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[192222_at] tyrosine-protein kinase

Description K10D3.5 /REP_DB=WormBase Gene ID /WP=CE06174 /TR=Q21419 /GB=CAA99887.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=Eukaryotic protein kinase domain
Cluster 6grp_total > 65      4grp_total > 07      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 23
1 2 3 4 range
A 23.6
(3)
A 		3.6
(-3)
A 		4.5
(-2.7)
A 		16.6
(0.9)
A 		20
B 4.3
(-2.6)
A 		9.1
(3)
A 		4
(-3)
A 		6.8
(0.3)
A 		5
C 21.4
(1.7)
A 		3.1
(-3)
A 		26.5
(3)
A 		26.5
(3)
A 		23
avr 16.4
(2.9) 		5.3
(-3) 		11.7
(0.4) 		16.6
(3) 		11

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 33
1 2 3 4 5 6 range
A 4.1
(-1.8)
A 		3.4
(-2.1)
A 		1.2
(-3)
A 		5.9
(-1.1)
A 		8.7
(-0)
A 		16.3
(3)
A 		15
B 2.7
(-2.9)
A 		2.3
(-3)
A 		3.3
(-2.6)
A 		2.3
(-3)
A 		12.5
(0.6)
A 		19.4
(3)
A 		17
C 16.7
(-0.3)
A 		8.9
(-1.8)
A 		33.8
(3)
A 		9.5
(-1.7)
A 		2.7
(-3)
A 		14.7
(-0.7)
A 		31
avr 7.8
(-1.5) 		4.9
(-3) 		12.8
(1) 		5.9
(-2.5) 		8
(-1.4) 		16.8
(3) 		12
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 8
1 2 3 4 range
A 8.6
(3)
A 		0.8
(-3)
A 		1.2
(-2.7)
A 		2.4
(-1.8)
A 		8
B 1.4
(-0.7)
A 		2.2
(3)
A 		0.9
(-3)
A 		1.5
(-0.2)
A 		1
C 7.1
(1.5)
A 		0.9
(-3)
A 		9.2
(3)
A 		4.5
(-0.4)
A 		8
avr 5.7
(3) 		1.3
(-3) 		3.8
(0.4) 		2.8
(-1) 		4

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 8
1 2 3 4 5 6 range
A 0.8
(-2.2)
A 		1.2
(-1.5)
A 		0.3
(-3)
A 		1.5
(-1.1)
A 		2.6
(0.7)
A 		4
(3)
A 		4
B 1
(-2.6)
A 		0.8
(-2.8)
A 		0.8
(-2.8)
A 		0.6
(-3)
A 		5.1
(1.1)
A 		7.2
(3)
A 		7
C 6.2
(1.1)
A 		2.7
(-1.6)
A 		8.6
(3)
A 		1.9
(-2.2)
A 		0.9
(-3)
A 		4.9
(0.1)
A 		8
avr 2.7
(-1) 		1.6
(-2.6) 		3.2
(-0.2) 		1.3
(-3) 		2.9
(-0.7) 		5.4
(3) 		4
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192222_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.907
Sequence Type Exemplar sequence
Representative Public ID K10D3.5 NCBI
Target Description K10D3.5 /REP_DB=WormBase Gene ID /WP=CE06174 /TR=Q21419 /GB=CAA99887.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=Eukaryotic protein kinase domain
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_059621(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_059621 NCBI Caenorhabditis elegans H37N21.1 (H37N21.1) mRNA, complete cds. 11/11 None
SNAP00000021177 ENSEMBL cdna:SNAP chromosome:CEL140:I:7148410:7151823:-1 11/11 None
GENEFINDER00000021179 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:7148410:7151501:-1 11/11 None
H37N21.1 ENSEMBL cdna:known chromosome:CEL140:I:7148410:7155362:-1 gene:H37N21.1 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:7148340-7152658(-) 100.0 100.0
Public Domain and Genome References
Gene Title tyrosine-protein kinase
Ensembl H37N21.1
Entrez Gene 186807 Entrez gene
SwissProt O45668 EMBL-EBI
WormBase CE36873 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1586649_AT similar to nuclear receptor binding protein cfa
CANINE_2:CFA.8989.1.A1_AT similar to nuclear receptor binding protein cfa
CANINE_2:CFAAFFX.8356.1.S1_AT similar to nuclear receptor binding protein cfa
CANINE_2:CFAAFFX.8356.1.S1_S_AT similar to nuclear receptor binding protein cfa
DROSOPHILA_2:1639453_AT MLF1-adaptor molecule dm
DROSGENOME1:144182_AT MLF1-adaptor molecule dm
CHICKEN:GGA.7224.2.S1_AT nuclear receptor binding protein gga
CHICKEN:GGA.7224.2.S1_S_AT nuclear receptor binding protein gga
CHICKEN:GGAAFFX.10561.1.S1_AT nuclear receptor binding protein gga
CHICKEN:GGAAFFX.10561.2.S1_S_AT nuclear receptor binding protein gga
HG-U133_PLUS_2:217765_AT nuclear receptor binding protein hs
HG-U133A:217765_AT nuclear receptor binding protein hs
HG-FOCUS:217765_AT nuclear receptor binding protein hs
HG-U133A_2:217765_AT nuclear receptor binding protein hs
HU35KSUBC:RC_AA610087_F_AT nuclear receptor binding protein hs
HU35KSUBD:RC_W59987_AT nuclear receptor binding protein hs
HU35KSUBD:RC_W45701_F_AT nuclear receptor binding protein hs
HU35KSUBD:RC_R45977_F_AT nuclear receptor binding protein hs
U133_X3P:G7019332_3P_X_AT nuclear receptor binding protein hs
U133_X3P:G7019332_3P_AT nuclear receptor binding protein hs
HG-U95B:56439_AT nuclear receptor binding protein hs
HU35KSUBD:RC_C21229_AT Nuclear receptor binding protein hs
MG-U74AV2:94059_AT nuclear receptor binding protein mm
MOE430A:1423864_AT nuclear receptor binding protein mm
MOUSE430A_2:1423864_AT nuclear receptor binding protein mm
MOUSE430_2:1423864_AT nuclear receptor binding protein mm
MOUSE430_2:1444600_AT Nuclear receptor binding protein (Nrbp), mRNA mm
MOE430B:1444600_AT Nuclear receptor binding protein (Nrbp), mRNA mm
MU19KSUBB:TC31595_AT Nuclear receptor binding protein (Nrbp), mRNA mm
MU19KSUBB:TC31595_G_AT Nuclear receptor binding protein (Nrbp), mRNA mm
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA99888 Hypothetical protein H37N21.1 [Caenorhabditis elegans] emb|CAA15621.2| Hypothetical protein H37N21.1 [Caenorhabditis elegans] ref|NP_492022.2| H37N21.1 [Caenorhabditis elegans] 0.0
blast T23574 hypothetical protein K10D3.5 - Caenorhabditis elegans 0.0
blast CAE73126 Hypothetical protein CBG20509 [Caenorhabditis briggsae] 1.0E-122
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 0.34
Pfam IPR000719 EMBL-EBI Protein kinase 1.5E-7
Pfam IPR000719 EMBL-EBI Protein kinase 0.34
Pfam IPR000719 EMBL-EBI Protein kinase 1.5E-7
Pfam IPR000719 EMBL-EBI Protein kinase 7.3E-13
Pfam IPR000719 EMBL-EBI Protein kinase 0.068
Pfam IPR000719 EMBL-EBI Protein kinase 1.5E-7
Sequence
Target Sequence 
>C. ELEGANS:192222_AT
ggaccatcttccatcggtaaatcagcaagtcctgaagcagttgataagaaaatcggtgaa
gttacgagtacggaatcaacgagtaaagtcgaagttgaagtcaatggagcaaatgttaca
ataggatcatcaaatgggcgtgatgctggatcaccgactccggaagaagaaggagaacca
aatggggagagagatatgcggttagaaaatagacacattttggagatcaatgtgcatatt
gaaaatgaagaaatgtcaattgttcttctattagaagatcaaatgcatcggcaattaaca
acgtcgatcaacaagggtgacaatccagaaactttgactgaaaatctgattacacacggt
tttatgtgtcagctggattcggaaggagtcgaaaaagcaattgcagtggcttttgatatt
cgtgctgctcgtattgcagaaggtgttcaggaagaggagaatgaaacatcaacgagagag
tcaaactctgaggctccaattgaacacggtacttcaagctcgataacgaattcggtaaaa
ccaattgttgattcggttgctccttc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GGACCATCTTCCATCGGTAAATCAG 484 523 799 Antisense
TGGGCGTGATGCTGGATCACCGACT 153 555 933 Antisense
AATGCATCGGCAATTAACAACGTCG 397 165 1080 Antisense
AAATCTGATTACACACGGTTTTATG 86 119 1140 Antisense
ATGTGTCAGCTGGATTCGGAAGGAG 203 49 1162 Antisense
GCAATTGCAGTGGCTTTTGATATTC 425 323 1195 Antisense
TTGATATTCGTGCTGCTCGTATTGC 435 701 1211 Antisense
AGAGTCAAACTCTGAGGCTCCAATT 91 67 1275 Antisense
GAGGCTCCAATTGAACACGGTACTT 448 399 1288 Antisense
ACACGGTACTTCAAGCTCGATAACG 534 107 1302 Antisense
CAATTGTTGATTCGGTTGCTCCTTC 688 179 1340 Antisense
Sequence Source Affymetrix Proprietary Database