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[192376_at]

Description Y75B8A.36 /REP_DB=WormBase Gene ID /WP=CE23047 /TR=Q9XW89 /GB=CAA22080.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=Eukaryotic protein kinase domain
Cluster 6grp_total > 67      4grp_total > 62      6grp_cgc > 47      6grp_total_sub > Increase      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 59
1 2 3 4 range
A 58.8
(1.7)
A 		15.4
(-3)
A 		71.2
(3)
A 		21.3
(-2.4)
A 		56
B 14
(-2.7)
A 		17.4
(-0.6)
A 		23
(3)
A 		13.6
(-3)
A 		9
C 73
(3)
A 		39.7
(-0.4)
A 		15.1
(-2.9)
A 		13.9
(-3)
A 		59
avr 48.6
(3) 		24.2
(-1.5) 		36.4
(0.7) 		16.3
(-3) 		32

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 50
1 2 3 4 5 6 range
A 24
(-1.1)
A 		11.8
(-2.6)
A 		49.1
(2)
A 		9.7
(-2.8)
A 		8.4
(-3)
A 		57.2
(3)
A 		49
B 16.3
(-2.4)
A 		14.5
(-2.7)
A 		38.6
(1.2)
A 		12.9
(-3)
A 		31.2
(0)
A 		49.4
(3)
A 		37
C 23.1
(-0.9)
A 		18.5
(-1.5)
A 		18.5
(-1.5)
A 		6.9
(-3)
A 		37.6
(1)
A 		53.1
(3)
A 		46
avr 21.1
(-1.4) 		14.9
(-2.3) 		35.4
(0.5) 		9.8
(-3) 		25.7
(-0.8) 		53.2
(3) 		43
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 22
1 2 3 4 range
A 21.4
(3)
A 		3.3
(-2.9)
A 		18.6
(2.1)
A 		3.1
(-3)
A 		18
B 4.5
(1)
A 		4.3
(0.5)
A 		5.3
(3)
A 		2.9
(-3)
A 		2
C 24.2
(3)
A 		11.4
(-0.5)
A 		5.3
(-2.2)
A 		2.3
(-3)
A 		22
avr 16.7
(3) 		6.3
(-1.5) 		9.7
(-0) 		2.8
(-3) 		14

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 17
1 2 3 4 5 6 range
A 4.4
(-2)
A 		4.2
(-2.1)
A 		10.7
(1.3)
A 		2.5
(-3)
A 		2.5
(-3)
A 		13.9
(3)
A 		11
B 5.7
(-2.1)
A 		4.8
(-2.4)
A 		9.4
(-0.6)
A 		3.4
(-3)
A 		12.7
(0.7)
A 		18.4
(3)
A 		15
C 8.6
(-0.4)
A 		5.6
(-1.5)
A 		4.7
(-1.8)
A 		1.4
(-3)
A 		12.2
(1)
A 		17.8
(3)
A 		16
avr 6.2
(-1.4) 		4.9
(-2) 		8.3
(-0.5) 		2.4
(-3) 		9.1
(-0.2) 		16.7
(3) 		14
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192376_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.6029
Sequence Type Exemplar sequence
Representative Public ID Y75B8A.36 NCBI
Target Description Y75B8A.36 /REP_DB=WormBase Gene ID /WP=CE23047 /TR=Q9XW89 /GB=CAA22080.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=Eukaryotic protein kinase domain
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_067170(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_067170 NCBI Caenorhabditis elegans ZYGote defective: embryonic lethal family member (zyg-8) (zyg-8) mRNA, complete cds. 11/11 A 
GENEFINDER00000020188 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:12069359:12071873:1 11/11 None
SNAP00000020062 ENSEMBL cdna:SNAP chromosome:CEL140:III:12069371:12071873:1 11/11 None
Y79H2A.11 ENSEMBL cdna:known chromosome:CEL140:III:12061615:12072152:1 gene:Y79H2A.11 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:12069354-12071869(+) 100.0 100.0
Public Domain and Genome References
Gene Title
Gene Symbol zyg-8
Ensembl Y79H2A.11
Entrez Gene 176639 Entrez gene
SwissProt Q95QC4 EMBL-EBI
WormBase CE31133 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1593187_AT similar to doublecortin kinase 2 cfa
CANINE_2:CFA.14783.1.A1_AT similar to doublecortin kinase 2 cfa
CANINE_2:CFAAFFX.12607.1.S1_AT similar to doublecortin kinase 2 cfa
CANINE_2:CFAAFFX.12610.1.S1_AT similar to doublecortin kinase 2 cfa
CHICKEN:GGA.16742.1.S1_S_AT doublecortin and CaM kinase-like 2 gga
CHICKEN:GGAAFFX.23098.3.S1_S_AT doublecortin and CaM kinase-like 2 gga
CHICKEN:GGAAFFX.23098.5.S1_AT doublecortin and CaM kinase-like 2 gga
HU35KSUBC:RC_AA411675_AT doublecortin and CaM kinase-like 2 hs
U133_X3P:HS.45057.0.A1_3P_AT doublecortin and CaM kinase-like 2 hs
HG-U133_PLUS_2:227666_AT doublecortin and CaM kinase-like 2 hs
HG-U133B:227666_AT doublecortin and CaM kinase-like 2 hs
HG-U95B:52134_AT doublecortin and CaM kinase-like 2 hs
HG-U133_PLUS_2:216724_AT Doublecortin and CaM kinase-like 2 hs
HG-U133A_2:216724_AT Doublecortin and CaM kinase-like 2 hs
HG-U133A:216724_AT Doublecortin and CaM kinase-like 2 hs
HG-U133_PLUS_2:216725_AT Doublecortin and CaM kinase-like 2 hs
HG-U133A_2:216725_AT Doublecortin and CaM kinase-like 2 hs
HG-U133A:216725_AT Doublecortin and CaM kinase-like 2 hs
HG-U133_PLUS_2:240505_AT Doublecortin and CaM kinase-like 2 hs
HG-U133B:240505_AT Doublecortin and CaM kinase-like 2 hs
HG-U95E:72255_AT Doublecortin and CaM kinase-like 2 hs
U133_X3P:HS.224170.0.A1_3P_AT Doublecortin and CaM kinase-like 2 hs
MU11KSUBB:MSA.6668.0_S_AT doublecortin and CaM kinase-like 2 mm
MG-U74BV2:108470_AT doublecortin and CaM kinase-like 2 mm
MG-U74CV2:140700_R_AT doublecortin and CaM kinase-like 2 mm
MOE430B:1428222_AT doublecortin and CaM kinase-like 2 mm
MOUSE430_2:1428222_AT doublecortin and CaM kinase-like 2 mm
MOE430B:1458488_AT doublecortin and CaM kinase-like 2 mm
MOUSE430_2:1458488_AT doublecortin and CaM kinase-like 2 mm
MG-U74BV2:106845_AT Doublecortin and CaM kinase-like 2 (Dcamkl2), mRNA mm
MOE430B:1456025_AT Doublecortin and CaM kinase-like 2 (Dcamkl2), mRNA mm
MOUSE430_2:1456025_AT Doublecortin and CaM kinase-like 2 (Dcamkl2), mRNA mm
MOUSE430_2:1459950_AT Doublecortin and CaM kinase-like 2 (Dcamkl2), mRNA mm
MOE430B:1459950_AT Doublecortin and CaM kinase-like 2 (Dcamkl2), mRNA mm
MU19KSUBA:TC18210_AT Doublecortin and CaM kinase-like 2 (Dcamkl2), mRNA mm
MU19KSUBC:TC37776_AT Doublecortin and CaM kinase-like 2 (Dcamkl2), mRNA mm
RAE230B:1393370_AT similar to RIKEN cDNA 6330415M09 (predicted) rn
RAT230_2:1393370_AT similar to RIKEN cDNA 6330415M09 (predicted) rn
RAE230A:1376461_AT Similar to RIKEN cDNA 6330415M09 (predicted) rn
RAT230_2:1376461_AT Similar to RIKEN cDNA 6330415M09 (predicted) rn
RAE230B:1396890_AT Similar to RIKEN cDNA 6330415M09 (predicted) rn
RAT230_2:1396890_AT Similar to RIKEN cDNA 6330415M09 (predicted) rn
RG-U34C:RC_AA818566_AT Similar to RIKEN cDNA 6330415M09 (predicted) rn
RG-U34C:RC_AI072654_AT Similar to RIKEN cDNA 6330415M09 (predicted) rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5876 spindle microtubule inferred from direct assay QuickGO AmiGO
5737 cytoplasm inferred from direct assay QuickGO AmiGO
5813 centrosome inferred from direct assay QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
4685 calcium- and calmodulin-dependent protein kinase activity inferred from sequence similarity QuickGO AmiGO
8017 microtubule binding inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB54507 Hypothetical protein Y79H2A.11 [Caenorhabditis elegans] emb|CAD36501.1| Hypothetical protein Y79H2A.11 [Caenorhabditis elegans] emb|CAC67459.1| ZYG-8 protein [Caenorhabditis elegans] ref|NP_499571.2| ZYGote defective: embryonic lethal family member (zyg-8) [Caenorhabditis elegans] 0.0
blast CAE71285 Hypothetical protein CBG18173 [Caenorhabditis briggsae] 0.0
blast EAA14780 ENSANGP00000019521 [Anopheles gambiae str. PEST] ref|XP_319785.2| ENSANGP00000019521 [Anopheles gambiae str. PEST] 1.0E-103
blast T27380 hypothetical protein Y75B8A.36 - Caenorhabditis elegans 1.0E-103
blast CAB54507 Hypothetical protein Y79H2A.11 [Caenorhabditis elegans] emb|CAD36501.1| Hypothetical protein Y79H2A.11 [Caenorhabditis elegans] emb|CAC67459.1| ZYG-8 protein [Caenorhabditis elegans] ref|NP_499571.2| ZYGote defective: embryonic lethal family member (zyg-8) [Caenorhabditis elegans] 1.0E-101
blast T27380 hypothetical protein Y75B8A.36 - Caenorhabditis elegans 1.0E-101
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 3.0E-62
hanks 2.1.8 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; DdMLCK 7.0E-70
hanks 1.1.1 AGC group; AGC I Cyclic nucleotide regulated protein kinase (PKA & PKG); cAPKa 4.0E-22
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 1.5E-35
Pfam IPR000719 EMBL-EBI Protein kinase 1.5E-35
Pfam IPR003533 EMBL-EBI Doublecortin 5.8E-31
Pfam IPR003533 EMBL-EBI Doublecortin 1.9E-25
Pfam IPR000719 EMBL-EBI Protein kinase 2.1E-76
Sequence
Target Sequence 
>C. ELEGANS:192376_AT
taaagctcgcagacttcggattggccgccgagatgccgaaagattttggagttctatcaa
caatctgtggaacgccgacctacgttgccccggaagtactcaacaaaacggggtacggct
gcaaagttgatatttgggctgccggagtgattctctatgcgattctcgtcgggtttccgc
cattccagagctctgatggatcggagcaagacttgttcagtgcgattatgagcggagaat
tcagcttcccatcaccatcttgggatgatgtctcttggtcagtgcgacatctgataatgt
gtctcattcatacggatccattccatcggtattcagccggtgagcttctcaatgacgaat
ggatggtgaatctcggcgacgtggatcccgagtacgaggagtgggctcatcgatttgtgc
aatctaaaatgcacgtggaagaagagcaagagacaccgtacgagtactacacttctcgac
gaacttcg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TAAAGCTCGCAGACTTCGGATTGGC 190 641 56 Antisense
CAACAATCTGTGGAACGCCGACCTA 6 191 113 Antisense
TACGTTGCCCCGGAAGTACTCAACA 326 645 136 Antisense
ATTCTCTATGCGATTCTCGTCGGGT 183 11 205 Antisense
TCCGCCATTCCAGAGCTCTGATGGA 321 597 231 Antisense
TGAGCGGAGAATTCAGCTTCCCATC 322 569 284 Antisense
GGATGATGTCTCTTGGTCAGTGCGA 52 515 318 Antisense
GTGTCTCATTCATACGGATCCATTC 323 487 354 Antisense
GATCCATTCCATCGGTATTCAGCCG 63 417 370 Antisense
TGAATCTCGGCGACGTGGATCCCGA 143 575 422 Antisense
GTACTACACTTCTCGACGAACTTCG 131 459 519 Antisense
Sequence Source Affymetrix Proprietary Database