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[192174_at] C2 domain (2 domains)

Description F43G9.6 /REP_DB=WormBase Gene ID /WP=CE10364 /GEN=fer-1 /TR=Q17388 /GB=CAB02109.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=C2 domain (2 domains)
Cluster 6grp_total > 97      4grp_total > 42      6grp_cgc > 69      6grp_cgc_sub > Da      6grp_total_sub > Increase      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 89
1 2 3 4 range
A 46.5
(1.5)
A 		27.8
(-3)
A 		52.8
(3)
A 		43
(0.6)
A 		25
B 15.1
(-3)
A 		63.6
(1.8)
A 		64.4
(1.9)
A 		76
(3)
A 		61
C 64.2
(0.1)
A 		104.4
(3)
A 		47.8
(-1.1)
A 		21.7
(-3)
A 		83
avr 41.9
(-3) 		65.3
(3) 		55
(0.4) 		46.9
(-1.7) 		23

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 121
1 2 3 4 5 6 range
A 46.5
(-3)
A 		86.7
(-0.3)
A 		51.2
(-2.7)
A 		68.8
(-1.5)
A 		137.1
(3)
A 		106
(0.9)
P 		91
B 40.4
(-2.2)
A 		42.6
(-2)
A 		33.2
(-3)
A 		58.8
(-0.2)
A 		38.5
(-2.4)
A 		87.2
(3)
P 		54
C 41.4
(-1.4)
A 		16.4
(-3)
A 		57.7
(-0.3)
A 		45
(-1.1)
A 		62.6
(0)
A 		107.8
(3)
P 		91
avr 42.8
(-3) 		48.6
(-2.4) 		47.4
(-2.5) 		57.5
(-1.5) 		79.4
(0.8) 		100.3
(3) 		58
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 26
1 2 3 4 range
A 16.9
(3)
A 		6
(-3)
A 		13.8
(1.3)
A 		6.3
(-2.8)
A 		11
B 4.8
(-3)
A 		15.7
(2.7)
A 		14.9
(2.3)
A 		16.2
(3)
A 		11
C 21.2
(1)
A 		30
(3)
A 		16.7
(-0)
A 		3.7
(-3)
A 		26
avr 14.3
(1) 		17.2
(3) 		15.1
(1.5) 		8.7
(-3) 		9

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 36
1 2 3 4 5 6 range
A 8.6
(-3)
A 		30.8
(1.1)
A 		11.1
(-2.5)
A 		17.5
(-1.4)
A 		41.4
(3)
A 		25.8
(0.1)
P 		33
B 14
(-1.5)
A 		14.2
(-1.5)
A 		8.1
(-3)
A 		15.6
(-1.2)
A 		15.6
(-1.2)
A 		32.5
(3)
P 		24
C 15.3
(-1)
A 		5
(-3)
A 		14.7
(-1.1)
A 		9.1
(-2.2)
A 		20.3
(-0)
A 		36.1
(3)
P 		31
avr 12.6
(-2.6) 		16.7
(-1.4) 		11.3
(-3) 		14.1
(-2.2) 		25.8
(1.3) 		31.5
(3) 		20
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192174_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.738
Sequence Type Exemplar sequence
Representative Public ID F43G9.6 NCBI
Target Description F43G9.6 /REP_DB=WormBase Gene ID /WP=CE10364 /GEN=fer-1 /TR=Q17388 /GB=CAB02109.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=C2 domain (2 domains)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_059936(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_059936 NCBI Caenorhabditis elegans FERtilization defective (abnormal sperm) family member (fer-1) (fer-1) mRNA, complete cds. 11/11 None
SNAP00000043541 ENSEMBL cdna:SNAP chromosome:CEL140:I:8631281:8639309:-1 11/11 None
GENEFINDER00000043555 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:8631281:8639309:-1 11/11 None
F43G9.6 ENSEMBL cdna:known chromosome:CEL140:I:8631212:8639309:-1 gene:F43G9.6 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:8631211-8639240(-) 100.0 100.0
Public Domain and Genome References
Gene Title C2 domain (2 domains)
Gene Symbol fer-1
Ensembl F43G9.6
Entrez Gene 172659 Entrez gene
SwissProt Q17388 EMBL-EBI
WormBase CE10364 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFA.16990.1.S1_AT similar to Dysferlin (Dystrophy associated fer-1-like protein) (Fer-1 like protein 1) cfa
CANINE_2:CFAAFFX.14261.1.S1_S_AT similar to Dysferlin (Dystrophy associated fer-1-like protein) (Fer-1 like protein 1) cfa
HG-U133_PLUS_2:218660_AT dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) hs
HG-U133A:218660_AT dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) hs
HG-FOCUS:218660_AT dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) hs
HG-U133A_2:218660_AT dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) hs
HU35KSUBB:RC_R63695_AT dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) hs
U133_X3P:G4503430_3P_S_AT dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) hs
U133_X3P:G4503430_3P_AT dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) hs
U133_X3P:218660_3P_AT dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) hs
HG-U95B:43293_AT dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) hs
HG-U95D:87785_R_AT Dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) hs
MOE430A:1451891_A_AT dysferlin mm
MOUSE430A_2:1451891_A_AT dysferlin mm
MOUSE430_2:1451891_A_AT dysferlin mm
MG-U74BV2:115504_G_AT dysferlin mm
MG-U74BV2:115503_AT dysferlin mm
MG-U74BV2:112940_I_AT dysferlin mm
MG-U74CV2:130918_AT dysferlin mm
MOE430A:1427318_S_AT dysferlin mm
MOUSE430A_2:1427318_S_AT dysferlin mm
MOUSE430_2:1427318_S_AT dysferlin mm
RG-U34B:RC_AA850891_AT dysferlin (predicted) rn
RAE230B:1379847_AT dysferlin (predicted) rn
RAT230_2:1379847_AT dysferlin (predicted) rn
Gene Ontology
GO Cellular Component (view graph)
ID Description Evidence Links
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB02109 Hypothetical protein F43G9.6 [Caenorhabditis elegans] ref|NP_492337.1| FERtilization defective (abnormal sperm) family member (fer-1) [Caenorhabditis elegans] sp|Q17388|FER1_CAEEL Sperm vesicle fusion protein fer-1 gb|AAB02243.1| FER-1 0.0
blast CAE68964 Hypothetical protein CBG14944 [Caenorhabditis briggsae] 0.0
blast AAB52425 Hypothetical protein T05E8.1 [Caenorhabditis elegans] ref|NP_491602.1| T05E8.1 [Caenorhabditis elegans] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000008 EMBL-EBI C2 domain 7.6E-7
Pfam IPR000008 EMBL-EBI C2 domain 2.1E-13
Pfam IPR000008 EMBL-EBI C2 domain 3.9E-4
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_492337.1 1 1997-2019
F43G9.6 1 1997-2019
SNAP00000043541 1 1997-2019
GENEFINDER00000043555 1 1997-2019
Sequence
Target Sequence 
>C. ELEGANS:192174_AT
catccgacgttggtgtctactcaacaaagaagagacagcgtggagtgaagtgtccaaagt
gttgtaccaggagaggatgtctctgcaaatgctgtatcttctgctttgagaccaagtgct
tgtgtggaaaacgcaaagtgaagaagaagccattcccgaagcctgtgttgttcgtggaac
cagaaggttacgatgatactgtgaacatcttcgaatctcgcaacttgtacggttggtggc
caatgcttaccgaggagtatccacacgaggaacctcagaatgccaagaagaagaatgatg
acgttggaaaggatcctaaatggatcatgggtcttgttgagatggacatgctacttctca
ccaaacaagaagccgatcaagagccagctggaaagaaacgatccgagccgaaccacagcc
cattcttggaaaaacctgatcggaagtcatgggccaactcgtggttggtgtcccgaatca
agccgtgcatcaagtatttctggcactactatggtcttcaaattctgctctggctcatca
ttattgttattctgattctcacaattttcgtgttgttgcacacttggccga

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CATCCGACGTTGGTGTCTACTCAAC 465 211 5492 Antisense
ATGCTGTATCTTCTGCTTTGAGACC 171 43 5580 Antisense
CCATTCCCGAAGCCTGTGTTGTTCG 370 265 5641 Antisense
GAACATCTTCGAATCTCGCAACTTG 344 351 5694 Antisense
GAGATGGACATGCTACTTCTCACCA 593 395 5830 Antisense
CGAACCACAGCCCATTCTTGGAAAA 543 253 5900 Antisense
GGAAGTCATGGGCCAACTCGTGGTT 443 529 5933 Antisense
ACTCGTGGTTGGTGTCCCGAATCAA 215 59 5948 Antisense
ATTTCTGGCACTACTATGGTCTTCA 436 17 5987 Antisense
ATTCTGCTCTGGCTCATCATTATTG 306 11 6013 Antisense
TTCGTGTTGTTGCACACTTGGCCGA 404 691 6058 Antisense
Sequence Source Affymetrix Proprietary Database