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[192015_s_at]

Description C38C3.5A /REP_DB=WormBase Gene ID /WP=CE20547 /GEN=unc-60 /GB=AAD14703.1 /SUBMIT=ST.LOUIS /CHR=5 /FEA=Sanger Annotation /DEF=actin depolymerizing factor
Cluster 6grp_highest_10_10 > 70      6grp_high1_10_10 > 07      4grp_highest_8_8 > 25      4grp_high_8_8 > 60      6grp_highest_nonorm > 0      6grp_total > 18      4grp_total > 59      6grp_highest_sub > De      6grp_cgc > 01      6grp_total_sub > Decrease      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1366
1 2 3 4 range
A 1800.8
(1.3)
P 		1892.1
(1.8)
P 		2113.8
(3)
P 		1017.8
(-3)
P 		1096
B 1901.3
(1.4)
P 		1909.9
(1.5)
P 		2219.9
(3)
P 		989.3
(-3)
P 		1231
C 1790.1
(1.2)
P 		2184
(3)
P 		2052.5
(2.4)
P 		854.4
(-3)
P 		1330
avr 1830.7
(1.5) 		1995.3
(2.3) 		2128.7
(3) 		953.8
(-3) 		1175

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1808
1 2 3 4 5 6 range
A 1812.1
(3)
P 		1511.8
(-0.3)
P 		1267.4
(-3)
P 		1360.6
(-2)
P 		1507.5
(-0.4)
P 		1598.6
(0.6)
P 		545
B 1785.5
(3)
P 		1610.2
(1.6)
P 		1397.3
(-0.1)
P 		1629.1
(1.8)
P 		1426.5
(0.2)
P 		1027.7
(-3)
P 		758
C 2835.6
(3)
P 		1685.2
(-1.1)
P 		1226.3
(-2.7)
P 		1606.9
(-1.3)
P 		1342.9
(-2.3)
P 		1136.9
(-3)
P 		1699
avr 2144.4
(3) 		1602.4
(-0.7) 		1297
(-2.7) 		1532.2
(-1.1) 		1425.6
(-1.8) 		1254.4
(-3) 		890
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 571
1 2 3 4 range
A 655.7
(3)
P 		410.7
(0.1)
P 		552.6
(1.8)
P 		149
(-3)
P 		507
B 606.3
(3)
P 		471.7
(1)
P 		514.4
(1.6)
P 		210.8
(-3)
P 		396
C 592.6
(1.7)
P 		627.9
(2.1)
P 		715.3
(3)
P 		144.1
(-3)
P 		571
avr 618.2
(3) 		503.4
(1.5) 		594.1
(2.7) 		168
(-3) 		450

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 775
1 2 3 4 5 6 range
A 334
(-1.7)
P 		537.7
(3)
P 		276
(-3)
P 		345.1
(-1.4)
P 		454.9
(1.1)
P 		389.2
(-0.4)
P 		262
B 621.3
(3)
P 		536
(1.2)
P 		339.3
(-3)
P 		431.5
(-1)
P 		579.6
(2.1)
P 		383.2
(-2.1)
P 		282
C 1051
(3)
P 		514.2
(-1.4)
P 		312.1
(-3)
P 		323.2
(-2.9)
P 		434.5
(-2)
P 		380.6
(-2.4)
P 		739
avr 668.8
(3) 		529.3
(0.7) 		309.1
(-3) 		366.6
(-2) 		489.7
(0) 		384.3
(-1.7) 		360
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 192015_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.14939
Sequence Type Exemplar sequence
Representative Public ID C38C3.5A NCBI
Target Description C38C3.5A /REP_DB=WormBase Gene ID /WP=CE20547 /GEN=unc-60 /GB=AAD14703.1 /SUBMIT=ST.LOUIS /CHR=5 /FEA=Sanger Annotation /DEF=actin depolymerizing factor
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_071025(11), NM_071024(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_071025 NCBI Caenorhabditis elegans UNCoordinated family member (unc-60) (unc-60) mRNA, complete cds. 11/11 None
NM_071024 NCBI Caenorhabditis elegans UNCoordinated family member (unc-60) (unc-60) mRNA, complete cds. 11/11 None
SNAP00000040087 ENSEMBL cdna:SNAP chromosome:CEL140:V:1475153:1475901:1 10/11 None
GENEFINDER00000040106 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:1475153:1475901:1 10/11 None
C38C3.5b ENSEMBL cdna:known chromosome:CEL140:V:1474901:1479407:1 gene:C38C3.5 11/11 None
C38C3.5a ENSEMBL cdna:known chromosome:CEL140:V:1474915:1476608:1 gene:C38C3.5 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Splice Variants
Entrez Total Refseq Isoforms Total Detected By This Probeset Refseq Probesets
178640 3 2 NM_071024 171748_x_at (11), 174141_at (11), 192015_s_at (11)
NM_071025 192015_s_at (11)
NM_071026 193210_s_at (11)
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:1475139-1475901(+) 99.6 99.6
Public Domain and Genome References
Ensembl C38C3.5
Functional Annotations
Protein Similarities
Method ID Description E-Value
blast AAL02462 Uncoordinated protein 60, isoform b [Caenorhabditis elegans] ref|NP_503426.2| UNCoordinated family member (unc-60) [Caenorhabditis elegans] 1.0E-114
blast AAL02461 Uncoordinated protein 60, isoform a [Caenorhabditis elegans] ref|NP_503425.2| UNCoordinated family member (unc-60) [Caenorhabditis elegans] sp|Q07750|ADF1_CAEEL Actin-depolymerizing factor 1 (Uncoordinated protein 60) gb|AAC14458.1| putative. cofilin/destrin homolog. This CDS encodes the first transcript produced from the unc-60 locus. Both transcripts exhibit cofilin/destrin homologies, and share only the 5'-most exon which encodes the initiator methionine [Caenorhabditis elegans] 5.0E-89
blast AAL02461 Uncoordinated protein 60, isoform a [Caenorhabditis elegans] ref|NP_503425.2| UNCoordinated family member (unc-60) [Caenorhabditis elegans] sp|Q07750|ADF1_CAEEL Actin-depolymerizing factor 1 (Uncoordinated protein 60) gb|AAC14458.1| putative. cofilin/destrin homolog. This CDS encodes the first transcript produced from the unc-60 locus. Both transcripts exhibit cofilin/destrin homologies, and share only the 5'-most exon which encodes the initiator methionine [Caenorhabditis elegans] 2.0E-86
blast AAL02462 Uncoordinated protein 60, isoform b [Caenorhabditis elegans] ref|NP_503426.2| UNCoordinated family member (unc-60) [Caenorhabditis elegans] 5.0E-83
blast AAL02461 Uncoordinated protein 60, isoform a [Caenorhabditis elegans] ref|NP_503425.2| UNCoordinated family member (unc-60) [Caenorhabditis elegans] sp|Q07750|ADF1_CAEEL Actin-depolymerizing factor 1 (Uncoordinated protein 60) gb|AAC14458.1| putative. cofilin/destrin homolog. This CDS encodes the first transcript produced from the unc-60 locus. Both transcripts exhibit cofilin/destrin homologies, and share only the 5'-most exon which encodes the initiator methionine [Caenorhabditis elegans] 1.0E-82
Protein Domains
Database ID Description E-Value
Pfam IPR002108 EMBL-EBI Actin-binding, cofilin/tropomyosin type 1.2E-57
Pfam IPR002108 EMBL-EBI Actin-binding, cofilin/tropomyosin type 7.1E-20
Pfam IPR002108 EMBL-EBI Actin-binding, cofilin/tropomyosin type 1.2E-61
Pfam IPR002108 EMBL-EBI Actin-binding, cofilin/tropomyosin type 1.2E-61
Pfam IPR002108 EMBL-EBI Actin-binding, cofilin/tropomyosin type 3.6E-52
Sequence
Target Sequence 
>C. ELEGANS:192015_S_AT
gtgtcatggtcgacccagatgtgcagacatctttccaaaagctctccgagggacgcaagg
agtaccgctacatcattttcaagatcgacgagaacaaggtgatcgtggaagccgcggtga
ctcaggatcagctcggcatcactggagacgactatgatgactcttccaaggccgctttcg
acaaattcgtcgaggacgtgaagtctcgaaccgataatctgaccgattgccgctacgccg
ttttcgacttcaagttcacgtgcagtcgtgttggagccggcacgagcaagatggacaaga
tcatcttcctccagatctgcccagatggtgcttctatcaagaaaaagatggtgtacgctt
cgtccgccgccgccatcaagacttctctcggaaccggcaaaatccttcagttccag

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTGTCATGGTCGACCCAGATGTGCA 260 487 23 Antisense
AGACATCTTTCCAAAAGCTCTCCGA 618 71 47 Antisense
GAGTACCGCTACATCATTTTCAAGA 334 399 82 Antisense
TCAGGATCAGCTCGGCATCACTGGA 414 623 144 Antisense
CGACTATGATGACTCTTCCAAGGCC 16 253 171 Antisense
GCCGTTTTCGACTTCAAGTTCACGT 30 283 259 Antisense
CGTGCAGTCGTGTTGGAGCCGGCAC 294 243 281 Antisense
GATCTGCCCAGATGGTGCTTCTATC 455 419 336 Antisense
AAAAGATGGTGTACGCTTCGTCCGC 65 131 365 Antisense
CCGCCATCAAGACTTCTCTCGGAAC 137 263 392 Antisense
AACCGGCAAAATCCTTCAGTTCCAG 376 145 414 Antisense
Sequence Source Affymetrix Proprietary Database