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[192285_at] Human VHL binding protein like

Description T06G6.9 /REP_DB=WormBase Gene ID /WP=CE13349 /TR=SW:O18054 /GB=CAB04707.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=Human VHL binding protein like
Cluster 6grp_highest_10_10 > 45      6grp_high1_10_10 > 54      4grp_highest_8_8 > 09      4grp_high_8_8 > 62      6grp_highest_nonorm > 86      6grp_total > 55      4grp_total > 58      6grp_cgc > 45      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 961
1 2 3 4 range
A 1317.7
(-1.4)
P 		1895.4
(2.4)
P 		1994.7
(3)
P 		1064.8
(-3)
P 		930
B 1423.7
(-0.7)
P 		1587.5
(0.4)
P 		1986.7
(3)
P 		1080.8
(-3)
P 		906
C 1335.4
(-0.7)
P 		1803.5
(2.8)
P 		1829
(3)
P 		1033.8
(-3)
P 		795
avr 1358.9
(-1) 		1762.1
(1.8) 		1936.8
(3) 		1059.8
(-3) 		877

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 417
1 2 3 4 5 6 range
A 860.7
(-1.5)
P 		1174.4
(3)
P 		1053.2
(1.3)
P 		1144.6
(2.6)
P 		757.9
(-3)
P 		997.5
(0.5)
P 		417
B 1009.7
(1.7)
P 		1004.2
(1.6)
P 		1075.2
(3)
P 		763
(-3)
P 		892.3
(-0.5)
P 		990.6
(1.4)
P 		312
C 953.3
(-1.1)
P 		888.4
(-2.7)
P 		1115.2
(3)
P 		875.8
(-3)
P 		920
(-1.9)
P 		1077.5
(2.1)
P 		239
avr 941.2
(-0.7) 		1022.3
(1.4) 		1081.2
(3) 		927.8
(-1.1) 		856.7
(-3) 		1021.9
(1.4) 		225
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 482
1 2 3 4 range
A 479.8
(2.3)
P 		411.4
(1.2)
P 		521.5
(3)
P 		155.9
(-3)
P 		366
B 454
(2.8)
P 		392.1
(1.2)
P 		460.4
(3)
P 		230.3
(-3)
P 		230
C 442
(0.5)
P 		518.5
(1.5)
P 		637.5
(3)
P 		174.3
(-3)
P 		463
avr 458.6
(1.6) 		440.7
(1.3) 		539.8
(3) 		186.8
(-3) 		353

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 259
1 2 3 4 5 6 range
A 158.7
(-3)
P 		417.7
(3)
P 		229.4
(-1.4)
P 		290.3
(0)
P 		228.7
(-1.4)
P 		242.9
(-1)
P 		259
B 351.3
(2.4)
P 		334.3
(1.7)
P 		261.1
(-0.9)
P 		202.1
(-3)
P 		362.5
(2.8)
P 		369.4
(3)
P 		167
C 353.4
(2.8)
P 		271.1
(0.1)
P 		283.8
(0.5)
P 		176.1
(-3)
P 		297.7
(1)
P 		360.7
(3)
P 		185
avr 287.8
(0.3) 		341
(3) 		258.1
(-1.2) 		222.8
(-3) 		296.3
(0.7) 		324.3
(2.2) 		118
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192285_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.2505
Sequence Type Exemplar sequence
Representative Public ID T06G6.9 NCBI
Target Description T06G6.9 /REP_DB=WormBase Gene ID /WP=CE13349 /TR=SW:O18054 /GB=CAB04707.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=Human VHL binding protein like
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_060827(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_060827 NCBI Caenorhabditis elegans VHL (von Hippel-Landau) Binding Protein family member (vbp-1) (vbp-1) mRNA, complete cds. 11/11 None
SNAP00000021715 ENSEMBL cdna:SNAP chromosome:CEL140:I:12732982:12737797:1 9/11 None
GENEFINDER00000021721 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:12732982:12737797:1 11/11 None
T06G6.9 ENSEMBL cdna:known chromosome:CEL140:I:12736302:12737923:1 gene:T06G6.9 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:12736306-12737728(+) 100.0 100.0
Public Domain and Genome References
Gene Title Human VHL binding protein like
Gene Symbol vbp-1
Ensembl T06G6.9
Entrez Gene 173141 Entrez gene
SwissProt O18054 EMBL-EBI
WormBase CE13349 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:248589_AT VHL binding protein, putative / prefoldin, putative at
CANINE:1588040_AT similar to von Hippel-Lindau binding protein 1 cfa
CANINE_2:CFA.15385.1.A1_AT similar to von Hippel-Lindau binding protein 1 cfa
CANINE_2:CFAAFFX.30026.1.S1_S_AT similar to von Hippel-Lindau binding protein 1 cfa
DROSOPHILA_2:1639895_AT dm
DROSGENOME1:149683_AT dm
CHICKEN:GGA.1896.1.S1_AT similar to von Hippel-Lindau binding protein 1; VHL binding protein-1; prefoldin 3 gga
HG-U95AV2:171_AT von Hippel-Lindau binding protein 1 hs
HC-G110:171_AT von Hippel-Lindau binding protein 1 hs
HG-FOCUS:201472_AT von Hippel-Lindau binding protein 1 hs
HG-U133_PLUS_2:201472_AT von Hippel-Lindau binding protein 1 hs
HG-U133A:201472_AT von Hippel-Lindau binding protein 1 hs
HG-U133A_2:201472_AT von Hippel-Lindau binding protein 1 hs
HU35KSUBA:AA071106_F_AT von Hippel-Lindau binding protein 1 hs
HUGENEFL:U56833_AT von Hippel-Lindau binding protein 1 hs
U133_X3P:G9257253_3P_AT von Hippel-Lindau binding protein 1 hs
HU35KSUBB:RC_N63261_AT Von Hippel-Lindau binding protein 1 hs
U133_X3P:HS.24906.0.A1_3P_AT Von Hippel-Lindau binding protein 1 hs
HG-U133_PLUS_2:236476_AT Von Hippel-Lindau binding protein 1 hs
HG-U133B:236476_AT Von Hippel-Lindau binding protein 1 hs
HG-U95C:60086_R_AT Von Hippel-Lindau binding protein 1 hs
HG-U133_PLUS_2:230922_X_AT Von Hippel-Lindau binding protein 1 hs
HG-U133B:230922_X_AT Von Hippel-Lindau binding protein 1 hs
HG-U133_PLUS_2:242152_AT Von Hippel-Lindau binding protein 1 hs
HG-U133B:242152_AT Von Hippel-Lindau binding protein 1 hs
HG-U95B:47828_R_AT Von Hippel-Lindau binding protein 1 hs
HG-U95B:48242_AT Von Hippel-Lindau binding protein 1 hs
HG-U95E:71226_AT Von Hippel-Lindau binding protein 1 hs
U133_X3P:HS.292980.0.A1_3P_AT Von Hippel-Lindau binding protein 1 hs
U133_X3P:HS.292980.0.A1_3P_X_AT Von Hippel-Lindau binding protein 1 hs
HU35KSUBB:RC_T17155_AT Von Hippel-Lindau binding protein 1 hs
HU35KSUBD:RC_R59585_AT Von Hippel-Lindau binding protein 1 hs
U133_X3P:HS.6917.0.A1_3P_AT Von Hippel-Lindau binding protein 1 hs
MOE430A:1421750_A_AT von Hippel-Lindau binding protein 1 mm
MOUSE430_2:1421750_A_AT von Hippel-Lindau binding protein 1 mm
MOUSE430A_2:1421750_A_AT von Hippel-Lindau binding protein 1 mm
MG-U74AV2:101509_AT von Hippel-Lindau binding protein 1 mm
MU19KSUBA:TC23822_AT Von Hippel-Lindau binding protein 1 (Vbp1), mRNA mm
MU19KSUBC:TC37074_AT Von Hippel-Lindau binding protein 1 (Vbp1), mRNA mm
MU19KSUBC:TC37074_G_AT Von Hippel-Lindau binding protein 1 (Vbp1), mRNA mm
YEAST_2:1770624_AT Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6457 protein folding inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16272 prefoldin complex inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB04704 Hypothetical protein T06G6.8 [Caenorhabditis elegans] ref|NP_493227.1| T06G6.8 [Caenorhabditis elegans] 1.0E-177
blast CAB04704 Hypothetical protein T06G6.8 [Caenorhabditis elegans] ref|NP_493227.1| T06G6.8 [Caenorhabditis elegans] 1.0E-169
blast CAB04707 Hypothetical protein T06G6.9 [Caenorhabditis elegans] ref|NP_493228.1| VHL (von Hippel-Landau) Binding Protein family member (vbp-1) [Caenorhabditis elegans] sp|O18054|PFD3_CAEEL Probable prefoldin subunit 2.0E-97
blast CAB04707 Hypothetical protein T06G6.9 [Caenorhabditis elegans] ref|NP_493228.1| VHL (von Hippel-Landau) Binding Protein family member (vbp-1) [Caenorhabditis elegans] sp|O18054|PFD3_CAEEL Probable prefoldin subunit 4.0E-86
blast CAB04707 Hypothetical protein T06G6.9 [Caenorhabditis elegans] ref|NP_493228.1| VHL (von Hippel-Landau) Binding Protein family member (vbp-1) [Caenorhabditis elegans] sp|O18054|PFD3_CAEEL Probable prefoldin subunit 6.0E-86
blast CAE67990 Hypothetical protein CBG13600 [Caenorhabditis briggsae] 5.0E-84
blast CAE67990 Hypothetical protein CBG13600 [Caenorhabditis briggsae] 3.0E-76
blast CAE67990 Hypothetical protein CBG13600 [Caenorhabditis briggsae] 4.0E-76
Protein Domains
Database ID Description E-Value
Pfam IPR004127 EMBL-EBI Putative prefoldin chaperone 1.6E-39
Pfam IPR005514 EMBL-EBI Protein of unknown function DUF316 3.5E-71
Pfam IPR004127 EMBL-EBI Putative prefoldin chaperone 1.6E-39
Pfam IPR004127 EMBL-EBI Putative prefoldin chaperone 1.6E-39
Sequence
Target Sequence 
>C. ELEGANS:192285_AT
gtcggacacagcggacagtctatcagcacgtggaatcccaaaaagcgagctcattgaaga
cgtcgagtcatggctcacaaaggagaagctttcgatcgaggaagccgaagttgtgctccg
tgagaaatacggaaagtacaaatacgtcgaatcatcgatgctcgctcaaaaagtacgaat
gagcgaaaaaatcccggaattcgagaacagtttgagcattatcgacacattaatcgcgaa
aagagccgccgatgagtcgttcgagacgactttcctgctctccgatgatgtctacacaaa
agccactgttcagaagcccgagaaggtatcaatctggcttggagccaacgtaatggtcga
atatgaccttgaaaatgctcgaaaactgctcgacaaaaaccgtggctccgttcaaaaagt
ggtcga

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTCGGACACAGCGGACAGTCTATCA 206 473 15 Antisense
GTCTATCAGCACGTGGAATCCCAAA 124 469 32 Antisense
GAAGACGTCGAGTCATGGCTCACAA 360 339 70 Antisense
GAGGAAGCCGAAGTTGTGCTCCGTG 394 403 112 Antisense
TCGAATCATCGATGCTCGCTCAAAA 254 601 161 Antisense
GAGTCGTTCGAGACGACTTTCCTGC 108 401 268 Antisense
TGCTCTCCGATGATGTCTACACAAA 551 581 290 Antisense
AAAGCCACTGTTCAGAAGCCCGAGA 630 123 313 Antisense
GAAGGTATCAATCTGGCTTGGAGCC 418 335 336 Antisense
AACTGCTCGACAAAAACCGTGGCTC 532 137 398 Antisense
GTGGCTCCGTTCAAAAAGTGGTCGA 525 487 416 Antisense
Sequence Source Affymetrix Proprietary Database