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[192199_at] Eukaryotic protein kinase domain

Description F11E6.8 /REP_DB=WormBase Gene ID /WP=CE19788 /TR=Q9XVQ7 /GB=CAB02923.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Eukaryotic protein kinase domain
Cluster 6grp_highest_10_10 > 07      6grp_high1_10_10 > 70      4grp_high_8_8 > 61      6grp_highest_nonorm > 72      6grp_total > 81      4grp_total > 59      6grp_highest_sub > 04      6grp_high1_sub > 04      6grp_total_sub > Hat      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 437
1 2 3 4 range
A 354.3
(-0.9)
P 		637.9
(3)
P 		432.4
(0.2)
P 		200.6
(-3)
A 		437
B 476.6
(0)
P 		482.5
(0.1)
P 		625.6
(3)
P 		324.5
(-3)
P 		301
C 415
(-0.7)
P 		440.2
(-0.2)
P 		598.4
(3)
P 		301.6
(-3)
P 		297
avr 415.3
(0) 		520.2
(2.3) 		552.1
(3) 		275.6
(-3) 		277

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 484
1 2 3 4 5 6 range
A 362.5
(-1.1)
P 		499
(2.2)
P 		411.9
(0)
P 		534
(3)
P 		461.6
(1.2)
P 		286
(-3)
P 		248
B 336.7
(-1.5)
P 		487.9
(1)
P 		392.5
(-0.6)
P 		614.4
(3)
P 		502.4
(1.2)
P 		243.4
(-3)
P 		371
C 275.9
(-3)
P 		487.2
(-0.2)
P 		371.4
(-1.7)
P 		727.5
(3)
P 		337.9
(-2.2)
P 		286.8
(-2.9)
P 		452
avr 325
(-2.1) 		491.4
(0.7) 		391.9
(-1) 		625.3
(3) 		434
(-0.2) 		272.1
(-3) 		353
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 179
1 2 3 4 range
A 129
(2.5)
P 		138.5
(3)
P 		113
(1.6)
P 		29.4
(-3)
A 		109
B 152
(3)
P 		119.2
(0.6)
P 		145
(2.5)
P 		69.1
(-3)
P 		83
C 137.4
(0.3)
P 		126.5
(-0.1)
P 		208.6
(3)
P 		50.9
(-3)
P 		158
avr 139.5
(2.1) 		128.1
(1.4) 		155.5
(3) 		49.8
(-3) 		106

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 137
1 2 3 4 5 6 range
A 66.8
(-3)
P 		177.5
(3)
P 		89.7
(-1.8)
P 		135.4
(0.7)
P 		139.3
(0.9)
P 		69.6
(-2.8)
P 		111
B 117.1
(-1.6)
P 		162.4
(0.8)
P 		95.3
(-2.8)
P 		162.7
(0.8)
P 		204.1
(3)
P 		90.8
(-3)
P 		113
C 102.3
(-2.1)
P 		148.7
(3)
P 		94.5
(-3)
P 		146.3
(2.7)
P 		109.3
(-1.4)
P 		96
(-2.8)
P 		54
avr 95.4
(-2.2) 		162.9
(3) 		93.2
(-2.4) 		148.1
(1.9) 		150.9
(2.1) 		85.5
(-3) 		77
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192199_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.8726
Sequence Type Exemplar sequence
Representative Public ID F11E6.8 NCBI
Target Description F11E6.8 /REP_DB=WormBase Gene ID /WP=CE19788 /TR=Q9XVQ7 /GB=CAB02923.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Eukaryotic protein kinase domain
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_070710(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_070710 NCBI Caenorhabditis elegans F11E6.8 (F11E6.8) mRNA, complete cds. 11/11 None
SNAP00000042530 ENSEMBL cdna:SNAP chromosome:CEL140:IV:17444492:17447384:-1 11/11 None
GENEFINDER00000042542 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:17444492:17450435:-1 11/11 None
F11E6.8 ENSEMBL cdna:known chromosome:CEL140:IV:17444111:17450498:-1 gene:F11E6.8 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:17444497-17450441(-) 100.0 100.0
Public Domain and Genome References
Gene Title Eukaryotic protein kinase domain
Ensembl F11E6.8
Entrez Gene 178530 Entrez gene
SwissProt Q9XVQ7 EMBL-EBI
WormBase CE19788 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFA.10759.1.S1_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) cfa
CANINE_2:CFA.10759.1.S1_S_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) cfa
CANINE_2:CFAAFFX.17154.1.S1_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) cfa
CHICKEN:GGAAFFX.1880.1.S1_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) gga
CHICKEN:GGAAFFX.1954.1.S1_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) gga
HG-U133_PLUS_2:205455_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) hs
HG-U133A:205455_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) hs
HG-FOCUS:205455_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) hs
HG-U133A_2:205455_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) hs
HG-U95AV2:1317_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) hs
HC-G110:1317_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) hs
HUGENEFL:X70040_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) hs
U133_X3P:G4505264_3P_X_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) hs
U133_X3P:G4505264_3P_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) hs
MOE430A:1420461_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) mm
MOUSE430A_2:1420461_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) mm
MOUSE430_2:1420461_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) mm
MU11KSUBA:U65949_S_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) mm
MG-U74AV2:97719_AT macrophage stimulating 1 receptor (c-met-related tyrosine kinase) mm
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB02923 Hypothetical protein F11E6.8 [Caenorhabditis elegans] ref|NP_503111.1| F11E6.8 [Caenorhabditis elegans] 0.0
blast CAE57477 Hypothetical protein CBG00445 [Caenorhabditis briggsae] 0.0
blast XP_603857 PREDICTED: similar to macrophage stimulating 1 receptor (c-met-related tyrosine kinase) [Bos taurus] 5.0E-69
Protein Families
Method ID Description E-Value
hanks 2.1.18 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; MRE4 5.0E-55
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 5.0E-76
Pfam IPR000719 EMBL-EBI Protein kinase 5.0E-76
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_503111.1 1 47-69
F11E6.8 1 47-69
GENEFINDER00000042542 1 47-69
Sequence
Target Sequence 
>C. ELEGANS:192199_AT
gttcttgagctccttgactttgctcatcaagtggctcaaggcatgagttatttggcagct
caacacttcgttcatcgtgacttggccgctcgtaactgtatgatatcagctgatcgaatt
gtgaaagtcgcagactttggtttggctgttgatttattggataaagaaagttatattgat
gagagtgaaacaggaccagcccgtcttccattaaaatggctagcaccagagagtcttcgt
gatagaagagttttcagttcagctactgatgtgtggtcatttggagtattaatgtgggaa
ttgttgacacgagctgcttctccatatggtgaagtatcaaatacaaaagtgagacactac
ttggaaactggaatgcgactcccacaaccaacgcattgcccggatattatttatgatttg
atgcaatgttgttggcgctcaactccagaagacaggcctgatttcgtctttctatcacat
cgattgagagcattactgcaggaaaatactccagatcctttcactcgcagagttcgt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTTCTTGAGCTCCTTGACTTTGCTC 488 443 724 Antisense
GTTATTTGGCAGCTCAACACTTCGT 448 447 770 Antisense
AACACTTCGTTCATCGTGACTTGGC 570 135 785 Antisense
ACTTGGCCGCTCGTAACTGTATGAT 132 105 803 Antisense
GAGAGTGAAACAGGACCAGCCCGTC 478 393 904 Antisense
ACCAGCCCGTCTTCCATTAAAATGG 503 85 918 Antisense
ATTGTTGACACGAGCTGCTTCTCCA 169 5 1023 Antisense
ACAACCAACGCATTGCCCGGATATT 54 113 1107 Antisense
TGTTGTTGGCGCTCAACTCCAGAAG 707 561 1150 Antisense
AGACAGGCCTGATTTCGTCTTTCTA 101 71 1173 Antisense
AGATCCTTTCACTCGCAGAGTTCGT 455 65 1236 Antisense
Sequence Source Affymetrix Proprietary Database