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[192177_s_at] Mannose 6-phosphate isomerase

Description ZK632.4 /REP_DB=WormBase Gene ID /WP=CE00421 /TR=SW:P34650 /GB=CAA80181.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=Mannose 6-phosphate isomerase
Cluster 6grp_highest_10_10 > 42      6grp_high1_10_10 > 25      4grp_highest_8_8 > 53      4grp_high_8_8 > 09      6grp_highest_nonorm > 57      6grp_total > 25      4grp_total > 23      6grp_highest_sub > 02      6grp_high1_sub > 01_02      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1663
1 2 3 4 range
A 3341.7
(3)
P 		1879.3
(-2.9)
P 		1851.4
(-3)
P 		2794.4
(0.8)
P 		1490
B 3432.2
(3)
P 		1849.9
(-3)
P 		2098.1
(-2.1)
P 		2913.7
(1)
P 		1582
C 3512.6
(3)
P 		1932.2
(-3)
P 		1931.7
(-3)
P 		3139.3
(1.6)
P 		1581
avr 3428.8
(3) 		1887.1
(-3) 		1960.4
(-2.7) 		2949.1
(1.1) 		1542

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1301
1 2 3 4 5 6 range
A 2797.9
(3)
P 		2616
(1.7)
P 		2410.9
(0.3)
P 		2217.9
(-1.1)
P 		2248.8
(-0.8)
P 		1938.9
(-3)
P 		859
B 2719.4
(2.4)
P 		2786.9
(3)
P 		2417
(-0.5)
P 		2286.6
(-1.7)
P 		2147.7
(-3)
P 		2331.9
(-1.3)
P 		639
C 2468.6
(0.7)
P 		2968.9
(3)
P 		2175.7
(-0.7)
P 		2645.4
(1.5)
P 		1668.1
(-3)
P 		2166.5
(-0.7)
P 		1301
avr 2662
(2) 		2790.6
(3) 		2334.5
(-0.6) 		2383.3
(-0.2) 		2021.5
(-3) 		2145.8
(-2) 		769
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 809
1 2 3 4 range
A 1216.7
(3)
P 		407.9
(-3)
P 		484
(-2.4)
P 		409
(-3)
P 		809
B 1094.5
(3)
P 		456.9
(-3)
P 		486.2
(-2.7)
P 		620.9
(-1.5)
P 		638
C 1162.8
(3)
P 		555.5
(-2.8)
P 		673.3
(-1.6)
P 		529.3
(-3)
P 		634
avr 1158
(3) 		473.4
(-3) 		547.8
(-2.3) 		519.7
(-2.6) 		685

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 474
1 2 3 4 5 6 range
A 515.8
(-2.4)
P 		930.4
(3)
P 		525.1
(-2.3)
P 		562.5
(-1.8)
P 		678.6
(-0.3)
P 		472.1
(-3)
P 		458
B 946.2
(3)
P 		927.6
(2.7)
P 		586.9
(-3)
P 		605.7
(-2.7)
P 		872.6
(1.8)
P 		869.6
(1.7)
P 		359
C 915
(3)
P 		905.9
(2.9)
P 		553.8
(-2.7)
P 		532
(-3)
P 		539.8
(-2.9)
P 		725.3
(0)
P 		383
avr 792.3
(0.9) 		921.3
(3) 		555.3
(-3) 		566.7
(-2.8) 		697
(-0.7) 		689
(-0.8) 		366
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 192177_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.7803
Sequence Type Exemplar sequence
Representative Public ID ZK632.4 NCBI
Target Description ZK632.4 /REP_DB=WormBase Gene ID /WP=CE00421 /TR=SW:P34650 /GB=CAA80181.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=Mannose 6-phosphate isomerase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_066773(10)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_066773 NCBI Caenorhabditis elegans ZK632.4 (ZK632.4) mRNA, complete cds. 10/11 None
SNAP00000031473 ENSEMBL cdna:SNAP chromosome:CEL140:III:9805606:9807348:-1 10/11 None
GENEFINDER00000031488 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:9805606:9807348:-1 10/11 None
ZK632.4 ENSEMBL cdna:known chromosome:CEL140:III:9805409:9807348:-1 gene:ZK632.4 10/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:9805601-9807344(-) 99.92 99.92
Public Domain and Genome References
Gene Title Mannose 6-phosphate isomerase
Ensembl ZK632.4
Entrez Gene 176388 Entrez gene
SwissProt P34650 EMBL-EBI
WormBase CE36417 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:258483_AT phosphomannose isomerase type I family protein at
CANINE_2:CFAAFFX.27528.1.S1_S_AT similar to mannose-6- phosphate isomerase cfa
DROSOPHILA_2:1633934_AT dm
DROSGENOME1:152323_AT dm
HG-FOCUS:202472_AT mannose phosphate isomerase hs
HG-U133A:202472_AT mannose phosphate isomerase hs
HG-U133_PLUS_2:202472_AT mannose phosphate isomerase hs
HG-U133A_2:202472_AT mannose phosphate isomerase hs
HU35KSUBB:RC_R46576_AT mannose phosphate isomerase hs
HUGENEFL:X76057_AT mannose phosphate isomerase hs
U133_X3P:G4505234_3P_X_AT mannose phosphate isomerase hs
U133_X3P:G4505234_3P_AT mannose phosphate isomerase hs
HG-U95AV2:36673_AT mannose phosphate isomerase hs
HG-U95C:57208_AT mannose phosphate isomerase hs
HU35KSUBB:RC_H15442_AT Mannose phosphate isomerase hs
U133_X3P:HS.75694.1.S1_3P_AT Mannose phosphate isomerase hs
HG-U133_PLUS_2:230524_AT Mannose phosphate isomerase hs
HG-U133B:230524_AT Mannose phosphate isomerase hs
MG-U74BV2:162874_AT mannose phosphate isomerase 1 mm
MOE430A:1451540_AT mannose phosphate isomerase 1 mm
MOUSE430A_2:1451540_AT mannose phosphate isomerase 1 mm
MOUSE430_2:1451540_AT mannose phosphate isomerase 1 mm
MU19KSUBB:TC28719_AT Mannose phosphate isomerase 1, mRNA (cDNA clone MGC:6520 IMAGE:2650791) mm
RG-U34A:RC_AA799505_AT mannose phosphate isomerase rn
RAE230A:1373681_AT mannose phosphate isomerase rn
RAT230_2:1373681_AT mannose phosphate isomerase rn
YEAST_2:1774627_AT Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
5975 carbohydrate metabolism inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4476 mannose-6-phosphate isomerase activity inferred from electronic annotation QuickGO AmiGO
8270 zinc ion binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA80181 Hypothetical protein ZK632.4 [Caenorhabditis elegans] ref|NP_499174.3| ZK632.4 [Caenorhabditis elegans] sp|P34650|MANA_CAEEL Probable mannose-6-phosphate isomerase (Phosphomannose isomerase) (PMI) (Phosphohexomutase) 0.0
blast CAE65125 Hypothetical protein CBG09990 [Caenorhabditis briggsae] 0.0
blast AAH09068 Mpi1 protein [Mus musculus] 1.0E-74
Protein Domains
Database ID Description E-Value
Pfam IPR001250 EMBL-EBI Mannose-6-phosphate isomerase, type I 1.0E-126
Sequence
Target Sequence 
>C. ELEGANS:192177_S_AT
ttgtctaccttttcacattgtaccctggagatgttggtgtatttgctccaattttcttga
actacttcaaattacaacctggagaggcaacatttttagaaccaaacatgccacatgctt
atttgaaaggagattgtgttgagtgtatggcagacagtgacaatactattcgagctggat
taacaccaaaatatattgatgtagaatcattggttgaaatgttgaattatgatgagaccc
tgcttccaaaatatattccaaatgaactggacgatggatcactactatttactccacgtg
gaattgatgagttctgggtgcaggaagtcaaaggacccgctggatcgatctaccaacttc
cttactccgaatcatgttctgtcttgacggttctctatggtactgcaacagttacattgg
gagatgcatcacaagtattgaatcgaggagaagtcgttttcattggagctacacatgacg
ctgaacgtcccaagattaatatttctgatgattttcttgtattccgagcgttca

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TTGTCTACCTTTTCACATTGTACCC 497 705 659 Antisense
GGTGTATTTGCTCCAATTTTCTTGA 208 501 694 Antisense
ATTATGATGAGACCCTGCTTCCAAA 399 13 884 Antisense
GGATCACTACTATTTACTCCACGTG 298 511 934 Antisense
AAGTCAAAGGACCCGCTGGATCGAT 102 153 983 Antisense
TGGATCGATCTACCAACTTCCTTAC 257 549 999 Antisense
AACTTCCTTACTCCGAATCATGTTC 452 139 1013 Antisense
GAATCATGTTCTGTCTTGACGGTTC 500 327 1027 Antisense
CTTGACGGTTCTCTATGGTACTGCA 474 5 1041 Antisense
GGAGCTACACATGACGCTGAACGTC 501 521 1123 Antisense
GATTTTCTTGTATTCCGAGCGTTCA 323 429 1168 Antisense
Sequence Source Affymetrix Proprietary Database