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[192241_at] 6-phosphogluconate dehydrogenase

Description T25B9.9 /REP_DB=WormBase Gene ID /WP=CE06508 /TR=Q17761 /GB=CAA94380.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=6-phosphogluconate dehydrogenase
Cluster 6grp_highest_10_10 > 25      6grp_high1_10_10 > 40      4grp_highest_8_8 > 16      4grp_high_8_8 > 60      6grp_highest_nonorm > 25      6grp_total > 52      4grp_total > 60      6grp_highest_sub > 03      6grp_high1_sub > 03      6grp_total_sub > Hat      6grp_rule_based > S3      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 2156
1 2 3 4 range
A 2271.6
(1.2)
P 		2461.8
(1.9)
P 		2803.6
(3)
P 		991
(-3)
P 		1813
B 2308.4
(0.9)
P 		2758.3
(2.3)
P 		2994.9
(3)
P 		1028.5
(-3)
P 		1966
C 2506
(2.5)
P 		2655.5
(3)
P 		2586.3
(2.8)
P 		838.8
(-3)
P 		1817
avr 2362
(1.6) 		2625.2
(2.4) 		2794.9
(3) 		952.8
(-3) 		1842

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 4135
1 2 3 4 5 6 range
A 3376.2
(-1.3)
P 		3840.6
(-0.6)
P 		6103.4
(3)
P 		3290
(-1.5)
P 		2313.1
(-3)
P 		2843.6
(-2.2)
P 		3790
B 3333.7
(-1.5)
P 		3375.6
(-1.5)
P 		6443.7
(3)
P 		3803.1
(-0.8)
P 		2308.9
(-3)
P 		2709.8
(-2.4)
P 		4135
C 2715.3
(-2.4)
P 		3657.8
(-0.6)
P 		5601
(3)
P 		4377.3
(0.7)
P 		2366.8
(-3)
P 		3118.7
(-1.6)
P 		3234
avr 3141.7
(-1.7) 		3624.7
(-0.9) 		6049.4
(3) 		3823.5
(-0.6) 		2329.6
(-3) 		2890.7
(-2.1) 		3720
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 760
1 2 3 4 range
A 827.1
(3)
P 		534.4
(0.4)
P 		732.9
(2.2)
P 		145.1
(-3)
P 		682
B 736.1
(3)
P 		681.2
(2.4)
P 		694
(2.5)
P 		219.2
(-3)
P 		517
C 829.5
(2.4)
P 		763.5
(1.9)
P 		901.4
(3)
P 		141.4
(-3)
P 		760
avr 797.6
(3) 		659.7
(1.7) 		776.1
(2.8) 		168.6
(-3) 		629

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 942
1 2 3 4 5 6 range
A 622.4
(-3)
P 		1365.9
(3)
P 		1329.2
(2.7)
P 		834.4
(-1.3)
P 		698
(-2.4)
P 		692.3
(-2.4)
P 		744
B 1160
(-0.9)
P 		1123.6
(-1.2)
P 		1564.7
(3)
P 		1007.3
(-2.3)
P 		938.1
(-3)
P 		1010.5
(-2.3)
P 		627
C 1006.4
(-0.8)
P 		1116.1
(0.2)
P 		1425.5
(3)
P 		880.3
(-2)
P 		765.9
(-3)
P 		1044
(-0.5)
P 		660
avr 929.6
(-1.8) 		1201.9
(0.8) 		1439.8
(3) 		907.3
(-2) 		800.7
(-3) 		915.6
(-1.9) 		639
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192241_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.8368
Sequence Type Exemplar sequence
Representative Public ID T25B9.9 NCBI
Target Description T25B9.9 /REP_DB=WormBase Gene ID /WP=CE06508 /TR=Q17761 /GB=CAA94380.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=6-phosphogluconate dehydrogenase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_069597(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_069597 NCBI Caenorhabditis elegans T25B9.9 (T25B9.9) mRNA, complete cds. 11/11 None
SNAP00000028242 ENSEMBL cdna:SNAP chromosome:CEL140:IV:10774686:10777529:1 11/11 None
GENEFINDER00000028249 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:10774059:10777529:1 11/11 None
T25B9.9.2 ENSEMBL cdna:known chromosome:CEL140:IV:10769623:10777720:1 gene:T25B9.9 11/11 None
T25B9.9.1 ENSEMBL cdna:known chromosome:CEL140:IV:10769625:10777720:1 gene:T25B9.9 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:10769638-10777535(+) 100.0 100.0
Public Domain and Genome References
Gene Title 6-phosphogluconate dehydrogenase
Ensembl T25B9.9
Entrez Gene 177971 Entrez gene
SwissProt Q17761 EMBL-EBI
WormBase CE06508 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:256328_AT 6-phosphogluconate dehydrogenase family protein at
CANINE:1591948_AT similar to 6-phosphogluconate dehydrogenase, decarboxylating cfa
CANINE:1583431_AT similar to 6-phosphogluconate dehydrogenase, decarboxylating cfa
CANINE_2:CFA.11536.1.A1_AT similar to 6-phosphogluconate dehydrogenase, decarboxylating cfa
CANINE_2:CFA.20176.1.S1_S_AT similar to 6-phosphogluconate dehydrogenase, decarboxylating cfa
CANINE_2:CFA.20176.2.S1_AT similar to 6-phosphogluconate dehydrogenase, decarboxylating cfa
DROSOPHILA_2:1631588_AT Phosphogluconate dehydrogenase dm
DROSGENOME1:152781_AT Phosphogluconate dehydrogenase dm
CHICKEN:GGAAFFX.12747.1.S1_S_AT phosphogluconate dehydrogenase gga
PLASMODIUM_ANOPHELES:201118_AT phosphogluconate dehydrogenase hs
HG-U133_PLUS_2:201118_AT phosphogluconate dehydrogenase hs
HG-U133A_2:201118_AT phosphogluconate dehydrogenase hs
HG-U133A:201118_AT phosphogluconate dehydrogenase hs
HG-FOCUS:201118_AT phosphogluconate dehydrogenase hs
HUGENEFL:U30255_AT phosphogluconate dehydrogenase hs
U133_X3P:G4505758_3P_S_AT phosphogluconate dehydrogenase hs
U133_X3P:G4505758_3P_AT phosphogluconate dehydrogenase hs
HG-U95AV2:36963_AT phosphogluconate dehydrogenase hs
HG-U95E:71426_F_AT Phosphogluconate dehydrogenase hs
HG-U95D:88700_AT Phosphogluconate dehydrogenase hs
MOUSE430_2:1438627_X_AT phosphogluconate dehydrogenase mm
MOE430A:1438627_X_AT phosphogluconate dehydrogenase mm
MOUSE430A_2:1438627_X_AT phosphogluconate dehydrogenase mm
MU11KSUBA:C81475_RC_F_AT phosphogluconate dehydrogenase mm
MG-U74AV2:95420_AT phosphogluconate dehydrogenase mm
MG-U74AV2:161975_R_AT phosphogluconate dehydrogenase mm
MOE430A:1423706_A_AT phosphogluconate dehydrogenase mm
MOUSE430A_2:1423706_A_AT phosphogluconate dehydrogenase mm
MOUSE430_2:1423706_A_AT phosphogluconate dehydrogenase mm
MOE430A:1436771_X_AT phosphogluconate dehydrogenase mm
MOUSE430A_2:1436771_X_AT phosphogluconate dehydrogenase mm
MOUSE430_2:1436771_X_AT phosphogluconate dehydrogenase mm
MOE430A:1437380_X_AT phosphogluconate dehydrogenase mm
MOUSE430A_2:1437380_X_AT phosphogluconate dehydrogenase mm
MOUSE430_2:1437380_X_AT phosphogluconate dehydrogenase mm
MU19KSUBB:TC33763_AT Phosphogluconate dehydrogenase, mRNA (cDNA clone MGC:18955 IMAGE:3984654) mm
MU19KSUBC:TC36551_AT Phosphogluconate dehydrogenase, mRNA (cDNA clone MGC:18955 IMAGE:3984654) mm
RG-U34B:RC_AI008441_AT phosphogluconate dehydrogenase rn
RAE230A:1371646_AT phosphogluconate dehydrogenase rn
RAT230_2:1371646_AT phosphogluconate dehydrogenase rn
YEAST_2:1773961_AT 6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6098 pentose-phosphate shunt inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4616 phosphogluconate dehydrogenase (decarboxylating) activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA94380 Hypothetical protein T25B9.9 [Caenorhabditis elegans] emb|CAA94326.1| Hypothetical protein T25B9.9 [Caenorhabditis elegans] ref|NP_501998.1| T25B9.9 [Caenorhabditis elegans] sp|Q17761|6PGD_CAEEL 6-phosphogluconate dehydrogenase, decarboxylating 0.0
blast CAE70848 Hypothetical protein CBG17632 [Caenorhabditis briggsae] 0.0
blast CAG32303 hypothetical protein [Gallus gallus] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR006114 EMBL-EBI 6-phosphogluconate dehydrogenase, C-terminal 1.0E-126
Pfam IPR006115 EMBL-EBI 6-phosphogluconate dehydrogenase, NAD binding domain 3.6E-124
Pfam IPR006114 EMBL-EBI 6-phosphogluconate dehydrogenase, C-terminal 1.0E-126
Pfam IPR006115 EMBL-EBI 6-phosphogluconate dehydrogenase, NAD binding domain 4.3E-24
Pfam IPR006114 EMBL-EBI 6-phosphogluconate dehydrogenase, C-terminal 1.0E-126
Pfam IPR006115 EMBL-EBI 6-phosphogluconate dehydrogenase, NAD binding domain 4.3E-24
Sequence
Target Sequence 
>C. ELEGANS:192241_AT
tcgtgcttcgaaacaacttcctcgtccacaagtctcaccagataccgtcgttcaggacaa
aagagtcttcatcaagcaaatcagcaaggctctttacgcctcaaaaatcgtcagttatgc
tcaaggatttatgcttcttgccgaagcatctaaacaattcaactggaatttgaactttgg
agctattgctttgatgtggagaggaggatgcattattcgttcaagattcctcggagacat
tgaacacgctttccaaaagaacaagcaactttccaatcttcttctcgatgatttcttcac
caaggccatcaccgaagcgcaggattcatggcgtgttgttgtgtgtgcagctgttcgtct
cggaattccagttccagcattctcatcggccctcgctttctatgatggatacaccagtga
ggtagttccggctaacttgcttcaagcccaaagagactatttcggagcccacacctacga
gcttctcgccaagccaggtacatgggt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TCGTGCTTCGAAACAACTTCCTCGT 196 605 903 Antisense
CTCACCAGATACCGTCGTTCAGGAC 151 229 936 Antisense
TCAGCAAGGCTCTTTACGCCTCAAA 284 623 983 Antisense
ATTCGTTCAAGATTCCTCGGAGACA 389 9 1117 Antisense
CAAGCAACTTTCCAATCTTCTTCTC 417 185 1164 Antisense
TCGATGATTTCTTCACCAAGGCCAT 446 603 1187 Antisense
TTGTTGTGTGTGCAGCTGTTCGTCT 88 707 1238 Antisense
GCTGTTCGTCTCGGAATTCCAGTTC 293 295 1252 Antisense
GCCCTCGCTTTCTATGATGGATACA 296 287 1291 Antisense
GTTCCGGCTAACTTGCTTCAAGCCC 590 439 1327 Antisense
TTCTCGCCAAGCCAGGTACATGGGT 419 691 1385 Antisense
Sequence Source Affymetrix Proprietary Database