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[192197_at] PH (pleckstrin homology) domain

Description F31D4.5 /REP_DB=WormBase Gene ID /WP=CE15931 /TR=O45420 /GB=CAB07373.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=PH (pleckstrin homology) domain
Cluster 6grp_high1_10_10 > 67      4grp_high_8_8 > 29      6grp_total > 57      4grp_total > 41      6grp_high1_sub > Da      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 60
1 2 3 4 range
A 21.2
(-2.9)
A 		37.7
(0.5)
A 		49.6
(3)
P 		20.6
(-3)
A 		29
B 42.4
(-2.7)
P 		80.1
(3)
P 		66
(0.9)
M 		40.7
(-3)
A 		39
C 26.6
(-3)
A 		71.7
(2.1)
P 		65.2
(1.3)
P 		80
(3)
P 		53
avr 30.1
(-3) 		63.2
(3) 		60.3
(2.5) 		47.1
(0.1) 		33

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 100
1 2 3 4 5 6 range
A 48.4
(-0.8)
P 		61.9
(0.5)
P 		38.1
(-1.8)
A 		25
(-3)
A 		53.9
(-0.3)
P 		88.3
(3)
P 		63
B 69.7
(0.8)
P 		54.9
(-0.1)
P 		41
(-0.9)
P 		6.1
(-3)
A 		37.5
(-1.1)
P 		105.6
(3)
P 		100
C 52
(-0)
P 		60.3
(0.6)
P 		28.9
(-1.6)
A 		51.1
(-0.1)
P 		7.8
(-3)
A 		96.5
(3)
P 		89
avr 56.7
(-0.5) 		59
(-0.3) 		36
(-2.3) 		27.4
(-3) 		33.1
(-2.5) 		96.8
(3) 		69
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 20
1 2 3 4 range
A 7.7
(-0.2)
A 		8.2
(0.1)
A 		13
(3)
P 		3
(-3)
A 		10
B 13.5
(-0.4)
P 		19.8
(3)
P 		15.3
(0.6)
M 		8.7
(-3)
A 		11
C 8.8
(-3)
A 		20.6
(2.1)
P 		22.7
(3)
P 		13.5
(-1)
P 		14
avr 10
(-1.9) 		16.2
(2.4) 		17
(3) 		8.4
(-3) 		9

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 38
1 2 3 4 5 6 range
A 8.9
(-2)
P 		22
(3)
P 		8.3
(-2.2)
A 		6.3
(-3)
A 		16.3
(0.8)
P 		21.5
(2.8)
P 		16
B 24.3
(0.6)
P 		18.3
(-0.3)
P 		10
(-1.7)
P 		1.6
(-3)
A 		15.3
(-0.8)
P 		39.4
(3)
P 		38
C 19.3
(0.4)
P 		18.4
(0.2)
P 		7.4
(-2)
A 		10.3
(-1.4)
P 		2.5
(-3)
A 		32.3
(3)
P 		30
avr 17.5
(-0.3) 		19.6
(0.2) 		8.6
(-2.4) 		6.1
(-3) 		11.4
(-1.7) 		31.1
(3) 		25
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192197_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.14529
Sequence Type Exemplar sequence
Representative Public ID F31D4.5 NCBI
Target Description F31D4.5 /REP_DB=WormBase Gene ID /WP=CE15931 /TR=O45420 /GB=CAB07373.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=PH (pleckstrin homology) domain
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_075628(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_075628 NCBI Caenorhabditis elegans F31D4.5 (F31D4.5) mRNA, complete cds. 11/11 None
SNAP00000041984 ENSEMBL cdna:SNAP chromosome:CEL140:V:20852194:20856627:1 11/11 None
GENEFINDER00000041992 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:20852194:20856627:1 11/11 None
F31D4.5 ENSEMBL cdna:known chromosome:CEL140:V:20852194:20856150:1 gene:F31D4.5 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:20852193-20856150(+) 100.0 100.0
Public Domain and Genome References
Gene Title PH (pleckstrin homology) domain
Ensembl F31D4.5
Entrez Gene 180373 Entrez gene
SwissProt O45420 EMBL-EBI
WormBase CE15931 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CHICKEN:GGAAFFX.5946.1.S1_AT similar to pleckstrin homology domain protein (5V327) gga
HU35KSUBA:HUM_ALU_AT similar to pleckstrin homology domain protein (5V327) hs
HU35KSUBB:HUM_ALU_AT similar to pleckstrin homology domain protein (5V327) hs
HU35KSUBC:HUM_ALU_AT similar to pleckstrin homology domain protein (5V327) hs
HU35KSUBD:HUM_ALU_AT similar to pleckstrin homology domain protein (5V327) hs
HUGENEFL:HUM_ALU_AT similar to pleckstrin homology domain protein (5V327) hs
HC-G110:HUM_ALU_AT similar to pleckstrin homology domain protein (5V327) hs
MG-U74CV2:129277_AT RIKEN cDNA 3830431G21 gene mm
MOE430B:1436035_AT RIKEN cDNA 3830431G21 gene mm
MOUSE430_2:1436035_AT RIKEN cDNA 3830431G21 gene mm
RAE230B:1398520_AT Similar to pleckstrin homology domain protein (5V327) rn
RAT230_2:1398520_AT Similar to pleckstrin homology domain protein (5V327) rn
RG-U34B:RC_AI060100_AT Similar to pleckstrin homology domain protein (5V327) rn
Protein Similarities
Method ID Description E-Value
blast CAB07373 Hypothetical protein F31D4.5 [Caenorhabditis elegans] ref|NP_508029.1| F31D4.5 [Caenorhabditis elegans] 0.0
blast CAE61633 Hypothetical protein CBG05563 [Caenorhabditis briggsae] 0.0
blast XP_126991 PREDICTED: similar to pleckstrin homology domain protein (5V327) [Mus musculus] 2.0E-57
Protein Domains
Database ID Description E-Value
scop a.2.6.Effector domain of the protein kinase pkn/prk1 All alpha proteins; Long alpha-hairpin; Effector domain of the protein kinase pkn/prk1; Effector domain of the protein kinase pkn/prk1 6.09999990463257
scop a.2.6.Effector domain of the protein kinase pkn/prk1 All alpha proteins; Long alpha-hairpin; Effector domain of the protein kinase pkn/prk1; Effector domain of the protein kinase pkn/prk1 5.90000009536743
scop a.2.6.Effector domain of the protein kinase pkn/prk1 All alpha proteins; Long alpha-hairpin; Effector domain of the protein kinase pkn/prk1; Effector domain of the protein kinase pkn/prk1 3.90000009536743
Pfam IPR001849 EMBL-EBI Pleckstrin-like 4.3E-19
Sequence
Target Sequence 
>C. ELEGANS:192197_AT
gagcttgaactccaaaaccgagcatcttcaagcaaatatggagagcttgaacattgaaaa
agaaaagatccacgaacaattacaagaaattgtacgggaacgagaaaaggttttgatcga
caatcagaatctatctactgataaatgtcaattaaacaatagattgatggaaattgagac
ttcgcgcaattgtataatgaccgaaaaggaaaaaattgaaaatttattgaagatgaacga
acagaaaactcaagatttggaaaaagaacgtcagtactatacgatgaagacatctgaact
aatggatcatttgaaagaagtcagtgagcaaagagatctaactgaaagcgagttgaaaga
acaaatgatggctcgtcttggagcagaaaagcaacttcaagcagctgaaaaagcattgga
acatcttgaaatggcattgaagatgactggggcgcagatgactgagttgcaagagcatat
tatgccagatgttcataaacttagagagttctttgagcagtgtgctgaagaatccagatt
tgaagcgaatcgtaccggcatcatg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAGCTTGAACTCCAAAACCGAGCAT 668 387 882 Antisense
AACCGAGCATCTTCAAGCAAATATG 289 147 897 Antisense
GATCGACAATCAGAATCTATCTACT 654 417 996 Antisense
TGATGGAAATTGAGACTTCGCGCAA 431 563 1046 Antisense
GACTTCGCGCAATTGTATAATGACC 373 371 1059 Antisense
GAACGTCAGTACTATACGATGAAGA 322 341 1147 Antisense
GCATTGAAGATGACTGGGGCGCAGA 574 307 1315 Antisense
GGGGCGCAGATGACTGAGTTGCAAG 233 497 1330 Antisense
GAGCATATTATGCCAGATGTTCATA 403 389 1354 Antisense
AGAGAGTTCTTTGAGCAGTGTGCTG 273 67 1384 Antisense
TGAAGCGAATCGTACCGGCATCATG 493 573 1422 Antisense
Sequence Source Affymetrix Proprietary Database