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[192144_s_at] sphingomyelin phosphodiesterase

Description ZK455.4 /REP_DB=WormBase Gene ID /WP=CE15335 /TR=Q23498 /GB=CAA91493.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=sphingomyelin phosphodiesterase
Cluster 6grp_highest_10_10 > 16      6grp_high1_10_10 > 51      4grp_highest_8_8 > 51      4grp_high_8_8 > 32      6grp_highest_nonorm > 43      6grp_total > 51      4grp_total > 47      6grp_highest_sub > 03_04      6grp_cgc > 83      6grp_high1_sub > 03      6grp_cgc_sub > 03      6grp_total_sub > Hat      6grp_rule_based > S3      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1057
1 2 3 4 range
A 1643.4
(3)
P 		630.6
(-3)
P 		680.4
(-2.7)
P 		639.3
(-2.9)
P 		1013
B 1687.8
(3)
P 		743
(-2.5)
P 		834.1
(-1.9)
P 		652.5
(-3)
P 		1035
C 1653
(3)
P 		634.8
(-3)
P 		677.8
(-2.7)
P 		712.4
(-2.5)
P 		1018
avr 1661.4
(3) 		669.5
(-3) 		730.8
(-2.6) 		668.1
(-3) 		993

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 899
1 2 3 4 5 6 range
A 948.1
(-0.6)
P 		1271.1
(1.7)
P 		1453.5
(3)
P 		1258.6
(1.6)
P 		950.9
(-0.6)
P 		609.5
(-3)
P 		844
B 978.5
(-0.7)
P 		1149.3
(0.5)
P 		1498.8
(2.9)
P 		1508.4
(3)
P 		1002.4
(-0.6)
P 		653.3
(-3)
P 		855
C 945.1
(-0.7)
P 		1060.9
(0.4)
P 		1330
(3)
P 		1249.4
(2.2)
P 		993.9
(-0.2)
P 		699
(-3)
P 		631
avr 957.2
(-0.6) 		1160.4
(0.9) 		1427.4
(3) 		1338.8
(2.3) 		982.4
(-0.5) 		653.9
(-3) 		774
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 505
1 2 3 4 range
A 598.4
(3)
P 		136.9
(-2.5)
P 		177.9
(-2)
P 		93.6
(-3)
P 		505
B 538.2
(3)
P 		183.5
(-2.3)
P 		193.3
(-2.2)
P 		139
(-3)
P 		399
C 547.2
(3)
P 		182.5
(-2.1)
P 		236.2
(-1.4)
P 		120.1
(-3)
P 		427
avr 561.3
(3) 		167.6
(-2.3) 		202.5
(-1.9) 		117.6
(-3) 		444

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 304
1 2 3 4 5 6 range
A 174.8
(-2.5)
P 		452.1
(3)
P 		316.5
(0.3)
P 		319.2
(0.4)
P 		286.9
(-0.3)
P 		148.4
(-3)
P 		304
B 340.5
(0.6)
P 		382.5
(2.1)
P 		364
(1.4)
P 		399.5
(2.7)
P 		407.3
(3)
P 		243.6
(-3)
P 		164
C 350.3
(3)
P 		323.7
(1.6)
P 		338.5
(2.4)
P 		251.3
(-2.1)
P 		321.6
(1.5)
P 		234
(-3)
P 		116
avr 288.5
(-0.3) 		386.1
(3) 		339.7
(1.4) 		323.3
(0.9) 		338.6
(1.4) 		208.7
(-3) 		177
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 192144_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.16467
Sequence Type Exemplar sequence
Representative Public ID ZK455.4 NCBI
Target Description ZK455.4 /REP_DB=WormBase Gene ID /WP=CE15335 /TR=Q23498 /GB=CAA91493.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=sphingomyelin phosphodiesterase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077493(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077493 NCBI Caenorhabditis elegans Acid SphingoMyelinase family member (asm-2) (asm-2) mRNA, complete cds. 11/11 None
SNAP00000004973 ENSEMBL cdna:SNAP chromosome:CEL140:X:11321079:11324175:-1 11/11 None
GENEFINDER00000004982 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:11321079:11326674:-1 11/11 None
ZK455.4 ENSEMBL cdna:known chromosome:CEL140:X:11321016:11324175:-1 gene:ZK455.4 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:11321078-11324175(-) 100.0 100.0
Public Domain and Genome References
Gene Title sphingomyelin phosphodiesterase
Gene Symbol asm-2
Ensembl ZK455.4
Entrez Gene 181323 Entrez gene
SwissProt Q23498 EMBL-EBI
WormBase CE31674 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1584078_AT sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) cfa
CANINE_2:CFA.12162.1.A1_AT sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) cfa
CANINE_2:CFAAFFX.10577.1.S1_S_AT sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) cfa
CANINE_2:CFAAFFX.10581.1.S1_S_AT sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) cfa
DROSOPHILA_2:1639637_A_AT dm
DROSGENOME1:152558_AT dm
CHICKEN:GGAAFFX.11117.1.S1_AT similar to Sphingomyelin phosphodiesterase precursor (Acid sphingomyelinase) (aSMase) gga
CHICKEN:GGAAFFX.9244.1.S1_AT similar to Sphingomyelin phosphodiesterase precursor (Acid sphingomyelinase) (aSMase) gga
HG-U133_PLUS_2:209420_S_AT sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) hs
HG-FOCUS:209420_S_AT sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) hs
HG-U133A:209420_S_AT sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) hs
HG-U133A_2:209420_S_AT sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) hs
HU35KSUBD:RC_AA416890_I_AT sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) hs
HU35KSUBD:RC_AA416890_S_AT sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) hs
HUGENEFL:M81780_CDS5_AT sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) hs
HUGENEFL:M59916_AT sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) hs
U133_X3P:G179094_3P_A_AT sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) hs
U133_X3P:HS.77813.2.S1_3P_X_AT sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) hs
U133_X3P:HS.77813.2.S1_3P_S_AT sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) hs
U133_X3P:HS.77813.2.S1_3P_A_AT sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) hs
U133_X3P:HS.247962.0.S1_3P_AT sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) hs
U133_X3P:216230_3P_X_AT sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) hs
HG-U133A_2:216230_X_AT sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) hs
HG-U133_PLUS_2:216230_X_AT sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) hs
HG-U133A:216230_X_AT sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) hs
HG-U133A_2:217171_AT sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) hs
HG-U133_PLUS_2:217171_AT sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) hs
HG-U133A:217171_AT sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) hs
HG-U95AV2:32574_AT sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) hs
HG-U95AV2:37372_AT sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) hs
MOUSE430_2:1447874_X_AT sphingomyelin phosphodiesterase 1, acid lysosomal mm
MOE430B:1447874_X_AT sphingomyelin phosphodiesterase 1, acid lysosomal mm
MU11KSUBB:Z14252_S_AT sphingomyelin phosphodiesterase 1, acid lysosomal mm
MG-U74AV2:100099_AT sphingomyelin phosphodiesterase 1, acid lysosomal mm
MOE430A:1448621_A_AT sphingomyelin phosphodiesterase 1, acid lysosomal mm
MOUSE430A_2:1448621_A_AT sphingomyelin phosphodiesterase 1, acid lysosomal mm
MOUSE430_2:1448621_A_AT sphingomyelin phosphodiesterase 1, acid lysosomal mm
MG-U74AV2:161789_R_AT Sphingomyelin phosphodiesterase 1, acid lysosomal, mRNA (cDNA clone MGC:25355 IMAGE:4482098) mm
RG-U34C:RC_AI169302_AT sphingomyelin phosphodiesterase 1, acid lysosomal rn
RAE230A:1388552_AT sphingomyelin phosphodiesterase 1, acid lysosomal rn
RAT230_2:1388552_AT sphingomyelin phosphodiesterase 1, acid lysosomal rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6629 lipid metabolism inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
16787 hydrolase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA91493 Hypothetical protein ZK455.4 [Caenorhabditis elegans] ref|NP_509894.2| Acid SphingoMyelinase family member (asm-2) [Caenorhabditis elegans] sp|Q23498|ASM2_CAEEL Sphingomyelin phosphodiesterase 2 precursor (Acid sphingomyelinase 2) 0.0
blast CAE70658 Hypothetical protein CBG17365 [Caenorhabditis briggsae] 0.0
blast CAA91490 Hypothetical protein ZK455.5 [Caenorhabditis elegans] ref|NP_509895.2| ZK455.5 [Caenorhabditis elegans] 1.0E-154
blast AAH83780 Sphingomyelin phosphodiesterase 1, acid lysosomal [Rattus norvegicus] ref|NP_001006998.1| sphingomyelin phosphodiesterase 1, acid lysosomal [Rattus norvegicus] 6.0E-99
Protein Domains
Database ID Description E-Value
Pfam IPR004843 EMBL-EBI Metallo-phosphoesterase 2.5E-12
Pfam IPR007856 EMBL-EBI Saposin-like type B, 1 1.6E-11
Pfam IPR004843 EMBL-EBI Metallo-phosphoesterase 2.5E-12
Pfam IPR005069 EMBL-EBI Protein of unknown function DUF271 1.5E-126
Pfam IPR007856 EMBL-EBI Saposin-like type B, 1 1.6E-11
Trans Membrane
ID Number Of Domains Domain Boundaries
GENEFINDER00000004982 1 12-34
Sequence
Target Sequence 
>C. ELEGANS:192144_S_AT
tacgcagtgtacccgaaacctggtctcaaactgatttcactcaacactatttactgctcg
gagttcaatttctatttgtatgtaaatgaagtagatcccgatgcaacattggagtggtta
attgaagaattgcaggattcggaaaataagggagagctcgttcacatcatttctcatatt
ccaccgggcgataattattgtttgaaaggatggtcatggaacttcttcgagattgtgaag
cgttatgagaacaccattgcacaaatgttttatggacacactcattatgatcaattcatg
acggtcaaggatgcgaaaacatactttgcaaatgttactgaagccaatatgaaaaacaag
gaaccagaatgggtgctttcttacgacaccagagaacactatcaaatggctgatttctca
cctcaatcgtggtccgatttgagtgacaaactttggactaacactacactgtttagggat
tacgtgaggctctattaccgaaatcactac

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TACGCAGTGTACCCGAAACCTGGTC 378 643 1117 Antisense
ACCTGGTCTCAAACTGATTTCACTC 417 87 1134 Antisense
AACACTATTTACTGCTCGGAGTTCA 271 127 1159 Antisense
GAAGTAGATCCCGATGCAACATTGG 114 333 1204 Antisense
GTTCACATCATTTCTCATATTCCAC 402 445 1276 Antisense
CTCATATTCCACCGGGCGATAATTA 52 229 1289 Antisense
GGATGGTCATGGAACTTCTTCGAGA 676 513 1324 Antisense
ATGGGTGCTTTCTTACGACACCAGA 368 51 1485 Antisense
TCAAATGGCTGATTTCTCACCTCAA 155 629 1518 Antisense
TTCTCACCTCAATCGTGGTCCGATT 89 691 1531 Antisense
GAGGCTCTATTACCGAAATCACTAC 10 407 1602 Antisense
Sequence Source Affymetrix Proprietary Database