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[192275_s_at] 3',5' cyclic phosphodieterase

Description T04D3.3 /REP_DB=WormBase Gene ID /WP=CE16340 /TR=SW:O18696 /GB=CAB03289.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=3prime,5prime cyclic phosphodieterase
Cluster 6grp_highest_10_10 > 60      6grp_high1_10_10 > 17      4grp_highest_8_8 > 60      4grp_high_8_8 > 25      6grp_highest_nonorm > 50      6grp_total > 16      4grp_total > 39      6grp_highest_sub > De      6grp_cgc > 12      6grp_high1_sub > De      6grp_cgc_sub > De      6grp_total_sub > Decrease      6grp_rule_based > S1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 588
1 2 3 4 range
A 760.9
(3)
P 		446.6
(-0.8)
P 		268.2
(-3)
P 		593.2
(1)
P 		493
B 856.3
(3)
P 		419
(-2.8)
P 		404.3
(-3)
P 		483.2
(-2)
P 		452
C 820.6
(3)
P 		404.2
(-2.1)
P 		332.1
(-3)
P 		465.1
(-1.4)
P 		489
avr 812.6
(3) 		423.3
(-1.9) 		334.9
(-3) 		513.8
(-0.8) 		478

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 576
1 2 3 4 5 6 range
A 745.9
(3)
P 		621.1
(1.1)
P 		361.7
(-2.8)
P 		351.7
(-3)
P 		391.1
(-2.4)
P 		431
(-1.8)
P 		394
B 774.1
(3)
P 		513.1
(-0.2)
P 		344.7
(-2.2)
P 		321.9
(-2.5)
P 		304.6
(-2.7)
P 		282.9
(-3)
P 		491
C 845.4
(3)
P 		535
(-0.2)
P 		449.1
(-1.1)
P 		378.9
(-1.9)
P 		415.8
(-1.5)
P 		269.5
(-3)
P 		576
avr 788.5
(3) 		556.4
(-0) 		385.2
(-2.3) 		350.8
(-2.7) 		370.5
(-2.4) 		327.8
(-3) 		461
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 207
1 2 3 4 range
A 277.1
(3)
P 		96.9
(-2.2)
P 		70.1
(-3)
P 		86.8
(-2.5)
P 		207
B 273.1
(3)
P 		103.5
(-2.7)
P 		93.7
(-3)
P 		103
(-2.7)
P 		179
C 271.6
(3)
P 		116.2
(-1.8)
P 		115.7
(-1.8)
P 		78.4
(-3)
P 		193
avr 273.9
(3) 		105.5
(-2.5) 		93.2
(-2.9) 		89.4
(-3) 		185

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 237
1 2 3 4 5 6 range
A 137.5
(-0.5)
P 		220.9
(3)
P 		78.8
(-3)
P 		89.2
(-2.6)
P 		118
(-1.3)
P 		104.9
(-1.9)
P 		142
B 269.3
(3)
P 		170.8
(-0.2)
P 		83.7
(-3)
P 		85.3
(-2.9)
P 		123.8
(-1.7)
P 		105.5
(-2.3)
P 		186
C 313.4
(3)
P 		163.2
(-0.8)
P 		114.3
(-2)
P 		76.2
(-3)
P 		134.5
(-1.5)
P 		90.2
(-2.6)
P 		237
avr 240.1
(3) 		185
(0.9) 		92.3
(-2.7) 		83.6
(-3) 		125.4
(-1.4) 		100.2
(-2.4) 		157
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 192275_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.1625
Sequence Type Exemplar sequence
Representative Public ID T04D3.3 NCBI
Target Description T04D3.3 /REP_DB=WormBase Gene ID /WP=CE16340 /TR=SW:O18696 /GB=CAB03289.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=3prime,5prime cyclic phosphodieterase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_060942(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_060942 NCBI Caenorhabditis elegans PhosphoDiEsterase family member (pde-1) (pde-1) mRNA, complete cds. 11/11 None
GENEFINDER00000016268 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:13319124:13323077:-1 11/11 None
SNAP00000016262 ENSEMBL cdna:SNAP chromosome:CEL140:I:13319212:13323077:-1 11/11 None
T04D3.3 ENSEMBL cdna:known chromosome:CEL140:I:13319034:13326823:-1 gene:T04D3.3 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:13319142-13326754(-) 100.0 100.0
Public Domain and Genome References
Gene Title 3',5' cyclic phosphodieterase
Gene Symbol pde-1
Ensembl T04D3.3
Entrez Gene 173200 Entrez gene
SwissProt O18696 EMBL-EBI
WormBase CE16340 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1596351_S_AT similar to phosphodiesterase 1C, calmodulin-dependent 70kDa cfa
CANINE:1596350_AT similar to phosphodiesterase 1C, calmodulin-dependent 70kDa cfa
CANINE_2:CFA.20309.1.S1_S_AT similar to phosphodiesterase 1C, calmodulin-dependent 70kDa cfa
CANINE_2:CFA.2553.1.A1_AT similar to phosphodiesterase 1C, calmodulin-dependent 70kDa cfa
CANINE_2:CFAAFFX.5657.1.S1_AT similar to phosphodiesterase 1C, calmodulin-dependent 70kDa cfa
DROSGENOME1:146255_AT Phosphodiesterase 1c dm
DROSOPHILA_2:1625724_AT Phosphodiesterase 1c dm
DROSGENOME1:146254_AT Phosphodiesterase 1c dm
CHICKEN:GGAAFFX.7745.2.S1_AT similar to calmodulin-dependent cyclic nucleotide phosphodiesterase gga
CHICKEN:GGAAFFX.7745.3.S1_S_AT similar to calmodulin-dependent cyclic nucleotide phosphodiesterase gga
HG-U95AV2:32418_AT phosphodiesterase 1C, calmodulin-dependent 70kDa hs
HG-U133_PLUS_2:207303_AT phosphodiesterase 1C, calmodulin-dependent 70kDa hs
HG-FOCUS:207303_AT phosphodiesterase 1C, calmodulin-dependent 70kDa hs
HG-U133A:207303_AT phosphodiesterase 1C, calmodulin-dependent 70kDa hs
HG-U133A_2:207303_AT phosphodiesterase 1C, calmodulin-dependent 70kDa hs
HU35KSUBC:RC_N59154_AT phosphodiesterase 1C, calmodulin-dependent 70kDa hs
HUGENEFL:U40371_AT phosphodiesterase 1C, calmodulin-dependent 70kDa hs
HUGENEFL:U40372_AT phosphodiesterase 1C, calmodulin-dependent 70kDa hs
U133_X3P:G4826893_3P_AT phosphodiesterase 1C, calmodulin-dependent 70kDa hs
U133_X3P:HS2.41718.2.S1_3P_S_AT phosphodiesterase 1C, calmodulin-dependent 70kDa hs
U133_X3P:HS.41718.1.S1_3P_AT phosphodiesterase 1C, calmodulin-dependent 70kDa hs
HG-U133_PLUS_2:1554378_A_AT phosphodiesterase 1C, calmodulin-dependent 70kDa hs
HG-U133A_2:216869_AT phosphodiesterase 1C, calmodulin-dependent 70kDa hs
HG-U133_PLUS_2:216869_AT phosphodiesterase 1C, calmodulin-dependent 70kDa hs
HG-U133A:216869_AT phosphodiesterase 1C, calmodulin-dependent 70kDa hs
HG-U95AV2:32419_AT phosphodiesterase 1C, calmodulin-dependent 70kDa hs
HG-U133_PLUS_2:241145_AT Phosphodiesterase 1C, calmodulin-dependent 70kDa hs
HG-U133B:241145_AT Phosphodiesterase 1C, calmodulin-dependent 70kDa hs
U133_X3P:HS.279063.0.A1_3P_AT Phosphodiesterase 1C, calmodulin-dependent 70kDa hs
MOUSE430_2:1426036_A_AT phosphodiesterase 1C mm
MOE430A:1426036_A_AT phosphodiesterase 1C mm
MOUSE430A_2:1426036_A_AT phosphodiesterase 1C mm
MU11KSUBA:L76946_S_AT phosphodiesterase 1C mm
MG-U74AV2:100502_AT phosphodiesterase 1C mm
MG-U74CV2:135249_AT phosphodiesterase 1C mm
MOE430A:1429643_A_AT phosphodiesterase 1C mm
MOUSE430A_2:1429643_A_AT phosphodiesterase 1C mm
MOUSE430_2:1429643_A_AT phosphodiesterase 1C mm
MOE430B:1436251_AT phosphodiesterase 1C mm
MOUSE430_2:1436251_AT phosphodiesterase 1C mm
MOE430B:1444067_AT phosphodiesterase 1C mm
MOUSE430_2:1444067_AT phosphodiesterase 1C mm
MOE430B:1444386_AT phosphodiesterase 1C mm
MOUSE430_2:1444386_AT phosphodiesterase 1C mm
MG-U74BV2:105240_AT Phosphodiesterase 1C, mRNA (cDNA clone MGC:40631 IMAGE:5400689) mm
MOE430B:1440374_AT Phosphodiesterase 1C, mRNA (cDNA clone MGC:40631 IMAGE:5400689) mm
MOUSE430_2:1440374_AT Phosphodiesterase 1C, mRNA (cDNA clone MGC:40631 IMAGE:5400689) mm
RAT230_2:1388020_A_AT phosphodiesterase 1C rn
RAE230A:1388020_A_AT phosphodiesterase 1C rn
RG-U34A:L41045_AT phosphodiesterase 1C rn
RAT230_2:1371219_A_AT phosphodiesterase 1C rn
RAE230A:1371219_A_AT phosphodiesterase 1C rn
RAE230B:1378598_AT Phosphodiesterase 1C rn
RAT230_2:1378598_AT Phosphodiesterase 1C rn
RAE230B:1394973_AT Phosphodiesterase 1C rn
RAT230_2:1394973_AT Phosphodiesterase 1C rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
7165 signal transduction inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3824 catalytic activity inferred from electronic annotation QuickGO AmiGO
4114 3',5'-cyclic-nucleotide phosphodiesterase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB03289 Hypothetical protein T04D3.3 [Caenorhabditis elegans] ref|NP_493343.1| PhosphoDiEsterase family member (pde-1) [Caenorhabditis elegans] sp|O18696|PDE1_CAEEL Probable 3',5'-cyclic phosphodiesterase pde-1 0.0
blast CAE73007 Hypothetical protein CBG20362 [Caenorhabditis briggsae] 0.0
blast NP_035184 phosphodiesterase 1C isoform a [Mus musculus] gb|AAC37703.1| calmodulin-dependent cyclic nucleotide phosphodiesterase gb|AAC37702.1| calmodulin-dependent cyclic nucleotide phosphodiesterase 1.0E-138
blast NP_112340 cyclic nucleotide phosphodiesterase 1 C [Rattus norvegicus] sp|Q63421|PDE1C_RAT Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) gb|AAB00868.1| cyclic nucleotide phosphodiesterase 1.0E-137
Protein Domains
Database ID Description E-Value
Pfam IPR002073 EMBL-EBI 35-cyclic nucleotide phosphodiesterase 1.0E-126
Pfam IPR002073 EMBL-EBI 35-cyclic nucleotide phosphodiesterase 1.0E-126
Pfam IPR002073 EMBL-EBI 35-cyclic nucleotide phosphodiesterase 1.0E-126
Sequence
Target Sequence 
>C. ELEGANS:192275_S_AT
tgaagtccatgctgagcttgccggagggaattgacaaaaacaaagcattatgcctaatcg
tccacgcttgcgacatatctcatccagcaaaaccatggaatcttcacgaacgttggacag
aaggagttctagaggaattcttccgtcagggagacctcgaagcctcaatgggactaccgt
actccccgttatgtgatcgtcatactgtacacgtggctgacagtcaaatcggattcattg
attttattgtggaaccgacgatggtggtttgtggagagttgctcgtgaaaatggttgaac
cgctggtctcattgcctccaacagattctctattcccaccaagtgtcgatggaggagacg
acaaatcaccatcaaatgcgttgagtccactacctgatctacgcaactcatccacttcac
catcgtcgattcgtag

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TGAAGTCCATGCTGAGCTTGCCGGA 362 575 1379 Antisense
TAATCGTCCACGCTTGCGACATATC 626 625 1433 Antisense
GCGACATATCTCATCCAGCAAAACC 523 289 1448 Antisense
GGAATTCTTCCGTCAGGGAGACCTC 531 531 1512 Antisense
GAAGCCTCAATGGGACTACCGTACT 678 343 1537 Antisense
TACTCCCCGTTATGTGATCGTCATA 172 647 1558 Antisense
AATGGTTGAACCGCTGGTCTCATTG 129 161 1668 Antisense
TCATTGCCTCCAACAGATTCTCTAT 444 619 1687 Antisense
TCTCTATTCCCACCAAGTGTCGATG 397 611 1705 Antisense
CAAATGCGTTGAGTCCACTACCTGA 515 191 1751 Antisense
CCACTTCACCATCGTCGATTCGTAG 400 273 1790 Antisense
Sequence Source Affymetrix Proprietary Database