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[192244_s_at] zinc metalloprotease

Description C04A11.4 /REP_DB=WormBase Gene ID /WP=CE07906 /GEN=adm-2 /TR=O17569 /GB=CAA94147.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=zinc metalloprotease
Cluster 6grp_highest_10_10 > 70      6grp_high1_10_10 > 08      4grp_highest_8_8 > 06      4grp_high_8_8 > 22      6grp_highest_nonorm > 60      6grp_total > 19      4grp_total > 17      6grp_highest_sub > De      6grp_cgc > 01      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 282
1 2 3 4 range
A 407.9
(-2.6)
P 		401.7
(-2.9)
P 		398.1
(-3)
P 		545
(3)
P 		147
B 304.9
(-3)
P 		413
(-0.7)
P 		399.8
(-1)
P 		586.9
(3)
P 		282
C 364.6
(-3)
P 		418.4
(0.1)
P 		414.9
(-0.1)
P 		468.6
(3)
P 		104
avr 359.1
(-3) 		411
(-1.2) 		404.3
(-1.4) 		533.5
(3) 		174

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 326
1 2 3 4 5 6 range
A 500.8
(3)
P 		427.5
(1.4)
P 		226.7
(-3)
P 		372
(0.2)
P 		342.5
(-0.5)
P 		277.9
(-1.9)
P 		274
B 552.5
(3)
P 		361.6
(-0.8)
P 		331.2
(-1.4)
P 		299.1
(-2)
P 		320.4
(-1.6)
P 		250
(-3)
P 		303
C 544
(3)
P 		366.5
(-1.7)
P 		371.1
(-1.6)
P 		428.2
(-0.1)
P 		455.9
(0.7)
P 		317.1
(-3)
P 		227
avr 532.4
(3) 		385.2
(-0.5) 		309.7
(-2.3) 		366.4
(-1) 		372.9
(-0.8) 		281.7
(-3) 		251
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 70
1 2 3 4 range
A 148.5
(3)
P 		87.2
(-2.4)
P 		104.1
(-0.9)
P 		79.8
(-3)
P 		69
B 97.2
(-2.2)
P 		102
(-1.3)
P 		92.6
(-3)
P 		125.1
(3)
P 		33
C 120.7
(0.8)
P 		120.3
(0.8)
P 		144.6
(3)
P 		79
(-3)
P 		66
avr 122.1
(3) 		103.2
(-1.1) 		113.8
(1.2) 		94.6
(-3) 		28

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 152
1 2 3 4 5 6 range
A 92.3
(-0.5)
P 		152.1
(3)
P 		49.4
(-3)
P 		94.3
(-0.4)
P 		103.4
(0.2)
P 		67.7
(-1.9)
P 		103
B 192.2
(3)
P 		120.4
(-0.8)
P 		80.4
(-2.9)
P 		79.2
(-3)
P 		130.2
(-0.3)
P 		93.2
(-2.3)
P 		113
C 201.6
(3)
P 		111.8
(-1.7)
P 		94.5
(-2.6)
P 		86.1
(-3)
P 		147.5
(0.2)
P 		106.1
(-2)
P 		116
avr 162
(3) 		128.1
(0.7) 		74.8
(-3) 		86.5
(-2.2) 		127
(0.6) 		89
(-2) 		87
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 192244_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.17703
Sequence Type Exemplar sequence
Representative Public ID C04A11.4 NCBI
Target Description C04A11.4 /REP_DB=WormBase Gene ID /WP=CE07906 /GEN=adm-2 /TR=O17569 /GB=CAA94147.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=zinc metalloprotease
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077890(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077890 NCBI Caenorhabditis elegans ADAM (disintegrin plus metalloprotease) family member (adm-2) (adm-2) mRNA, complete cds. 11/11 None
C04A11.4 ENSEMBL cdna:known chromosome:CEL140:X:13687892:13695692:1 gene:C04A11.4 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000007391 6/11 Cross Hyb Matching Probes None
GENEFINDER00000007395 6/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:13687891-13695342(+) 100.0 100.0
Public Domain and Genome References
Gene Title zinc metalloprotease
Gene Symbol adm-2
Ensembl C04A11.4
Entrez Gene 181489 Entrez gene
SwissProt O17569 EMBL-EBI
WormBase CE07906 Wormbase
Functional Annotations
Ortholog
ID Title Organism
DROSOPHILA_2:1627649_AT dm
DROSGENOME1:151744_AT dm
DROSOPHILA_2:1635984_AT dm
DROSGENOME1:142994_AT dm
HU35KSUBB:RC_T54117_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HU35KSUBB:RC_R73567_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U133A:204943_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U133_PLUS_2:204943_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-FOCUS:204943_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U133A_2:204943_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U133A:202952_S_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U133_PLUS_2:202952_S_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U133A_2:202952_S_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
U133_X3P:G13259517_3P_A_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
U133_X3P:G11496999_3P_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
U133_X3P:HS.8850.2.A1_3P_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U95AV2:38769_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U133_PLUS_2:232268_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U133B:232268_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U133_PLUS_2:213790_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U133A_2:213790_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U133A:213790_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U133_PLUS_2:226777_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U133B:226777_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HU35KSUBA:RC_AA190993_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HU35KSUBA:RC_AA411621_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
U133_X3P:HS.8895.0.A1_3P_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
U133_X3P:HS.296700.0.S1_3P_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
U133_X3P:HS.221652.0.S1_3P_X_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
U133_X3P:HS.221652.0.S1_3P_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U133A_2:215613_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U133_PLUS_2:215613_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U133A:215613_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U95AV2:38770_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U95B:55567_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U95D:72342_R_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U133_PLUS_2:241022_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U133B:241022_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U133_PLUS_2:241026_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U133B:241026_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U133_PLUS_2:242460_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U133B:242460_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U95B:42092_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U95B:43862_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U95C:57845_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U95C:64964_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U95E:70318_I_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U95E:70321_R_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U95D:79204_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HG-U95E:84880_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HU35KSUBD:RC_H04021_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HU35KSUBB:RC_R37814_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HU35KSUBB:RC_R75860_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HU35KSUBB:RC_T89614_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
HU35KSUBD:RC_AA291503_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
U133_X3P:HS.102485.0.A1_3P_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
U133_X3P:HS.25244.0.A1_3P_AT ADAM metallopeptidase domain 12 (meltrin alpha) hs
MG-U74AV2:92414_AT a disintegrin and metallopeptidase domain 12 (meltrin alpha) mm
MOUSE430A_2:1421172_AT a disintegrin and metallopeptidase domain 12 (meltrin alpha) mm
MOE430A:1421172_AT a disintegrin and metallopeptidase domain 12 (meltrin alpha) mm
MOUSE430_2:1421172_AT a disintegrin and metallopeptidase domain 12 (meltrin alpha) mm
MU11KSUBA:D50411_S_AT a disintegrin and metallopeptidase domain 12 (meltrin alpha) mm
MOE430A:1421171_AT a disintegrin and metallopeptidase domain 12 (meltrin alpha) mm
MOUSE430A_2:1421171_AT a disintegrin and metallopeptidase domain 12 (meltrin alpha) mm
MOUSE430_2:1421171_AT a disintegrin and metallopeptidase domain 12 (meltrin alpha) mm
MOE430B:1440053_AT A disintegrin and metallopeptidase domain 12 (meltrin alpha) (Adam12), mRNA mm
MOUSE430_2:1440053_AT A disintegrin and metallopeptidase domain 12 (meltrin alpha) (Adam12), mRNA mm
MU19KSUBB:TC29312_AT A disintegrin and metallopeptidase domain 12 (meltrin alpha) (Adam12), mRNA mm
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4222 metalloendopeptidase activity inferred from electronic annotation QuickGO AmiGO
8237 metallopeptidase activity inferred from electronic annotation QuickGO AmiGO
8270 zinc ion binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA94147 Hypothetical protein C04A11.4 [Caenorhabditis elegans] emb|CAB03832.1| Hypothetical protein C04A11.4 [Caenorhabditis elegans] ref|NP_510291.1| ADAM (disintegrin plus metalloprotease) family member (adm-2) [Caenorhabditis elegans] 0.0
blast CAE63097 Hypothetical protein CBG07388 [Caenorhabditis briggsae] 0.0
blast XP_394078 PREDICTED: similar to ADAM metalloprotease [Apis mellifera] 1.0E-122
Protein Domains
Database ID Description E-Value
Pfam IPR001762 EMBL-EBI Disintegrin 5.3E-32
Pfam IPR001590 EMBL-EBI Peptidase M12B, ADAM/reprolysin 2.1E-58
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_510291.1 1 673-695
C04A11.4 1 673-695
Sequence
Target Sequence 
>C. ELEGANS:192244_S_AT
gaagatcattctcatgtggcggtcgctcaaccggctcatcctcgaaattgctacaactcg
tgctgtcgtcaaccaccacgttttgatccaccgtcaattccaatggttactttgaagaat
ccaaatcttgctagtccaacgccattgctgaatccagcagagaaagaagagcaaaatcaa
gaaagagcaacgcatcagcatgtggaactctatccagttgcggaaagtttcagaagtgat
tcggcggcttccttcaacacgcgcactggatccttccgtcccaatgtacaaccaccgccc
gttcctcgaccgagtgatgacgtactgagtaaactgaatgaggacctggcaaaggagaaa
aatgcgaaatttgatcgactaaacaaaacgttgccactgccaccaccactacccaaggaa
aaaccgaaaactgcaagttctacgagcctgagaagaaatgagagtatacgacccgagcag
gcaccaccaccacctccaccagcacatgctaaacctacactccctacgaagcaacccaaa
gtctctgaagatgcagctgcaaccgaagaaaaagtagatgttcgctccatggct

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAAGATCATTCTCATGTGGCGGTCG 643 337 2248 Antisense
GGCTCATCCTCGAAATTGCTACAAC 231 539 2280 Antisense
AAATTGCTACAACTCGTGCTGTCGT 593 115 2292 Antisense
GATCCACCGTCAATTCCAATGGTTA 671 415 2332 Antisense
CAAATCTTGCTAGTCCAACGCCATT 408 193 2369 Antisense
CGCATCAGCATGTGGAACTCTATCC 277 255 2438 Antisense
CCCGTTCCTCGACCGAGTGATGACG 673 259 2545 Antisense
AAACTGCAAGTTCTACGAGCCTGAG 658 125 2675 Antisense
TGAGAGTATACGACCCGAGCAGGCA 588 567 2706 Antisense
CCCTACGAAGCAACCCAAAGTCTCT 77 257 2769 Antisense
AAAAGTAGATGTTCGCTCCATGGCT 253 129 2817 Antisense
Sequence Source Affymetrix Proprietary Database