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[192159_at] Protein kinase C terminal domain

Description F46F6.2 /REP_DB=WormBase Gene ID /WP=CE18699 /TR=O17874 /GB=CAA90345.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=Protein kinase C terminal domain
Cluster 6grp_highest_10_10 > 52      6grp_high1_10_10 > 35      4grp_highest_8_8 > 44      4grp_high_8_8 > 16      6grp_highest_nonorm > 60      6grp_total > 36      4grp_total > 31      6grp_highest_sub > 01_02      6grp_high1_sub > 02      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 247
1 2 3 4 range
A 482.2
(3)
P 		318.9
(-2.4)
P 		299.5
(-3)
P 		414.2
(0.8)
P 		183
B 514.7
(3)
P 		267.4
(-3)
P 		303.4
(-2.1)
P 		418.3
(0.7)
P 		247
C 431.9
(3)
P 		353.9
(-3)
P 		371.3
(-1.7)
P 		356.1
(-2.8)
P 		78
avr 476.3
(3) 		313.4
(-3) 		324.7
(-2.6) 		396.2
(0) 		163

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 402
1 2 3 4 5 6 range
A 422.6
(0.6)
P 		531.1
(3)
P 		282.9
(-2.5)
P 		259.2
(-3)
P 		367.6
(-0.6)
P 		435.2
(0.9)
P 		272
B 375.5
(-0.1)
P 		471.4
(3)
P 		409.2
(1)
P 		362.1
(-0.5)
P 		283.9
(-3)
P 		395.3
(0.6)
P 		188
C 660.9
(3)
P 		549.3
(0.8)
P 		353.2
(-3)
P 		390.5
(-2.3)
P 		369
(-2.7)
P 		469.8
(-0.7)
P 		308
avr 486.3
(2) 		517.3
(3) 		348.4
(-2.6) 		337.3
(-3) 		340.2
(-2.9) 		433.4
(0.2) 		180
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 116
1 2 3 4 range
A 175.6
(3)
P 		69.2
(-2.6)
P 		78.3
(-2.1)
P 		60.6
(-3)
P 		115
B 164.1
(3)
P 		66
(-3)
P 		70.3
(-2.7)
P 		89.1
(-1.6)
P 		98
C 143
(3)
P 		101.7
(0)
P 		129.4
(2)
P 		60
(-3)
P 		83
avr 160.9
(3) 		79
(-2.4) 		92.7
(-1.5) 		69.9
(-3) 		91

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 183
1 2 3 4 5 6 range
A 77.9
(-2.2)
P 		188.9
(3)
P 		61.6
(-3)
P 		65.7
(-2.8)
P 		110.9
(-0.7)
P 		106
(-0.9)
P 		127
B 130.7
(0.4)
P 		156.9
(3)
P 		99.4
(-2.7)
P 		95.9
(-3)
P 		115.3
(-1.1)
P 		147.4
(2.1)
P 		61
C 245
(3)
P 		167.6
(0.2)
P 		89.9
(-2.6)
P 		78.5
(-3)
P 		119.4
(-1.5)
P 		157.3
(-0.2)
P 		167
avr 151.2
(1.7) 		171.1
(3) 		83.6
(-2.8) 		80
(-3) 		115.2
(-0.7) 		136.9
(0.7) 		91
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192159_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.16375
Sequence Type Exemplar sequence
Representative Public ID F46F6.2 NCBI
Target Description F46F6.2 /REP_DB=WormBase Gene ID /WP=CE18699 /TR=O17874 /GB=CAA90345.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=Protein kinase C terminal domain
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077341(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077341 NCBI Caenorhabditis elegans F46F6.2 (F46F6.2) mRNA, complete cds. 11/11 None
F46F6.2 ENSEMBL cdna:known chromosome:CEL140:X:10397171:10402492:1 gene:F46F6.2 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:10397323-10401857(+) 100.0 100.0
Public Domain and Genome References
Gene Title Protein kinase C terminal domain
Ensembl F46F6.2
Entrez Gene 181244 Entrez gene
SwissProt O17874 EMBL-EBI
WormBase CE31703 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.30975.1.S1_AT similar to protein kinase N2 cfa
CANINE_2:CFAAFFX.30977.1.S1_S_AT similar to protein kinase N2 cfa
CANINE_2:CFAAFFX.30980.1.S1_S_AT similar to protein kinase N2 cfa
DROSOPHILA_2:1640417_A_AT Protein kinase related to protein kinase N dm
DROSGENOME1:142919_S_AT Protein kinase related to protein kinase N dm
CHICKEN:GGA.19651.1.S1_AT protein kinase N2 gga
CHICKEN:GGA.19651.1.S1_S_AT protein kinase N2 gga
CHICKEN:GGA.2682.1.A1_AT protein kinase N2 gga
CHICKEN:GGA.2682.1.A1_S_AT protein kinase N2 gga
CHICKEN:GGA.8657.1.S1_AT protein kinase N2 gga
HG-U133_PLUS_2:210969_AT protein kinase N2 hs
HG-U133A:210969_AT protein kinase N2 hs
HG-U133A_2:210969_AT protein kinase N2 hs
HG-U95AV2:199_S_AT protein kinase N2 hs
HC-G110:199_S_AT protein kinase N2 hs
HUGENEFL:U33052_S_AT protein kinase N2 hs
U133_X3P:G6650823_RC_3P_AT protein kinase N2 hs
U133_X3P:G6650823_RC_3P_A_AT protein kinase N2 hs
U133_X3P:HS.69171.3.A1_3P_AT protein kinase N2 hs
U133_X3P:HS.69171.2.S1_3P_A_AT protein kinase N2 hs
HG-U133A_2:212629_S_AT protein kinase N2 hs
HG-U133_PLUS_2:212629_S_AT protein kinase N2 hs
HG-U133A:212629_S_AT protein kinase N2 hs
HG-U133_PLUS_2:230400_S_AT protein kinase N2 hs
HG-U133B:230400_S_AT protein kinase N2 hs
HG-U95AV2:36835_AT protein kinase N2 hs
HG-U133_PLUS_2:216112_AT Protein kinase N2 hs
HG-U133A_2:216112_AT Protein kinase N2 hs
HG-U133A:216112_AT Protein kinase N2 hs
HU35KSUBD:RC_AA252537_AT Protein kinase N2 hs
U133_X3P:HS.69171.2.S2_3P_AT Protein kinase N2 hs
U133_X3P:HS.301390.0.S1_3P_X_AT Protein kinase N2 hs
U133_X3P:HS.301390.0.S1_3P_AT Protein kinase N2 hs
U133_X3P:216112_3P_AT Protein kinase N2 hs
HG-U133A_2:212628_AT Protein kinase N2 hs
HG-FOCUS:212628_AT Protein kinase N2 hs
HG-U133_PLUS_2:212628_AT Protein kinase N2 hs
HG-U133A:212628_AT Protein kinase N2 hs
HG-U95B:55492_AT Protein kinase N2 hs
HG-U133_PLUS_2:241271_AT Protein kinase N2 hs
HG-U133B:241271_AT Protein kinase N2 hs
HG-U95C:52487_AT Protein kinase N2 hs
HG-U95E:89563_AT Protein kinase N2 hs
HU35KSUBB:RC_H93319_AT Protein kinase N2 hs
U133_X3P:HS.34262.0.A1_3P_AT Protein kinase N2 hs
MU11KSUBB:MSA.33934.0_S_AT protein kinase N2 mm
MG-U74AV2:104503_AT protein kinase N2 mm
MG-U74BV2:109357_AT protein kinase N2 mm
MG-U74CV2:135668_AT protein kinase N2 mm
MG-U74CV2:140939_AT protein kinase N2 mm
MG-U74BV2:163931_AT protein kinase N2 mm
MG-U74CV2:170612_AT protein kinase N2 mm
MOE430B:1437296_AT protein kinase N2 mm
MOUSE430_2:1437296_AT protein kinase N2 mm
MOE430B:1437295_AT protein kinase N2 mm
MOUSE430_2:1437295_AT protein kinase N2 mm
MU19KSUBA:TC17025_AT Protein kinase N2 (Pkn2), mRNA mm
MU19KSUBA:TC23305_AT Protein kinase N2 (Pkn2), mRNA mm
MU19KSUBC:TC41027_AT Protein kinase N2 (Pkn2), mRNA mm
RG-U34A:U75358_AT protein kinase C-like 2 rn
RAE230A:1393055_AT protein kinase C-like 2 rn
RAT230_2:1393055_AT protein kinase C-like 2 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7165 signal transduction inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5622 intracellular inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA90345 Hypothetical protein F46F6.2 [Caenorhabditis elegans] emb|CAA90339.4| Hypothetical protein F46F6.2 [Caenorhabditis elegans] ref|NP_509742.2| F46F6.2 [Caenorhabditis elegans] 0.0
blast CAE70574 Hypothetical protein CBG17230 [Caenorhabditis briggsae] 0.0
blast AAF58959 CG2049-PE, isoform E [Drosophila melanogaster] ref|NP_788294.1| CG2049-PE, isoform E [Drosophila melanogaster] 1.0E-121
Protein Families
Method ID Description E-Value
hanks 1.2.14 AGC group; AGC I Diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family; pck1+ 1.0E-82
Protein Domains
Database ID Description E-Value
scop a.2.6.Effector domain of the protein kinase pkn/prk1 All alpha proteins; Long alpha-hairpin; Effector domain of the protein kinase pkn/prk1; Effector domain of the protein kinase pkn/prk1 2.09999990463257
scop a.2.6.Effector domain of the protein kinase pkn/prk1 All alpha proteins; Long alpha-hairpin; Effector domain of the protein kinase pkn/prk1; Effector domain of the protein kinase pkn/prk1 0.025000000372529
scop a.2.6.Effector domain of the protein kinase pkn/prk1 All alpha proteins; Long alpha-hairpin; Effector domain of the protein kinase pkn/prk1; Effector domain of the protein kinase pkn/prk1 5.59999990463257
scop a.2.6.Effector domain of the protein kinase pkn/prk1 All alpha proteins; Long alpha-hairpin; Effector domain of the protein kinase pkn/prk1; Effector domain of the protein kinase pkn/prk1 0.0659999996423721
Pfam IPR000861 EMBL-EBI PKN/rhophilin/rhotekin rho-binding repeat 7.6E-22
Pfam IPR000719 EMBL-EBI Protein kinase 4.9E-75
Pfam IPR000961 EMBL-EBI Protein kinase C-terminal domain 1.7E-15
Sequence
Target Sequence 
>C. ELEGANS:192159_AT
aagttggacaatctcctcttggacagagaaggatatgtcaaaattgccgattttggtcta
tgtaaagagaacatgggaccatttgacaagactagcactttttgtggaactccagagttt
cttgctcctgaagtcttgtctgattcttcatacactcgtgcgattgactggtggggactc
ggagttcttattttcgaaatgcttgtaggagagccaccattcagtggagatgacgaagaa
gagatatttgactcgattatctccgaagacgttcgctatccaagatatttgtctgttgag
tcgattgccattatgagaagactccttcgcaaggtgcctgaaaaacgtcttggatacgga
gagcgagacgctgaagatatcaagattcaacgattcttccgtcacatctcatgggaatgg
gacaaattgctgaatcgtgagattcgtccaccattccaaccacaaattcgcaacccagaa
gacgtgtctaactttgacctggaattcacccaagagaaagctcgtttttctgctgcttcg
agcactcgtccaatcactgaagccgat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AAGTTGGACAATCTCCTCTTGGACA 198 155 2461 Antisense
ACTCCAGAGTTTCTTGCTCCTGAAG 513 97 2569 Antisense
GCTCCTGAAGTCTTGTCTGATTCTT 236 299 2584 Antisense
GATTCTTCATACACTCGTGCGATTG 650 431 2602 Antisense
TGACTGGTGGGGACTCGGAGTTCTT 339 567 2625 Antisense
ATCTCCGAAGACGTTCGCTATCCAA 203 33 2719 Antisense
GACTCCTTCGCAAGGTGCCTGAAAA 172 375 2780 Antisense
ATTCTTCCGTCACATCTCATGGGAA 563 11 2853 Antisense
AATCGTGAGATTCGTCCACCATTCC 520 169 2893 Antisense
AGAAAGCTCGTTTTTCTGCTGCTTC 273 73 2975 Antisense
CACTCGTCCAATCACTGAAGCCGAT 227 195 3003 Antisense
Sequence Source Affymetrix Proprietary Database