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[192290_s_at] serine/threonine-protein kinase

Description K08B12.5 /REP_DB=WormBase Gene ID /WP=CE11916 /TR=O01583 /GB=AAB52260.1 /SUBMIT=ST.LOUIS /CHR=5 /FEA=Sanger Annotation /DEF=serine-threonine-protein kinase
Cluster 6grp_highest_10_10 > 70      6grp_high1_10_10 > 17      4grp_highest_8_8 > 41      4grp_high_8_8 > 50      6grp_highest_nonorm > 60      6grp_total > 17      4grp_total > 62      6grp_highest_sub > De      6grp_cgc > 11      6grp_high1_sub > De      6grp_cgc_sub > De      6grp_total_sub > Decrease      6grp_rule_based > S1      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 266
1 2 3 4 range
A 405.6
(3)
P 		185.3
(-2.7)
P 		255.4
(-0.9)
P 		175
(-3)
P 		231
B 320.6
(2.3)
P 		343.6
(3)
P 		304.6
(1.9)
P 		139.6
(-3)
P 		204
C 381.2
(3)
P 		317.3
(1.3)
P 		293
(0.7)
P 		150.9
(-3)
P 		230
avr 369.1
(3) 		282.1
(0.6) 		284.3
(0.6) 		155.2
(-3) 		214

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 450
1 2 3 4 5 6 range
A 497.6
(3)
P 		363.3
(0.1)
P 		224.4
(-3)
P 		248
(-2.5)
P 		292.8
(-1.5)
P 		298.9
(-1.4)
P 		273
B 473.8
(3)
P 		373.2
(0.2)
P 		264.1
(-2.8)
P 		345.4
(-0.6)
P 		258.5
(-3)
P 		281
(-2.4)
P 		215
C 643.4
(3)
P 		315.6
(-1.4)
P 		324.5
(-1.3)
P 		287.8
(-1.7)
P 		281.9
(-1.8)
P 		193.7
(-3)
P 		450
avr 538.3
(3) 		350.7
(-1) 		271
(-2.7) 		293.7
(-2.2) 		277.7
(-2.6) 		257.9
(-3) 		280
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 122
1 2 3 4 range
A 147.7
(3)
P 		40.2
(-2.3)
P 		66.8
(-1)
P 		25.6
(-3)
P 		122
B 102.2
(3)
P 		84.9
(1.6)
P 		70.6
(0.4)
P 		29.8
(-3)
P 		72
C 126.2
(3)
P 		91.2
(0.9)
P 		102.1
(1.6)
P 		25.4
(-3)
P 		101
avr 125.4
(3) 		72.1
(-0.2) 		79.8
(0.2) 		26.9
(-3) 		99

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 190
1 2 3 4 5 6 range
A 91.7
(0.2)
P 		129.2
(3)
P 		48.9
(-3)
P 		62.9
(-2)
P 		88.4
(-0)
P 		72.8
(-1.2)
P 		80
B 164.8
(3)
P 		124.2
(0.6)
P 		64.1
(-3)
P 		91.5
(-1.4)
P 		105
(-0.6)
P 		104.8
(-0.6)
P 		101
C 238.5
(3)
P 		96.3
(-1.7)
P 		82.6
(-2.2)
P 		57.9
(-3)
P 		91.2
(-1.9)
P 		64.8
(-2.8)
P 		181
avr 165
(3) 		116.6
(0.1) 		65.2
(-3) 		70.8
(-2.7) 		94.9
(-1.2) 		80.8
(-2.1) 		100
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 192290_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.11565
Sequence Type Exemplar sequence
Representative Public ID K08B12.5 NCBI
Target Description K08B12.5 /REP_DB=WormBase Gene ID /WP=CE11916 /TR=O01583 /GB=AAB52260.1 /SUBMIT=ST.LOUIS /CHR=5 /FEA=Sanger Annotation /DEF=serine-threonine-protein kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_072198(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_072198 NCBI Caenorhabditis elegans Temporarily Assigned Gene name family member (tag-59) (tag-59) mRNA, complete cds. 11/11 A 
GENEFINDER00000019130 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:6261245:6261772:-1 10/11 None
K08B12.5 ENSEMBL cdna:known chromosome:CEL140:V:6259986:6269785:-1 gene:K08B12.5 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:6260623-6269785(-) 100.0 100.0
Public Domain and Genome References
Gene Title serine/threonine-protein kinase
Gene Symbol tag-59
Ensembl K08B12.5
Entrez Gene 179013 Entrez gene
SwissProt O01583 EMBL-EBI
WormBase CE30818 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1606140_AT similar to CDC42-binding protein kinase alpha isoform B cfa
CANINE:1592126_AT similar to CDC42-binding protein kinase alpha isoform B cfa
CANINE_2:CFA.17259.1.S1_S_AT similar to CDC42-binding protein kinase alpha isoform B cfa
CANINE_2:CFA.17259.2.A1_S_AT similar to CDC42-binding protein kinase alpha isoform B cfa
CANINE_2:CFAAFFX.24562.1.S1_AT similar to CDC42-binding protein kinase alpha isoform B cfa
DROSOPHILA_2:1640589_AT genghis khan dm
DROSGENOME1:154234_AT genghis khan dm
CHICKEN:GGA.6160.1.S1_AT similar to CDC42-binding protein kinase alpha isoform B; ser-thr protein kinase related to the myotonic dystrophy protein kinase; ser-thr protein kinase PK428; myotonic dystrophy kinase-related CDC42-binding protein kinase alpha; CDC42 binidng prot... gga
CHICKEN:GGAAFFX.22822.1.S1_S_AT similar to CDC42-binding protein kinase alpha isoform B; ser-thr protein kinase related to the myotonic dystrophy protein kinase; ser-thr protein kinase PK428; myotonic dystrophy kinase-related CDC42-binding protein kinase alpha; CDC42 binidng prot... gga
CHICKEN:GGAAFFX.22822.3.S1_AT similar to CDC42-binding protein kinase alpha isoform B; ser-thr protein kinase related to the myotonic dystrophy protein kinase; ser-thr protein kinase PK428; myotonic dystrophy kinase-related CDC42-binding protein kinase alpha; CDC42 binidng prot... gga
CHICKEN:GGAAFFX.5788.1.S1_AT similar to CDC42-binding protein kinase alpha isoform B; ser-thr protein kinase related to the myotonic dystrophy protein kinase; ser-thr protein kinase PK428; myotonic dystrophy kinase-related CDC42-binding protein kinase alpha; CDC42 binidng prot... gga
CHICKEN:GGAAFFX.5788.1.S1_S_AT similar to CDC42-binding protein kinase alpha isoform B; ser-thr protein kinase related to the myotonic dystrophy protein kinase; ser-thr protein kinase PK428; myotonic dystrophy kinase-related CDC42-binding protein kinase alpha; CDC42 binidng prot... gga
HG-U133A:203794_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HG-U133_PLUS_2:203794_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HG-U133A_2:203794_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HG-U133_PLUS_2:214464_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HG-U133A_2:214464_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HG-FOCUS:214464_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HG-U133A:214464_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HU35KSUBA:RC_AA011682_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HU35KSUBA:RC_AA400909_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HU35KSUBC:RC_N39214_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HU35KSUBD:RC_AA424486_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HG-U133_PLUS_2:213595_S_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HG-U133A_2:213595_S_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HG-U133A:213595_S_AT CDC42 binding protein kinase alpha (DMPK-like) hs
U133_X3P:G7662135_3P_AT CDC42 binding protein kinase alpha (DMPK-like) hs
U133_X3P:HS.44708.0.S1_3P_AT CDC42 binding protein kinase alpha (DMPK-like) hs
U133_X3P:HS.326691.0.A1_3P_S_AT CDC42 binding protein kinase alpha (DMPK-like) hs
U133_X3P:HS.18586.1.S1_3P_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HG-U133A_2:215296_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HG-U133_PLUS_2:215296_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HG-U133A:215296_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HG-U95AV2:32206_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HG-U95AV2:39962_AT CDC42 binding protein kinase alpha (DMPK-like) hs
U133_X3P:HS2.283066.1.S1_3P_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HG-U133_PLUS_2:1553546_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HG-U133_PLUS_2:240735_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HG-U133B:240735_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HG-U95B:45082_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HG-U95B:53427_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HG-U95B:58024_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HG-U95D:81867_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HU35KSUBB:RC_R95672_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HU35KSUBC:RC_N70203_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HU35KSUBC:RC_N71361_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HU35KSUBD:RC_AA262895_S_AT CDC42 binding protein kinase alpha (DMPK-like) hs
HU35KSUBD:RC_AA478592_AT CDC42 binding protein kinase alpha (DMPK-like) hs
U133_X3P:HS.102496.0.A1_3P_AT CDC42 binding protein kinase alpha (DMPK-like) hs
MOE430A:1435847_AT Cdc42 binding protein kinase alpha mm
MOUSE430A_2:1435847_AT Cdc42 binding protein kinase alpha mm
MOUSE430_2:1435847_AT Cdc42 binding protein kinase alpha mm
MG-U74BV2:114120_AT Cdc42 binding protein kinase alpha mm
MOUSE430_2:1436380_AT Cdc42 binding protein kinase alpha mm
MOE430B:1436380_AT Cdc42 binding protein kinase alpha mm
MG-U74BV2:116640_AT Cdc42 binding protein kinase alpha mm
MOE430B:1438449_AT Cdc42 binding protein kinase alpha mm
MOUSE430_2:1438449_AT Cdc42 binding protein kinase alpha mm
MOE430B:1442260_AT Cdc42 binding protein kinase alpha mm
MOUSE430_2:1442260_AT Cdc42 binding protein kinase alpha mm
RN-U34:AF021935_AT CDC42 binding protein kinase alpha rn
RT-U34:AF021935_AT CDC42 binding protein kinase alpha rn
RG-U34A:AF021935_AT CDC42 binding protein kinase alpha rn
RN-U34:RC_AI069982_S_AT CDC42 binding protein kinase alpha rn
RG-U34A:RC_AI069982_S_AT CDC42 binding protein kinase alpha rn
RAE230A:1369040_AT CDC42 binding protein kinase alpha rn
RAT230_2:1369040_AT CDC42 binding protein kinase alpha rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5083 small GTPase regulator activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAB52260 Temporarily assigned gene name protein 59 [Caenorhabditis elegans] ref|NP_504599.2| Temporarily Assigned Gene name family member (tag-59) [Caenorhabditis elegans] 0.0
blast CAE71853 Hypothetical protein CBG18897 [Caenorhabditis briggsae] 0.0
blast XP_395596 PREDICTED: similar to CG4012-PA, partial [Apis mellifera] 0.0
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 3.0E-60
hanks 1.9.1 AGC group; AGC Other; DM 1.0E-108
Protein Domains
Database ID Description E-Value
scop a.4.5.MarR-like transcriptional regulators All alpha proteins; DNA/RNA-binding 3-helical bundle; "Winged helix" DNA-binding domain; MarR-like transcriptional regulators 0.46000000834465
Pfam IPR002219 EMBL-EBI Protein kinase C, phorbol ester/diacylglycerol binding 5.8E-15
Pfam IPR000719 EMBL-EBI Protein kinase 2.3E-54
Pfam IPR001180 EMBL-EBI Citron-like 1.0E-99
Pfam IPR001849 EMBL-EBI Pleckstrin-like 1.9E-7
Pfam IPR000961 EMBL-EBI Protein kinase C-terminal domain 7.4E-5
Sequence
Target Sequence 
>C. ELEGANS:192290_S_AT
ggcatctggaagcactgatggacggaaagtgacgcgacggaagttcaccttccgaacaat
cggaaaagatgataggagtgcttcggagcgtcggagtcacatacaaatctcgaccccatc
ggatttcatgcatatagttcatatgggtcccgcaccggtcatggagctacaacaaaattt
cattgacttgcagtcgaatcattcgcatacttcatccgataaggat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GGCATCTGGAAGCACTGATGGACGG 350 537 4404 Antisense
GATGGACGGAAAGTGACGCGACGGA 377 407 4420 Antisense
GATAGGAGTGCTTCGGAGCGTCGGA 292 425 4474 Antisense
GCTTCGGAGCGTCGGAGTCACATAC 687 305 4483 Antisense
AGTCACATACAAATCTCGACCCCAT 74 61 4498 Antisense
GACCCCATCGGATTTCATGCATATA 17 383 4515 Antisense
TATAGTTCATATGGGTCCCGCACCG 609 659 4536 Antisense
CACCGGTCATGGAGCTACAACAAAA 483 199 4556 Antisense
TTGACTTGCAGTCGAATCATTCGCA 603 703 4586 Antisense
GAATCATTCGCATACTTCATCCGAT 38 329 4599 Antisense
TTCGCATACTTCATCCGATAAGGAT 205 697 4605 Antisense
Sequence Source Affymetrix Proprietary Database