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[192126_s_at] zinc metalloprotease

Description T24A11.3 /REP_DB=WormBase Gene ID /WP=CE02359 /GEN=toh-1 /TR=Q22710 /GB=CAA88882.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=zinc metalloprotease
Cluster 6grp_highest_10_10 > 48      6grp_high1_10_10 > 84      4grp_highest_8_8 > 10      4grp_high_8_8 > 55      6grp_highest_nonorm > 82      6grp_total > 73      4grp_total > 57      6grp_cgc > 65      6grp_total_sub > Hat      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 524
1 2 3 4 range
A 200.4
(-2.4)
P 		548.9
(2.6)
P 		578.9
(3)
P 		161.8
(-3)
P 		417
B 175.8
(-3)
P 		421.3
(-0.1)
P 		685.4
(3)
P 		203.5
(-2.7)
P 		510
C 194.4
(-2.8)
P 		567.3
(2)
P 		647.3
(3)
P 		177.1
(-3)
P 		470
avr 190.2
(-2.9) 		512.5
(1.4) 		637.2
(3) 		180.8
(-3) 		456

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 264
1 2 3 4 5 6 range
A 240.6
(-3)
P 		308
(-0.9)
P 		390.8
(1.7)
P 		321.8
(-0.4)
P 		430.9
(3)
P 		344.9
(0.3)
P 		190
B 210.2
(-3)
P 		361.5
(0.8)
P 		448.6
(3)
P 		356.7
(0.7)
P 		398.1
(1.7)
P 		403.6
(1.9)
P 		238
C 184.9
(-3)
P 		338
(1.2)
P 		329.9
(1)
P 		404.8
(3)
P 		388.3
(2.5)
P 		376
(2.2)
P 		220
avr 211.9
(-3) 		335.8
(0.8) 		389.8
(2.5) 		361.1
(1.6) 		405.8
(3) 		374.8
(2) 		194
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 202
1 2 3 4 range
A 73
(-0.7)
P 		119.2
(1.5)
P 		151.3
(3)
P 		23.7
(-3)
P 		128
B 56.1
(-2.3)
P 		104
(0.2)
P 		158.8
(3)
P 		43.4
(-3)
P 		115
C 64.4
(-1.9)
P 		163.1
(1.1)
P 		225.6
(3)
P 		29.9
(-3)
P 		196
avr 64.5
(-1.7) 		128.8
(1) 		178.6
(3) 		32.3
(-3) 		146

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 117
1 2 3 4 5 6 range
A 44.3
(-3)
P 		109.5
(1.6)
P 		85.1
(-0.1)
P 		81.6
(-0.4)
P 		130
(3)
P 		84
(-0.2)
P 		86
B 73.1
(-3)
P 		120.3
(0.2)
P 		108.9
(-0.6)
P 		94.5
(-1.6)
P 		161.7
(3)
P 		150.5
(2.2)
P 		89
C 68.5
(-3)
P 		103.1
(0.6)
P 		84
(-1.4)
P 		81.4
(-1.7)
P 		125.6
(3)
P 		125.9
(3)
P 		57
avr 62
(-3) 		111
(0.8) 		92.7
(-0.6) 		85.8
(-1.1) 		139.1
(3) 		120.1
(1.5) 		77
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 192126_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.7017
Sequence Type Exemplar sequence
Representative Public ID T24A11.3 NCBI
Target Description T24A11.3 /REP_DB=WormBase Gene ID /WP=CE02359 /GEN=toh-1 /TR=Q22710 /GB=CAA88882.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=zinc metalloprotease
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_065368(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_065368 NCBI Caenorhabditis elegans TOllisH (Tolloid and BMP-1 family) family member (toh-1) (toh-1) mRNA, complete cds. 11/11 None
SNAP00000027680 ENSEMBL cdna:SNAP chromosome:CEL140:III:3805086:3808992:-1 11/11 None
GENEFINDER00000027681 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:3805086:3809008:-1 11/11 None
T24A11.3 ENSEMBL cdna:known chromosome:CEL140:III:3804750:3809008:-1 gene:T24A11.3 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:3805085-3807714(-) 99.83 99.83
Public Domain and Genome References
Gene Title zinc metalloprotease
Gene Symbol toh-1
Ensembl T24A11.3
Entrez Gene 175491 Entrez gene
SwissProt Q22710 EMBL-EBI
WormBase CE35909 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
8237 metallopeptidase activity inferred from electronic annotation QuickGO AmiGO
8533 astacin activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA88882 Hypothetical protein T24A11.3 [Caenorhabditis elegans] ref|NP_497769.3| TOllisH (Tolloid and BMP-1 family) family member (toh-1) [Caenorhabditis elegans] sp|Q22710|NAS26_CAEEL Zinc metalloproteinase nas-26 precursor (Nematode astacin 26) (Tollish protein 1) 0.0
blast CAE64502 Hypothetical protein CBG09229 [Caenorhabditis briggsae] 0.0
blast CAE61297 Hypothetical protein CBG05121 [Caenorhabditis briggsae] 9.0E-71
Protein Domains
Database ID Description E-Value
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 6.1E-52
Pfam IPR000859 EMBL-EBI CUB 4.9E-5
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 6.1E-52
Pfam IPR000859 EMBL-EBI CUB 4.9E-5
Trans Membrane
ID Number Of Domains Domain Boundaries
GENEFINDER00000027681 1 7-29
Sequence
Target Sequence 
>C. ELEGANS:192126_S_AT
tcgccacgaagggtaccgtacgattacggtagtctgatgcattatcatacagttgctcat
gcggttaaggtgtcggattttacgattgttccaaaggaattgaagtatgtcacaacgatg
ggaactgagaaaatggcattcctagatgcaaaagttatcaatgatatttattgtccaaac
gcatgccaaggaagaaatcatttgaactgtcttgctggaggttatccagatccaaacaac
tgcaacgtttgtaggtgtcctgaaggacttggaggacccgactgtggtcgacttcagcca
tcaccttgtggtggagaaattcatgcatctgatcaatggcagacactctccagtccgtct
ggacgtgatgttcactgttattggaggatttctgtccccgaaggctcccgagttcgtttc
cgtttgtcagatggagaattcccatgctcctacggatgtcaatcgtacgtcgaaatcaag
cacaagcttgatgtaaggttgactggtttcagaagttgttgctaccgtccaaaagaggac
acagtctcggaaagcaatcaaatttttgtgatctaccatccaaatggccgtaccgc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TCGCCACGAAGGGTACCGTACGATT 444 597 562 Antisense
CAGTTGCTCATGCGGTTAAGGTGTC 497 205 611 Antisense
GAAATCATTTGAACTGTCTTGCTGG 368 363 755 Antisense
CTGCAACGTTTGTAGGTGTCCTGAA 643 235 801 Antisense
TGGAGGACCCGACTGTGGTCGACTT 628 549 831 Antisense
GATCAATGGCAGACACTCTCCAGTC 388 421 892 Antisense
GTCCGTCTGGACGTGATGTTCACTG 208 477 914 Antisense
CGAGTTCGTTTCCGTTTGTCAGATG 388 249 970 Antisense
TCCCATGCTCCTACGGATGTCAATC 112 599 1001 Antisense
GTTTCAGAAGTTGTTGCTACCGTCC 293 449 1067 Antisense
TCTACCATCCAAATGGCCGTACCGC 554 611 1133 Antisense
Sequence Source Affymetrix Proprietary Database