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[192153_at] pyrroline-5-carboxylate reductase

Description M153.1 /REP_DB=WormBase Gene ID /WP=CE03511 /TR=Q21544 /GB=CAA91943.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=pyrroline-5-carboxylate reductase
Cluster 6grp_highest_10_10 > 28      6grp_high1_10_10 > 81      4grp_highest_8_8 > 10      4grp_high_8_8 > 54      6grp_highest_nonorm > 53      6grp_total > 81      4grp_total > 57      6grp_highest_sub > 04      6grp_high1_sub > 04      6grp_total_sub > Hat      6grp_rule_based > S4      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 2273
1 2 3 4 range
A 421.3
(-2.5)
P 		2052.4
(1.8)
P 		2504.5
(3)
P 		250.2
(-3)
P 		2254
B 525.7
(-2.3)
P 		2124.2
(2.2)
P 		2397.3
(3)
P 		286.7
(-3)
P 		2111
C 429
(-2.3)
P 		1917.8
(2.6)
P 		2031.2
(3)
P 		231.7
(-3)
P 		1800
avr 458.7
(-2.4) 		2031.5
(2.2) 		2311
(3) 		256.2
(-3) 		2055

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1056
1 2 3 4 5 6 range
A 502.1
(-3)
P 		884.7
(-0.7)
P 		789.7
(-1.3)
P 		1517.9
(3)
P 		1202.4
(1.1)
P 		781.3
(-1.4)
P 		1016
B 461.5
(-3)
P 		878.1
(-0.4)
P 		895.9
(-0.3)
P 		1412
(3)
P 		1129.6
(1.2)
P 		617.3
(-2)
P 		951
C 485.5
(-3)
P 		892.7
(-0.3)
P 		1087.8
(1)
P 		1400.1
(3)
P 		1138.9
(1.3)
P 		711
(-1.5)
P 		915
avr 483
(-3) 		885.2
(-0.5) 		924.5
(-0.2) 		1443.3
(3) 		1157
(1.2) 		703.2
(-1.6) 		960
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 671
1 2 3 4 range
A 153.4
(-1.9)
P 		445.5
(1)
P 		654.7
(3)
P 		36.6
(-3)
P 		618
B 167.7
(-1.7)
P 		524.6
(2.6)
P 		555.5
(3)
P 		61.1
(-3)
P 		494
C 142
(-2.1)
P 		551.4
(1.6)
P 		707.9
(3)
P 		39.1
(-3)
P 		669
avr 154.4
(-1.9) 		507.2
(1.7) 		639.4
(3) 		45.6
(-3) 		594

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 366
1 2 3 4 5 6 range
A 92.6
(-3)
P 		314.6
(1.6)
P 		172
(-1.4)
P 		385
(3)
P 		362.8
(2.5)
P 		190.2
(-1)
P 		292
B 160.6
(-3)
P 		292.3
(-0.4)
P 		217.5
(-1.9)
P 		374
(1.3)
P 		459
(3)
P 		230.2
(-1.6)
P 		298
C 179.9
(-3)
P 		272.4
(-0.1)
P 		276.9
(0.1)
P 		281.6
(0.2)
P 		368.5
(3)
P 		238
(-1.2)
P 		189
avr 144.4
(-3) 		293.1
(0.5) 		222.1
(-1.2) 		346.9
(1.8) 		396.8
(3) 		219.5
(-1.2) 		252
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192153_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.16003
Sequence Type Exemplar sequence
Representative Public ID M153.1 NCBI
Target Description M153.1 /REP_DB=WormBase Gene ID /WP=CE03511 /TR=Q21544 /GB=CAA91943.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=pyrroline-5-carboxylate reductase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077631(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077631 NCBI Caenorhabditis elegans M153.1 (M153.1) mRNA, complete cds. 11/11 None
GENEFINDER00000043670 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:12144035:12148171:1 11/11 None
SNAP00000043667 ENSEMBL cdna:SNAP chromosome:CEL140:X:12146766:12148171:1 11/11 None
M153.1 ENSEMBL cdna:known chromosome:CEL140:X:12146755:12148610:1 gene:M153.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:12146765-12148171(+) 100.0 100.0
Public Domain and Genome References
Gene Title pyrroline-5-carboxylate reductase
Ensembl M153.1
Entrez Gene 181380 Entrez gene
SwissProt Q21544 EMBL-EBI
WormBase CE03511 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:246594_AT pyrroline-5-carboxylate reductase at
CANINE_2:CFAAFFX.2881.1.S1_S_AT similar to pyrroline-5-carboxylate reductase-like cfa
DROSOPHILA_2:1631266_A_AT dm
DROSGENOME1:150080_AT dm
CHICKEN:GGA.5903.1.S1_AT similar to pyrroline-5-carboxylate reductase-like gga
HU35KSUBC:RC_AA436257_AT pyrroline-5-carboxylate reductase-like hs
HG-U133A:218944_AT pyrroline-5-carboxylate reductase-like hs
HG-U133_PLUS_2:218944_AT pyrroline-5-carboxylate reductase-like hs
HG-U133A_2:218944_AT pyrroline-5-carboxylate reductase-like hs
U133_X3P:G12751492_3P_AT pyrroline-5-carboxylate reductase-like hs
HG-U95B:58329_AT pyrroline-5-carboxylate reductase-like hs
MU11KSUBA:C76019_RC_AT pyrroline-5-carboxylate reductase-like mm
MU11KSUBA:C76019_RC_G_AT pyrroline-5-carboxylate reductase-like mm
MG-U74AV2:160197_AT pyrroline-5-carboxylate reductase-like mm
MOE430A:1416400_AT pyrroline-5-carboxylate reductase-like mm
MOUSE430A_2:1416400_AT pyrroline-5-carboxylate reductase-like mm
MOUSE430_2:1416400_AT pyrroline-5-carboxylate reductase-like mm
MG-U74CV2:166965_AT Pyrroline-5-carboxylate reductase-like, mRNA (cDNA clone MGC:35759 IMAGE:4987954) mm
MU19KSUBA:TC23433_AT Pyrroline-5-carboxylate reductase-like, mRNA (cDNA clone MGC:35759 IMAGE:4987954) mm
RAE230B:1381832_AT pyrroline-5-carboxylate reductase-like (predicted) rn
RAT230_2:1381832_AT pyrroline-5-carboxylate reductase-like (predicted) rn
RAE230B:1392535_AT pyrroline-5-carboxylate reductase-like (predicted) rn
RAT230_2:1392535_AT pyrroline-5-carboxylate reductase-like (predicted) rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6561 proline biosynthesis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4735 pyrroline-5-carboxylate reductase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA91943 Hypothetical protein M153.1 [Caenorhabditis elegans] ref|NP_510032.1| M153.1 [Caenorhabditis elegans] 1.0E-151
blast CAE69881 Hypothetical protein CBG16221 [Caenorhabditis briggsae] 1.0E-148
blast CAE69881 Hypothetical protein CBG16221 [Caenorhabditis briggsae] 1.0E-147
blast CAA91945 Hypothetical protein M153.3 [Caenorhabditis elegans] ref|NP_510031.1| M153.3 [Caenorhabditis elegans] 1.0E-115
blast XP_418406 PREDICTED: similar to pyrroline-5-carboxylate reductase-like [Gallus gallus] 6.0E-67
Protein Domains
Database ID Description E-Value
Pfam IPR000304 EMBL-EBI Delta 1-pyrroline-5-carboxylate reductase 1.0E-126
Pfam IPR000304 EMBL-EBI Delta 1-pyrroline-5-carboxylate reductase 1.0E-126
Sequence
Target Sequence 
>C. ELEGANS:192153_AT
aagttgcttctgaaatcgctccagcccttagcaaagaacatttggtagtttctattgcac
ttggaatcactataagaaatattgaatcgcttctcccaacgaaatctcgagtggtacgtg
tcatgccaaataccccatcagttgttcgcgccggtgcatcagcgttcgccatgggatctg
cttgtcgtgatggcgacgccgaaactgtagagaaactcttgagcactgttggttttgcag
tggaggttccagaaattcatatcgacccagtaacaggactctccggctctggaccaagtt
atatgttcgctgtgatcgaagggcttgctgacggcggtgttaaagttggacttccacgtg
accttgctctgaagcttgcggcttatactttacttggagccgcaaagatggttctagaaa
ctggtattcatccagctcagttgaaggatgacgttcaaagtcctgcaggttcatcagtat
atggaatgcacaaattggagagtggagggctcaagggtgttcttatggatgctgtcgagg
cggctacaaaccggtcaa

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AAGTTGCTTCTGAAATCGCTCCAGC 633 155 242 Antisense
TCGCTCCAGCCCTTAGCAAAGAACA 373 599 257 Antisense
TGAATCGCTTCTCCCAACGAAATCT 483 575 324 Antisense
AATCTCGAGTGGTACGTGTCATGCC 607 169 344 Antisense
GCCAAATACCCCATCAGTTGTTCGC 542 277 366 Antisense
TGCATCAGCGTTCGCCATGGGATCT 426 579 396 Antisense
CATGGGATCTGCTTGTCGTGATGGC 305 209 411 Antisense
TATCGACCCAGTAACAGGACTCTCC 536 657 501 Antisense
AAAGTTGGACTTCCACGTGACCTTG 248 123 583 Antisense
AGCTTGCGGCTTATACTTTACTTGG 606 77 614 Antisense
GTCGAGGCGGCTACAAACCGGTCAA 119 473 775 Antisense
Sequence Source Affymetrix Proprietary Database