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[192044_at] Clathrin coat assembly protein

Description F02E8.3 /REP_DB=WormBase Gene ID /WP=CE07018 /TR=Q19123 /GB=AAA96207.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=Clathrin coat assembly protein
Cluster 6grp_highest_10_10 > 05      6grp_high1_10_10 > 50      4grp_highest_8_8 > 01      4grp_high_8_8 > 54      6grp_highest_nonorm > 32      6grp_total > 41      4grp_total > 50      6grp_highest_sub > 03_04      6grp_cgc > 71      6grp_high1_sub > 03_04      6grp_cgc_sub > 03      6grp_total_sub > Hat      6grp_rule_based > S3      4grp_rule_based > L2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 747
1 2 3 4 range
A 552.9
(-2)
P 		1139.1
(3)
P 		1025
(2)
P 		442.6
(-3)
P 		697
B 541.3
(-1.8)
P 		1119.4
(3)
P 		1093.8
(2.8)
P 		392.1
(-3)
P 		727
C 569
(-1.9)
P 		1070.1
(3)
P 		1029.3
(2.6)
P 		451.3
(-3)
P 		619
avr 554.4
(-1.9) 		1109.5
(3) 		1049.4
(2.5) 		428.7
(-3) 		681

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1279
1 2 3 4 5 6 range
A 1173.7
(1)
P 		1021.2
(0.3)
P 		1594.3
(3)
P 		1160.1
(1)
P 		713.6
(-1.1)
P 		315.3
(-3)
P 		1279
B 1250.8
(1.4)
P 		1196.9
(1.1)
P 		1514.5
(3)
P 		1166.6
(0.9)
P 		857.1
(-1)
P 		532.4
(-3)
P 		982
C 921.7
(-0.2)
P 		1091.3
(1.3)
P 		1053.9
(1)
P 		1276.9
(3)
P 		612.3
(-3)
P 		727.9
(-2)
P 		665
avr 1115.4
(1.1) 		1103.1
(1) 		1387.6
(3) 		1201.2
(1.7) 		727.7
(-1.6) 		525.2
(-3) 		862
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 294
1 2 3 4 range
A 201.3
(1)
P 		247.3
(2.4)
P 		268
(3)
P 		64.8
(-3)
P 		203
B 172.6
(-0.2)
P 		276.5
(3)
P 		253.5
(2.3)
P 		83.6
(-3)
P 		193
C 188.3
(-0.6)
P 		307.7
(1.9)
P 		358.7
(3)
P 		76.1
(-3)
P 		283
avr 187.4
(0.1) 		277.2
(2.6) 		293.4
(3) 		74.8
(-3) 		219

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 358
1 2 3 4 5 6 range
A 216.4
(-0.1)
P 		363.2
(3)
P 		347.2
(2.7)
P 		294.2
(1.6)
P 		215.3
(-0.1)
P 		76.8
(-3)
P 		286
B 435.2
(3)
P 		398.4
(2.1)
P 		367.8
(1.3)
P 		309
(-0.2)
P 		348.2
(0.8)
P 		198.5
(-3)
P 		237
C 341.6
(3)
P 		333
(2.6)
P 		268.2
(-0.1)
P 		256.8
(-0.5)
P 		198.1
(-3)
P 		243.7
(-1.1)
P 		144
avr 331.1
(1.9) 		364.9
(3) 		327.7
(1.8) 		286.7
(0.6) 		253.9
(-0.5) 		173
(-3) 		192
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 192044_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.17287
Sequence Type Exemplar sequence
Representative Public ID F02E8.3 NCBI
Target Description F02E8.3 /REP_DB=WormBase Gene ID /WP=CE07018 /TR=Q19123 /GB=AAA96207.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=Clathrin coat assembly protein
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_076366(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_076366 NCBI Caenorhabditis elegans AP-2 Small chain (clathrin associated complex) family member (aps-2) (aps-2) mRNA, complete cds. 11/11 None
SNAP00000018047 ENSEMBL cdna:SNAP chromosome:CEL140:X:4458245:4459093:1 11/11 None
GENEFINDER00000018056 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:4458245:4459093:1 11/11 None
F02E8.3 ENSEMBL cdna:known chromosome:CEL140:X:4458245:4459238:1 gene:F02E8.3 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:4458245-4459094(+) 100.0 100.0
Public Domain and Genome References
Gene Title Clathrin coat assembly protein
Gene Symbol aps-2
Ensembl F02E8.3
Entrez Gene 184091 Entrez gene
SwissProt Q19123 EMBL-EBI
WormBase CE07018 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:261733_AT clathrin coat assembly protein, putative at
CANINE_2:CFAAFFX.7214.1.S1_AT similar to adaptor-related protein complex 2, sigma 1 subunit isoform AP17delta cfa
DROSOPHILA_2:1627202_AT dm
DROSGENOME1:150308_AT dm
HG-U133_PLUS_2:211047_X_AT adaptor-related protein complex 2, sigma 1 subunit hs
HG-U133A:211047_X_AT adaptor-related protein complex 2, sigma 1 subunit hs
HG-U133A_2:211047_X_AT adaptor-related protein complex 2, sigma 1 subunit hs
HG-U133A_2:202120_X_AT adaptor-related protein complex 2, sigma 1 subunit hs
HG-U133A:202120_X_AT adaptor-related protein complex 2, sigma 1 subunit hs
HG-U133_PLUS_2:202120_X_AT adaptor-related protein complex 2, sigma 1 subunit hs
HG-U133_PLUS_2:208074_S_AT adaptor-related protein complex 2, sigma 1 subunit hs
HG-U133A:208074_S_AT adaptor-related protein complex 2, sigma 1 subunit hs
HG-FOCUS:208074_S_AT adaptor-related protein complex 2, sigma 1 subunit hs
HG-U133A_2:208074_S_AT adaptor-related protein complex 2, sigma 1 subunit hs
HUGENEFL:X97074_AT adaptor-related protein complex 2, sigma 1 subunit hs
U133_X3P:G13623468_3P_S_AT adaptor-related protein complex 2, sigma 1 subunit hs
U133_X3P:G11038642_3P_S_AT adaptor-related protein complex 2, sigma 1 subunit hs
HG-U95AV2:39347_AT adaptor-related protein complex 2, sigma 1 subunit hs
MU11KSUBB:MSA.5523.0_S_AT adaptor-related protein complex 2, sigma 1 subunit mm
MOE430A:1433612_AT adaptor-related protein complex 2, sigma 1 subunit mm
MOUSE430A_2:1433612_AT adaptor-related protein complex 2, sigma 1 subunit mm
MOUSE430_2:1433612_AT adaptor-related protein complex 2, sigma 1 subunit mm
MG-U74AV2:96638_AT Adaptor-related protein complex 2, sigma 1 subunit (Ap2s1), mRNA mm
MG-U74AV2:96639_AT Adaptor-related protein complex 2, sigma 1 subunit (Ap2s1), mRNA mm
MU11KSUBB:MSA.15146.0_AT Adaptor-related protein complex 2, sigma 1 subunit (Ap2s1), mRNA mm
MU19KSUBC:TC39179_AT Adaptor-related protein complex 2, sigma 1 subunit (Ap2s1), mRNA mm
MU19KSUBC:TC39180_AT Adaptor-related protein complex 2, sigma 1 subunit (Ap2s1), mRNA mm
MU11KSUBB:W29424_AT Adaptor-related protein complex 2, sigma 1 subunit (Ap2s1), mRNA mm
MU11KSUBA:D18822_RC_AT Adaptor-related protein complex 2, sigma 1 subunit (Ap2s1), mRNA mm
RG-U34A:U75917_AT adaptor-related protein complex 2, sigma 1 subunit rn
RG-U34A:U75917_G_AT adaptor-related protein complex 2, sigma 1 subunit rn
RAE230A:1386877_AT adaptor-related protein complex 2, sigma 1 subunit rn
RAT230_2:1386877_AT adaptor-related protein complex 2, sigma 1 subunit rn
YEAST_2:1769735_AT Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6886 intracellular protein transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
30125 clathrin vesicle coat inferred from electronic annotation QuickGO AmiGO
5623 cell inferred from direct assay QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
30276 clathrin binding inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAA96207 Ap-2 small chain (clathrin associated complex) protein 2 [Caenorhabditis elegans] ref|NP_508767.1| AP-2 Small chain (clathrin associated complex) family member (aps-2) [Caenorhabditis elegans] emb|CAE68596.1| Hypothetical protein CBG14467 [Caenorhabditis briggsae] 9.0E-79
blast NP_001016325 hypothetical protein LOC549079 [Xenopus tropicalis] gb|AAH78470.1| MGC85224 protein [Xenopus laevis] gb|AAH58042.1| Zgc:65827 [Danio rerio] ref|NP_998320.1| hypothetical protein LOC406429 [Danio rerio] 1.0E-74
blast XP_512774 PREDICTED: hypothetical protein XP_512774 [Pan troglodytes] ref|NP_004060.2| adaptor-related protein complex 2, sigma 1 subunit isoform AP17 [Homo sapiens] ref|XP_533634.1| PREDICTED: similar to Clathrin coat assembly protein AP17 (Clathrin coat associated protein AP17) (Plasma membrane adaptor AP-2 17 kDa protein) (Clathrin assembly protein 2 small chain) isoform 1 [Canis familiaris] emb|CAH91720.1| hypothetical protein [Pongo pygmaeus] gb|AAH06337.1| Adaptor-related protein complex 2, sigma 1 subunit, isoform AP17 [Homo sapiens] gb|AAH88138.1| Adaptor-related protein complex 2, sigma 1 subunit [Rattus norvegicus] dbj|BAE27279.1| unnamed protein product [Mus musculus] ref|NP_075241.2| adaptor-related protein complex 2, sigma 1 subunit [Rattus norvegicus] sp|P62744|AP2S1_RAT Clathrin coat assembly protein AP17 (Clathrin coat-associated protein AP17) (Plasma membrane adaptor AP-2 17 kDa protein) (Clathrin assembly protein 2 small chain) sp|Q5R940|AP2S1_PONPY Clathrin coat assembly protein AP17 (Clathrin coat-associated protein AP17) (Plasma membrane adaptor AP-2 17 kDa protein) (Clathrin assembly protein 2 small chain) sp|P62743|AP2S1_MOUSE Clathrin coat assembly protein AP17 (Clathrin coat-associated protein AP17) (Plasma membrane adaptor AP-2 17 kDa protein) (Clathrin assembly protein 2 small chain) sp|P53680|AP2S1_HUMAN Clathrin coat assembly protein AP17 (Clathrin coat-associated protein AP17) (Plasma membrane adaptor AP-2 17 kDa protein) (HA2 17 kDa subunit) (Clathrin assembly protein 2 small chain) pdb|1GW5|S Chain S, Ap2 Clathrin Adaptor Core gb|AAA40742.1| clathrin-associated protein 4.0E-74
Protein Domains
Database ID Description E-Value
Pfam IPR000804 EMBL-EBI Clathrin adaptor complex, small chain 5.5E-91
Sequence
Target Sequence 
>C. ELEGANS:192044_AT
tattctgatccaaaaccgtgccggtaagacaagattggccaaatggtatatgcactttga
cgacgatgagaaacaaaaactgatcgaagaagttcatgcgtgtgtgaccgtgcgagatgc
caagcacacgaatttcgtcgagttccgcaacttcaaaatcgtatatcgtcgctacgccgg
gctgtacttctgcatttgtgttgacatcaccgacaataacctttactatctggaagctat
tcacaattttgtcgaggttctcaacgagtacttccacaatgtgtgcgagctcgatttggt
gttcaacttctacaaagtgtacacagtcgtcgacgagatgttccttgccggcgagatccg
tgaaa

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TATTCTGATCCAAAACCGTGCCGGT 664 663 24 Antisense
GAAGTTCATGCGTGTGTGACCGTGC 298 335 112 Antisense
GTGTGTGACCGTGCGAGATGCCAAG 428 487 123 Antisense
AGATGCCAAGCACACGAATTTCGTC 470 65 138 Antisense
CGAATTTCGTCGAGTTCCGCAACTT 667 251 152 Antisense
AAAATCGTATATCGTCGCTACGCCG 625 131 178 Antisense
GACATCACCGACAATAACCTTTACT 433 365 226 Antisense
GTACTTCCACAATGTGTGCGAGCTC 503 459 291 Antisense
GTGCGAGCTCGATTTGGTGTTCAAC 275 479 306 Antisense
CAAAGTGTACACAGTCGTCGACGAG 23 193 336 Antisense
TTCCTTGCCGGCGAGATCCGTGAAA 625 697 364 Antisense
Sequence Source Affymetrix Proprietary Database