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[192377_at] serine/threonine kinase

Description C10C6.1 /REP_DB=WormBase Gene ID /WP=CE20493 /GEN=kin-4 /TR=P90744 /GB=CAB05684.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=serine-threonine kinase
Cluster 6grp_highest_10_10 > 94      6grp_high1_10_10 > 59      4grp_highest_8_8 > 46      4grp_high_8_8 > 10      6grp_highest_nonorm > 84      6grp_total > 49      4grp_total > 14      6grp_highest_sub > Cu      6grp_cgc > 18      6grp_high1_sub > Cu      6grp_cgc_sub > Cu      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 458
1 2 3 4 range
A 671.6
(1.4)
P 		417.7
(-2)
P 		342.7
(-3)
P 		787.8
(3)
P 		445
B 700.4
(1.9)
P 		409.6
(-2)
P 		330.1
(-3)
P 		784.9
(3)
P 		455
C 617.2
(2.3)
P 		358
(-2.8)
P 		347.5
(-3)
P 		651.1
(3)
P 		304
avr 663.1
(1.8) 		395.1
(-2.2) 		340.1
(-3) 		741.3
(3) 		401

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 602
1 2 3 4 5 6 range
A 804
(1.2)
P 		640.7
(-0.4)
P 		386.7
(-3)
P 		458
(-2.3)
P 		728.2
(0.5)
P 		978.6
(3)
P 		592
B 768.6
(3)
P 		673.3
(0.8)
P 		508.1
(-3)
P 		530.9
(-2.5)
P 		557.9
(-1.9)
P 		755.8
(2.7)
P 		261
C 650.9
(2.2)
P 		681.8
(2.8)
P 		564.6
(0.5)
P 		377
(-3)
P 		688.5
(2.9)
P 		695
(3)
P 		318
avr 741.2
(1.8) 		665.3
(0.6) 		486.5
(-2.5) 		455.3
(-3) 		658.2
(0.4) 		809.8
(3) 		355
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 168
1 2 3 4 range
A 244.5
(3)
P 		90.7
(-3)
P 		89.6
(-3)
P 		115.3
(-2)
P 		155
B 223.3
(3)
P 		101.2
(-2)
P 		76.5
(-3)
P 		167.3
(0.7)
P 		147
C 204.3
(3)
P 		102.9
(-3)
P 		121.1
(-1.9)
P 		109.8
(-2.6)
P 		101
avr 224
(3) 		98.3
(-2.9) 		95.7
(-3) 		130.8
(-1.4) 		128

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 206
1 2 3 4 5 6 range
A 148.2
(-0.5)
P 		227.9
(2.6)
P 		84.2
(-3)
P 		116.2
(-1.8)
P 		219.7
(2.3)
P 		238.3
(3)
P 		154
B 267.4
(2.5)
P 		224.1
(0.8)
P 		123.4
(-3)
P 		140.6
(-2.3)
P 		226.7
(0.9)
P 		281.8
(3)
P 		158
C 241.3
(3)
P 		208
(1.8)
P 		143.7
(-0.5)
P 		75.8
(-3)
P 		222.8
(2.3)
P 		232.7
(2.7)
P 		166
avr 219
(1.6) 		220
(1.7) 		117.1
(-2.7) 		110.9
(-3) 		223.1
(1.8) 		250.9
(3) 		140
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192377_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.10251
Sequence Type Exemplar sequence
Representative Public ID C10C6.1 NCBI
Target Description C10C6.1 /REP_DB=WormBase Gene ID /WP=CE20493 /GEN=kin-4 /TR=P90744 /GB=CAB05684.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=serine-threonine kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_069760(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_069760 NCBI Caenorhabditis elegans protein KINase family member (kin-4) (kin-4) mRNA, complete cds. 11/11 None
GENEFINDER00000034493 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:11436121:11446616:1 11/11 None
C10C6.1 ENSEMBL cdna:known chromosome:CEL140:IV:11439402:11447021:1 gene:C10C6.1 11/11 A 
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000034483 1/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:11439407-11446622(+) 100.0 100.0
Public Domain and Genome References
Gene Title serine/threonine kinase
Gene Symbol kin-4
Ensembl C10C6.1
Entrez Gene 178068 Entrez gene
SwissProt P90744 EMBL-EBI
WormBase CE20493 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.7547.1.S1_AT similar to Microtubule-associated serine/threonine-protein kinase 2 cfa
CANINE_2:CFAAFFX.7549.1.S1_S_AT similar to Microtubule-associated serine/threonine-protein kinase 2 cfa
CANINE_2:CFAAFFX.7571.1.S1_S_AT similar to Microtubule-associated serine/threonine-protein kinase 2 cfa
CANINE_2:CFAAFFX.7583.1.S1_S_AT similar to Microtubule-associated serine/threonine-protein kinase 2 cfa
DROSOPHILA_2:1630573_AT dm
DROSGENOME1:151608_S_AT dm
DROSGENOME1:142528_AT dm
CHICKEN:GGA.9937.1.S1_AT similar to Mast2 protein gga
CHICKEN:GGAAFFX.6491.1.S1_AT similar to Mast2 protein gga
CHICKEN:GGAAFFX.6507.1.S1_AT similar to Mast2 protein gga
CHICKEN:GGAAFFX.6507.2.S1_S_AT similar to Mast2 protein gga
CHICKEN:GGAAFFX.6507.4.S1_S_AT similar to Mast2 protein gga
CHICKEN:GGAAFFX.6507.5.S1_S_AT similar to Mast2 protein gga
HG-U133_PLUS_2:215903_S_AT microtubule associated serine/threonine kinase 2 hs
HG-U133A_2:215903_S_AT microtubule associated serine/threonine kinase 2 hs
HG-U133A:215903_S_AT microtubule associated serine/threonine kinase 2 hs
HG-U133_PLUS_2:215661_AT microtubule associated serine/threonine kinase 2 hs
HG-U133A_2:215661_AT microtubule associated serine/threonine kinase 2 hs
HG-U133A:215661_AT microtubule associated serine/threonine kinase 2 hs
HG-U133_PLUS_2:211593_S_AT microtubule associated serine/threonine kinase 2 hs
HG-U133A:211593_S_AT microtubule associated serine/threonine kinase 2 hs
HG-U133A_2:211593_S_AT microtubule associated serine/threonine kinase 2 hs
HG-U133_PLUS_2:215660_S_AT microtubule associated serine/threonine kinase 2 hs
HG-U133A_2:215660_S_AT microtubule associated serine/threonine kinase 2 hs
HG-U133A:215660_S_AT microtubule associated serine/threonine kinase 2 hs
HU35KSUBB:RC_R53574_AT microtubule associated serine/threonine kinase 2 hs
U133_X3P:G13537203_3P_S_AT microtubule associated serine/threonine kinase 2 hs
U133_X3P:HS.306804.0.A1_3P_S_AT microtubule associated serine/threonine kinase 2 hs
U133_X3P:HS.306804.0.A1_3P_AT microtubule associated serine/threonine kinase 2 hs
U133_X3P:HS.101474.1.S1_3P_AT microtubule associated serine/threonine kinase 2 hs
U133_X3P:215660_3P_S_AT microtubule associated serine/threonine kinase 2 hs
HG-U95AV2:41114_AT microtubule associated serine/threonine kinase 2 hs
HG-U133_PLUS_2:215662_AT Microtubule associated serine/threonine kinase 2 hs
HG-U133A_2:215662_AT Microtubule associated serine/threonine kinase 2 hs
HG-U133A:215662_AT Microtubule associated serine/threonine kinase 2 hs
U133_X3P:HS.306804.0.S1_3P_AT Microtubule associated serine/threonine kinase 2 hs
HG-U95B:59575_AT Microtubule associated serine/threonine kinase 2 hs
HU35KSUBC:RC_N25619_AT Microtubule associated serine/threonine kinase 2 hs
HU35KSUBD:RC_D20269_AT Microtubule associated serine/threonine kinase 2 hs
MU11KSUBB:MSA.240.0_S_AT microtubule associated serine/threonine kinase 2 mm
MG-U74CV2:134878_AT microtubule associated serine/threonine kinase 2 mm
MG-U74AV2:160938_AT microtubule associated serine/threonine kinase 2 mm
MOE430A:1417324_AT microtubule associated serine/threonine kinase 2 mm
MOUSE430A_2:1417324_AT microtubule associated serine/threonine kinase 2 mm
MOUSE430_2:1417324_AT microtubule associated serine/threonine kinase 2 mm
MOE430B:1456927_AT microtubule associated serine/threonine kinase 2 mm
MOUSE430_2:1456927_AT microtubule associated serine/threonine kinase 2 mm
MOE430B:1444813_AT Microtubule associated serine/threonine kinase 2 (Mast2), mRNA mm
MOUSE430_2:1444813_AT Microtubule associated serine/threonine kinase 2 (Mast2), mRNA mm
MG-U74CV2:129245_AT Microtubule associated serine/threonine kinase 2 (Mast2), mRNA mm
MOE430B:1440321_AT Microtubule associated serine/threonine kinase 2 (Mast2), mRNA mm
MOUSE430_2:1440321_AT Microtubule associated serine/threonine kinase 2 (Mast2), mRNA mm
MOE430B:1441847_AT Microtubule associated serine/threonine kinase 2 (Mast2), mRNA mm
MOUSE430_2:1441847_AT Microtubule associated serine/threonine kinase 2 (Mast2), mRNA mm
MU19KSUBA:TC23567_S_AT Microtubule associated serine/threonine kinase 2 (Mast2), mRNA mm
MU19KSUBA:TC23568_S_AT Microtubule associated serine/threonine kinase 2 (Mast2), mRNA mm
RG-U34C:RC_AI230817_AT microtubule associated serine/threonine kinase 2 (predicted) rn
RAE230A:1388399_AT microtubule associated serine/threonine kinase 2 (predicted) rn
RAT230_2:1388399_AT microtubule associated serine/threonine kinase 2 (predicted) rn
RAE230B:1380873_AT microtubule associated serine/threonine kinase 2 (predicted) rn
RAT230_2:1380873_AT microtubule associated serine/threonine kinase 2 (predicted) rn
RAE230A:1375255_AT Microtubule associated serine/threonine kinase 2 (predicted) rn
RAT230_2:1375255_AT Microtubule associated serine/threonine kinase 2 (predicted) rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5515 protein binding inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast NP_502161 protein KINase family member (kin-4) [Caenorhabditis elegans] 0.0
blast CAB05684 Hypothetical protein C10C6.1 [Caenorhabditis elegans] emb|CAJ31105.1| KIN-4 protein [Caenorhabditis elegans] 0.0
blast CAE62116 Hypothetical protein CBG06155 [Caenorhabditis briggsae] 0.0
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 9.0E-67
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 3.0E-67
hanks 1.9.3 AGC group; AGC Other; Mast205 1.0E-118
Protein Domains
Database ID Description E-Value
Pfam IPR001478 EMBL-EBI PDZ/DHR/GLGF domain 4.0E-8
Pfam IPR000719 EMBL-EBI Protein kinase 1.0E-81
Pfam IPR001478 EMBL-EBI PDZ/DHR/GLGF domain 3.9E-8
Pfam IPR000719 EMBL-EBI Protein kinase 1.0E-81
Sequence
Target Sequence 
>C. ELEGANS:192377_AT
agatagagacaaaccgtccttcctcccttcgttctacttccaattcccatcatcatcacc
accatcccgcttccacatcctccgtagcttctgctcctgccacattaccgtcgacaactc
catccaatctgtctcgaatggcctcttcgtctccatcttcgtctgcttcaaattctggaa
cctcttctcctgccgccacatcttcaggcatttccattgtaaagcagaaatcacagtcga
tagctgttagtcctttggcaagagatacgcgaatgagaagtccatcgccatctcatcttc
accatcgtcccgcgtcgagttcatacacaacacggcccgacggcgttgtaactccggcaa
cctcgtcgtctccaaacaacagcggcttcgtccaagatctgatttcttctagacagtcac
cgaatctaagtgctcgacgtcgttcatatcaaccaactaccacaacttcaatgatcgtac
caccgactacccatcatttgcgtggtttctctgcagctgcacaatca

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AGATAGAGACAAACCGTCCTTCCTC 683 63 3530 Antisense
ATCCAATCTGTCTCGAATGGCCTCT 681 39 3651 Antisense
CATCTTCGTCTGCTTCAAATTCTGG 446 213 3683 Antisense
TCAAATTCTGGAACCTCTTCTCCTG 36 629 3697 Antisense
CCACATCTTCAGGCATTTCCATTGT 444 275 3725 Antisense
GTCGATAGCTGTTAGTCCTTTGGCA 354 471 3765 Antisense
AAACAACAGCGGCTTCGTCCAAGAT 323 127 3903 Antisense
GTGCTCGACGTCGTTCATATCAACC 17 479 3959 Antisense
TTCAATGATCGTACCACCGACTACC 167 631 3996 Antisense
GACTACCCATCATTTGCGTGGTTTC 21 373 4014 Antisense
TGGTTTCTCTGCAGCTGCACAATCA 504 551 4032 Antisense
Sequence Source Affymetrix Proprietary Database