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[192114_s_at] cystathionine gamma-lyase

Description ZK1127.10 /REP_DB=WormBase Gene ID /WP=CE07648 /TR=SW:P55216 /GB=AAB93432.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=cystathionine gamma-lyase
Cluster 6grp_highest_10_10 > 25      6grp_high1_10_10 > 51      4grp_highest_8_8 > 38      4grp_high_8_8 > 03      6grp_highest_nonorm > 26      6grp_total > 40      4grp_total > 13      6grp_highest_sub > 03      6grp_high1_sub > 03      6grp_total_sub > Hat      6grp_rule_based > S3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 10681
1 2 3 4 range
A 9623.7
(-0.2)
P 		4783.4
(-3)
P 		4834
(-3)
P 		15053.3
(3)
P 		10270
B 9830.7
(1.1)
P 		5085
(-3)
P 		5028.7
(-3)
P 		12028.1
(3)
P 		6999
C 9009.4
(-0.1)
P 		4371.9
(-3)
P 		4588
(-2.9)
P 		13824.4
(3)
P 		9453
avr 9487.9
(0.2) 		4746.8
(-3) 		4816.9
(-3) 		13635.3
(3) 		8889

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 4770
1 2 3 4 5 6 range
A 4649.3
(-1.2)
P 		6184.7
(1.4)
P 		7183.5
(3)
P 		6353.3
(1.6)
P 		4134.1
(-2)
P 		3529.9
(-3)
P 		3654
B 4351.5
(-0.9)
P 		6058.2
(2.4)
P 		5741.4
(1.8)
P 		6357.6
(3)
P 		3791.8
(-2)
P 		3300
(-3)
P 		3058
C 4412.1
(-1.5)
P 		5839.2
(0.3)
P 		7963.5
(3)
P 		5725.5
(0.2)
P 		4155.2
(-1.8)
P 		3193.4
(-3)
P 		4770
avr 4471
(-1.1) 		6027.4
(1.5) 		6962.8
(3) 		6145.5
(1.6) 		4027
(-1.9) 		3341.1
(-3) 		3622
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 2466
1 2 3 4 range
A 3504
(3)
P 		1038.4
(-3)
P 		1263.7
(-2.5)
P 		2203.5
(-0.2)
P 		2466
B 3134.9
(3)
P 		1255.9
(-2.7)
P 		1165.3
(-3)
P 		2563.2
(1.3)
P 		1970
C 2982.4
(3)
P 		1257
(-3)
P 		1599
(-1.8)
P 		2331
(0.7)
P 		1725
avr 3207.1
(3) 		1183.8
(-3) 		1342.7
(-2.5) 		2365.9
(0.5) 		2023

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1343
1 2 3 4 5 6 range
A 857.1
(-3)
P 		2199.6
(3)
P 		1564.4
(0.2)
P 		1611.3
(0.4)
P 		1247.5
(-1.3)
P 		859.4
(-3)
P 		1343
B 1514.1
(-0.8)
P 		2016.5
(3)
P 		1394.2
(-1.8)
P 		1683.9
(0.5)
P 		1540.6
(-0.6)
P 		1230.5
(-3)
P 		786
C 1635.4
(0.5)
P 		1781.7
(1.5)
P 		2026.8
(3)
P 		1151.4
(-2.5)
P 		1344.6
(-1.3)
P 		1069
(-3)
P 		958
avr 1335.5
(-1.2) 		1999.3
(3) 		1661.8
(0.9) 		1482.2
(-0.3) 		1377.6
(-0.9) 		1053
(-3) 		946
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 192114_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.5955
Sequence Type Exemplar sequence
Representative Public ID ZK1127.10 NCBI
Target Description ZK1127.10 /REP_DB=WormBase Gene ID /WP=CE07648 /TR=SW:P55216 /GB=AAB93432.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=cystathionine gamma-lyase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_063048(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_063048 NCBI Caenorhabditis elegans ZK1127.10 (ZK1127.10) mRNA, complete cds. 11/11 None
SNAP00000033594 ENSEMBL cdna:SNAP chromosome:CEL140:II:7056246:7057873:-1 11/11 None
GENEFINDER00000033611 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:7056246:7057873:-1 11/11 None
ZK1127.10.1 ENSEMBL cdna:known chromosome:CEL140:II:7056107:7057998:-1 gene:ZK1127.10 11/11 None
ZK1127.10.2 ENSEMBL cdna:known chromosome:CEL140:II:7056118:7058160:-1 gene:ZK1127.10 11/11 None
ZK1127.10.3 ENSEMBL cdna:known chromosome:CEL140:II:7056121:7057918:-1 gene:ZK1127.10 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:7056241-7057869(-) 100.0 100.0
Public Domain and Genome References
Gene Title cystathionine gamma-lyase
Ensembl ZK1127.10
Entrez Gene 174155 Entrez gene
SwissProt P55216 EMBL-EBI
WormBase CE07648 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1604740_S_AT similar to cystathionase isoform 1 cfa
CANINE:1593421_AT similar to cystathionase isoform 1 cfa
CANINE_2:CFA.2065.1.A1_AT similar to cystathionase isoform 1 cfa
CANINE_2:CFA.359.1.S1_AT similar to cystathionase isoform 1 cfa
CANINE_2:CFAAFFX.31268.1.S1_AT similar to cystathionase isoform 1 cfa
CANINE_2:CFAAFFX.31268.1.S1_S_AT similar to cystathionase isoform 1 cfa
DROSOPHILA_2:1623861_AT dm
DROSGENOME1:154085_AT dm
CHICKEN:GGA.2872.1.S1_AT cystathionase (cystathionine gamma-lyase) gga
CHICKEN:GGAAFFX.23528.1.S1_AT cystathionase (cystathionine gamma-lyase) gga
HG-U95AV2:32962_AT cystathionase (cystathionine gamma-lyase) hs
HUGENEFL:S52028_S_AT cystathionase (cystathionine gamma-lyase) hs
HG-U133A:206085_S_AT cystathionase (cystathionine gamma-lyase) hs
HG-U133_PLUS_2:206085_S_AT cystathionase (cystathionine gamma-lyase) hs
HG-U133A_2:206085_S_AT cystathionase (cystathionine gamma-lyase) hs
U133_X3P:G4503124_3P_A_AT cystathionase (cystathionine gamma-lyase) hs
HG-U133A_2:217127_AT cystathionase (cystathionine gamma-lyase) hs
HG-FOCUS:217127_AT cystathionase (cystathionine gamma-lyase) hs
HG-U133_PLUS_2:217127_AT cystathionase (cystathionine gamma-lyase) hs
HG-U133A:217127_AT cystathionase (cystathionine gamma-lyase) hs
HG-U95E:77777_AT cystathionase (cystathionine gamma-lyase) hs
HG-U95C:63445_AT Cystathionase (cystathionine gamma-lyase) hs
HU35KSUBC:RC_H71497_AT Cystathionase (cystathionine gamma-lyase) hs
HU35KSUBD:RC_AA435975_AT Cystathionase (cystathionine gamma-lyase) hs
MG-U74BV2:108481_AT cystathionase (cystathionine gamma-lyase) mm
MG-U74BV2:162718_F_AT cystathionase (cystathionine gamma-lyase) mm
MOE430A:1426243_AT cystathionase (cystathionine gamma-lyase) mm
MOUSE430A_2:1426243_AT cystathionase (cystathionine gamma-lyase) mm
MOUSE430_2:1426243_AT cystathionase (cystathionine gamma-lyase) mm
MU19KSUBA:TC20511_AT Cystathionase (cystathionine gamma-lyase) (Cth), mRNA mm
MU19KSUBA:TC20781_AT Cystathionase (cystathionine gamma-lyase) (Cth), mRNA mm
RG-U34A:D17370_G_AT CTL target antigen rn
RG-U34A:D17370_AT CTL target antigen rn
RAE230A:1367838_AT CTL target antigen rn
RAT230_2:1367838_AT CTL target antigen rn
YEAST_2:1773888_AT Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6520 amino acid metabolism inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAB93432 Hypothetical protein ZK1127.10 [Caenorhabditis elegans] ref|NP_495449.1| ZK1127.10 [Caenorhabditis elegans] sp|P55216|CGL_CAEEL Putative cystathionine gamma-lyase (Gamma-cystathionase) 0.0
blast CAE56905 Hypothetical protein CBG24746 [Caenorhabditis briggsae] 0.0
blast CAB05492 Hypothetical protein F22B8.6 [Caenorhabditis elegans] ref|NP_507053.1| F22B8.6 [Caenorhabditis elegans] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000277 EMBL-EBI Cys/Met metabolism pyridoxal-phosphate-dependent enzymes 1.0E-126
Sequence
Target Sequence 
>C. ELEGANS:192114_S_AT
ggagcggatgttgtcgttcattcaattaccaagtatattaatggacattctgatgttgtt
atgggtgctgttatcactgataatgacgagttccaacaacatcttttcttcatgcaactt
gccgtcggagcagtcccatctccatttgattgcttccttgttaatcgtggactcaaaact
cttcacatcagaatgagagctcactatgaaaatgctcttgctgttgccaaataccttgaa
gccaatgatcgtatcgaatcagttctctatccagctcttccatctcatccacaacatgaa
gttcatgagaaacaaacaaagggaatgtctggaatgatctcattctatcttaaaggagaa
cttcaagagagtcgtgctttcctttctgctctcaaagtattcactttggctgaatctctt
ggaggatatgaatcacttgccgagcttccatctatcatgactcatgcttcagtgcctgct
gaaactcgaattgttcttggaatcactgataaccttatccgtatctctgt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GGAGCGGATGTTGTCGTTCATTCAA 44 523 589 Antisense
AGTTCCAACAACATCTTTTCTTCAT 560 63 677 Antisense
CATGCAACTTGCCGTCGGAGCAGTC 304 209 699 Antisense
CATCTCCATTTGATTGCTTCCTTGT 222 213 725 Antisense
GAAAATGCTCTTGCTGTTGCCAAAT 670 353 796 Antisense
TCTTCCATCTCATCCACAACATGAA 190 619 864 Antisense
TCAAGAGAGTCGTGCTTTCCTTTCT 342 631 951 Antisense
CACTTTGGCTGAATCTCTTGGAGGA 333 197 990 Antisense
GATATGAATCACTTGCCGAGCTTCC 530 425 1013 Antisense
GCTTCCATCTATCATGACTCATGCT 218 307 1032 Antisense
CTGATAACCTTATCCGTATCTCTGT 49 239 1094 Antisense
Sequence Source Affymetrix Proprietary Database