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[192084_s_at] Activin receptor

Description C32D5.2 /REP_DB=WormBase Gene ID /WP=CE01842 /GEN=sma-6 /TR=SW:Q09488 /GB=AAC46790.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=Activin receptor
Cluster 6grp_highest_10_10 > 14      6grp_high1_10_10 > 20      4grp_highest_8_8 > 51      4grp_high_8_8 > 32      6grp_highest_nonorm > 52      6grp_total > 41      4grp_total > 47      6grp_cgc > 71      6grp_cgc_sub > 03      6grp_total_sub > Hat      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1110
1 2 3 4 range
A 1482.9
(3)
P 		553.9
(-2.4)
P 		453.4
(-3)
P 		500.9
(-2.7)
P 		1030
B 1378
(3)
P 		450.5
(-3)
P 		491
(-2.7)
P 		585.4
(-2.1)
P 		928
C 1560.3
(3)
P 		555.8
(-2.5)
P 		529
(-2.6)
P 		464.7
(-3)
P 		1096
avr 1473.7
(3) 		520.1
(-2.8) 		491.1
(-3) 		517
(-2.8) 		983

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 506
1 2 3 4 5 6 range
A 661.7
(1.9)
P 		710.8
(2.7)
P 		725.6
(3)
P 		697.2
(2.5)
P 		402.1
(-2.6)
P 		379.9
(-3)
P 		346
B 724.9
(0.9)
P 		598
(-0.7)
P 		885.5
(3)
P 		632.7
(-0.3)
P 		466.8
(-2.4)
P 		421.8
(-3)
P 		464
C 676.2
(0.4)
P 		598.3
(-0.6)
P 		874
(3)
P 		745.6
(1.3)
P 		484.4
(-2.1)
P 		411.6
(-3)
P 		462
avr 687.6
(1) 		635.7
(0.3) 		828.4
(3) 		691.8
(1.1) 		451.1
(-2.3) 		404.4
(-3) 		424
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 467
1 2 3 4 range
A 539.9
(3)
P 		120.2
(-2.4)
P 		118.5
(-2.4)
P 		73.3
(-3)
P 		467
B 439.4
(3)
P 		111.3
(-3)
P 		113.8
(-3)
P 		124.7
(-2.8)
P 		328
C 516.5
(3)
P 		159.8
(-1.9)
P 		184.4
(-1.5)
P 		78.4
(-3)
P 		438
avr 498.6
(3) 		130.4
(-2.4) 		138.9
(-2.3) 		92.1
(-3) 		407

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 160
1 2 3 4 5 6 range
A 122
(-1.9)
P 		252.8
(3)
P 		158
(-0.5)
P 		176.8
(0.2)
P 		121.3
(-1.9)
P 		92.5
(-3)
P 		160
B 252.2
(3)
P 		199
(-0.4)
P 		215
(0.6)
P 		167.6
(-2.3)
P 		189.7
(-1)
P 		157.3
(-3)
P 		95
C 250.7
(3)
P 		182.6
(-0.6)
P 		222.5
(1.5)
P 		149.9
(-2.4)
P 		156.7
(-2)
P 		137.8
(-3)
P 		113
avr 208.3
(2.8) 		211.5
(3) 		198.5
(2.1) 		164.8
(-0.4) 		155.9
(-1.1) 		129.2
(-3) 		82
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 192084_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.5893
Sequence Type Exemplar sequence
Representative Public ID C32D5.2 NCBI
Target Description C32D5.2 /REP_DB=WormBase Gene ID /WP=CE01842 /GEN=sma-6 /TR=SW:Q09488 /GB=AAC46790.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=Activin receptor
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_062870(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_062870 NCBI Caenorhabditis elegans SMAll family member (sma-6) (sma-6) mRNA, complete cds. 11/11 A 
SNAP00000026826 ENSEMBL cdna:SNAP chromosome:CEL140:II:6324436:6327087:1 11/11 None
GENEFINDER00000026845 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:6324436:6327087:1 11/11 None
C32D5.2 ENSEMBL cdna:known chromosome:CEL140:II:6324431:6327299:1 gene:C32D5.2 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:6324432-6327084(+) 100.0 100.0
Public Domain and Genome References
Gene Title Activin receptor
Gene Symbol sma-6
Ensembl C32D5.2
Entrez Gene 174044 Entrez gene
SwissProt Q09488 EMBL-EBI
WormBase CE01842 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.24677.1.S1_AT similar to bone morphogenetic protein receptor, type IA precursor cfa
DROSOPHILA_2:1636221_A_AT thickveins dm
DROSGENOME1:143377_AT thickveins dm
CHICKEN:GGA.755.1.S1_AT bone morphogenetic protein receptor, type IA gga
HG-U95AV2:39565_AT bone morphogenetic protein receptor, type IA hs
HG-U133_PLUS_2:204832_S_AT bone morphogenetic protein receptor, type IA hs
HG-U133A_2:204832_S_AT bone morphogenetic protein receptor, type IA hs
HG-U133A:204832_S_AT bone morphogenetic protein receptor, type IA hs
HG-FOCUS:213578_AT bone morphogenetic protein receptor, type IA hs
HG-U133A_2:213578_AT bone morphogenetic protein receptor, type IA hs
HG-U133_PLUS_2:213578_AT bone morphogenetic protein receptor, type IA hs
HG-U133A:213578_AT bone morphogenetic protein receptor, type IA hs
HG-U95C:58485_AT bone morphogenetic protein receptor, type IA hs
HU35KSUBA:N34737_S_AT bone morphogenetic protein receptor, type IA hs
HUGENEFL:Z22535_AT bone morphogenetic protein receptor, type IA hs
U133_X3P:G4757853_3P_A_AT bone morphogenetic protein receptor, type IA hs
HG-U133_PLUS_2:230979_AT Bone morphogenetic protein receptor, type IA hs
HG-U133B:230979_AT Bone morphogenetic protein receptor, type IA hs
HG-U133_PLUS_2:243275_AT Bone morphogenetic protein receptor, type IA hs
HG-U133B:243275_AT Bone morphogenetic protein receptor, type IA hs
HG-U95D:78287_AT Bone morphogenetic protein receptor, type IA hs
HG-U95D:80703_AT Bone morphogenetic protein receptor, type IA hs
HU35KSUBC:RC_N63609_AT Bone morphogenetic protein receptor, type IA hs
HU35KSUBC:RC_N27448_AT Bone morphogenetic protein receptor, type IA hs
U133_X3P:HS.150647.0.A1_3P_AT Bone morphogenetic protein receptor, type IA hs
U133_X3P:HS.283320.0.A1_3P_AT Bone morphogenetic protein receptor, type IA hs
MU11KSUBA:U04672_S_AT bone morphogenetic protein receptor, type 1A mm
MG-U74AV2:92767_AT bone morphogenetic protein receptor, type 1A mm
MG-U74BV2:115356_S_AT bone morphogenetic protein receptor, type 1A mm
MG-U74BV2:108468_AT bone morphogenetic protein receptor, type 1A mm
MG-U74BV2:113907_AT bone morphogenetic protein receptor, type 1A mm
MG-U74CV2:171502_R_AT bone morphogenetic protein receptor, type 1A mm
MOE430A:1425491_AT bone morphogenetic protein receptor, type 1A mm
MOUSE430A_2:1425491_AT bone morphogenetic protein receptor, type 1A mm
MOUSE430_2:1425491_AT bone morphogenetic protein receptor, type 1A mm
MOE430A:1425494_S_AT bone morphogenetic protein receptor, type 1A mm
MOUSE430A_2:1425494_S_AT bone morphogenetic protein receptor, type 1A mm
MOUSE430_2:1425494_S_AT bone morphogenetic protein receptor, type 1A mm
MOE430A:1425493_AT bone morphogenetic protein receptor, type 1A mm
MOUSE430A_2:1425493_AT bone morphogenetic protein receptor, type 1A mm
MOUSE430_2:1425493_AT bone morphogenetic protein receptor, type 1A mm
MOE430A:1451729_AT bone morphogenetic protein receptor, type 1A mm
MOUSE430A_2:1451729_AT bone morphogenetic protein receptor, type 1A mm
MOUSE430_2:1451729_AT bone morphogenetic protein receptor, type 1A mm
MOE430A:1425492_AT bone morphogenetic protein receptor, type 1A mm
MOUSE430A_2:1425492_AT bone morphogenetic protein receptor, type 1A mm
MOUSE430_2:1425492_AT bone morphogenetic protein receptor, type 1A mm
MU19KSUBB:TC33237_AT Bone morphogenetic protein receptor, type 1A (Bmpr1a), mRNA mm
MU19KSUBC:TC40436_AT Bone morphogenetic protein receptor, type 1A (Bmpr1a), mRNA mm
RG-U34A:S75359_S_AT bone morphogenetic protein receptor, type 1A rn
RAE230A:1368899_AT bone morphogenetic protein receptor, type 1A rn
RAT230_2:1368899_AT bone morphogenetic protein receptor, type 1A rn
RAE230B:1378892_AT Bone morphogenetic protein receptor, type 1A rn
RAT230_2:1378892_AT Bone morphogenetic protein receptor, type 1A rn
RAE230A:1390398_AT Bone morphogenetic protein receptor, type 1A rn
RAT230_2:1390398_AT Bone morphogenetic protein receptor, type 1A rn
RG-U34C:RC_AI179372_AT Bone morphogenetic protein receptor, type 1A rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7178 transmembrane receptor protein serine/threonine kinase signaling pathway inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4675 transmembrane receptor protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4702 receptor signaling protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5024 transforming growth factor beta receptor activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAC46790 Small protein 6 [Caenorhabditis elegans] ref|NP_495271.1| SMAll family member (sma-6) [Caenorhabditis elegans] sp|Q09488|SMA6_CAEEL Serine/threonine-protein kinase sma-6 precursor gb|AAD12261.1| serine-threonine kinase SMA-6 [Caenorhabditis elegans] 0.0
blast CAE59292 Hypothetical protein CBG02627 [Caenorhabditis briggsae] 0.0
blast AAL06642 serine-threonine protein kinase [Ancylostoma caninum] 1.0E-148
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 2.2E-44
Pfam IPR000472 EMBL-EBI TGF-beta receptor/activin receptor, type I/II 1.4E-11
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_495271.1 1 191-213
C32D5.2 1 191-213
SNAP00000026826 1 191-213
GENEFINDER00000026845 1 191-213
Sequence
Target Sequence 
>C. ELEGANS:192084_S_AT
ggcagatatctactcaatggcacttgttatgtgggaagttgcaatcagggttgaggtaaa
cacctgtgaggaagtgttaactgtcgatgagacctctcctgatcacagtgcatcaagtgg
tatcggagagtcagttagttcatctggtaatatatcgagaatgcatctacaaaaaacaaa
tgtagaaggacattctacatctctgaaagcaaaacaacatgtcccaccattcgatggaat
cgtgcacaatgatcccaattttgacgagatgaacgatgtaatttgtgtacgtcgaatacg
tccaccaccggatcttgcctggaaaaacgtcccagcacttaatgaattgagcaagttgat
ggaagacagttggcattcaattccacacttccgacattctgctcttaaattgaaaaaaga
aatggctgagttgatcaaaaaccccgacagacagaatcaatcgcagcgta

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GGCAGATATCTACTCAATGGCACTT 309 535 1395 Antisense
TTAACTGTCGATGAGACCTCTCCTG 128 685 1471 Antisense
CCTCTCCTGATCACAGTGCATCAAG 651 267 1487 Antisense
AGGACATTCTACATCTCTGAAAGCA 642 53 1581 Antisense
CAACATGTCCCACCATTCGATGGAA 409 189 1609 Antisense
GATGGAATCGTGCACAATGATCCCA 412 407 1627 Antisense
CACCACCGGATCTTGCCTGGAAAAA 370 201 1697 Antisense
GGAAAAACGTCCCAGCACTTAATGA 133 527 1715 Antisense
AGTTGGCATTCAATTCCACACTTCC 519 65 1762 Antisense
CTTCCGACATTCTGCTCTTAAATTG 388 219 1782 Antisense
GACAGACAGAATCAATCGCAGCGTA 428 367 1840 Antisense
Sequence Source Affymetrix Proprietary Database