)
P 		464
(-3)
P 		482.9
(-2.2)
P 		136
B 765.7
(3)
P 		597.7
(0.6)
P 		512.1
(-0.6)
P 		464.5
(-1.3)
P 		516.2
(-0.6)
P 		347.6
(-3)
P 		418
C 835.7
(3)
P 		625.6
(0.2)
P 		524.4
(-1.1)
P 		567.9
(-0.6)
P 		513.9
(-1.3)
P 		383.3
(-3)
P 		452
avr 733.9
(3) 		603.7
(0.6) 		522.8
(-0.8) 		503.4
(-1.2) 		498
(-1.3) 		404.6
(-3) 		329
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 138
1 2 3 4 range
A 196
(3)
P 		58.5
(-3)
P 		70.8
(-2.5)
P 		127.3
(0)
P 		138
B 155.6
(1.5)
P 		75.8
(-2.5)
P 		64.8
(-3)
P 		185.3
(3)
P 		121
C 183.2
(3)
P 		123
(-2.5)
P 		127.1
(-2.1)
P 		117.3
(-3)
P 		66
avr 178.3
(3) 		85.8
(-3) 		87.6
(-2.9) 		143.3
(0.7) 		93

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 199
1 2 3 4 5 6 range
A 110.7
(-3)
P 		209.1
(3)
P 		115.8
(-2.7)
P 		121.1
(-2.4)
P 		140
(-1.2)
P 		117.6
(-2.6)
P 		98
B 266.4
(3)
P 		198.9
(0.2)
P 		124.4
(-2.9)
P 		123
(-3)
P 		209.7
(0.6)
P 		129.6
(-2.7)
P 		143
C 309.7
(3)
P 		190.9
(-0.6)
P 		133.5
(-2.4)
P 		114.2
(-3)
P 		166.3
(-1.4)
P 		128.3
(-2.6)
P 		196
avr 228.9
(3) 		199.6
(1.4) 		124.6
(-2.7) 		119.4
(-3) 		172
(-0.1) 		125.2
(-2.7) 		110
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192392_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.15974
Sequence Type Exemplar sequence
Representative Public ID R03G5.2 NCBI
Target Description R03G5.2 /REP_DB=WormBase Gene ID /WP=CE07399 /GEN=sek-1 /TR=Q21669 /GB=AAA96067.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=SER-THR-protein kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_076921(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_076921 NCBI Caenorhabditis elegans SAPK/ERK kinase family member (sek-1) (sek-1) mRNA, complete cds. 11/11 A 
GENEFINDER00000013525 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:7815930:7823447:1 11/11 None
SNAP00000013518 ENSEMBL cdna:SNAP chromosome:CEL140:X:7816743:7820122:1 11/11 None
R03G5.2 ENSEMBL cdna:known chromosome:CEL140:X:7816673:7820982:1 gene:R03G5.2 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:7816741-7819271(+) 100.0 100.0
Public Domain and Genome References
Gene Title SER/THR-protein kinase
Gene Symbol sek-1
Ensembl R03G5.2
Entrez Gene 181043 Entrez gene
SwissProt Q95YI9 EMBL-EBI
WormBase CE31210 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1599085_AT similar to mitogen-activated protein kinase kinase 6 isoform 1 cfa
CANINE:1589949_AT similar to mitogen-activated protein kinase kinase 6 isoform 1 cfa
CANINE_2:CFA.13618.1.A1_AT similar to mitogen-activated protein kinase kinase 6 isoform 1 cfa
CANINE_2:CFA.13636.1.A1_AT similar to mitogen-activated protein kinase kinase 6 isoform 1 cfa
CANINE_2:CFA.13636.1.A1_S_AT similar to mitogen-activated protein kinase kinase 6 isoform 1 cfa
CANINE_2:CFAAFFX.16824.1.S1_AT similar to mitogen-activated protein kinase kinase 6 isoform 1 cfa
HG-U95AV2:2014_S_AT mitogen-activated protein kinase kinase 6 hs
HC-G110:2014_S_AT mitogen-activated protein kinase kinase 6 hs
HG-U95AV2:1543_AT mitogen-activated protein kinase kinase 6 hs
HC-G110:1543_AT mitogen-activated protein kinase kinase 6 hs
HG-U133_PLUS_2:205699_AT mitogen-activated protein kinase kinase 6 hs
HG-U133A:205699_AT mitogen-activated protein kinase kinase 6 hs
HG-U133A_2:205699_AT mitogen-activated protein kinase kinase 6 hs
HG-FOCUS:205698_S_AT mitogen-activated protein kinase kinase 6 hs
HG-U133A:205698_S_AT mitogen-activated protein kinase kinase 6 hs
HG-U133_PLUS_2:205698_S_AT mitogen-activated protein kinase kinase 6 hs
HG-U133A_2:205698_S_AT mitogen-activated protein kinase kinase 6 hs
HUGENEFL:U39657_AT mitogen-activated protein kinase kinase 6 hs
U133_X3P:G1203817_3P_AT mitogen-activated protein kinase kinase 6 hs
U133_X3P:G10835026_3P_A_AT mitogen-activated protein kinase kinase 6 hs
HG-U95D:76095_AT Mitogen-activated protein kinase kinase 6 hs
MU11KSUBA:U39066_S_AT mitogen activated protein kinase kinase 6 mm
MG-U74AV2:102828_AT mitogen activated protein kinase kinase 6 mm
MG-U74AV2:102829_S_AT mitogen activated protein kinase kinase 6 mm
MOE430A:1426850_A_AT mitogen activated protein kinase kinase 6 mm
MOUSE430A_2:1426850_A_AT mitogen activated protein kinase kinase 6 mm
MOUSE430_2:1426850_A_AT mitogen activated protein kinase kinase 6 mm
MOE430B:1459292_AT MAP Kinase Kinase mm
MOUSE430_2:1459292_AT MAP Kinase Kinase mm
MU19KSUBB:TC31221_S_AT MAP Kinase Kinase mm
MU19KSUBB:TC31223_S_AT MAP Kinase Kinase mm
RT-U34:RC_AI176689_AT mitogen-activated protein kinase kinase 6 rn
RG-U34A:RC_AI176689_AT mitogen-activated protein kinase kinase 6 rn
RAE230A:1387809_AT mitogen-activated protein kinase kinase 6 rn
RAT230_2:1387809_AT mitogen-activated protein kinase kinase 6 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAA96067 Sapk/erk kinase protein 1 [Caenorhabditis elegans] ref|NP_509322.2| SAPK/ERK kinase family member (sek-1) [Caenorhabditis elegans] dbj|BAC11708.1| SEK-1 [Caenorhabditis elegans] dbj|BAB43977.2| MAP kinase kinase SEK-1 [Caenorhabditis elegans] 0.0
blast CAE70285 Hypothetical protein CBG16802 [Caenorhabditis briggsae] 0.0
blast BAC36972.1 unnamed protein product [Mus musculus] 1.0E-91
Protein Families
Method ID Description E-Value
hanks 1.4.6 AGC group; AGC IV GPCR kinases; GRK6 2.0E-14
hanks 1.4.6 AGC group; AGC IV GPCR kinases; GRK6 8.0E-15
hanks 1.4.6 AGC group; AGC IV GPCR kinases; GRK6 5.0E-15
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 7.6E-60
Pfam IPR000719 EMBL-EBI Protein kinase 7.6E-60
Sequence
Target Sequence 
>C. ELEGANS:192392_AT
ggctctgtcggtcattgaaggactcaactttatgaaagagcaactgaatttgattcatcg
agacgtgaaaccgtcgaacattctgttaaatcgacatggacaagtcaagatttgcgattt
tggaatttcaggtcacttgacaaacagcatggccaagactgtacaagccggatgcaaacc
ttacatgccaccagagagaattgatggagagactaagtcagcctatgatgtgagagctga
tgtatggagtttgggtataacaataattgaaatcgccgttggcacccatccctacgcaaa
ttggaaaaccccatttgaacaattgaaacaggttgtgaaagagccgccaccaaaattgcc
gatggaaagtggttttagtgttgattgtcagtactttgtcaagagatgtcttgaaaagga
ttacaatgaacgtcccaaatatccggaattattggcgatgccgtttatggagcaggcaag
aaatgagaagcaatttagtatggctcggtttatc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GGCTCTGTCGGTCATTGAAGGACTC 462 539 477 Antisense
GTGAAACCGTCGAACATTCTGTTAA 369 481 541 Antisense
GGTCACTTGACAAACAGCATGGCCA 594 503 607 Antisense
GCCAAGACTGTACAAGCCGGATGCA 120 277 628 Antisense
GGATGCAAACCTTACATGCCACCAG 400 513 646 Antisense
AATTGAAATCGCCGTTGGCACCCAT 648 177 741 Antisense
CACCCATCCCTACGCAAATTGGAAA 81 201 759 Antisense
AACAGGTTGTGAAAGAGCCGCCACC 289 135 803 Antisense
AGCCGCCACCAAAATTGCCGATGGA 278 83 818 Antisense
GAACGTCCCAAATATCCGGAATTAT 182 347 904 Antisense
GCAATTTAGTATGGCTCGGTTTATC 374 323 966 Antisense
Sequence Source Affymetrix Proprietary Database