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[192201_at] FK506-binding protein

Description F36H1.1 /REP_DB=WormBase Gene ID /WP=CE05813 /GEN=fkb-1 /TR=Q20107 /GB=CAA92994.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=FK506-binding protein
Cluster 6grp_highest_10_10 > 16      6grp_high1_10_10 > 50      4grp_highest_8_8 > 16      4grp_high_8_8 > 52      6grp_highest_nonorm > 27      6grp_total > 51      4grp_total > 59      6grp_highest_sub > 03_04      6grp_cgc > 93      6grp_high1_sub > 03_04      6grp_cgc_sub > 03      6grp_total_sub > Hat      6grp_rule_based > S3      4grp_rule_based > L2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 7281
1 2 3 4 range
A 6288.9
(-0.1)
P 		9790.7
(3)
P 		8714.4
(2.1)
P 		2968.1
(-3)
P 		6823
B 6625.9
(0.8)
P 		8612.3
(2.7)
P 		8932.4
(3)
P 		2665
(-3)
P 		6267
C 6356.4
(0.9)
P 		8161
(2.7)
P 		8484.1
(3)
P 		2509.6
(-3)
P 		5975
avr 6423.7
(0.6) 		8854.7
(3) 		8710.3
(2.9) 		2714.2
(-3) 		6141

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 6031
1 2 3 4 5 6 range
A 7823.4
(0.4)
P 		7197.9
(-0.4)
P 		9801.1
(3)
P 		8245
(0.9)
P 		5933.5
(-2.1)
P 		5247.2
(-3)
P 		4554
B 7236.3
(-0.7)
P 		6995.3
(-1)
P 		10140.2
(3)
P 		7876.9
(0.1)
P 		6382
(-1.7)
P 		5381.5
(-3)
P 		4759
C 5722.8
(-2.4)
P 		7112
(-1)
P 		8948.9
(0.9)
P 		11107.7
(3)
P 		5077.2
(-3)
P 		5501.1
(-2.6)
P 		6031
avr 6927.5
(-0.8) 		7101.7
(-0.6) 		9630.1
(3) 		9076.5
(2.2) 		5797.6
(-2.4) 		5376.6
(-3) 		4254
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 2534
1 2 3 4 range
A 2289.8
(3)
P 		2125.3
(2.5)
P 		2278.1
(3)
P 		434.5
(-3)
P 		1855
B 2113
(2.9)
P 		2127
(3)
P 		2069.8
(2.8)
P 		567.9
(-3)
P 		1559
C 2104.2
(1)
P 		2346.3
(1.6)
P 		2957
(3)
P 		423.2
(-3)
P 		2534
avr 2169
(2.2) 		2199.5
(2.3) 		2435
(3) 		475.2
(-3) 		1960

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1315
1 2 3 4 5 6 range
A 1442.2
(-2.2)
P 		2559.9
(3)
P 		2134.5
(1)
P 		2091.1
(0.8)
P 		1790.5
(-0.6)
P 		1277.5
(-3)
P 		1282
B 2517.9
(2.2)
P 		2328.5
(0.3)
P 		2462.3
(1.7)
P 		2086.3
(-2.2)
P 		2592.9
(3)
P 		2006.7
(-3)
P 		586
C 2121.2
(1.5)
P 		2170.1
(2)
P 		2277.6
(3)
P 		2233.8
(2.6)
P 		1642.9
(-3)
P 		1841.5
(-1.1)
P 		635
avr 2027.1
(-0) 		2352.8
(3) 		2291.5
(2.4) 		2137.1
(1) 		2008.8
(-0.2) 		1708.6
(-3) 		644
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192201_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.9006
Sequence Type Exemplar sequence
Representative Public ID F36H1.1 NCBI
Target Description F36H1.1 /REP_DB=WormBase Gene ID /WP=CE05813 /GEN=fkb-1 /TR=Q20107 /GB=CAA92994.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=FK506-binding protein
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_069655(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_069655 NCBI Caenorhabditis elegans FK506-Binding protein family member (fkb-1) (fkb-1) mRNA, complete cds. 11/11 None
SNAP00000039958 ENSEMBL cdna:SNAP chromosome:CEL140:IV:11036556:11037071:1 11/11 None
GENEFINDER00000039973 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:11036556:11037071:1 11/11 None
F36H1.1 ENSEMBL cdna:known chromosome:CEL140:IV:11036552:11037413:1 gene:F36H1.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:11036561-11037077(+) 100.0 100.0
Public Domain and Genome References
Gene Title FK506-binding protein
Gene Symbol fkb-1
Ensembl F36H1.1
Entrez Gene 191634 Entrez gene
SwissProt Q20107 EMBL-EBI
WormBase CE05813 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:257820_AT FK506-binding protein 2-1 (FKBP15-1) / immunophilin / peptidyl-prolyl cis-trans isomerase / rotamase at
CANINE:1592541_AT similar to FK506-binding protein 2 precursor (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) (13 kDa FKBP) (FKBP-13) cfa
CANINE:1586025_AT similar to FK506-binding protein 2 precursor (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) (13 kDa FKBP) (FKBP-13) cfa
CANINE_2:CFA.4181.1.A1_S_AT similar to FK506-binding protein 2 precursor (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) (13 kDa FKBP) (FKBP-13) cfa
DROSOPHILA_2:1625141_AT dm
DROSGENOME1:142488_S_AT dm
DROSGENOME1:142486_AT dm
HG-U133_PLUS_2:203391_AT FK506 binding protein 2, 13kDa hs
HG-U133A:203391_AT FK506 binding protein 2, 13kDa hs
HG-FOCUS:203391_AT FK506 binding protein 2, 13kDa hs
HG-U133A_2:203391_AT FK506 binding protein 2, 13kDa hs
HUGENEFL:M75099_AT FK506 binding protein 2, 13kDa hs
U133_X3P:G4758381_3P_AT FK506 binding protein 2, 13kDa hs
HG-U95AV2:33409_AT FK506 binding protein 2, 13kDa hs
HG-U95E:87075_AT FK506 binding protein 2, 13kDa hs
MU11KSUBA:M77831_S_AT FK506 binding protein 2 mm
MG-U74AV2:99546_AT FK506 binding protein 2 mm
MOE430A:1450694_AT FK506 binding protein 2 mm
MOUSE430A_2:1450694_AT FK506 binding protein 2 mm
MOUSE430_2:1450694_AT FK506 binding protein 2 mm
MU19KSUBB:TC28144_F_AT FK506 binding protein 2, mRNA (cDNA clone MGC:18470 IMAGE:4196363) mm
MU19KSUBB:TC28144_I_AT FK506 binding protein 2, mRNA (cDNA clone MGC:18470 IMAGE:4196363) mm
RT-U34:C06598_AT similar to binding protein rn
RG-U34A:C06598_AT similar to binding protein rn
RT-U34:AA684963_AT similar to binding protein rn
RG-U34A:AA684963_AT similar to binding protein rn
RG-U34B:RC_AA998471_I_AT similar to binding protein rn
RG-U34B:RC_AA998471_F_AT similar to binding protein rn
RG-U34B:RC_AA998471_R_AT similar to binding protein rn
RG-U34C:RC_AI234272_AT similar to binding protein rn
RAE230A:1375669_AT similar to binding protein rn
RAT230_2:1375669_AT similar to binding protein rn
RAE230B:1380501_X_AT similar to binding protein rn
RAT230_2:1380501_X_AT similar to binding protein rn
RAE230B:1380500_S_AT similar to binding protein rn
RAT230_2:1380500_S_AT similar to binding protein rn
YEAST_2:1771892_AT Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6457 protein folding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA92994 Hypothetical protein F36H1.1 [Caenorhabditis elegans] ref|NP_502056.1| FK506-Binding protein family member (fkb-1) [Caenorhabditis elegans] 3.0E-76
blast CAE61984 Hypothetical protein CBG05991 [Caenorhabditis briggsae] 5.0E-69
blast XP_867180 PREDICTED: similar to FK506-binding protein 2 precursor (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) (13 kDa FKBP) (FKBP-13) isoform 4 [Canis familiaris] ref|XP_540885.2| PREDICTED: similar to FK506-binding protein 2 precursor (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) (13 kDa FKBP) (FKBP-13) isoform 1 [Canis familiaris] 8.0E-43
Protein Domains
Database ID Description E-Value
Pfam IPR001179 EMBL-EBI Peptidylprolyl isomerase, FKBP-type 3.3E-53
Sequence
Target Sequence 
>C. ELEGANS:192201_AT
gaaaaccgctgttatcgttggacttttgtgcctattggcgatcgcatatgctgccgatga
gcagaaaatcgataaattgcaaattggagtcaagaagcgtgccgagaactgcgttcagaa
atccagaaagggtgatcaattgcacatgcactacaccggaacccttctcgatggaactga
atttgattccagccgcactcgcaatgaagaattcactttcactcttggacaaggaaatgt
gatcaagggatgggatcaaggacttcttaacatgtgcgtcggagagcgtcgtattctcac
aattccaccacaccttggatacggagaacgtggagccccaccaaagattccaggcaactc
tgtcctc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAAAACCGCTGTTATCGTTGGACTT 300 355 15 Antisense
GTTGGACTTTTGTGCCTATTGGCGA 149 437 31 Antisense
ATTGGCGATCGCATATGCTGCCGAT 326 3 48 Antisense
AATTGCACATGCACTACACCGGAAC 692 177 152 Antisense
GGAACCCTTCTCGATGGAACTGAAT 211 531 172 Antisense
TTCCAGCCGCACTCGCAATGAAGAA 218 699 201 Antisense
AACATGTGCGTCGGAGAGCGTCGTA 237 137 283 Antisense
AGAGCGTCGTATTCTCACAATTCCA 58 69 297 Antisense
ACAATTCCACCACACCTTGGATACG 253 115 313 Antisense
GAACGTGGAGCCCCACCAAAGATTC 417 323 340 Antisense
AAAGATTCCAGGCAACTCTGTCCTC 347 123 357 Antisense
Sequence Source Affymetrix Proprietary Database