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[192233_at] Protein kinase C terminal domain

Description W10G6.2 /REP_DB=WormBase Gene ID /WP=CE14798 /TR=Q94365 /GB=CAB03485.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=Protein kinase C terminal domain
Cluster 6grp_highest_10_10 > 12      6grp_high1_10_10 > 02      4grp_highest_8_8 > 29      4grp_high_8_8 > 04      6grp_highest_nonorm > 61      6grp_total > 07      4grp_total > 05      6grp_cgc > 35      6grp_high1_sub > De      6grp_cgc_sub > Cu      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 324
1 2 3 4 range
A 809.4
(-0.1)
P 		669.6
(-3)
P 		710.1
(-2.2)
P 		962
(3)
P 		292
B 726.1
(-1.2)
P 		648.5
(-3)
P 		776.2
(0)
P 		903.2
(3)
P 		255
C 810
(-0.7)
P 		707.4
(-3)
P 		724.4
(-2.6)
P 		972
(3)
P 		265
avr 781.8
(-0.6) 		675.2
(-3) 		736.9
(-1.6) 		945.7
(3) 		271

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 267
1 2 3 4 5 6 range
A 523.3
(0.3)
P 		629
(3)
P 		462.4
(-1.3)
P 		491.4
(-0.5)
P 		394.6
(-3)
P 		532.3
(0.5)
P 		234
B 587.6
(3)
P 		386.9
(-3)
P 		502.6
(0.5)
P 		469.4
(-0.5)
P 		392.1
(-2.8)
P 		405.1
(-2.5)
P 		201
C 543.7
(1.9)
P 		424.3
(-1.3)
P 		585.2
(3)
P 		512.9
(1.1)
P 		362.2
(-3)
P 		510.6
(1)
P 		223
avr 551.5
(3) 		480.1
(0.5) 		516.7
(1.8) 		491.2
(0.9) 		383
(-3) 		482.7
(0.6) 		169
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 154
1 2 3 4 range
A 294.7
(3)
P 		145.4
(-2.8)
P 		185.6
(-1.3)
P 		140.8
(-3)
P 		154
B 231.5
(3)
P 		160.2
(-3)
P 		179.9
(-1.3)
P 		192.5
(-0.3)
P 		71
C 268.1
(3)
P 		203.4
(-0.7)
P 		252.5
(2.1)
P 		163.9
(-3)
P 		104
avr 264.8
(3) 		169.7
(-2.8) 		206
(-0.6) 		165.7
(-3) 		99

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 127
1 2 3 4 5 6 range
A 96.5
(-3)
P 		223.7
(3)
P 		100.7
(-2.8)
P 		124.6
(-1.7)
P 		119.1
(-1.9)
P 		129.6
(-1.4)
P 		127
B 204.5
(3)
P 		128.8
(-2.5)
P 		122
(-3)
P 		124.3
(-2.8)
P 		159.3
(-0.3)
P 		151.1
(-0.9)
P 		83
C 201.5
(3)
P 		129.5
(-1.4)
P 		148.9
(-0.2)
P 		103.2
(-3)
P 		117.2
(-2.1)
P 		170.9
(1.1)
P 		98
avr 167.5
(3) 		160.7
(2.2) 		123.9
(-2.2) 		117.4
(-3) 		131.9
(-1.3) 		150.5
(1) 		50
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192233_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.17427
Sequence Type Exemplar sequence
Representative Public ID W10G6.2 NCBI
Target Description W10G6.2 /REP_DB=WormBase Gene ID /WP=CE14798 /TR=Q94365 /GB=CAB03485.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=Protein kinase C terminal domain
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_078246(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_078246 NCBI Caenorhabditis elegans Serum- and Glucocorticoid- inducible kinase homolog family member (sgk-1) (sgk-1) mRNA, complete cds. 11/11 None
GENEFINDER00000020045 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:16247833:16260033:-1 9/11 None
SNAP00000020041 ENSEMBL cdna:SNAP chromosome:CEL140:X:16256624:16260033:-1 9/11 None
W10G6.2.2 ENSEMBL cdna:known chromosome:CEL140:X:16254768:16260041:-1 gene:W10G6.2 11/11 None
W10G6.2.1 ENSEMBL cdna:known chromosome:CEL140:X:16254768:16262014:-1 gene:W10G6.2 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:16254926-16259192(-) 100.0 100.0
Public Domain and Genome References
Gene Title Protein kinase C terminal domain
Gene Symbol sgk-1
Ensembl W10G6.2
Entrez Gene 181697 Entrez gene
SwissProt Q94365 EMBL-EBI
WormBase CE14798 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1583086_AT serum/glucocorticoid regulated kinase cfa
CANINE_2:CFA.18962.1.S1_S_AT serum/glucocorticoid regulated kinase cfa
CANINE_2:CFA.3512.1.S1_S_AT serum/glucocorticoid regulated kinase cfa
CANINE_2:CFAAFFX.1288.1.S1_AT serum/glucocorticoid regulated kinase cfa
CANINE:1583085_AT serum/glucocorticoid regulated kinase cfa
CHICKEN:GGA.9334.1.S1_AT serum/glucocorticoid regulated kinase gga
CHICKEN:GGA.9334.2.S1_A_AT serum/glucocorticoid regulated kinase gga
HG-U133A:201739_AT serum/glucocorticoid regulated kinase hs
HG-FOCUS:201739_AT serum/glucocorticoid regulated kinase hs
HG-U133A_2:201739_AT serum/glucocorticoid regulated kinase hs
HG-U133_PLUS_2:201739_AT serum/glucocorticoid regulated kinase hs
HG-U95AV2:973_AT serum/glucocorticoid regulated kinase hs
HC-G110:973_AT serum/glucocorticoid regulated kinase hs
HU35KSUBB:RC_R97759_AT serum/glucocorticoid regulated kinase hs
HUGENEFL:Y10032_AT serum/glucocorticoid regulated kinase hs
U133_X3P:G5032090_3P_AT serum/glucocorticoid regulated kinase hs
MOE430A:1416041_AT serum/glucocorticoid regulated kinase mm
MOUSE430A_2:1416041_AT serum/glucocorticoid regulated kinase mm
MOUSE430_2:1416041_AT serum/glucocorticoid regulated kinase mm
MU11KSUBA:AA217550_S_AT serum/glucocorticoid regulated kinase mm
MU11KSUBB:MSA.32536.0_F_AT serum/glucocorticoid regulated kinase mm
MU11KSUBB:MSA.32326.0_S_AT serum/glucocorticoid regulated kinase mm
MU11KSUBB:MSA.25610.0_S_AT serum/glucocorticoid regulated kinase mm
MU11KSUBB:MSA.11687.0_F_AT serum/glucocorticoid regulated kinase mm
MU11KSUBB:MSA.10402.0_AT serum/glucocorticoid regulated kinase mm
MG-U74AV2:97890_AT serum/glucocorticoid regulated kinase mm
MG-U74CV2:171080_AT serum/glucocorticoid regulated kinase mm
RG-U34A:L01624_AT serum/glucocorticoid regulated kinase rn
RAE230A:1367802_AT serum/glucocorticoid regulated kinase rn
RAT230_2:1367802_AT serum/glucocorticoid regulated kinase rn
YEAST_2:1775390_AT Protein kinase with similarityto serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB03485 Hypothetical protein W10G6.2 [Caenorhabditis elegans] ref|NP_510647.1| Serum- and Glucocorticoid- inducible kinase homolog family member (sgk-1) [Caenorhabditis elegans] 0.0
blast CAE69987 Hypothetical protein CBG16386 [Caenorhabditis briggsae] 0.0
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 1.0E-63
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 9.0E-64
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 5.0E-65
hanks 1.9.2 AGC group; AGC Other; Sgk 4.0E-99
hanks 1.9.2 AGC group; AGC Other; Sgk 1.0E-100
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 6.4E-84
Pfam IPR000961 EMBL-EBI Protein kinase C-terminal domain 4.2E-10
Pfam IPR000719 EMBL-EBI Protein kinase 6.4E-84
Pfam IPR000961 EMBL-EBI Protein kinase C-terminal domain 4.2E-10
Pfam IPR000719 EMBL-EBI Protein kinase 6.4E-84
Pfam IPR000961 EMBL-EBI Protein kinase C-terminal domain 4.2E-10
Trans Membrane
ID Number Of Domains Domain Boundaries
GENEFINDER00000020045 1 624-642
Sequence
Target Sequence 
>C. ELEGANS:192233_AT
aggttacttggtgctcaccgactttgggctctgtaaagaagatatgcaaggaagcaagac
aacttccacattttgtgggacgccggagtacttggccccggaaattattctgaaaaagcc
ttacgacaagactgttgactggtggtgtttgggatcggttctctatgaaatgatttttgg
attgcctccattctactcaaaagatcataacgagatgtacgacaagatcatcaaccagcc
acttcgtctcaagcacaacatctctgtgccatgcagtgagctcatcaccgggctcttgca
aaaagaccgttcaaagcgtctgggccatcgcaatgatttccgtgacattcgtgatcatcc
attcttccttccggttgattgggataagcttctgaatcgtgagcttaaggctccgttcat
tccgaaagtgaaaaacgcaatggatacatccaatatttcaaaggagttcgtggagattca
aattgatccatcttcgttggcaccgcaacaacttgctgtcactcatcgagatcacg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AGGTTACTTGGTGCTCACCGACTTT 426 1 699 Antisense
GTACTTGGCCCCGGAAATTATTCTG 666 451 786 Antisense
TTTTGGATTGCCTCCATTCTACTCA 411 677 873 Antisense
ATCTCTGTGCCATGCAGTGAGCTCA 490 31 958 Antisense
GTTCAAAGCGTCTGGGCCATCGCAA 707 443 1007 Antisense
GGCCATCGCAATGATTTCCGTGACA 305 543 1021 Antisense
GACATTCGTGATCATCCATTCTTCC 311 371 1042 Antisense
CATTCTTCCTTCCGGTTGATTGGGA 583 213 1058 Antisense
TTAAGGCTCCGTTCATTCCGAAAGT 327 635 1103 Antisense
TTGGCACCGCAACAACTTGCTGTCA 223 709 1195 Antisense
CTTGCTGTCACTCATCGAGATCACG 563 217 1210 Antisense
Sequence Source Affymetrix Proprietary Database